Pediatric Cardiology最新文献_第6页

Comparison of Necrotizing Enterocolitis After Surgical Norwood versus Hybrid Stage 1 Palliation. 诺伍德手术后坏死性小肠结肠炎与混合第一期姑息术后坏死性小肠结肠炎的比较。

IF 1.5 4区医学

Pediatric Cardiology Pub Date : 2024-11-10 DOI: 10.1007/s00246-024-03704-5

Alyson R Pierick, Hillary Liken, Jeffrey D Zampi, Jennifer C Romano, Courtney Strohacker, Ray Lowery, Sunkyung Yu, Ashley Duimstra, C Todd Sower

{"title":"Comparison of Necrotizing Enterocolitis After Surgical Norwood versus Hybrid Stage 1 Palliation.","authors":"Alyson R Pierick, Hillary Liken, Jeffrey D Zampi, Jennifer C Romano, Courtney Strohacker, Ray Lowery, Sunkyung Yu, Ashley Duimstra, C Todd Sower","doi":"10.1007/s00246-024-03704-5","DOIUrl":"https://doi.org/10.1007/s00246-024-03704-5","url":null,"abstract":"Hybrid stage 1 palliation (HS1P) is used as an alternative to the surgical Norwood for single ventricle patients and specific other conditions. Necrotizing enterocolitis (NEC) occurs in 5%-18% of infants after surgical Norwood, contributing to significant morbidity. We sought to compare the NEC incidences in HS1P versus Norwood patients. A single-center retrospective cohort study of all infants undergoing HS1P or Norwood over a 12-year period. Demographics, underlying cardiac diagnosis, surgical details, and NEC episodes were queried for each patient. The cumulative incidences of NEC between HS1P and Norwood patients were compared. A total of 305 infants were included; 200 Norwood and 105 HS1P. HS1P infants were more often premature (gestational age < 37 weeks; 23.8% vs 1.5%) and had lower birth weight (mean 2.8 ± 0.66 kg versus 3.3 ± 0.47 kg) than their Norwood counterparts. Most infants who underwent the Norwood procedure had hypoplastic left heart syndrome (79.5%), with variable underlying cardiac diagnosis for those who underwent HS1P. Incidence of NEC was significantly higher in the HS1P group (53.3% versus 37.0%, p = 0.01), with increased risk independent of birth weight or underlying cardiac diagnosis (adjusted odds ratio 1.8, p = 0.03). Infants after HS1P had a median of 2 episodes of NEC (interquartile range [IQR] 1-3) versus 1 episode in the Norwood group (IQR 1-2). Infants after HS1P are at higher risk of NEC in comparison to infants after the Norwood procedure. More studies are needed to help predict which infants after HS1P are at highest risk for NEC.","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Cardioversion of Atrial Arrhythmias with Ibutilide in Children and Adults with Congenital Heart Disease. 使用伊布利特对患有先天性心脏病的儿童和成人的房性心律失常进行化学心脏复律。

IF 1.5 4区医学

Pediatric Cardiology Pub Date : 2024-11-08 DOI: 10.1007/s00246-024-03703-6

Utkarsh Kohli, Christopher Mercer, Tracy Coup, Larry Rhodes, John Phillips

引用次数: 0

Health Disparities in Exercise Performance in Patients with Repaired Tetralogy of Fallot. 法洛氏四联症修复患者运动表现的健康差异。

IF 1.5 4区医学

Pediatric Cardiology Pub Date : 2024-11-07 DOI: 10.1007/s00246-024-03706-3

Andrea L Jones, Rui Xiao, Ariel A Williamson, Hadiya Benn, Paul Stephens, Shivani M Bhatt, Laura Mercer-Rosa, Pamela F Weiss

{"title":"Health Disparities in Exercise Performance in Patients with Repaired Tetralogy of Fallot.","authors":"Andrea L Jones, Rui Xiao, Ariel A Williamson, Hadiya Benn, Paul Stephens, Shivani M Bhatt, Laura Mercer-Rosa, Pamela F Weiss","doi":"10.1007/s00246-024-03706-3","DOIUrl":"https://doi.org/10.1007/s00246-024-03706-3","url":null,"abstract":"Black patients with tetralogy of Fallot (TOF) have higher mortality than White patients. Health disparities related to other patient-important outcomes, such as exercise performance, have not been studied in this population. We aimed to determine if there are racial disparities related to exercise performance in patients with TOF and to investigate possible mediators of those disparities. We conducted a retrospective single center study of patients aged 8-25 years with repaired TOF who completed maximal cardiorespiratory exercise tests between 2007 and 2020. The primary outcome was percent predicted oxygen consumption at peak exercise. We used linear regression to determine if race was associated with exercise performance. We used mediation analysis to investigate insurance coverage and neighborhood Child Opportunity Index as possible mediators of this relationship. The study cohort included 163 patients with TOF (136 non-Hispanic/Latinx White and 27 non-Hispanic/Latinx Black). In multivariable analysis, Black patients had a lower percent predicted peak oxygen consumption than White patients by 6.71 percentage points (95% CI - 12.71, - 0.70; p = 0.029). Mediation analysis revealed that the indirect effect of race through insurance coverage accounted for 34.1% of the decrease in exercise performance. Child Opportunity Index was not a statistically significant mediator. Black patients with TOF had worse exercise performance than White patients. Differences in insurance coverage accounted for a significant portion of this difference. Exercise performance is an important outcome for patients with TOF, and further investigation is needed to better understand this disparity and develop interventions to address it.","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Ewing's Sarcoma Metastazing from the Right Pelvis via the Inferior Vena Cava into the Heart: Diagnosis and Successful Surgical Treatment. 更正：从右骨盆经下腔静脉进入心脏的尤文肉瘤转移：诊断和成功的手术治疗。

IF 1.5 4区医学

Pediatric Cardiology Pub Date : 2024-11-06 DOI: 10.1007/s00246-024-03690-8

Joachim Peter Sturmberg, Hans Meyer, Reiner Körfer, Wolfgang Matthies, Wolf-Rüdiger Thies, Alfred Schauer, Peter Weinel

引用次数: 0

Utility of Serum Matrix Metalloproteinase-7 as a Biomarker in Cholestatic Infants with Congenital Heart Disease. 血清基质金属蛋白酶-7作为先天性心脏病胆汁淤积婴儿生物标志物的效用

IF 1.5 4区医学

Pediatric Cardiology Pub Date : 2024-11-05 DOI: 10.1007/s00246-024-03696-2

Sindhu Pandurangi, Michael E Kim, Nicolas Noriega, Bradley Conant, JangDong Seo, Reena Mourya, Pranavkumar Shivakumar, Anna L Peters, Andrew Misfeldt, Meghan Chlebowski

{"title":"Utility of Serum Matrix Metalloproteinase-7 as a Biomarker in Cholestatic Infants with Congenital Heart Disease.","authors":"Sindhu Pandurangi, Michael E Kim, Nicolas Noriega, Bradley Conant, JangDong Seo, Reena Mourya, Pranavkumar Shivakumar, Anna L Peters, Andrew Misfeldt, Meghan Chlebowski","doi":"10.1007/s00246-024-03696-2","DOIUrl":"10.1007/s00246-024-03696-2","url":null,"abstract":"Background: Matrix metalloproteinase 7 (MMP-7) is a novel biomarker for diagnosis of biliary atresia (BA), the most common cholestatic liver disease in infancy. There is a pressing need to determine the utility of MMP-7 levels in infants with congenital heart disease (CHD) to avoid unnecessary invasive diagnostic procedures in this high-risk population. We investigated the utility of MMP-7 in discriminating BA from non-BA cholestasis in infants with CHD and whether MMP-7 elevation was present in infants requiring treatment for clinically significant PH.Methods: This is a single-center cross-sectional study including infants < 180 days of age with cholestasis and serum MMP-7 levels collected from 2019 to 2023. Demographic data and descriptive statistics were summarized with medians with interquartile ranges and frequencies with percentages. Median MMP-7 levels were assessed via Wilcoxon rank-sum test.Results: A total of 149 patients were included. Patients with CHD had significantly elevated MMP-7 levels relative to the non-CHD cohort (50 vs. 34 ng/mL, p = 0.009). Sub-analysis comparing infants with and without PH revealed significantly elevated median MMP-7 levels in those with clinically significant PH (125 vs. 39 ng/mL, p = 0.010). CHD patients with PH had greater median MMP-7 compared to CHD patients without PH (154 vs 43 ng/mL, p = 0.028).Conclusion: Serum MMP-7 levels in infants with congenital heart disease with cholestasis (CHD-C) were significantly elevated compared to those with cholestasis alone. MMP-7 may help identify non-BA cholestatic infants who have concurrent clinically significant pulmonary hypertension. Larger, prospective studies are needed to validate this finding and establish CHD-specific MMP-7 cut-offs.","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations Between Exercise Capacity and Psychological Functioning in Children and Adolescents with Fontan Circulation. 方坦循环儿童和青少年的运动能力与心理功能之间的关系。

IF 1.5 4区医学

Pediatric Cardiology Pub Date : 2024-11-05 DOI: 10.1007/s00246-024-03701-8

Nicholas P Seivert, Kathryn M Dodds, Shannon O'Malley, David J Goldberg, Stephen Paridon, Michael McBride, Jack Rychik

{"title":"Associations Between Exercise Capacity and Psychological Functioning in Children and Adolescents with Fontan Circulation.","authors":"Nicholas P Seivert, Kathryn M Dodds, Shannon O'Malley, David J Goldberg, Stephen Paridon, Michael McBride, Jack Rychik","doi":"10.1007/s00246-024-03701-8","DOIUrl":"https://doi.org/10.1007/s00246-024-03701-8","url":null,"abstract":"Individuals with Fontan circulation (FC) often have diminished exercise capacity and are at risk for psychological problems. The current study examines associations between exercise capacity and psychological functioning in children and adolescents with FC. A multidisciplinary team evaluated participants in a clinic for pediatric patients with FC. Participants completed cardiopulmonary exercise testing (CPET). Parent and child were administered a psychological questionnaire (BASC-3) to measure child depression, anxiety, and inattention symptoms. Individuals who completed CPET with adequate effort and a psychological measure were eligible for inclusion. Clinical sample (n = 51) was 55% male with a mean age of 13.6 years (SD = 2.5). A majority had hypoplastic left heart syndrome (51%). Parent-report of inattention was negatively correlated with peak VO2 (R = - .307, 95% CI - .549/ - .018, P = 0.038). Self-report of anxiety was positively correlated with HR recovery at 3 (R = .438, 95% CI .155/.655, P = 0.004) and 8 (R = .432, 95% CI .147/.651, P = 0.004) minutes post exercise. Depression was positively correlated with HR recovery at 3 min for parent-report (R = .294, 95% CI .004/.538, P = 0.047) and 8 min for self-report (R = .410, 95% CI .122/.635, P = 0.007). Greater inattention may have negatively impacted CPET engagement, reflected in lower peak VO2. The more rapid decline from max HR to recovery for those with greater depression and anxiety symptoms was unexpected, perhaps explained by a reduction in anxiety state after exercise or possibly an age effect, as a blunted HR decline has been found in adult cardiac patients with depression/anxiety.","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis and Visualization of Inter-/Intra-surgeon Variability Using Surgical Simulation for Partial Anomalous Pulmonary Venous Connection Repair. 利用部分异常肺静脉连接修复手术模拟，分析和直观显示医生间/医生内的变异性。

IF 1.5 4区医学

Pediatric Cardiology Pub Date : 2024-11-01 DOI: 10.1007/s00246-024-03699-z

Yuki Nakamura, Elizabeth Joy Trimble, Aswathy Kumar Vaikom House, Harold MacDonald Burkhart

{"title":"Analysis and Visualization of Inter-/Intra-surgeon Variability Using Surgical Simulation for Partial Anomalous Pulmonary Venous Connection Repair.","authors":"Yuki Nakamura, Elizabeth Joy Trimble, Aswathy Kumar Vaikom House, Harold MacDonald Burkhart","doi":"10.1007/s00246-024-03699-z","DOIUrl":"https://doi.org/10.1007/s00246-024-03699-z","url":null,"abstract":"There may be inter-/intra-surgeon variability in the repair of congenital heart defects. The objective was to analyze and visualize inter-/intra-surgeon variability in the level of patch suture lines and in the shape and size of patches developed through surgical simulation for partial anomalous pulmonary venous connection (PAPVC) repair using a patient-specific 3D-printed heart model. A patient with PAPVC and preoperative computed tomography data were selected, and a patient-specific heart model was obtained. Two different exposures on the model were tested. Two surgeons were enrolled. Both surgeons performed a single-patch repair on four heart models with one exposure and four models with the other. On the potential suture line, 20 points common in each model were allocated. The level of patch suture lines was represented as a deviation from the 20 points. The shape and size of the patches were analyzed and visualized using geometric morphometrics approaches, using the 20 points as landmarks to represent the patches. There was inter-surgeon variability in the level of patch suture lines, and the variability was higher in particular locations. There was inter-surgeon variability in the shape and size of patches, which was not affected by the exposures. The inter-surgeon variability in the shape of patches was higher in particular locations. There was intra-surgeon variability in the shape of patches. Inter-/intra-surgeon variability was analyzed and visualized by the surgical simulation using geometric morphometrics approaches. Further studies are needed to scrutinize whether the variability affects postoperative hemodynamics in actual surgery.","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ectopic Calcification in Congenital Heart Surgery: A Material-Centric Review. 先天性心脏病手术中的异位钙化：以材料为中心的综述。

IF 1.5 4区医学

Pediatric Cardiology Pub Date : 2024-11-01 DOI: 10.1007/s00246-024-03622-6

Tatsuya Watanabe, Satoshi Yuhara, Joseph T Leland, J Logan Spiess, Aditya Thodla, Raghav Ramachandiran, John M Kelly, Toshiharu Shinoka, Christopher K Breuer

{"title":"Ectopic Calcification in Congenital Heart Surgery: A Material-Centric Review.","authors":"Tatsuya Watanabe, Satoshi Yuhara, Joseph T Leland, J Logan Spiess, Aditya Thodla, Raghav Ramachandiran, John M Kelly, Toshiharu Shinoka, Christopher K Breuer","doi":"10.1007/s00246-024-03622-6","DOIUrl":"https://doi.org/10.1007/s00246-024-03622-6","url":null,"abstract":"The modern congenital heart surgeon has an array of materials available for cardiovascular repair. With advancements in the surgical outcomes for pediatric cardiac defects, choice of material has become increasingly dependent on late-term complications associated with each material. Calcification is a leading long-term complication and is increasing in prevalence with materials lasting longer in patients. Material calcification can impair functionality, lead to subsequent complications, and require additional interventions. A comprehensive literature review was conducted to investigate ectopic calcification of commonly used materials for congenital heart defect repair. Mechanisms of ectopic calcification among commonly used materials were investigated. Ectopic calcification is initiated by material-specific immunological reactions. Recent efforts have focused on developing new materials that are not prone to calcification. ePTFE was widely used in cardiovascular applications but still has reported instances of calcification in various situations, such as long-term use. Tissue engineering techniques have shown reduced calcification in reports. Calcification can occur in all conventional materials we reviewed and, in some cases, has led to life-threatening complications. Favorable outcomes have been reported with tissue-engineered materials, with the expectation of continued positive results in future reports. With an array of synthetic and biological materials now displaying acceptable surgical and short-term outcomes, there is a pressing need to review the long-term viability of these materials, especially considering improved patient survival to adulthood. Furthermore, developing new materials to mitigate calcification remains a promising avenue of research in this field.","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "Biomarkers and Related Factors for the Diagnosis, Risk of Coronary Artery Lesions, and Resistance to Intravenous Immunoglobulin in Kawasaki Disease: An Umbrella Review of Meta-Analyses". 关于 "川崎病诊断、冠状动脉病变风险和静脉注射免疫球蛋白耐受性的生物标志物和相关因素：Meta分析综述"。

IF 1.5 4区医学

Pediatric Cardiology Pub Date : 2024-10-31 DOI: 10.1007/s00246-024-03692-6

Rachana Mehta, Ashok Kumar Balaraman, Muhammed Shabil, Sanjit Sah

引用次数: 0

Cardiogenic Necrotizing Enterocolitis in Infants with Congenital Heart Disease: A Systematic Review and Meta-analysis. 先天性心脏病婴儿的心源性坏死性小肠结肠炎：系统回顾与元分析》。

IF 1.5 4区医学

Pediatric Cardiology Pub Date : 2024-10-29 DOI: 10.1007/s00246-024-03686-4

Ivor B Asztalos, Stephanie N Hill, Dustin B Nash, Susan K Schachtner, Kelsey J Palm

{"title":"Cardiogenic Necrotizing Enterocolitis in Infants with Congenital Heart Disease: A Systematic Review and Meta-analysis.","authors":"Ivor B Asztalos, Stephanie N Hill, Dustin B Nash, Susan K Schachtner, Kelsey J Palm","doi":"10.1007/s00246-024-03686-4","DOIUrl":"https://doi.org/10.1007/s00246-024-03686-4","url":null,"abstract":"Necrotizing enterocolitis (NEC) is a known cause of morbidity and mortality in infants with congenital heart disease (CHD), but reports about the burden of cardiogenic NEC frequently conflict. To synthesize the extant literature on the incidence, risk factors, and prognosis of NEC in patients with CHD. Medline, Cochrane, and EMBASE were searched from 1946 through 2023 for studies of NEC in infants 0-12 months of age with CHD. Risk of bias was assessed with validated tools for incidence and risk factors. Pooled estimates were meta-analyzed by risk of bias or synthesized without meta-analysis. Eighty-six studies with a total of 67,924 participants were included. The incidence of cardiogenic NEC was 7.1% (95% CI 4.7-10.5%) in term infants and 13.0% (10.2-16.5%) in low birthweight preterm infants. NEC required surgery in 0.8% (0.5-1.1%) of term and 2.7% (2.0-3.7%) of premature infants, respectively. Only gestational age and birth weight were consistently associated with risk of NEC. Restricting pooled estimates to studies of moderate or low risk of bias significantly reduced the number of studies included. Necrotizing enterocolitis is a common cause of morbidity in infants with CHD, but additional research is needed to determine which infants are at highest risk of developing NEC and would benefit most from a change in management. This systematic review and meta-analysis was conducted according to a prespecified protocol registered at the Prospective Register of Systematic Reviews (CRD42021282114).","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0