Pathologie-biologie最新文献_第5页

Hyaluronan, a truly “youthful” polysaccharide. Its medical applications 透明质酸，一种真正“年轻”的多糖。它的医学应用

Pathologie-biologie Pub Date : 2015-02-01 DOI: 10.1016/j.patbio.2014.05.019

L. Robert

引用次数: 45

Erratum à : « Association entre les marqueurs du remodelage osseux, la densité minérale osseuse et le statut vitaminique D chez des femmes ménopausées d’origine marocaine » [Pathol. Biol. 62 (1) (2014) 49–54] 勘误表:“摩洛哥绝经妇女骨重塑标志物、骨密度和维生素D状态之间的关联”[Pathol。Biol. 62 (1) (2014) 49 - 54]

Pathologie-biologie Pub Date : 2015-02-01 DOI: 10.1016/j.patbio.2014.11.002

A. El maataoui , S. Elmachtani Idrissi , A. Dami , S. Bouhsain , L. Chabraoui , Z. Ouzzif

引用次数: 0

Les thérapies ciblées dans le cancer de la thyroïde : vers un traitement personnalisé ? 甲状腺癌的靶向治疗:走向个性化治疗?

Pathologie-biologie Pub Date : 2015-02-01 DOI: 10.1016/j.patbio.2014.11.003

S. Lkhoyaali, S. Benhmida, M. Ait Elhaj, M. Layachi, Y. Bensouda, H. Errihani

引用次数: 1

The CC-genotype of the cyclooxygenase-2 gene associates with decreased risk of nasopharyngeal carcinoma in a Tunisian population 在突尼斯人群中，环氧化酶-2基因的cc基因型与鼻咽癌风险降低相关

Pathologie-biologie Pub Date : 2015-02-01 DOI: 10.1016/j.patbio.2014.10.008

T. Mamoghli , H. Douik , S. Mehri , A. Ghanem , A. Ben Chaabane , J. Bouassida , G. Kablouti , L. Harzallah , S. Gritli , F. Guemira

{"title":"The CC-genotype of the cyclooxygenase-2 gene associates with decreased risk of nasopharyngeal carcinoma in a Tunisian population","authors":"T. Mamoghli , H. Douik , S. Mehri , A. Ghanem , A. Ben Chaabane , J. Bouassida , G. Kablouti , L. Harzallah , S. Gritli , F. Guemira","doi":"10.1016/j.patbio.2014.10.008","DOIUrl":"10.1016/j.patbio.2014.10.008","url":null,"abstract":"<div><h3>Background</h3><p>The cyclooxygenase-2 (cox-2) pathway is now recognized to be important in human cancer development and progression. The gene for cox-2 carries a common single nucleotide polymorphism, T8473C, located within a potential functional region in the 3′-UTR of cox-2 gene was identified. We have investigated the frequencies of cox-2 genotypes in Tunisian population to determine whether that polymorphism was associated with the risk of nasopharyngeal carcinoma (NPC) in Tunisian population.</p></div><div><h3>Material and methods</h3><p>One hundred and eighty-nine NPC patients were compared to 237 healthy controls.</p></div><div><h3>Results</h3><p>The cox-2 T8473C polymorphism was significantly associated with NPC (<em>P</em>    =0.013; 95% CI: 0.17–0.81; C: OR=0.72; <em>P</em>  =0.013). Tumor sizes, histologic grade, presence of primary lymph node metastases, age or sex were not associated with cox-2 genotypes.</p></div><div><h3>Conclusion</h3><p>We conclude that the CC-genotype and C allele of cox-2 T8473C gene polymorphism are associated with decreased risk of nasopharyngeal carcinoma in a Tunisian population.</p></div>","PeriodicalId":19743,"journal":{"name":"Pathologie-biologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.patbio.2014.10.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32849491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Prevalence and clinical distribution of multidrug-resistant bacteria (3537 isolates) in a tertiary Chinese hospital (January 2012–December 2013) 2012年1月- 2013年12月某三级医院耐多药菌(3537株)流行及临床分布

Pathologie-biologie Pub Date : 2015-02-01 DOI: 10.1016/j.patbio.2014.12.002

X.-Q. Jia , F. Pang , J.-Z. Chen , L.-X. Jiang

{"title":"Prevalence and clinical distribution of multidrug-resistant bacteria (3537 isolates) in a tertiary Chinese hospital (January 2012–December 2013)","authors":"X.-Q. Jia , F. Pang , J.-Z. Chen , L.-X. Jiang","doi":"10.1016/j.patbio.2014.12.002","DOIUrl":"10.1016/j.patbio.2014.12.002","url":null,"abstract":"<div><h3>Objective</h3><p>Multidrug-resistant organisms (MDROs) have become a widespread serious problem in recent years. Our objective was to determine the prevalence and clinical distribution of MDROs in a tertiary care hospital in China from January 1, 2012 to December 31, 2013.</p></div><div><h3>Methods</h3><p>The strains were cultured according to standard methods; bacterial identification and susceptibility testing were detected by Vitek 2 system. The prevalence and clinical distribution of extended-spectrum β-lactamases (ESBLs)-producing <em>enterobacteriaceae</em>, carbapenem-resistant <em>enterobacteriaceae</em> (CRE), multiple-drug/pan-drug resistant <em>P. aeruginosa</em> (MDR/PDR-PA), carbapenem-resistant <em>A. baumannii</em> (CR-AB), methicillin-resistant <em>S. aureus</em> (MRSA) and vancomycin-resistant enterococcus (VRE) were analyzed by WHONET 5.6.</p></div><div><h3>Results</h3><p>A total of 3537 (33.4%) MDROs were found among 10,594 microbial isolates. ESBLs producing <em>E. coli</em> (ESBLs-ECO) (1153 cases) were the most frequent MDROs, followed by CR-AB (827 cases). The proportion of acquired resistance of <em>A. baumannii</em> (48.9%) accounted for the highest in all the MDROs. These MDROs were mainly isolated from respiratory (70.3%) and secretions (12.7%). Various types of intensive care unit (ICU) and surgery were the main source departments. The proportion of CRE and VRE were relatively few. CRE was most isolated from respiratory tract and closed body cavity fluid, while the distribution of VRE was relatively dispersed.</p></div><div><h3>Conclusion</h3><p>High prevalence of MDROs has emerged in our hospital, particular in various ICU and surgical department. The effective way to prevent the further spread of MDROs is to strengthen the protection of respiratory tract and surgical wounds.</p></div>","PeriodicalId":19743,"journal":{"name":"Pathologie-biologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.patbio.2014.12.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32947499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Quantification of viral DNA during HIV-1 infection: A review of relevant clinical uses and laboratory methods HIV-1感染期间病毒DNA的定量:相关临床应用和实验室方法的综述

Pathologie-biologie Pub Date : 2015-02-01 DOI: 10.1016/j.patbio.2014.07.007

E.K. Alidjinou, L. Bocket, D. Hober

{"title":"Quantification of viral DNA during HIV-1 infection: A review of relevant clinical uses and laboratory methods","authors":"E.K. Alidjinou, L. Bocket, D. Hober","doi":"10.1016/j.patbio.2014.07.007","DOIUrl":"10.1016/j.patbio.2014.07.007","url":null,"abstract":"<div><p>Effective antiretroviral therapy usually leads to undetectable HIV-1 RNA in the plasma. However, the virus persists in some cells of infected patients as various DNA forms, both integrated and unintegrated. This reservoir represents the greatest challenge to the complete cure of HIV-1 infection and its characteristics highly impact the course of the disease. The quantification of HIV-1 DNA in blood samples constitutes currently the most practical approach to measure this residual infection. Real-time quantitative PCR (qPCR) is the most common method used for HIV-DNA quantification and many strategies have been developed to measure the different forms of HIV-1 DNA. In the literature, several “in-house” PCR methods have been used and there is a need for standardization to have comparable results. In addition, qPCR is limited for the precise quantification of low levels by background noise. Among new assays in development, digital PCR was shown to allow an accurate quantification of HIV-1 DNA. Total HIV-1 DNA is most commonly measured in clinical routine. The absolute quantification of proviruses and unintegrated forms is more often used for research purposes.</p></div>","PeriodicalId":19743,"journal":{"name":"Pathologie-biologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.patbio.2014.07.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32650908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

A genetic anomaly of oriented collagen biosynthesis and cross-linking: Keratoconus 定向胶原生物合成和交联的遗传异常:圆锥角膜

Pathologie-biologie Pub Date : 2015-02-01 DOI: 10.1016/j.patbio.2014.10.004

J.L. Bourges , A.M. Robert , L. Robert

引用次数: 4

Applications de la technologie MALDI-TOF en microbiologie clinique MALDI-TOF技术在临床微生物学中的应用

Pathologie-biologie Pub Date : 2015-02-01 DOI: 10.1016/j.patbio.2014.10.002

S. Suarez, X. Nassif, A. Ferroni

引用次数: 9

The “psychomicrobiotic”: Targeting microbiota in major psychiatric disorders: A systematic review “精神微生物学”:主要精神疾病的目标微生物群:系统综述

Pathologie-biologie Pub Date : 2015-02-01 DOI: 10.1016/j.patbio.2014.10.003

G. Fond , W. Boukouaci , G. Chevalier , A. Regnault , G. Eberl , N. Hamdani , F. Dickerson , A. Macgregor , L. Boyer , A. Dargel , J. Oliveira , R. Tamouza , M. Leboyer

引用次数: 180

LPS induces pro-inflammatory response in mastitis mice and mammary epithelial cells: Possible involvement of NF-κB signaling and OPN LPS诱导乳腺炎小鼠和乳腺上皮细胞的促炎反应:可能与NF-κB信号和OPN有关

Pathologie-biologie Pub Date : 2015-02-01 DOI: 10.1016/j.patbio.2014.10.005

H.-B. Xiao , C.-R. Wang , Z.-K. Liu , J.-Y. Wang

{"title":"LPS induces pro-inflammatory response in mastitis mice and mammary epithelial cells: Possible involvement of NF-κB signaling and OPN","authors":"H.-B. Xiao , C.-R. Wang , Z.-K. Liu , J.-Y. Wang","doi":"10.1016/j.patbio.2014.10.005","DOIUrl":"10.1016/j.patbio.2014.10.005","url":null,"abstract":"<div><h3>Background</h3><p>Lipopolysaccharide (LPS) has pro-inflammatory properties. This study was conducted to determine whether the LPS induced pro-inflammatory response in a model of mastitis and in mouse mammary epithelial cells (MEC).</p></div><div><h3>Methods</h3><p>To investigate the effects of LPS in vivo, 50μL of a solution of LPS (20ng/μL) were infused into the mammary glands of mice. To study the effects of LPS in vitro, MEC were exposed to LPS (20μg/mL) for 24h. Activation of nuclear factor kB (NF-κB) and myeloperoxidase (MPO) were studied. Production of pro-inflammatory cytokines (interleukin-6 [IL-6], tumor necrosis factor-alpha [TNF-alpha], interleukin-1 beta [IL-1beta]) and expression of osteopontin (OPN) were also evaluated.</p></div><div><h3>Results</h3><p>After LPS administration, route of NF-κB signaling is activated and the activity of MPO is increased. Furthermore, LPS increases the expression of OPN and production of TNF-alpha, IL-6 and IL-1beta.</p></div><div><h3>Conclusions</h3><p>Present results demonstrate that LPS induces a pro-inflammatory response in a murine model of mastitis and suggest the involvement of the NF-κB pathway and OPN.</p></div>","PeriodicalId":19743,"journal":{"name":"Pathologie-biologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.patbio.2014.10.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32875244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24