Zulkhah Noor, D. L. Kusindarta, A. Sadewa, D. S. Heriyanto, D. R. Hadiati, Mustofa
{"title":"Acute toxicity of the galactagogue phytomedicine containing Sauropus androgynous, Trigonella foenumgraecum, and Moringa oleifera","authors":"Zulkhah Noor, D. L. Kusindarta, A. Sadewa, D. S. Heriyanto, D. R. Hadiati, Mustofa","doi":"10.29090/psa.2022.04.21.217","DOIUrl":"https://doi.org/10.29090/psa.2022.04.21.217","url":null,"abstract":"This study aims to evaluate acute toxicity of the herbal preparation on rats as an early step to evaluate its safety. This study used 25 females Rattus norvegicus strain Sprague Dawley rats aged 8 weeks with a body weight of at least 120 g divided into 5 groups of doses of herbal preparation (0/aquadest, 50, 300, 2,000, 5,000) mg/kg BW. After administration of the herbal preparation, rats were observed using a camera continuously for 14 days and manual observation intensively for the first 24 hours and then once a day for up to 14 days. The toxic effects including death, behavioral changes, neural symptoms, and other abnormalities were recorded. The weight of the rats was monitored every three days. On the 15 th day, the rats were sacrificed to collect vital organs for macroscopic and histopathological examinations. The LD 50 was estimated based on OECD Guideline. No mortality and significant toxicity signs in any of the rats after receiving the herbal formula at highest dose of 5000 mg/kg was reported during the 14-day observation period. Body weight and organ weight did not show significant variation between controls and treatment groups. In addition, no abnormalities of liver, heart and lungs were also observed in macroscopic and histopathological examinations. In conclusion, the herbal preparation shows the LD 50 of greater than 5,000 mg/kg can be classified as category 5 or unclassified. Further sub chronic toxicity study will be conducted to evaluate its safety after repeated exposure.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87585349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nattawut Charoenthai, Kun Sodalee, S. Puttipipatkhachorn
{"title":"Octenyl succinic anhydride starch and its polyelectrolyte complexes as stabilizers in Pickering emulsions","authors":"Nattawut Charoenthai, Kun Sodalee, S. Puttipipatkhachorn","doi":"10.29090/psa.2022.05.22.198","DOIUrl":"https://doi.org/10.29090/psa.2022.05.22.198","url":null,"abstract":"Pickering emulsions, also known as emulsions stabilized by solid particles, have been increasingly applied in pharmaceutical products due to their high stability and non-toxicity. Due to unwanted toxicity from low molecular weight surfactants used as emulsifiers in classical emulsions, solid particles of biopolymers have been used as stabilizers in Pickering emulsions. This review summarizes the recent research on using octenyl succinic anhydride (OSA) starch and its polyelectrolyte complexes as stabilizers in Pickering emulsions. OSA starch-based Pickering emulsion has been reported to prepare various dosage forms such as emulsion, nanoemulsion, microcapsules, nanocapsules, and redispersible dry emulsion. The information obtained indicates the increasing trend in the application and practical uses of Pickering emulsions in the pharmaceutical industry.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"133 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76763883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Asthma control and medication adherence among asthmatic outpatients in Vietnam: A cross-sectional study","authors":"Sang Thanh Huynh, Ngoc Viet Nguyen, Ho Nhu Nguyen","doi":"10.29090/psa.2022.02.21.186","DOIUrl":"https://doi.org/10.29090/psa.2022.02.21.186","url":null,"abstract":"Suboptimal asthma control and medication non-adherence are common and associated with adverse disease outcomes. This study aimed to assess the medication adherence, level of asthma control, and determine factors associated with asthma control among asthmatic outpatients. A cross-sectional study was conducted on 250 asthmatic patients aged 12 visiting the Asthma Management Clinic at a tertiary hospital in Vietnam from April to June 2019. Data, including demographics, medication treatment and adherence, and asthma control, were collected through structured interviews and prescription review. Asthma control and medication adherence were measured using the Asthma Control Test (ACT) questionnaire and the Morisky Medication Adherence Scale 8-items (MMAS-8), respectively. Multivariable logistic regression analysis was used to determine the associated factors with asthma control. The mean age of the study participants was 59.1 years and the majority were women (67.2%). All patients were using inhaled corticosteroid (ICS)-containing controller therapy. The proportion of patients highly adhering to prescribed medications was 34.4%. Well-controlled asthma was observed in 64.4% of patients. Age group of 60 (aOR=3.43, 95%CI 1.21-9.68), low medication adherence (aOR=2.97, 95%CI 1.40-6.30), and using medium or high dose of ICS (aOR=3.38, 95%CI 1.64-6.97; aOR=4.28, 95%CI 1.90-9.65, respectively) were associated with poorly-controlled asthma. Poorly controlled asthma was still prevalent. Patient’s age, medication adherence, and ICS dosage are some factors which healthcare providers should consider when asthma control was under expectation.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84215249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Xylopic acid from Xylopia aethiopica (Annonaceae) inhibits morphine tolerance in rats","authors":"Priscilla Kolibea Mante, Kweku Abakah-Ewusi, Amanda Adoley Mingle, Mustapha Seidu Kpienaan, Samuel Offei-Twum, Nana Kofi Kusi-Boadum, Nana Ofori Adomako, Newman Osafo","doi":"10.29090/psa.2022.02.21.124","DOIUrl":"https://doi.org/10.29090/psa.2022.02.21.124","url":null,"abstract":"Traditionally, Xylopia aethiopica is used to manage pain disorders such as neuralgia, colic pain, rheu-matism and headache. Using animal models, this study aimed to investigate the ability of Xylopic Acid (XA), a kaurene diterpene obtained from Xylopia aethiopica , to cause tolerance when administered alone or combined with morphine. Development of withdrawal symptoms on discontinuation was also investigated. Tolerance to morphine was induced in rats through an 8-day regimen of chronic administration of morphine (10 mg/kg; twice daily). Effects of XA alone (100 mg/kg) or XA (10-100 mg/kg) on morphine tolerance and withdrawal syndrome precipitated with naloxone hydrochloride (3 mg/kg) were also assessed. XA’s mechanism of action was then explored through drug-receptor binding. 60)=29.88, p acid loss. similar jumps as XA Drug-receptor binding assays revealed a lack of significant interaction of XA on alpha-2 adrenoceptors (A, B, C) but exhibited significant DOR- selective antagonism similar to naltrindole. This study reveals that xylopic acid significantly inhibits morphine antinociceptive withdrawal in rats. This is the first report of xylopic acid’s antagonism on delta opioidergic receptors and potential as an inhibitor of chronic morphine tolerance.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83950595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pluchea indica: An updated review of its botany, uses, bioactive compounds and pharmacological properties","authors":"E. Chan, Ying Ki Ng, S. Wong, H. T. Chan","doi":"10.29090/psa.2022.01.21.113","DOIUrl":"https://doi.org/10.29090/psa.2022.01.21.113","url":null,"abstract":"Coastal plants are those growing on muddy shores, sandy beaches and rocky promontories. Represented by a wide array of trees, shrubs, vines and epiphytes, they have important ecological and environmental values such as coastal protection and habitats for fauna. Coastal flora are also important food and medicinal plants. Pluchea indica (L.) Less., one of the coastal plants, was chosen for the review since it has been utilized as sources of food and medicine. Its extracts exhibit several pharmacological activities promoting human health benefits. The botany, bioactive compounds and pharmacological properties of P. indica are reviewed for the first time. The pharmacological properties including antioxidant, antibacterial, anti-cancer, anti-inflammatory and other activities, are summarized. To date, there is only a review on the nutrition, health benefits and applications of P. indica leaves. Three other reviews emphasized on the phytochemistry and biological activities of the genus Pluchea Cass. Sources of information procured for this review were from Google Scholar, PubMed, PubMed Central, Science Direct, J-Stage, JSTOR, PubChem and Directory of Open Access Journals (DOAJ). The primary keywords for search are Pluchea indica and the secondary keywords include constituents, antioxidant, cancer, etc.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85790909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Narongchai Chaksupa, N. Sookvanichsilp, N. Soonthornchareonnon, P. Moongkarndi, O. Gerdprasert
{"title":"Effects of alcoholic extract from Clitoria ternatea flowers on the proliferation of human dermal papilla cells and hair growth in C57BL/6Mlac mice","authors":"Narongchai Chaksupa, N. Sookvanichsilp, N. Soonthornchareonnon, P. Moongkarndi, O. Gerdprasert","doi":"10.29090/psa.2022.05.22.102","DOIUrl":"https://doi.org/10.29090/psa.2022.05.22.102","url":null,"abstract":"Clitoria ternatea is a vine native to tropical and equatorial Asia. Previous review articles have mentioned about different biological activities of extracts from flowers and other parts of the plant, but none being related to hair growth-promoting activity. Scientific reports dealing with hair growth-promoting activity of this plant are scarce. In the present study, the effect of alcoholic extract from its flowers on the proliferation of dermal papilla cells (DPCs) from isolated hair papillae of normal human scalp hair follicles was performed in comparison with minoxidil. Moreover, its effect on hair growth was also tested in C57BL/6Mlac mice of both sexes in comparison with minoxidil and latanoprost. The results have indicated that the extract could increase human DPC proliferation and stimulate the initial hair growth of C57BL/6Mlac mice, but it has no ability to increase the number of hair follicles or to prolong the anagen hair follicles. The effects of the C. ternatea alcoholic extract were similar to those of minoxidil.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88470440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Melanogenesis inhibitory effect of Perilla Frutescens (L.) Britt on a hyperpigmentation model in rabbit","authors":"Ngoc Phuc Nguyen, Thanh-Hao Do, Le-Y Nguyen, Thi Ly Thu Pham, N. Huynh","doi":"10.29090/psa.2022.03.22.010","DOIUrl":"https://doi.org/10.29090/psa.2022.03.22.010","url":null,"abstract":"The study aims to evaluate the melanogenesis inhibitory action of the ethyl acetate (EA) extract from Perilla frutescens (L.) Britt on a hyperpigmented rabbit model induced by UVA-exposure combined to progesterone injection. The dorsal shaved skin of the experimental rabbits was exposed to UVA radiation (386 nm, 147 uW/cm 2 ) in 30 minutes each day for 28 days. Progesterone was intramuscularly injected every other day at the dose of 5 mg/kg. EA extract was topically applied daily from the first day of melasma appearance until the end of the experiment. Morphometric observation based on color thresholder application on MATLAB software. Moreover, melanin determination and histological analysis were also performed. The morphometric observation on the surface of melasma areas as well as the histological analysis from 5% EA-treated group are similar to these of 4% Hydroquinone-treated group at day 14, 21, 28. Melanin concentration in 5% EA-treated group was significantly decreased as compared to the hyperpigmentation group. In conclusion, EA extract of Perilla leaves clearly exhibited the inhibitory effect on melanogenesis in the hyperpigmented rabbit-induced by UVA exposure combined to progesterone injection.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91047621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phytochemical composition of Blumea lacera leaf and its inhibitory effects on the activity of enzymes related to metabolic diseases","authors":"M. R. Habib, Y. Igarashi, M. Rabbi","doi":"10.29090/psa.2022.03.22.029","DOIUrl":"https://doi.org/10.29090/psa.2022.03.22.029","url":null,"abstract":"in this context, plants extracts and natural products have been well recognized sources of bioactive components with enzymes inhibitory properties 11 . Some studies have ABSTRACT Blumea lacera (Bum. f.) DC is an important medicinal plant of Bangladesh having several ethnomedicinal values. To give the scientific basis of ethnomedicinal uses, the present study analyzed phytochemical composition of methanol extract of B. lacera leaves (designated as MBLE) and evaluated its inhibitory effects on pancreatic lipase, α-amylase, xanthine oxidase (XO) and angiotensin I-converting enzyme (ACE). Different in vitro methods were used to perform enzyme inhibition assays for MBLE and its phytochemical profile was analyzed by GC-MS. In case of all the enzyme inhibition assays, the percentage of inhibition by MBLE was increased with increasing in concentrations. Among these enzymes, MBLE showed strong activity (IC 50 :13.34±1.05 μg/mL) against ACE as compared with captopril (IC 50 :8.09±0.74 μg/mL) used as standard reference whereas it exhibited moderate activity against other enzymes. The IC 50 values of MBLE were found to be 9.87±0.25, 40.17±2.32 and 93.88±5.21 μg/mL for pancreatic lipase, α-amylase and XO, respectively. In addition, some compounds identified in MBLE by GC-MS, were also consistence with these enzyme inhibitory activities. Thus, this study demonstrates the enzyme inhibitory potentials of B. lacera leaves for the first time and it might be a potential tool for the treatment of metabolic diseases.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88438282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Gurav, Charmaine Dias, Nilambari S. Gurav, S. Nadaf, M. Ayyanar
{"title":"Toxicodendron succedaneum (L.) Kuntze (Japanese wax tree): A review on its phytochemistry, pharmacology, and toxicity","authors":"S. Gurav, Charmaine Dias, Nilambari S. Gurav, S. Nadaf, M. Ayyanar","doi":"10.29090/psa.2022.05.22.038","DOIUrl":"https://doi.org/10.29090/psa.2022.05.22.038","url":null,"abstract":"Toxicodendron succedaneum (L.) Kuntze (Anacardiaceae) is a deciduous tree widely distributed in South and Southeast Asia. The resin of T. succedaneum is used in decorating traditional handicrafts, and resinous latex is poisonous. The plant yields a commercially important wax and treats asthma, cough, fever, ear infections, pulmonary infections, diarrhoea, dysentery, nose bleeding, and liver disorders. The scientific literature on T. succedaneum was collected from Scopus, PubMed, and Google Scholar. Major bioactive compounds reported in the plant are urushiols, bichalcones, biflavonoids such as succedaneaflavanone, agathisflavone, rhusflavanone, amentoflavone, cupressuflavone, robustaflavone, volkensiflavone, morelloflavone, and hinokiflavone. In-vitro studies have demonstrated the antioxidant, antibacterial, antitumor, and antileukemic activities of T. succedaneum, supporting the rationale behind its traditional use. Biflavonoids exhibited a strong antiviral effect by inhibiting the replication of HIV, HBV, and HSV. However, with the presence of hinokiflavone and a skin-irritating oil (urushiol), the plant causes severe allergies in humans, which urges to standardize the effectiveness of this species. The available literature on T. succedaneum suggests insufficient data on pharmacological studies in experimental animals. Much research needs to be done to confirm its folk medicinal uses for developing phytopharmaceutical drugs.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87885591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}