Pediatric Critical Care Medicine最新文献

{"title":"Protocol for a Group-Sequential Two-Stratum Multicenter Open-Label Randomized Clinical Trial of Respiratory Support in Infants With Acute Bronchiolitis: Breathing Assistance in Children With Bronchiolitis (BACHb).","authors":"Isabel Johnson, Katy Bridges, Richard Cleaver, Rayka Malek, Mary Cross, Steve Cunningham, Katrina Cathie, Mark D Lyttle, Rebecca Mitting, Paul Mouncey, Damian Roland, Stephen Turner, Olu Onyimadu, Stavros Petrou, Debra Quantrill, Kate Chadwick, Leila Janani, Padmanabhan Ramnarayan","doi":"10.1097/PCC.0000000000003813","DOIUrl":"10.1097/PCC.0000000000003813","url":null,"abstract":"<p><strong>Objectives: </strong>The Breathing Assistance in Children with bronchiolitis (BACHb) trial aims to evaluate the clinical and cost-effectiveness of high-flow nasal cannula (HFNC) therapy compared with humidified standard oxygen (HSO) in infants with moderate bronchiolitis, and HFNC with continuous positive airway pressure (CPAP) in severe bronchiolitis.</p><p><strong>Design: </strong>Pragmatic, group-sequential, two-stratum, multicenter, open-label randomized clinical trial.</p><p><strong>Setting: </strong>Fifty hospitals across England, Scotland, and Wales.</p><p><strong>Patients: </strong>Hospitalized infants younger than 12 months old with a clinical diagnosis of bronchiolitis, assessed at least twice 15 minutes apart to fulfill criteria for either severe bronchiolitis (one or more of: respiratory rate > 70 breaths/min, grunting, marked chest recession, recurrent short apneas) or moderate bronchiolitis (lack of response to low-flow oxygen, indicated by persistent hypoxemia and/or moderate respiratory distress).</p><p><strong>Interventions: </strong>\"Moderate bronchiolitis stratum\": HFNC at a flow rate of 2 L/kg/min vs. HSO through a facemask or headbox at a flow rate up to 15 L/min. \"Severe bronchiolitis stratum\": HFNC at a flow rate of 2 L/kg/min vs. CPAP pressure set at 6-8 cm H 2 O.</p><p><strong>Measurements and main results: </strong>In each stratum, eligible infants will be randomly allocated on a 1:1 basis to the trial treatments using a web-based system by permuted block randomization, stratified by site of recruitment and age (< 6 wk and ≥ 6 wk). Due to the emergency nature of the treatments, written informed consent will be deferred. The primary outcome is time from randomization to hospital discharge within 30 days. Baseline clinical characteristics and hospital course, including details of respiratory support, and discharge and cost-effectiveness outcomes will be collected. The trial received Health Research Authority and Research Ethics Committee approval from the Yorkshire and The Humber-South Yorkshire Research Ethics Committee on August 3, 2023 (reference: 23/YH/0166). The trial registration is ISRCTN52937119.</p><p><strong>Conclusions: </strong>Trial findings will be disseminated in national and international conferences, in peer-reviewed journals and through social media.</p>","PeriodicalId":19760,"journal":{"name":"Pediatric Critical Care Medicine","volume":" ","pages":"e1275-e1285"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12502951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presence of Families at the Bedside in the PICU: Prospective, Mixed-Methods Study of Race and Insurance Disparities.","authors":"Michelle R Mayeda, Samuel Rosenblatt, Dorene F Balmer, Wynne Morrison, Paula Magee, Veronica Kirchner, Nadir Yehya","doi":"10.1097/PCC.0000000000003808","DOIUrl":"10.1097/PCC.0000000000003808","url":null,"abstract":"<p><strong>Objectives: </strong>To determine whether patient race, ethnicity, preferred language, insurance type, and social deprivation index (SDI) are associated with differences in caregiver presence in the PICU and to explore caregiver perspectives on decision-making about time spent at and away from bedside.</p><p><strong>Design: </strong>Single-center prospective, concurrent mixed-methods study including: 1) a quantitative point prevalence study of caregiver bedside presence, and 2) a qualitative study of interviews with caregivers.</p><p><strong>Setting: </strong>Seventy-five-bed PICU in a quaternary children's hospital in Philadelphia, PA.</p><p><strong>Patients: </strong>Over the period 2022-2023, we enrolled: 1) children with anticipated moderate-to-long PICU length of stay and 2) adult caregivers of children in our PICU.</p><p><strong>Interventions: </strong>None.</p><p><strong>Measurements and main results: </strong>Multivariable regression tested associations between caregiver presence and race, ethnicity, preferred language, insurance type, and SDI. Semi-structured interviews with caregivers were evaluated using thematic analysis. Among 159 subjects, Black patient race relative to White, and public insurance relative to private, were associated with 18 and 10 fewer hours of caregiver presence during a 48-hour period, respectively. Caregivers nearly universally shared a desire to be present, yet the ability to be present was affected by practical limitations, including job flexibility and family availability.</p><p><strong>Conclusions: </strong>Public insurance and Black patient race were associated with decreased caregiver presence, disparities that may be explained by practical limitations. Additional work is necessary to explore ways to mitigate barriers to presence and equitable family-centered care and to investigate potential impacts of caregiver presence on health outcomes.</p>","PeriodicalId":19760,"journal":{"name":"Pediatric Critical Care Medicine","volume":" ","pages":"e1253-e1263"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B-Type Natriuretic Peptide in Critically Ill Children: Single-Center Retrospective Study of Levels in the First 72 Hours of PICU Admission and Outcome.","authors":"Yulia Shtanko, Abhinav Totapally, Prithvi Sendi, Balagangadhar R Totapally","doi":"10.1097/PCC.0000000000003812","DOIUrl":"10.1097/PCC.0000000000003812","url":null,"abstract":"","PeriodicalId":19760,"journal":{"name":"Pediatric Critical Care Medicine","volume":" ","pages":"e1307-e1309"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Novel Cardiac Arrest Ventilation Rate Metronome: A Human Factors and Implementation Science Mixed-Methods Approach.","authors":"Amanda O'Halloran, James Sannino, Cheryl Dominick, Christine Bailey, Lori Boyle, Lindsay N Shepard, Vinay Nadkarni, Heather Wolfe, Ryan W Morgan, Akira Nishisaki, Meghan Lane-Fall, Robert Sutton","doi":"10.1097/PCC.0000000000003811","DOIUrl":"10.1097/PCC.0000000000003811","url":null,"abstract":"<p><strong>Objectives: </strong>Excessive ventilation adversely affects cardiopulmonary resuscitation (CPR) hemodynamics and outcomes. Pediatric providers rarely achieve guideline-recommended CPR ventilation rates. We aimed to use human factors engineering to design a metronome to improve compliance with recommended CPR ventilation rates. We hypothesized that in usability testing, our novel metronome would achieve: 1) a System Usability Scale (SUS) score greater than 68 and 2) greater than 70% of CPR epochs with ventilation rates within target range, which would be sufficient to support a pilot trial in our PICU.</p><p><strong>Design: </strong>Prospective single-center mixed-methods study.</p><p><strong>Setting: </strong>Seventy-five-bed academic PICU.</p><p><strong>Participants: </strong>Multidisciplinary clinicians.</p><p><strong>Interventions: </strong>None.</p><p><strong>Measurements and main results: </strong>We elicited clinician feedback on the proposed ventilation rate metronome with a survey. Participatory design sessions determined optimal metronome components. During high-fidelity simulation usability testing, we collected qualitative and quantitative measures reflecting participant feedback and performance. Average ventilation rates were calculated during 30-second epochs of CPR, with average rates ± 2 breaths/min (bpm) from the target considered to be within goal range. Among 107 survey respondents, perceptions of appropriateness, acceptability, and feasibility of the ventilation rate metronome were favorable. The final prototype used a bell sound for high saliency in noisy environments and a scrolling timed vertical bar, with pre-set options for three guideline-recommended CPR ventilation rates (infants: 30 bpm, children 1-17 yr old: 20 bpm, adults: 10 bpm). In usability testing (three groups, 34 clinicians), median SUS was 92.5 of 100 (interquartile range, 89.4-93.1), with 0 attributable errors. Overall, 34 of 36 (94% [95% CI, 81-99%]) epochs of simulated CPR with metronome use had ventilation rates ± 2 bpm from the target rate.</p><p><strong>Conclusions: </strong>Utilizing human factors engineering and implementation science, we successfully designed a novel ventilation rate metronome. When deployed during high-fidelity cardiac arrest simulations, metronome use had high usability scores and resulted in excellent compliance with recommended ventilation rates.</p>","PeriodicalId":19760,"journal":{"name":"Pediatric Critical Care Medicine","volume":" ","pages":"e1264-e1274"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Status and Mechanical Ventilation Practices in Pediatric Acute Respiratory Distress Syndrome: A Secondary Analysis of the 2017-2023 PARDSAsia Study.","authors":"Chen Yun Goh, Karen Ka Yan Leung, Jia Yueh Chong, Xuemei Zhu, Nattachai Anantasit, Lijia Fan, Chunfeng Liu, Louise Ngu, Kam Lun Ellis Hon, Jan Hau Lee, Wei Xu, Hiroshi Kurosawa, Dyah Kanya Wati, Rujipat Samransamruajkit, Li Huang, Muralidharan Jayashree, Yek Kee Chor, Hongxing Dang, Chin Seng Gan, Kah Min Pon, Chian Wern Tai, Phuc Huu Phan, Kazunori Aoki, Felix Liauw, Soo Lin Chuah, Suparyatha Ida Bagus Gede, Pei Chuen Lee, Jacqueline Soo May Ong, Siew Wah Lee, Chengsi Ong, Rehena Sultana, Judith Ju-Ming Wong","doi":"10.1097/PCC.0000000000003807","DOIUrl":"10.1097/PCC.0000000000003807","url":null,"abstract":"<p><strong>Objectives: </strong>In this non-prespecified secondary analysis of the PARDSAsia (NCT04068038) 2017-2023 dataset, we describe baseline nutrition status of children with pediatric acute respiratory distress syndrome (PARDS) and determine its association with positive end expiratory pressure (PEEP) during ventilation and mortality. We hypothesized that abnormal nutritional status was associated with adverse outcomes.</p><p><strong>Design: </strong>The dataset included anthropometric and nutritional data, and body mass index (BMI) z scores were obtained using the World Health Organization standards. Underweight is BMI z score less than -1 and overweight is BMI z score greater than +1. PEEP and F io2 combinations, by the standard grid, in underweight, overweight and normal nutrition groups were compared. Cox proportional hazard regression tested the association between nutrition status and 60-day mortality.</p><p><strong>Setting: </strong>Twenty-one PICUs across Asia, 2017-2023.</p><p><strong>Patients: </strong>PARDSAsia patients met the 2015 International Guidelines for the Diagnosis and Management of PARDS (PALICC) criteria.</p><p><strong>Interventions: </strong>None.</p><p><strong>Measurements and main results: </strong>Overall, of 693 PARDSAsia patients, we included 625 cases comprising 261 of 625 (41.8%) underweight, 235 of 625 (37.6%) normal, and 129 of 625 (20.6%) overweight patients. Being underweight compared with normal or overweight status, was associated with younger median (interquartile range) age: respectively, 1.0 (0.3, 3.7) vs. 1.4 (0.5, 4.6) vs. 1.9 (0.7, 8.5) years ( p < 0.001). The prescription of PEEP was more conservative in patients who were underweight compared with patients of normal or overweight nutritional status: PEEP/F io2 combinations were, respectively, -1.7 (-3.3, 0.0) vs. -0.9 (-2.7, 0.0) vs. -0.6 (-1.8, 0.4) cm H 2 O below recommended grid value ( p < 0.001). Underweight nutritional status was associated with greater risk of 60-day mortality (adjusted hazard ratio 1.85 [95% CI, 1.14-3.01]).</p><p><strong>Conclusions: </strong>Underweight nutritional status was prevalent among children within the PARDSAsia 2017-2023 dataset and was associated with poor clinical outcomes. The prescription of PEEP was more conservative in underweight patients compared with those with normal or overweight status.</p>","PeriodicalId":19760,"journal":{"name":"Pediatric Critical Care Medicine","volume":" ","pages":"e1242-e1252"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Moderate Pediatric Traumatic Brain Injury in Japan, 2019-2024.","authors":"Shu Utsumi, Nobuaki Shime","doi":"10.1097/PCC.0000000000003817","DOIUrl":"10.1097/PCC.0000000000003817","url":null,"abstract":"","PeriodicalId":19760,"journal":{"name":"Pediatric Critical Care Medicine","volume":" ","pages":"e1310-e1311"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145001204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot-Optimizing Transfusion Therapy in Critically Ill Children With Anemia: A Pilot Multicenter Electronic Health Record-Enabled Randomized Controlled Trial on Red Blood Cell Transfusion in Critically Ill Children.","authors":"Marisa Tucci, Avishay Sarfatti, Stéphane Leteurtre, Geneviève Du Pont-Thibodeau, Patricia Fontela, Samiran Ray, Simon J Stanworth, Paul C Hébert, Nadia Roumeliotis, Michaël Sauthier, Philip C Spinella, Thierry Ducruet, Philippe Jouvet, Benoît Mâsse, Nancy Robitaille, Helen Trottier, Jacques Lacroix","doi":"10.1097/PCC.0000000000003822","DOIUrl":"10.1097/PCC.0000000000003822","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the feasibility of conducting a large international electronic health record-enabled randomized controlled trial (RCT) designed to compare two strategies for RBC transfusion (RBCT) in almost all anemic critically ill children, and the ability to support data abstraction from electronic medical data monitoring systems (eMDMSs).</p><p><strong>Design: </strong>Two-arm parallel design pilot RCT.</p><p><strong>Setting: </strong>Four university-affiliated PICUs in Canada, France, and United Kingdom.</p><p><strong>Patients: </strong>Non-cyanotic critically ill children with hemoglobin (Hb) less than or equal to 9.5 g/dL.</p><p><strong>Interventions: </strong>Participants were randomly allocated to a restrictive strategy (no RBCT if Hb ≥ 7.0 g/dL) or to usual care (clinician discretion for RBCT).</p><p><strong>Measurements and main results: </strong>Feasibility outcomes were recruitment, adherence, separation of pre-RBCT Hb, and electronic data extraction from eMDMS. The proportion of patients with Hb less than or equal to 9.5 g/dL who were eligible for consent to participate in Pilot-Optimizing Transfusion Therapy in Critically Ill Children With Anemia (P-OpTTICCA) was 83% (feasibility criterion: ≥ 80%). We enrolled 120 patients, 63 in the restrictive and 57 in the usual care arms. We reached the planned recruitment rate (≥ 2 participants/wk in sites with > 800 admissions/yr, ≥ 1 in other sites). The pre-RBCT Hb concentration was 6.6 ± 7 and 6.7 ± 1.3 g/dL in the restrictive and usual care arms, respectively (separation = 0.1 g/dL; desired difference ≥ 1.0 g/dL). The pre-transfusion Hb concentration was greater than or equal to 7.0 g/dL for 6 of 20 RBCT (30%) given to patients allocated to the restrictive arm (success criterion for protocol adherence: < 20%). There were two protocol deviations, but no protocol violation. Using eMDMS, 87.7% of the 390 data elements in the case report form were extracted and/or calculated electronically (success criterion: > 80%).</p><p><strong>Conclusions: </strong>P-OpTTICCA demonstrated the feasibility of recruitment, adherence, and electronic data extraction, but we did not get a good separation of pre-RBCT Hb. Future trials need to clearly define transfusion Hb thresholds in both trial arms (NCT03871244).</p>","PeriodicalId":19760,"journal":{"name":"Pediatric Critical Care Medicine","volume":" ","pages":"e1218-e1230"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eight PICU Follow-Up Programs in the United States Established From 2013 to 2022: Report From the Pediatric Outcomes Studies After PICU (POST-PICU) Investigators.","authors":"Leslie A Dervan, Mary Hartman, Ericka L Fink, Julie C Fitzgerald, Trevor A Hall, Krista Laux, Lindsey A Morgan, Sarah Murphy, Neethi P Pinto, Elisabeth Schrock, Jane E Whitney, Cydni N Williams, Elizabeth Y Killien","doi":"10.1097/PCC.0000000000003804","DOIUrl":"10.1097/PCC.0000000000003804","url":null,"abstract":"<p><strong>Objectives: </strong>Children surviving critical illness are at risk for new morbidities collectively termed \"post-intensive care syndrome-pediatrics\" (PICS-p). Because PICU teams are familiar with PICS-p and motivated to improve patient outcomes, intensivists are ideally positioned to improve access to PICU follow-up care. We aimed to describe various models of care developed by existing U.S. PICU follow-up programs.</p><p><strong>Design: </strong>The Pediatric Outcomes Studies after PICU (POST-PICU) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators network convened a virtual meeting with presentations and discussion by 11 leaders of eight follow-up programs, structured using input from the 125 POST-PICU members including advance questions.</p><p><strong>Setting: </strong>Ninety-minute virtual meeting, September 2024. We recorded and transcribed the presentations and discussion to draft this report.</p><p><strong>Panel proceedings: </strong>Each leader presented their program and participated in discussion, organized into three domains based on the provided questions: 1) the program's target population and interventions; 2) program administration and funding; and 3) program outcomes. Each program aimed to identify patients considered at-risk for physiologic, neurologic, and/or psychologic PICU sequelae and to provide screening, referral to supportive or specialist services as indicated, and collaboration with their existing healthcare teams. Funding influenced program structure and processes. Many programs provided clinical services alongside services tied to research efforts. Tracking program outcomes helped programs advocate for long-term funding and institutional support. Panelists described their programs as providing \"wraparound care,\" \"transition care,\" and \"connection\"-supporting patients and families through different stages of the PICU and hospital stay, rehabilitation, and transition to home care.</p><p><strong>Conclusions: </strong>This information can support PICU teams in developing infrastructure to provide clinically indicated education, screening, and support for their patients, as the PICU community engages in further research and advocacy to improve access to PICU follow-up care.</p>","PeriodicalId":19760,"journal":{"name":"Pediatric Critical Care Medicine","volume":" ","pages":"e1296-e1306"},"PeriodicalIF":4.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of Central Venous Pressure Using Cardiac Ultrasound of Inferior Vena Cava in Ventilated Children: A Prospective Multicenter Observational Study, 2021-2023.","authors":"Perrine Sée, Aurélie Hayotte, Enora Le Roux, Anne-Sophie Guilbert, Charlotte Collignon, Solene Denante, Roman Klifa, Jérôme Rambaud, Olivier Brissaud, Stéphane Dauger","doi":"10.1097/PCC.0000000000003834","DOIUrl":"https://doi.org/10.1097/PCC.0000000000003834","url":null,"abstract":"<p><strong>Objectives: </strong>Despite its numerous limitations, especially in predicting fluid responsiveness, trends in central venous pressure (CVP) values may be useful for managing certain critically ill pediatric patients. Although ultrasound parameters of the inferior vena cava (IVC) cannot be used to estimate CVP in adults under mechanical ventilation (MV), the pediatric literature reports highly contradictory results.</p><p><strong>Design: </strong>Prospective, multicenter observational study.</p><p><strong>Setting: </strong>Six PICUs in France.</p><p><strong>Patients: </strong>Children 2 days to 12 years old undergoing MV and had a central venous catheter in the superior vena cava to monitor CVP, from November 1, 2021, to June 30, 2023.</p><p><strong>Interventions: </strong>None.</p><p><strong>Measurements and main results: </strong>Ultrasound measurements (i.e., IVC maximum diameter [IVCdmax], IVC minimum diameter [IVCdmin]) were performed by experienced intensivists in order to calculate the following parameters: 1) IVC-Collapsibility: ([IVCdmax-IVCdmin]/IVCdmax) × 100; 2) IVC-Distensibility: ([IVCdmax-IVCdmin]/IVCdmin) × 100; and 3) IVC/Aortic: (IVCdmax/Ao) × 100. The search for correlation was studied using Spearman correlation tests because of monotonic relationships. We included 120 children with a median (interquartile range] age of 11.5 months (2.0-46.3 mo) and a median weight of 9.0 kg (5.0-15.0 kg). A third of the patients were admitted for postoperative care, including cardiac surgery, and a quarter for respiratory failure, with a median CVP of 7.5 mm Hg (5.0-10.3 mm Hg). No significant relationship was found between CVP and IVC-Collapsibility (Spearman ρ = -0.09; p = 0.32), IVC/Ao (Spearman ρ = 0.17; p = 0.06), or IVC-Distensibility (Spearman ρ = -0.09; p = 0.29).</p><p><strong>Conclusions: </strong>There is no correlation between CVP and IVC-ultrasound parameters in children under MV.</p>","PeriodicalId":19760,"journal":{"name":"Pediatric Critical Care Medicine","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Delirium in the Emergency Department: An Underrecognized Sixth Vital Sign.","authors":"Jan N M Schieveld, Jacqueline J M H Strik","doi":"10.1097/PCC.0000000000003835","DOIUrl":"https://doi.org/10.1097/PCC.0000000000003835","url":null,"abstract":"","PeriodicalId":19760,"journal":{"name":"Pediatric Critical Care Medicine","volume":" ","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}