Pediatric Surgery International最新文献

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Mental health sequelae of violent injury in children: a review.
IF 1.5 3区 医学
Pediatric Surgery International Pub Date : 2025-03-04 DOI: 10.1007/s00383-025-05991-2
Jennifer M Schuh, Stephen J Molitor, Danielle J Wilson, Patricia K Marik, Elizabeth Fischer, Casey M Calkins, Katherine T Flynn-O'Brien
{"title":"Mental health sequelae of violent injury in children: a review.","authors":"Jennifer M Schuh, Stephen J Molitor, Danielle J Wilson, Patricia K Marik, Elizabeth Fischer, Casey M Calkins, Katherine T Flynn-O'Brien","doi":"10.1007/s00383-025-05991-2","DOIUrl":"https://doi.org/10.1007/s00383-025-05991-2","url":null,"abstract":"<p><p>In the last decade, increasing attention has been paid to the magnitude and characterization of the relationship between violent injury and mental health, with trauma centers progressively focusing on screening and intervention strategies. This review aims to characterize the mental health sequelae of violent injury on children, highlighting effective screening and intervention tools. Violent injury compared to non-violent injury incurs a greater risk for poor mental health outcomes. Risk of acute stress disorder and post-traumatic stress disorder are among the best characterized, but anxiety, depression, and substance use disorders are also correlated to violent injury in children. Mental health sequelae are pervasive, and have lasting, significant physical and psychosocial consequences. Globally, the impact of mental health sequelae of violent injury is underrecognized and undertreated. Provider awareness, and early and efficacious screening can facilitate tailored intervention strategies.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"90"},"PeriodicalIF":1.5,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of follow-up liver biopsy on long-term outcomes post-Kasai procedure in patients with biliary atresia.
IF 1.5 3区 医学
Pediatric Surgery International Pub Date : 2025-02-28 DOI: 10.1007/s00383-025-05979-y
Koki Takase, Takehisa Ueno, Sayaka Matsumoto, Naoko Uga, Koichi Deguchi, Motonari Nomura, Miho Watanabe, Masafumi Kamiyama, Yuko Tazuke, Takeshi Kimura, Hiroomi Okuyama
{"title":"Impact of follow-up liver biopsy on long-term outcomes post-Kasai procedure in patients with biliary atresia.","authors":"Koki Takase, Takehisa Ueno, Sayaka Matsumoto, Naoko Uga, Koichi Deguchi, Motonari Nomura, Miho Watanabe, Masafumi Kamiyama, Yuko Tazuke, Takeshi Kimura, Hiroomi Okuyama","doi":"10.1007/s00383-025-05979-y","DOIUrl":"10.1007/s00383-025-05979-y","url":null,"abstract":"<p><strong>Purpose: </strong>Patients with biliary atresia (BA) suffer from progressive liver damage, even after successful Kasai portoenterostomy (KPE). The purpose of this study is to analyze the relevance of follow-up percutaneous liver biopsy (LBx) and long-term prognosis of patients with BA.</p><p><strong>Methods: </strong>This study included patients with BA who were born between 1983 and 2005 and survived with their native liver until 10 years of age. Patient characteristics, laboratory data and Child-Pugh score at the time of LBx, and native-liver survival (NLS) and complication-free survival (CFS) in patients with mild (F0-F2) or severe fibrosis (F3, F4) on follow-up LBx were retrospectively analyzed.</p><p><strong>Results: </strong>Forty-three patients were gathered in this study and the most recent LBx was performed at age 21.1 ± 2.9 years. Thirty-three patients had mild fibrosis and ten patients had severe fibrosis on follow-up LBx. Long-term NLS and CFS were significantly worse in patients with severe fibrosis. Among those patients, 18 patients had follow-up LBx between the ages of 6 and 12 years, and CFS were significantly worse in patients with severe fibrosis.</p><p><strong>Conclusions: </strong>We found that patients with BA with severe liver fibrosis on follow-up LBx had worse long-term survival and a higher rate of progression of complications of BA.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"88"},"PeriodicalIF":1.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11870969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical characteristics, surgical approaches, and prognosis of follicular and papillary thyroid cancer in children and adolescents: a retrospective cohort study.
IF 1.5 3区 医学
Pediatric Surgery International Pub Date : 2025-02-28 DOI: 10.1007/s00383-025-05990-3
Yuhui Liu, Tingting Meng, Shuang Ma, Yanqing Zheng, Yutang Miao, Tao Zhang
{"title":"Clinical characteristics, surgical approaches, and prognosis of follicular and papillary thyroid cancer in children and adolescents: a retrospective cohort study.","authors":"Yuhui Liu, Tingting Meng, Shuang Ma, Yanqing Zheng, Yutang Miao, Tao Zhang","doi":"10.1007/s00383-025-05990-3","DOIUrl":"https://doi.org/10.1007/s00383-025-05990-3","url":null,"abstract":"<p><strong>Purpose: </strong>Follicular and papillary thyroid cancers are prevalent endocrine tumors in children and adolescents. This study seeks to highlight distinctions between papillary thyroid cancer  (PTC) and follicular thyroid cancer  (FTC) to inform subtype-specific guidelines.</p><p><strong>Patients and methods: </strong>Utilizing data from the SEER database, this study contrasts the clinical features, survival rates, causes of death, TNM staging, and surgical interventions for pediatric and adolescent patients diagnosed with PTC and FTC from 2000 to 2020.</p><p><strong>Results: </strong>We analyzed 3068 pediatric and adolescent patients with differentiated thyroid cancer (DTC). Since 2005, PTC incidence has increased, while FTC remains stable. Both subtypes exhibit excellent survival rates; FTC shows near-perfect outcomes, and PTC's overall survival (OS) at 2, 5, and 10 years is 99.6, 99.2, and 98.5%, respectively. Thyroid cancer accounted for only 20.9% of deaths among PTC patients. Significant differences in T and N staging were observed. Regarding surgery, 70% of FTC patients underwent total or near-total thyroidectomy compared to 90% of PTC patients. Lymph node dissection was performed in 41.7% of FTC and 77.5% of PTC patients, indicating distinct surgical approaches.</p><p><strong>Conclusion: </strong>Pediatric and adolescent patients with FTC and PTC have excellent prognoses. The extent of thyroidectomy and criteria for prophylactic central lymph node dissection should be tailored specifically for FTC and PTC, rather than generalizing under DTC.</p><p><strong>Clinical trial information: </strong>NCT06592118.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"89"},"PeriodicalIF":1.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143524062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Robotic-assisted Swenson procedure for Hirschsprung's disease with a median age of 35 days: a single-center retrospective study.
IF 1.5 3区 医学
Pediatric Surgery International Pub Date : 2025-02-27 DOI: 10.1007/s00383-025-05988-x
Jinfeng Hou, Wei Feng, Hanbin Zhao, Mengying Cui, Yi Wang, Zhenhua Guo, Wei Liu
{"title":"Robotic-assisted Swenson procedure for Hirschsprung's disease with a median age of 35 days: a single-center retrospective study.","authors":"Jinfeng Hou, Wei Feng, Hanbin Zhao, Mengying Cui, Yi Wang, Zhenhua Guo, Wei Liu","doi":"10.1007/s00383-025-05988-x","DOIUrl":"https://doi.org/10.1007/s00383-025-05988-x","url":null,"abstract":"<p><strong>Purpose: </strong>The treatment of Hirschsprung's disease (HD) in infants with the robotic-assisted Swenson procedure has been rarely reported. In this investigation, we aimed to explore the safety and the efficacy of robotic-assisted Swenson procedure for the HD in infants.</p><p><strong>Methods: </strong>From November 2022 to July 2023, 17 cases of HD were treated with the Da Vinci robotic Xi surgical system using a three-port approach. Preoperative, intraoperative, and postoperative data were collected and compared with 43 cases of HD treated with laparoscopy by the same lead surgeon.</p><p><strong>Results: </strong>The robotic-assisted surgery (RAS) group included 17 infants, and the laparoscopic surgery (LS) group included 43 infants, with a median surgical age of 35 days for both groups. There were no statistically significant differences between the two groups in terms of surgical age, gender, preoperative weight, preoperative hospital stay, preoperative enema time, and incidence of preoperative enterocolitis. Estimated intraoperative blood loss and transfusion rate in the RAS group were both lower than in the LS group, with statistically significant differences. There were no statistically significant differences in early and midterm postoperative complications (anastomotic leaks, anastomotic strictures, enterocolitis, etc.) between the two groups.</p><p><strong>Conclusion: </strong>This study demonstrates the efficacy and the safety of robotic-assisted Swenson procedure in infants.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"87"},"PeriodicalIF":1.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The predictive value of the aspartate aminotransferase to platelet ratio index combined with liver biochemical indexes for 2 years native liver survival in patients with biliary atresia.
IF 1.5 3区 医学
Pediatric Surgery International Pub Date : 2025-02-26 DOI: 10.1007/s00383-025-05986-z
Bingliang Li, Yingyu Jia, Hongwei Xi, Hongxia Ren
{"title":"The predictive value of the aspartate aminotransferase to platelet ratio index combined with liver biochemical indexes for 2 years native liver survival in patients with biliary atresia.","authors":"Bingliang Li, Yingyu Jia, Hongwei Xi, Hongxia Ren","doi":"10.1007/s00383-025-05986-z","DOIUrl":"https://doi.org/10.1007/s00383-025-05986-z","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the predictive value of the aspartate aminotransferase-to-platelet ratio index (APRI) in combination with liver biochemical indices on the time to native liver survival (NLS) in patients with biliary atresia (BA) two years after Kasai portoenterostomy (KPE).</p><p><strong>Methods: </strong>The clinical data from 2013 to 2022 at Shanxi Children's Hospital were analyzed. Patients were divided into two groups based on whether they survived with their native liver 2 years after KPE. General information and laboratory findings were reviewed before and then monthly after KPE until 3 months postoperatively. APRI was calculated.</p><p><strong>Results: </strong>A total of 125 children with type III BA were included. There were statistically significant differences in the preoperative AST, GGT, APRI, liver fibrosis stage and jaundice clearance rate between two groups. The AUC of APRI at 3 months for predicting NLS was 0.732. The AUC of APRI at 3 months in predicting the 2-year NLS time in children with BA was higher than the single index.</p><p><strong>Conclusion: </strong>The prediction value of APRI for 2-year NLS time increases when combined with other indicators, and is better than single indicator, the prediction value is strongest when APRI is combined with all indicators.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"85"},"PeriodicalIF":1.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of cervical versus thoracic spinal cord injury outcomes in pediatric trauma patients.
IF 1.5 3区 医学
Pediatric Surgery International Pub Date : 2025-02-26 DOI: 10.1007/s00383-024-05933-4
Alice M Martino, Areg Grigorian, Catherine M Kuza, Sigrid Burruss, Lourdes Swentek, Yigit Guner, Laura F Goodman, Jeffry Nahmias
{"title":"Comparison of cervical versus thoracic spinal cord injury outcomes in pediatric trauma patients.","authors":"Alice M Martino, Areg Grigorian, Catherine M Kuza, Sigrid Burruss, Lourdes Swentek, Yigit Guner, Laura F Goodman, Jeffry Nahmias","doi":"10.1007/s00383-024-05933-4","DOIUrl":"10.1007/s00383-024-05933-4","url":null,"abstract":"<p><strong>Purpose: </strong>To explore differences based on level of pediatric spinal cord injury (SCI), we compared cervical and thoracic SCI in pediatric trauma patients (PTPs), hypothesizing higher mortality and length of stay (LOS) for cervical SCI.</p><p><strong>Methods: </strong>The 2017-2021 Trauma Quality Improvement Program was queried for all PTPs ≤ 17 years-old with cervical or thoracic SCI. Bivariate analyses compared the two groups. The primary outcome was mortality and secondary outcomes included hospital LOS and injury severity scores (ISS). Logistic regression models were used to determine independent risk factors for death and prolonged ventilation.</p><p><strong>Results: </strong>Of 5280 PTPs, 2538 (65.9%) had cervical SCI and 1316 (34.1%) had thoracic SCI. Motor vehicle collisions were the most common cause of both cervical and thoracic SCI (37.8 and 41.9%). PTPs with thoracic SCI had higher rates of positive drug screen as compared to cervical SCI (39.2 vs 29.8%, p = 0.001). PTPs with thoracic SCI had higher median ISS (25 vs 16, p < 0.001), while cervical SCI had higher mortality (13 vs 6.1%, p < 0.001) but decreased hospital LOS (median 9 vs 5 days, p < 0.001. Cervical SCI were associated with a nearly fourfold increase in the risk of death (95% CI 2.750-5.799, p < 0.001) and a 1.6-fold increase in the risk of prolonged ventilator requirement (95% CI 1.228-2.068, p < 0.001).</p><p><strong>Conclusions: </strong>PTPs with cervical SCI have higher mortality while those with thoracic SCI have higher ISS and hospital LOS. Cervical SCI were associated with a fourfold higher risk of death. MVC was the most common cause of injury, and both groups had high rates of positive drug screens. Understanding differing outcomes may assist providers with prognostication and injury prevention.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"86"},"PeriodicalIF":1.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic factors of desmoplastic small round cell tumor in children and adolescents: a population-based study.
IF 1.5 3区 医学
Pediatric Surgery International Pub Date : 2025-02-24 DOI: 10.1007/s00383-025-05987-y
Dazhou Wu, Lingling Zhao, Zhenqi Liao, Laiyue Luo, Xianming Yao
{"title":"Prognostic factors of desmoplastic small round cell tumor in children and adolescents: a population-based study.","authors":"Dazhou Wu, Lingling Zhao, Zhenqi Liao, Laiyue Luo, Xianming Yao","doi":"10.1007/s00383-025-05987-y","DOIUrl":"https://doi.org/10.1007/s00383-025-05987-y","url":null,"abstract":"<p><strong>Purpose: </strong>Desmoplastic small round cell tumor (DSRCT) in children is extremely rare and aggressive. We aimed to conduct a population-based cohort study to predict overall survival (OS) in pediatric patients with DSRCT.</p><p><strong>Methods: </strong>Using the Surveillance, Epidemiology and End Results (SEER) database, all pediatric patients diagnosed with DSRCT between 2000 and 2018 were located. Kaplan-Meier estimates were used to generate survival curves based on different criteria. The survival curves were compared using the log-rank test. Cox proportional-hazards regression was used to identify the variables related to overall survival (OS).</p><p><strong>Results: </strong>A total of 129 pediatric DSRCT patients were identified. The tumors primarily affected males (70.5%) and distant metastasis was present in 65.9% of all cases. Most of them received surgery (61.3%). Chemotherapy and radiotherapy were utilized in 90% and 41.8% of cases, respectively. Overall 1-year, 3-year, and 5-year survival rates for all patients were 81.9%, 37.9%, and 22.6%, respectively. Patients with distant stage showed a greater risk of mortality (hazard ratio (HR) 4.75, 95% confidence interval (CI) 1.87-12.0; P = 0.001). In addition, patients who received radiotherapy had a lower risk of mortality (hazard ratio (HR) 0.45, 95% confidence interval (CI) 0.25-0.81; P = 0.008).</p><p><strong>Conclusions: </strong>DSRCT is a rare malignancy with a generally poor prognosis. Our findings demonstrated that SEER stage and radiotherapy were significant predictors of OS in pediatric DSRCT. Radiotherapy has the potential to improve the prognosis for pediatric patients.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"84"},"PeriodicalIF":1.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An enhanced recovery after surgery (ERAS) pathway for laparoscopic gastrostomy insertion facilitates 23-h discharge.
IF 1.5 3区 医学
Pediatric Surgery International Pub Date : 2025-02-17 DOI: 10.1007/s00383-025-05984-1
Hetal N Patel, Benjamin Martin, Bhavini Pisavadia, Giampiero Soccorso, Ingo Jester, Max Pachl, Michael Singh, Anthony Lander, G Suren Arul
{"title":"An enhanced recovery after surgery (ERAS) pathway for laparoscopic gastrostomy insertion facilitates 23-h discharge.","authors":"Hetal N Patel, Benjamin Martin, Bhavini Pisavadia, Giampiero Soccorso, Ingo Jester, Max Pachl, Michael Singh, Anthony Lander, G Suren Arul","doi":"10.1007/s00383-025-05984-1","DOIUrl":"https://doi.org/10.1007/s00383-025-05984-1","url":null,"abstract":"<p><strong>Background: </strong>Enhanced recovery after surgery (ERAS) pathways has become well established for operations as diverse as hip replacement and coronary artery bypass. We designed an ERAS gastrostomy pathway in children based on best practice to facilitate 23-h discharge.</p><p><strong>Methods: </strong>An ERAS pathway for laparoscopic Seldinger gastrostomy insertion was developed in 2018 with standardisation of all phases from first pre-operative visit to discharge. A series of videos uploaded to YouTube accessed via a QR code were created to educate parents. The post-operative feeding regime, nurse-led training and discharge plan were standardised on a single page so it could be shared and viewed easily on a smart phone.</p><p><strong>Results: </strong>Data were collected prospectively for isolated elective laparoscopic gastrotomy insertion from 2019 to 2022. A total of 155 patients were eligible for the ERAS gastrostomy pathway (median age: 3.9 years; median co-morbidities: 4). Length of post-operative stay was a median 26 h with 60/155 (39%) of patients leaving by 10 am the next morning. Post-operative complications were noted in 20 patients with 6 readmissions none of which were due to early discharge. Multiple non-clinical reasons were identified for delays to discharge.</p><p><strong>Conclusions: </strong>Multiple major co-morbidities were not a contraindication to following the ERAS. In total, 39% of the patients were discharged by 10 am the next morning. Key to success was having a single surgical technique, standardisation of pre- and post-operative pathways and nurse-led discharge. Further improvements should be possible by closer adherence to the guidelines.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"83"},"PeriodicalIF":1.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thymus transplantation for DiGeorge Syndrome: a systematic review.
IF 1.5 3区 医学
Pediatric Surgery International Pub Date : 2025-02-17 DOI: 10.1007/s00383-025-05976-1
H Shafeeq Ahmed, Akhil Fravis Dias, Sneha Reddy Pulkurthi
{"title":"Thymus transplantation for DiGeorge Syndrome: a systematic review.","authors":"H Shafeeq Ahmed, Akhil Fravis Dias, Sneha Reddy Pulkurthi","doi":"10.1007/s00383-025-05976-1","DOIUrl":"https://doi.org/10.1007/s00383-025-05976-1","url":null,"abstract":"<p><strong>Background: </strong>DiGeorge syndrome (DGS) is a condition typically associated with athymia, parathyroid hypoplasia or aplasia, and congenital heart defects. Athymia in these patients causes severe immunodeficiency, causing high mortality and morbidity, often requiring thymic tissue transplantation. The present systematic review aims to consolidate the present evidence on thymus transplantation in DGS.</p><p><strong>Methods: </strong>An electronic literature search of five databases (PubMed, Medline, Scopus, EBSCOhost, and CINAHL) was performed from inception till September 2024. Relevant articles were selected, and data was extracted by two independent reviewers.</p><p><strong>Results: </strong>A total of 16 articles were included from an initial set of 1227 articles. Patients diagnosed with DGS in the included studies were predominantly male, and the age at which thymus transplantation was done typically varied from 0.8 to 26 months. Several patients had chromosome 22q11 hemizygosity. Thymic tissue was taken from tissues of pediatric patients undergoing cardiothoracic surgery. Pre-transplant medication included immunosuppressants with rabbit anti-thymocyte globulin (RATGAM) being frequently used alongside steroids and tacrolimus. This tissue was cultured and transplanted into the quadriceps muscle of the patients under general anesthesia. Thymopoiesis was well described in most patients with graft failures and rejections occurring rarely. Naive T-cell development was noted in almost all patients with clearance of infections in many cases. Common postoperative complications include sepsis, haemorrhage, gastrointestinal disturbances, among others. Mortality was uncommon but often associated with intracerebral hemorrhages and sepsis.</p><p><strong>Conclusion: </strong>Thymus transplantation is a relatively safe and effective procedure in patients with DGS with athymia. Future research should explore the addition of allogenic parathyroid gland transplantation along with thymic tissue.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"82"},"PeriodicalIF":1.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced recovery after minimally invasive pneumonectomies in children.
IF 1.5 3区 医学
Pediatric Surgery International Pub Date : 2025-02-15 DOI: 10.1007/s00383-025-05977-0
Shuai Li, Mijing Fang, Rui Yin, Yali Wang, Rong Chen, Chen Wang, Kang Li, Wenjia Shi, Shao-Tao Tang
{"title":"Enhanced recovery after minimally invasive pneumonectomies in children.","authors":"Shuai Li, Mijing Fang, Rui Yin, Yali Wang, Rong Chen, Chen Wang, Kang Li, Wenjia Shi, Shao-Tao Tang","doi":"10.1007/s00383-025-05977-0","DOIUrl":"https://doi.org/10.1007/s00383-025-05977-0","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to explore the feasibility and effect of pulmonary rehabilitation (PR) in the recovery of children who underwent thoracoscopic pulmonary resection.</p><p><strong>Methods: </strong>From January 2015 to December 2021, consecutive patients who underwent thoracoscopic pulmonary resection were divided into group A and group B. All of them were treated with the same perioperative protocols except for group A with perioperative lung rehabilitation management, while group B was not. Demographics, operative data, postoperative complications and clinical outcomes were compared between these two groups.</p><p><strong>Results: </strong>Sixty eight cases enrolled with 33 in group A and 35 in group B. Demographic data was comparable between the two groups, as well as the dose of tramadol and diclofenac sodium. Few patients in group A had temperature higher than 38℃ in the first 3 days after the surgery. The mean time of the first ambulation after the operation was shorter in group A than that in group B. The drainage time and the postoperative hospital stay were similar. No interventions needed for complications.</p><p><strong>Conclusion: </strong>The application of perioperative PR in children who underwent thoracoscopic pulmonary resection is safe and feasible.</p>","PeriodicalId":19832,"journal":{"name":"Pediatric Surgery International","volume":"41 1","pages":"81"},"PeriodicalIF":1.5,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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