Pharmaceutical Sciences Asia最新文献_第9页

Phytochemical composition of Blumea lacera leaf and its inhibitory effects on the activity of enzymes related to metabolic diseases 蓝叶植物化学成分及其对代谢性疾病相关酶活性的抑制作用

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI: 10.29090/psa.2022.03.22.029

M. R. Habib, Y. Igarashi, M. Rabbi

{"title":"Phytochemical composition of Blumea lacera leaf and its inhibitory effects on the activity of enzymes related to metabolic diseases","authors":"M. R. Habib, Y. Igarashi, M. Rabbi","doi":"10.29090/psa.2022.03.22.029","DOIUrl":"https://doi.org/10.29090/psa.2022.03.22.029","url":null,"abstract":"in this context, plants extracts and natural products have been well recognized sources of bioactive components with enzymes inhibitory properties 11 . Some studies have ABSTRACT Blumea lacera (Bum. f.) DC is an important medicinal plant of Bangladesh having several ethnomedicinal values. To give the scientific basis of ethnomedicinal uses, the present study analyzed phytochemical composition of methanol extract of B. lacera leaves (designated as MBLE) and evaluated its inhibitory effects on pancreatic lipase, α-amylase, xanthine oxidase (XO) and angiotensin I-converting enzyme (ACE). Different in vitro methods were used to perform enzyme inhibition assays for MBLE and its phytochemical profile was analyzed by GC-MS. In case of all the enzyme inhibition assays, the percentage of inhibition by MBLE was increased with increasing in concentrations. Among these enzymes, MBLE showed strong activity (IC 50 :13.34±1.05 μg/mL) against ACE as compared with captopril (IC 50 :8.09±0.74 μg/mL) used as standard reference whereas it exhibited moderate activity against other enzymes. The IC 50 values of MBLE were found to be 9.87±0.25, 40.17±2.32 and 93.88±5.21 μg/mL for pancreatic lipase, α-amylase and XO, respectively. In addition, some compounds identified in MBLE by GC-MS, were also consistence with these enzyme inhibitory activities. Thus, this study demonstrates the enzyme inhibitory potentials of B. lacera leaves for the first time and it might be a potential tool for the treatment of metabolic diseases.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88438282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prevalence of bacterial contamination on mobile phones of pharmacy university students 药学类大学生手机细菌污染的流行情况

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI: 10.29090/psa.2022.04.22.084

Methee Sriprapun, Oraphan Atthakorn, Atchareeya Phuakwilai

{"title":"The prevalence of bacterial contamination on mobile phones of pharmacy university students","authors":"Methee Sriprapun, Oraphan Atthakorn, Atchareeya Phuakwilai","doi":"10.29090/psa.2022.04.22.084","DOIUrl":"https://doi.org/10.29090/psa.2022.04.22.084","url":null,"abstract":"Mobile phones (MPs) become one of the most important tools in professional and social life. Bacteria-contaminated MPs were reported in healthcare and non-healthcare workers but no study has investigated among pharmacy university students. We aimed to examine the prevalence of bacterial contamination on MPs and personal behaviors of MP usage. Fifty-three participants whose MPs had been used at least 3 months were enrolled. Each MP (n=53) was swabbed and cultured on sheep blood agar. Isolated colonies were characterized by conventionally bacterial identification methods. All participants were asked to complete questionnaires about behaviors of MP usage. Bacterial contamination was found in 52 of 53 MPs (98.11%) and 44 of 52 devices (84.62%) composed of heavy growth colonies (more than 15 colonies). The most abundant colonies were coagulase-negative staphylococci (CoNS) (42.72%), following by Bacillus spp. (27.18%), Staphylococcus aureus (20.39%), Micrococcus spp. (7.77%), Corynebacterium spp. (0.97%) and viridans streptococci (0.97%). Co-contamination with CoNS and Bacillus spp. was commonly found (28.85%). Most participants had risks for bacteria-contaminated MPs, which were visiting hospitals in past 6 months (56.60%), sharing with others (92.45%) and using in toilets (98.11%). Additionally, 44 of 53 (83.02%) participants regularly cleaned their MPs and 20 of them (45.45%) used clean clothes or tissue papers. No correlation between MP-using or cleaning behaviors and bacterial contamination was observed ( p >0.05). Our findings emphasized that bacteria-contaminated MPs are commonly found among pharmacy university students. MP users should increase awareness of personal hygiene and perform effective cleaning procedures to reduce bacterial persistence and transmission.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83025805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of life and willingness to pay for receiving hemodialysis in patients who received peritoneal dialysis in Thailand 泰国接受腹膜透析患者的生活质量和接受血液透析的支付意愿

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI: 10.29090/psa.2022.04.22.054

Wanchana Singhan, U. Permsuwan, S. Vongsanim, Yuttitham Suteeka, S. Deeprom

{"title":"Quality of life and willingness to pay for receiving hemodialysis in patients who received peritoneal dialysis in Thailand","authors":"Wanchana Singhan, U. Permsuwan, S. Vongsanim, Yuttitham Suteeka, S. Deeprom","doi":"10.29090/psa.2022.04.22.054","DOIUrl":"https://doi.org/10.29090/psa.2022.04.22.054","url":null,"abstract":"This cross-sectional study was conducted to evaluate quality of life (QoL), willingness to pay (WTP) for receiving hemodialysis (HD), and factors influencing QoL in patients who received peritoneal dialysis (PD) in Thailand. Data of PD patients visiting secondary or tertiary hospitals from December 2020 through June 2021 were collected. EuroQoL EQ-5D-5L questionnaire was used to evaluate QoL. After the patients completed the questionnaire, they were interviewed using the contingent valuation method to derive their WTP for switching to HD. Patients randomly picked up one payment card as an initial price for receiving HD, then bidding by 100 Thai Baht (THB) up and down to reach the maximum affordable WTP amount. Multiple linear regression was used to identify factors affecting QoL. A total of 102 patients were included in this study. The mean age was 58 years. EQ-5D utility score was 0.71±0.32. Five variables were the factors that affect QoL included serum albumin, hospitalization, age, urine output, and hemoglobin level. Average WTP was 233±293 THB (7.2±9.0 USD) per HD session. Quality of life among these study patients was slightly higher than reported in Thai patients with low hemoglobin level. Treatment anemia to reach hemoglobin target and preservation of residual urine output might improve QoL. The average WTP for switching to HD among PD patients was only one-sixth of general billing price for HD.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82606183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization and in vivo assay of chitosan alginate microencapsulation to deliver the combination of HBcAg and HBsAg as a hepatitis B oral vaccine candidate 海藻酸壳聚糖微胶囊递送HBcAg和HBsAg作为乙型肝炎口服候选疫苗的特性和体内实验

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI: 10.29090/psa.2022.05.22.098

N. Ekawati, Mohamad Taufik, A. Z. Mustopa, Ari Estuningtyas, I. R. Sianipar, A. Hertati, M. Nurfatwa, Djadjat Tisnadjaja, Tri Isyani Tungga Dewi

{"title":"Characterization and in vivo assay of chitosan alginate microencapsulation to deliver the combination of HBcAg and HBsAg as a hepatitis B oral vaccine candidate","authors":"N. Ekawati, Mohamad Taufik, A. Z. Mustopa, Ari Estuningtyas, I. R. Sianipar, A. Hertati, M. Nurfatwa, Djadjat Tisnadjaja, Tri Isyani Tungga Dewi","doi":"10.29090/psa.2022.05.22.098","DOIUrl":"https://doi.org/10.29090/psa.2022.05.22.098","url":null,"abstract":"Chronic hepatitis B infection is one of main factors of cirrhosis primary cause, which can develop into hepatocellular carcinoma. Medically, there are various disadvantages associated with administering hepatitis B vaccine through injection, include pain, reduced patient compliance, higher production costs, and inadequate mass vaccination. Therefore, it is necessary to develop an oral vaccine. This study aims to develop and characterize oral vaccine through combination of Hepatitis B Surface Antigen (HBsAg) and Hepatitis B Core Antigen (HBcAg) encapsulated within chitosan alginate. The vaccine formula was prepared by ionic gelation method that consists of HBcAg (marked as MPS) and a combination of HBcAg and HBsAg (which is marked as MPC) microparticles. Examined parameters include loading efficacy, particle characteristics, anti-HBcAg immune response, ALT & AST, and liver histology. It was found that loading efficacy of MPS and MPC were 82.5±9.57 and 75.0±11.78%. The mean particle size (Z-average), polydispersity index (PdI), and zeta potential of MPS and MPC were 4,869±739 nm and 8,712±2,110 nm, 0.32±0.032 and 0.37±0.088, -7.50±1.82 mV and -2.10±1.59 mV, respectively. The Hepatitis B core antibody (HBcAb) started forming on the 35 th day after first vaccination. The results show that both AST and ALT serum were in normal range. Therefore, antigen dose given in this study had no pathological effects on liver histology. Furthermore, based on its parameters such as loading efficacy, PdI, zeta potential, particle size, FTIR, and formation of HBcAb from the 35 th day after vaccination, it concluded that combination of HBcAg and HBsAg is safely encapsulated within microparticles (MP) chitosan alginate.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"58 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83412508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Terminalia arjuna flowers: Secondary metabolites and antifungal activity 阿尔朱那终叶花:次生代谢物和抗真菌活性

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI: 10.29090/psa.2022.03.21.149

Ahlam Elwekeel, Elham Amin, A. Khairallah, A. Moawad

{"title":"Terminalia arjuna flowers: Secondary metabolites and antifungal activity","authors":"Ahlam Elwekeel, Elham Amin, A. Khairallah, A. Moawad","doi":"10.29090/psa.2022.03.21.149","DOIUrl":"https://doi.org/10.29090/psa.2022.03.21.149","url":null,"abstract":"Fungal pathogens are able to cause serious infections to human. Candidiasis caused by Candida species and pulmonary aspergillosis caused by Aspergillus fumigatus may occur as secondary complication in immunocom-promised patients. Meanwhile, biologically guided isolation of bioactive constituents from natural sources represents a promising strategy in drug discovery process. In this concern, the antimicrobial screening of 11 plants collected from Egypt was performed against several microbes. Terminalia arjuna flower extract was among the most active extracts against C. albicans . The antifungal potential of n-hexane, dichloromethane (DCM), ethyl acetate (EtOAc) fractions of T. arjuna flower were tested against C. albicans , A. fumigatus and Fusarium avenaceum . Results revealed a potent activity of EtOAc extract against C. albicans (100% inhibition, MIC=7.81 µg/mL). Chromatographic investigation of T. arjuna flower afforded nine compounds; β-sitosterol ( 1 ), stigmasterol ( 2 ), β-sitosterol-3- O -β-D-glucopyranoside ( 3 ), rosamultin ( 4 ), niga-ichigoside Fl ( 5 ), luteolin ( 6 ), apigenin ( 7 ), gallic acid ( 8 ) and methyl gallate ( 9 ). The structures of the isolated compounds were elucidated using different spectroscopic techniques especially 1D and 2D NMR. Among the isolated compounds, the two triterpenoid glycosides ( 4 ) and ( 5 ) have not been previously tested for antifungal potential. The current study indicated moderate activity of rosamultin ( 4 ) and niga-ichigoside Fl ( 5 ) (MIC 250 µg/mL) against C. albicans .","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"125 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82250714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Anti-obesity potential of Capparis spinosa flower bud extracts in 3T3-L1 adipocytes and in high fat diet induced obese rats 荆芥花蕾提取物对3T3-L1脂肪细胞和高脂饮食诱导的肥胖大鼠的抗肥胖作用

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI: 10.29090/psa.2022.05.22.127

K. Athesh, P. Brindha

{"title":"Anti-obesity potential of Capparis spinosa flower bud extracts in 3T3-L1 adipocytes and in high fat diet induced obese rats","authors":"K. Athesh, P. Brindha","doi":"10.29090/psa.2022.05.22.127","DOIUrl":"https://doi.org/10.29090/psa.2022.05.22.127","url":null,"abstract":"Obesity is a raising pandemic and it needs alternative approaches to prevent or treat, as the existing approaches are not highly effective. In this context, the present study has been designed with the aim to investigate the antiobesity potential of aqueous flower buds extract of Capparis spinosa L. (AFBECS) in 3T3-L1 adipocytes and in high fat diet (HFD) induced obesity thereby giving scientific validation to its traditional use. The 3T3-L1 preadipocytes were cultured and differentiated in DMEM in the absence and presence of various concentrations of AFBECS (25, 50, 100, 250 and 500 µg/mL) and the influence of the extracts on 3T3-L1 adipocyte viability and lipid accumulation were determined. The results showed that AFBECS maintained the viability of the 3T3-L1 adipocytes and also reduced the lipid accumulation in 3T3-L1 cells, dose dependently. In-vitro pancreatic lipase inhibition assay of AFBECS had shown moderate level of inhibition when compared with Orlistat. For in-vivo studies, HFD induced obese rats were treated with 100, 200 and 300 mg/kg of extracts for a period of 60 days using orlistat as standard drug. Anti-obesity potential was assessed using food intake, body weight, organ weights, adipocyte area, lipid profiles and many other blood biochemical parameters. Data of in-vivo studies revealed, significant reduction in body weight, fat-pad and organ weights of AFBECS treated animals. Altered levels of glucose, insulin, leptin, lipid profiles and antioxidant status were also normalized upon AFBECS treatment. These findings suggested that AFBECS was found to have prominent anti-obesity potential and exhibited its therapeutic efficacy by inhibiting adipogenesis, promoting lipolysis and ameliorating oxidative stress.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74704327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prescription of antipsychotics and prevalence of metabolic syndrome in Vietnamese inpatients with schizophrenia 越南精神分裂症住院患者抗精神病药物处方及代谢综合征患病率

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI: 10.29090/psa.2022.04.22.063

Nguyễn Hoàng Minh Thuận, T. D. Khoa, Chau Van Tuan

{"title":"Prescription of antipsychotics and prevalence of metabolic syndrome in Vietnamese inpatients with schizophrenia","authors":"Nguyễn Hoàng Minh Thuận, T. D. Khoa, Chau Van Tuan","doi":"10.29090/psa.2022.04.22.063","DOIUrl":"https://doi.org/10.29090/psa.2022.04.22.063","url":null,"abstract":"Schizophrenia is a severe mental illness, characterized by psychotic symptoms including delusions, hallucinations, dystonia, adolescent behavior and language, and is accompanied by severe functional impairments. Antipsychotics, which are used mainly in the treatment of schizophrenia, have contributed to the development of metabolic syndrome. Studies on metabolic syndrome in schizophrenic patients have been still limited in Vietnam. The objective of this study was to investigate the prevalence of metabolic syndrome in Vietnamese inpatients with schizophrenia. The study population of this descriptive cross-sectional study was all patients with schizophrenia from September 2020 to June 2021 at Inpatient Department of Binh Dinh Provincial Psychiatric Hospital in Viet Nam. Three hundred and twelve patients who met the sampling requirements were enrolled in this study. The prevalence of schizophrenia in female patients was lower than in male patients (36.9% vs. 63.1%) in our study. The prevalence of metabolic syndrome was 30.4% (25.9% in men and 38.3% in women), more in patients  40 years old than in patients under 40 years old (the highest prevalence in patients  60 years). There was a significant relationship between age, body mass index (BMI), and duration of antipsychotic treatment with the frequency of metabolic syndrome. In conclusions, the prevalence of schizophrenia was higher in male inpatients than in female inpatients. However, the prevalence of metabolic syndrome was higher in female inpatients than male inpatients with schizophrenia, and increased with age, BMI, and duration of antipsychotic treatment.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76883071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of anti-hypertensive drug prescription in Thailand, a cross sectional study using National Health Security Office database 泰国抗高血压药物处方的流行，使用国家卫生安全办公室数据库的横断面研究

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI: 10.29090/psa.2022.02.21.086

Theerut Luangmonkong, Jiratchaya Wongsaardsakul, Rujipas Laobutree, S. Jindarat, N. Jaisupa

{"title":"Prevalence of anti-hypertensive drug prescription in Thailand, a cross sectional study using National Health Security Office database","authors":"Theerut Luangmonkong, Jiratchaya Wongsaardsakul, Rujipas Laobutree, S. Jindarat, N. Jaisupa","doi":"10.29090/psa.2022.02.21.086","DOIUrl":"https://doi.org/10.29090/psa.2022.02.21.086","url":null,"abstract":"Individual conditions are essential in pharmacotherapy of hypertension; however, information regarding the association between anti-hypertensive drugs and co-morbid diseases as recommended in clinical practice guidelines is not well acquainted. Therefore, this study aimed to report the prevalence of prescribed anti-hypertensive drugs using Thailand National Health Security Office database. In 2014, we found that calcium channel blockers (CCBs), angiotensin converting enzyme inhibitors (ACEIs), and diuretics, were prescribed in 56.11%, 42.70%, and 33.58% of total patients, respectively. Similarly in 2015, CCBs and ACEIs were prescribed in 57.69% and 41.01% of total patients, whereas the 3 rd most frequently prescribed was anti-adrenergics (28.55%). As recommended in the latest Thailand clinical practice guideline at that period, as a mono-therapy, patients younger than 55 years old without co-morbid diseases received either ACEIs (28.91% and 28.40%) or ARBs (6.70% and 6.33%); however, CCBs were prescribed to these patients in the highest percentage (33.25% and 40.35% in 2014 and 2015, respectively). Focusing on patients with co-morbid conditions, CCBs were prescribed at 54.23% and 55.72% in patients with diabetes mellitus and 62.53% and 62.58% in patients with chronic kidney diseases in 2014 and 2015, respectively. The percentages of patients with chronic kidney diseases who received CCBs were relatively higher than those treated with either ACEIs or ARBs, the first-line recommendation. Interestingly, we found the inappropriate combination between ACEIs and ARBs. Our finding revealed that although the anti-hypertensive drug prescription in Thailand was in line with the recommendations in clinical practice guidelines, certain problematic prescriptions remained available.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73034993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of combination of perindopril and indapamide on ambulatory arterial stiffness index in Vietnamese patients with primary hypertension 培哚普利联合吲达帕胺对越南原发性高血压患者动态动脉僵硬指数的影响

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI: 10.29090/psa.2022.05.22.107

S. Tran, H. T. Huynh, Toan Hoang Ngo, Anh Thi Hoang Nguyen, C. T. Vo, Thang Nguyen, Minh Van Huynh

{"title":"Effectiveness of combination of perindopril and indapamide on ambulatory arterial stiffness index in Vietnamese patients with primary hypertension","authors":"S. Tran, H. T. Huynh, Toan Hoang Ngo, Anh Thi Hoang Nguyen, C. T. Vo, Thang Nguyen, Minh Van Huynh","doi":"10.29090/psa.2022.05.22.107","DOIUrl":"https://doi.org/10.29090/psa.2022.05.22.107","url":null,"abstract":"Arterial stiffness is an independent prognostic factor for predicting adverse cardiovascular outcomes in hypertensive patients. This study aimed to investigate the rate of increase in arterial stiffness index and the relationship between the ambulatory arterial stiffness index (AASI) with some cardiovascular risks and the change of AASI after 3 months of treatment with perindopril/indapamide (PER/IND). We conducted this research on 75 untreated hypertensive patients at Can Tho University of medicine and pharmacy, Viet Nam. AASI and pulse pressure (PP) were calculated from 24-hour ambulatory blood pressure results. Our study showed that the mean AASI is 0.44±0.14. Female’s increased AASI is capable of 4.38 times as much as the male. Left ventricular hypertrophy (LVH) can increase arterial stiffness index about 3.93 times as much as the non-hypertrophy group ( p <0.05). AASI is positively correlated with mean pulse pressure and age with r=0.37 and r=0.3 ( p <0.05). After 3 months of treatment, results analysis of the subgroup revealed that AASI decreased 0.06±0.15 in women ( p <0.05). AASI reduced significantly in the group of people aged 65 or more with a mean change to 0.11±0.12 ( p <0.05). Moreover, the group of patients with grade 2 hypertension also indicated that AASI reduced 0.05±0.14 in post-treatment. In conclusion, AASI has been associated with several cardiovascular risk factors such as female, age, nocturnal non-dipper blood pressure, left ventricular hypertrophy, and increased mean pulse pressure. PER/IND has effectively reduced arterial stiffness in Vietnamese patients with primary hypertension, especially women, the elderly, and grade 2 hypertension.","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78679073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Assessment of direct-acting oral anticoagulants for the treatment of venous thromboembolism in cancer patients in Thai Tertiary Care Hospital 评估直接作用口服抗凝剂治疗癌症患者静脉血栓栓塞在泰国三级医院

Pharmaceutical Sciences Asia Pub Date : 2022-01-01 DOI: 10.29090/psa.2022.02.21.106

J. Meanwatthana, Phatcharin Mitsuntisuk

{"title":"Assessment of direct-acting oral anticoagulants for the treatment of venous thromboembolism in cancer patients in Thai Tertiary Care Hospital","authors":"J. Meanwatthana, Phatcharin Mitsuntisuk","doi":"10.29090/psa.2022.02.21.106","DOIUrl":"https://doi.org/10.29090/psa.2022.02.21.106","url":null,"abstract":"Venous thromboembolism (VTE) is an important cancer complication. Recent studies suggest direct-acting oral anticoagulants (DOACs) are possible alternatives for this population; nonetheless, there is limited evidence to support this decision in Thai cancer patients. The primary aim of this study was to measure the cumulative incidence of VTE recurrences and major bleeding among cancer patients who received DOACs that were available in Thailand. Secondary objective was to determine factors associated recurrent VTE and major bleeding. This is a retrospective cohort study conducted in tertiary care hospitals in Thailand. Data was collected from patients who had active cancer with new diagnosis of VTE and receiving approved DOACs. There were 32 cases, who received rivaroxaban, apixaban, or dabigatran, recruited to this study. We reported 4 cases (12.5%) of recurrent VTE at 6-month. There were 6 patients (18.75%), 2 patients (6.25%), and 1 patient (3.13%) with major bleeding, minor bleeding and intracranial hemorrhage, consecutively. No correlation was found between factors associated with recurrent VTE recurrence or bleeding. This study demonstrated that DOACs may be an acceptable option for preventing VTE recurrence. However, Thai population may be potentially prone to have clinically relevant bleeding. A further prospective study is warranted to draw a final conclusion in Thai cancer patients","PeriodicalId":19761,"journal":{"name":"Pharmaceutical Sciences Asia","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83254438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0