Pediatric Blood & Cancer最新文献

{"title":"Dental Health of Childhood Cancer Survivors—A Report From the Swiss Childhood Cancer Survivor Study (SCCSS)","authors":"Carina Nigg,&nbsp;Corinne Matti,&nbsp;Philippa Jörger,&nbsp;Andre O. von Bueren,&nbsp;Cornelia Filippi,&nbsp;Tamara Diesch-Furlanetto,&nbsp;Zuzana Tomášiková,&nbsp;Claudia E. Kuehni,&nbsp;Grit Sommer","doi":"10.1002/pbc.31629","DOIUrl":"10.1002/pbc.31629","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cancer and its treatments can affect dental health of childhood cancer survivors. We aimed to evaluate the prevalence of dental problems in survivors, compare them to their siblings, and investigate cancer-related risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>As part of the population-based Swiss Childhood Cancer Survivor Study, we sent questionnaires inquiring about dental problems to survivors aged 5–19 years and their siblings. We retrieved cancer-relevant information from the Swiss Childhood Cancer Registry and used logistic regressions to compare dental problems between survivors and siblings and to investigate cancer-related risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We included 735 survivors and 144 siblings. Almost half of survivors and siblings reported at least one dental problem. Compared to siblings, CCS might be more likely to have hypo- or microdontia (odds ratio [OR] 1.7; 95% CI: 0.9–3.2) and enamel hypoplasia (2.2; 0.8–6.0), but seem to be similarly likely to have cavities or cavity-related tooth loss (0.8; 0.6–1.3). Chemotherapy was associated with enamel hypoplasia (3.0; 1.2–10.4), cavities or cavity-related tooth loss (1.5; 1.0–2.3), and gum problems during (23.0; 9.4–76.2) and after (4.6; 2.0–13.5) treatment. Hematopoietic stem cell transplantation (HSCT) was related to hypo- or microdontia (5.4; 2.6–10.7), cavities or cavity-related tooth loss (2.1; 1.2–3.6), and gum problems during treatment (2.0; 1.2–3.6). For hypo- or microdontia and cavities, associations with treatment were driven by patients diagnosed before the age of 5 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Childhood cancer survivors treated with chemotherapy or HSCT, especially at a young age, might be more likely to have dental problems. Regular dental check-ups guided by healthcare teams and dental hygiene habits can mitigate risks and promote survivor's long-term dental health.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Invasive Fungal Diseases on Treatment Outcomes in Pediatric Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma: Insights From a Single-Center Study","authors":"Amrutha Narayana Murthy,&nbsp;Shyam Srinivasan,&nbsp;Vasundhara Patil,&nbsp;Gaurav Salunke,&nbsp;Chetan Dhamne,&nbsp;Nirmalya Roy Moulik,&nbsp;Maya Prasad,&nbsp;Badira C Parambil,&nbsp;Venkata Rama Mohan Gollamudi,&nbsp;Akanksha Chichra,&nbsp;Girish Chinnaswamy,&nbsp;Gaurav Narula,&nbsp;Shripad Banavali","doi":"10.1002/pbc.31643","DOIUrl":"10.1002/pbc.31643","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>Invasive fungal diseases (IFD) in children with newly diagnosed acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LBL) are poorly characterized, especially in lower–middle-income countries (LMICs). This study aims to identify the incidence, risk factors, and outcomes of IFD in a pediatric cohort with ALL/LBL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed pediatric patients diagnosed with ALL/LBL between January and December 2023 at a tertiary cancer center in India. Patients were risk-stratified and treated per the modified ICiCLe-ALL-14 protocol. IFDs were classified as proven, probable, and possible according to the revised EORTC/MSG consensus definition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 407 patients, 392(96%) had ALL. The overall incidence of IFD was 25%, with probable/proven infections in 12%. Mold infections predominated (79 cases, 77%), followed by yeast infections (21 cases, 21%). In comparison with patients without IFDs, those with IFDs were more likely to have received dexamethasone (30 vs. 20%; <i>p</i> = 0.009), anthracycline (28 vs. 14%; <i>p</i> = 0.001) during induction and have central venous access (27 vs. 18%; <i>p</i> = 0.008). The 6-week mortality rate of patients with IFD was 15%, rising to 26% in probable/proven cases. Coexisting bacterial infection was associated with increased mortality (odds ratio: 19.2[95%CI: 3.5–105]; <i>p</i> = 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>IFDs are common in newly diagnosed ALL/LBL patients in LMICs, particularly during early phases of therapy. These infections are associated with considerable mortality, often compounded by concomitant bacterial sepsis. Given these findings, consideration of antifungal prophylaxis is warranted to mitigate morbidity and mortality due to IFDs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/pbc.31643","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dabrafenib and Trametinib for the Treatment of Pediatric and Adolescent Melanoma: Single Center Experience Data From Italian Compassionate Use","authors":"Stefano Chiaravalli,&nbsp;Alice Indini,&nbsp;Michele Del Vecchio,&nbsp;Michela Casanova,&nbsp;Maura Massimino,&nbsp;Luca Bergamaschi,&nbsp;Andrea Ferrari","doi":"10.1002/pbc.31644","DOIUrl":"10.1002/pbc.31644","url":null,"abstract":"<p>Data on BRAF/MEK inhibitors in pediatric and adolescent melanoma patients are limited. We report data of patients treated with dabrafenib/trametinib for compassionate use at our institution. From January 2020, four patients with Stage III and two patients with Stage IV disease were treated. Our report demonstrates that targeted therapy in children and adolescents is safe and achieves survival rates comparable to those observed in adults. These findings support granting young patients with adult-onset tumors access to compassionate use, as well as increasing their inclusion in clinical trials. Such measures would ensure equitable access to treatments available for adult patients and contribute to improved treatment outcomes.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/pbc.31644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Trends in Management of the Nodal Basin for Pediatric Patients With Occult Stage III Melanoma in the United States","authors":"Catherine B. Beckhorn,&nbsp;Kristen E. Rhodin,&nbsp;Harold J. Leraas,&nbsp;Norma E. Farrow,&nbsp;Jay S. Lee,&nbsp;Georgia M. Beasley,&nbsp;Elisabeth T. Tracy","doi":"10.1002/pbc.31627","DOIUrl":"10.1002/pbc.31627","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Following the publication of recent trials (MSLT-I, MSLT-II, DeCOG), routine completion lymph node dissection (CLND) after positive sentinel lymph node biopsy (SLNB) is no longer recommended for adults with melanoma, while adjuvant immunotherapy (IO) was approved for selected patients with positive SLNB. Given the exclusion of pediatric patients from these studies, we aimed to characterize trends in nodal management for pediatric patients with Stage III melanoma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Procedure</h3>\u0000 \u0000 <p>The National Cancer Database (NCDB) was queried for pediatric patients (age ≤20 years) with melanoma (clinical Stage I/II; pathologic Stage III) who underwent resection from 2012 to 2019. The primary objective was to examine trends in the extent of nodal surgery, the number of lymph nodes examined, and adjuvant IO utilization. Secondary objectives included comparing overall survival (OS) by nodal management and receipt of adjuvant IO using Kaplan–Meier methods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Overall, 98 patients met inclusion criteria. From 2012 to 2019, the percentage of patients receiving SLNB alone increased (from 13% to 89%); conversely, therapeutic lymph node dissection (TLND) decreased (from 60% to 0%), as did CLND (from 27% to 11%). Median lymph nodes examined decreased from 2012 to 2019 (from 22 to 2), while receipt of adjuvant IO increased (from 33% to 44%). OS did not differ by nodal management nor receipt of adjuvant IO.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The findings of this study support clinical observation after SLNB in pediatric patients with melanoma, as we noted de-escalation in the extent of nodal surgery without compromising OS. We also noted increasing utilization of adjuvant IO among patients with positive SLNB. Multidisciplinary discussion remains vital for managing melanoma in pediatric patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Azacytidine Monotherapy in an Infant With Mosaic NRAS-Driven Juvenile Myelomonocytic Leukemia","authors":"Jeremy M. Grenier,&nbsp;Sarah K. Tasian,&nbsp;Elliot Stieglitz,&nbsp;Zied Abdullaev,&nbsp;Gerald B. Wertheim,&nbsp;Marilyn M. Li,&nbsp;Charles A. Phillips","doi":"10.1002/pbc.31647","DOIUrl":"10.1002/pbc.31647","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Mixed Phenotype Acute Leukemia With ETV6::ARNT Fusion Gene Successfully Treated by Allogeneic Hematopoietic Stem Cell Transplantation","authors":"Yaoyao Rui,&nbsp;Meiyun Kang,&nbsp;Yongjun Fang,&nbsp;Yongren Wang","doi":"10.1002/pbc.31648","DOIUrl":"10.1002/pbc.31648","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Unique Case of Recurrence After Adjuvant Chemotherapy in Pleuropulmonary Blastoma (PPB) Type I With Transformation to PPB Type III","authors":"Mikhail A. Lemeshev,&nbsp;Natalia A. Andreeva,&nbsp;Alexander E. Druy,&nbsp;Ilya V. Sidorov,&nbsp;Dmitry M. Konovalov,&nbsp;Ivan V. Tverdov,&nbsp;Nina V. Gegeliya,&nbsp;Ruslan Kh. Abasov,&nbsp;Natalia Yu. Usman,&nbsp;Tatyana V. Shamanskaya,&nbsp;Kris Ann P. Schultz,&nbsp;Denis Yu. Kachanov","doi":"10.1002/pbc.31642","DOIUrl":"10.1002/pbc.31642","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Toolkit for Healthcare Transition for Adolescents With Classical Myeloproliferative Neoplasms","authors":"Nicole Kucine,&nbsp;Holger Cario,&nbsp;Ghaith Abu-Zeinah,&nbsp;Maria Caterina Putti,&nbsp;Nicolas Boissel,&nbsp;Maria Luigi Randi,&nbsp;Linda Resar,&nbsp;Martin Griesshammer,&nbsp;Jean-Jacques Kiladjian","doi":"10.1002/pbc.31633","DOIUrl":"10.1002/pbc.31633","url":null,"abstract":"<p>Classical myeloproliferative neoplasms (MPNs) are being identified more frequently in adolescents. There is no guidance on the healthcare transition of young MPN patients from pediatric to adult medicine. Therefore, we convened an international panel of experts in both pediatric and adult MPN care to develop three tools to facilitate high-quality healthcare transition: a physician education tool, a transition readiness assessment tool, and a consensus statement of practice recommendations to ensure a more seamless transition in the care adolescents receive. These tools can help ensure a better healthcare transition for young patients. The next steps include evaluating the readiness assessment tool with adolescent patients.</p>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/pbc.31633","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clival Chordoma Presenting as Airway Obstruction in a Neonate With Tuberous Sclerosis and Good Response to sirolimus","authors":"Aastha Goel,&nbsp;Aakansha Kumari,&nbsp;Sameer Rastogi,&nbsp;Aman Chaudhary,&nbsp;Adarsh Barwad,&nbsp;Atin Kumar","doi":"10.1002/pbc.31632","DOIUrl":"10.1002/pbc.31632","url":null,"abstract":"<div>\u0000 \u0000 <p>We report the case of a 50-day-old infant with a nasopharyngeal mass causing respiratory distress at birth. Imaging revealed a mass from the clivus and features indicative of tuberous sclerosis complex (TSC), including cortical tubers and subependymal nodules. The mass was surgically excised, with histopathology confirming chordoma. Genetic analysis identified pathogenic mutation in TSC2 gene. Postsurgery, he had residual disease and was treated with mammalian target of rapamycin (mTOR) inhibitor sirolimus, leading to complete resolution. This case is notable as it represents the first instance of mTOR inhibitor use resulting in complete resolution of TSC-associated chordoma, suggesting potential for further research into mTOR therapy for chordomas.</p>\u0000 </div>","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pegcetacoplan for Breakthrough Hemolysis in an Adolescent With Classical Paroxysmal Nocturnal Hemoglobinuria on Eculizumab","authors":"Catherine Njeru,&nbsp;Danielle Baker,&nbsp;Hayley Merkeley,&nbsp;Ali Amid","doi":"10.1002/pbc.31649","DOIUrl":"10.1002/pbc.31649","url":null,"abstract":"","PeriodicalId":19822,"journal":{"name":"Pediatric Blood & Cancer","volume":"72 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}