Pediatric Nephrology最新文献

Membranous-like glomerulopathy with masked IgG-k deposits in a pediatric patient with juvenile idiopathic arthritis. 膜样肾小球病伴隐蔽性IgG-k沉积1例小儿特发性关节炎。

IF 2.6 3区医学

Pediatric Nephrology Pub Date : 2026-12-01 Epub Date: 2025-09-15 DOI: 10.1007/s00467-025-06954-4

Priyanka Chati, Jill Krissberg, Kammi Henriksen, Brian Nolan, Meredith Harris

引用次数: 0

Response to critical appraisal of "Thiamin deficiency in children with chronic kidney disease on peritoneal dialysis and its association with dialysis duration and transport peritoneal membrane status". 对“慢性肾病腹膜透析患儿硫胺素缺乏症及其与透析持续时间和腹膜转运状态的关系”批评性评价的回应。

IF 2.6 3区医学

Pediatric Nephrology Pub Date : 2026-12-01 Epub Date: 2025-10-07 DOI: 10.1007/s00467-025-06992-y

Phakwan Laohathai, Narumon Densupsoontorn

引用次数: 0

Ambulatory blood pressure variability in prediction of target organ injury: the SHIP AHOY study. 动态血压变异性预测靶器官损伤：SHIP AHOY研究。

IF 2.6 3区医学

Pediatric Nephrology Pub Date : 2026-12-01 Epub Date: 2025-05-19 DOI: 10.1007/s00467-025-06803-4

Coral D Hanevold, Jang Dong Seo, Stephen R Daniels, Bonita E Falkner, Michael A Ferguson, Joseph T Flynn, Julie R Ingelfinger, Philip R Khoury, Marc B Lande, Kevin E Meyers, Mark Mitsnefes, Joshua Samuels, Elaine M Urbina

{"title":"Ambulatory blood pressure variability in prediction of target organ injury: the SHIP AHOY study.","authors":"Coral D Hanevold, Jang Dong Seo, Stephen R Daniels, Bonita E Falkner, Michael A Ferguson, Joseph T Flynn, Julie R Ingelfinger, Philip R Khoury, Marc B Lande, Kevin E Meyers, Mark Mitsnefes, Joshua Samuels, Elaine M Urbina","doi":"10.1007/s00467-025-06803-4","DOIUrl":"10.1007/s00467-025-06803-4","url":null,"abstract":"Background: Ambulatory hypertension is associated with elevated left ventricular mass index (LVMI), cardiac dysfunction, and increased arterial stiffness in adolescents. Whether the addition of measures of BP variability improves the prediction of subclinical cardiovascular target organ damage (TOD) over mean BP measures is not known.Methods: We assessed clinic and ambulatory BP (ABP), anthropometrics, and TOD in 397 adolescents. ABP means standard deviation (SD), BP, and heart rate (HR) dipping were calculated; coefficients of variability (CV) were calculated (SD/mean) to assess ABP variabilities. Measures of TOD included LVMI, left ventricular hypertrophy (LVH), LV systolic shortening, LV diastolic function (e'/a'), and pulse wave velocity. General linear models were used to determine if increased ABP variability measures were significant determinants of TOD in models containing mean ABP percentiles, age, sex, race/ethnicity, BMI z-score, and HR.Results: Mean participant age was 15.6 ± 1.7 years (63% white, 59% male) with mean casual BP 122.6/71.6 mmHg ±12.4/10.5, and mean awake systolic ABP 124.2/72.0 ± 11.3/7.7 mmHg. In linear models, increased awake CV-DBP and HR dipping were significant determinants of LVMI. CV-HR was an independent determinant of diastolic (e'/a') but not systolic dysfunction. Using logistic regression, the combination of awake and asleep diastolic ABP variability and awake systolic ABP percentile improved the prediction of LVH.Conclusions: Consideration of ABP variability in addition to ABP percentile may aid in identifying adolescents at risk for LVH.","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"157-165"},"PeriodicalIF":2.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance of GFR estimation equations in pediatric hematology-oncology patients. 儿童血液肿瘤患者GFR估计方程的性能。

IF 2.6 3区医学

Pediatric Nephrology Pub Date : 2026-12-01 Epub Date: 2025-06-19 DOI: 10.1007/s00467-025-06857-4

Tyler J Benning, Asmaa Ferdjallah, Laura M Dinnes, Timothy S Larson, Silvia M Titan, Christian Hanna

引用次数: 0

Urinary periostin as a novel non-invasive biomarker for kidney scarring in pediatric vesicoureteral reflux patients. 尿骨膜蛋白作为儿科膀胱输尿管反流患者肾脏瘢痕形成的一种新的无创生物标志物。

IF 2.6 3区医学

Pediatric Nephrology Pub Date : 2026-12-01 Epub Date: 2025-09-27 DOI: 10.1007/s00467-025-06953-5

Reza Mohammadi Farsani, Amirreza Shamshirgaran, Seyyed Mohammad Ghahestani, Hossein Amirzargar, Fateme Guitynavard, Hossein Chivaee, Fardin Asgari, Mohammad Hadi Samadi, Parsa Nikoofar, Seyed Mohammad Kazem Aghamir

{"title":"Urinary periostin as a novel non-invasive biomarker for kidney scarring in pediatric vesicoureteral reflux patients.","authors":"Reza Mohammadi Farsani, Amirreza Shamshirgaran, Seyyed Mohammad Ghahestani, Hossein Amirzargar, Fateme Guitynavard, Hossein Chivaee, Fardin Asgari, Mohammad Hadi Samadi, Parsa Nikoofar, Seyed Mohammad Kazem Aghamir","doi":"10.1007/s00467-025-06953-5","DOIUrl":"10.1007/s00467-025-06953-5","url":null,"abstract":"Background: Vesicoureteral reflux (VUR) is a common pediatric urological condition associated with kidney scarring, which can lead to hypertension, proteinuria, and chronic kidney disease. Current diagnostic methods, such as 99mTc-dimercaptosuccinic acid (DMSA) scans, are costly, involve radiation, and fail to detect early fibrosis. Urinary periostin, an extracellular matrix protein upregulated in kidney fibrosis, holds promise as a non-invasive biomarker for kidney scarring in VUR patients. This study aimed to evaluate urinary periostin as a biomarker for kidney scarring in children with VUR and compare its diagnostic performance with DMSA scans.Methods: This prospective case-control study enrolled 60 children (35 males and 25 females) aged between 1 and 140 months (with mean (SD) of 43.7 (34.45)) with VUR (30 with kidney scarring [Scar+] and 30 without [Scar-]). Urinary periostin levels were measured via ELISA and corrected with urine creatinine. DMSA scans confirmed scarring. Receiver operating characteristic (ROC) analysis assessed periostin's diagnostic accuracy, and logistic regression identified predictors of scarring.Results: Urinary periostin levels were significantly higher in Scar+ patients (27.4 ± 6.64 ng/mL) than in Scar- patients (18.1 ± 4.63 ng/mL, p < 0.001). ROC analysis yielded an area under the curve of 0.869, with a 21.5 ng/mL cutoff showing 80.0% sensitivity and 76.6% specificity. Periostin (OR 1.44, p < 0.001) was the only independent predictor of scarring. Periostin levels correlated with VUR grade (r = 0.63, p < 0.001).Conclusions: Urinary periostin is a highly sensitive and specific non-invasive biomarker for detecting kidney scarring in VUR, potentially reducing reliance on DMSA scans.","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"109-118"},"PeriodicalIF":2.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical appraisal of "Thiamin deficiency in children with chronic kidney disease on peritoneal dialysis and its association with dialysis duration and transport peritoneal membrane status". “慢性肾病腹膜透析患儿硫胺素缺乏及其与透析持续时间和腹膜转运状态的关系”的批判性评价。

IF 2.6 3区医学

Pediatric Nephrology Pub Date : 2026-12-01 Epub Date: 2025-07-12 DOI: 10.1007/s00467-025-06902-2

Noaman Khan, Sameed Ahmad, Shahkar Ahmad

引用次数: 0

Incidence and risk factors associated with acute kidney injury in newborns receiving therapeutic hypothermia. 接受治疗性低温治疗的新生儿急性肾损伤的发生率和危险因素。

IF 2.6 3区医学

Pediatric Nephrology Pub Date : 2026-12-01 Epub Date: 2025-08-19 DOI: 10.1007/s00467-025-06926-8

Mariateresa Sinelli, Emanuela Zannin, Gaia Alessandra Kullmann, Ilaria Lombardo, Elena Malpezzi, Alessandro Rinaldi, Anna Riva, Maria Luisa Ventura

{"title":"Incidence and risk factors associated with acute kidney injury in newborns receiving therapeutic hypothermia.","authors":"Mariateresa Sinelli, Emanuela Zannin, Gaia Alessandra Kullmann, Ilaria Lombardo, Elena Malpezzi, Alessandro Rinaldi, Anna Riva, Maria Luisa Ventura","doi":"10.1007/s00467-025-06926-8","DOIUrl":"10.1007/s00467-025-06926-8","url":null,"abstract":"Background: To evaluate the incidence and potential predisposing factors for the development of acute kidney injury (AKI) in asphyxiated neonates undergoing hypothermic treatment.Methods: This retrospective study was conducted at the Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. All neonates above 34 weeks of gestation diagnosed with hypoxic-ischemic encephalopathy (HIE) and treated with hypothermia, weighing more than 1800 g, admitted from January 1, 2013 to December 31, 2022, were included. AKI was defined according to the neonatal KDIGO classification.Results: A total of 75 neonates were enrolled, including 13 (17%) with severe HIE. The incidence of AKI was 35%, with 62% of cases identified as a reduction in diuresis, 27% as changes in creatinine and oliguria, and only 11% as isolated creatinine elevation. The rate of AKI was significantly higher in infants with severe HIE (p < 0.001). The development of AKI added significantly (aOR = 41.2, p = 0.007) to the probability of death, even after adjusting for severe HIE. Infants who developed AKI required more inotropes, had higher rates of hyponatremia (serum sodium < 125 mEq/L), and were less likely to normalize lactate levels within 24 h of birth.Conclusions: In asphyxiated newborns, reduced kidney perfusion can cause kidney impairment in nearly 40% of those undergoing treatment. Enhancing the detection of AKI is crucial for improving patient outcomes. We recommend proactive monitoring of lactate trends, urinary output, and serum sodium levels to enable early interventions that protect kidney function and improve outcomes for these vulnerable infants.","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"217-223"},"PeriodicalIF":2.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of urinary extravasation in posterior urethral valves: clinical implications of urinomas and ascites on kidney function. 尿外渗对后尿道瓣膜的影响：尿瘤和腹水对肾功能的临床意义。

IF 2.6 3区医学

Pediatric Nephrology Pub Date : 2026-12-01 Epub Date: 2025-09-30 DOI: 10.1007/s00467-025-06984-y

Adree Khondker, Joana Dos Santos, Samer Maher, Michael Chua, Armando J Lorenzo, Mandy Rickard

{"title":"Impact of urinary extravasation in posterior urethral valves: clinical implications of urinomas and ascites on kidney function.","authors":"Adree Khondker, Joana Dos Santos, Samer Maher, Michael Chua, Armando J Lorenzo, Mandy Rickard","doi":"10.1007/s00467-025-06984-y","DOIUrl":"10.1007/s00467-025-06984-y","url":null,"abstract":"Background: Urinary extravasation (UE) in patients with posterior urethral valves (PUV), in the form of urinomas or urinary ascites, is thought to represent a pop-off mechanism. Previous literature has proposed a kidney protective mechanism, although this remains controversial. Here, we performed a matched comparison to assess the effect of UE on kidney outcomes.Methods: We retrospectively reviewed our PUV database, including all patients diagnosed < 3 months of age with at least 1-year follow-up. We collected demographics, management, vesicoureteral reflux (VUR) status, and kidney function parameters. UE was defined as postnatal urinoma or urinary ascites. We performed both unadjusted and propensity-matched comparisons of patients with and without UE. Matching was used to balance age, diversion status, urinary tract infection history, presence of VUR, and nadir creatinine. The primary outcomes were 1-, 3-, and 5-year kidney outcomes.Results: Of the 138 patients meeting inclusion criteria, 27 (20%) had UE (23 urinoma, 4 urinary ascites). The median age at presentation was 5 days. Six patients (26%) required percutaneous drainage, and the median time to resolution was 21 days. Patients with UE had significantly higher initial creatinine levels but no difference in nadir values. Of those with available data, 18 (18%) and 10 (14%) had chronic kidney disease (CKD) at 3 and 5 years. Overall, there was no difference in 3- and 5-year rates of CKD between patients with and without a history of UE.Conclusions: In a matched comparison, UE was not associated with long-term adverse or beneficial effects on kidney function. This study provides further evidence that the presence of UE may not be a relevant prognostic factor in children with PUV.","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"119-123"},"PeriodicalIF":2.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145200642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.6 3区医学

Pediatric Nephrology Pub Date : 2026-12-01 Epub Date: 2025-09-18 DOI: 10.1007/s00467-025-06795-1

Charlotte Gimpel, Susanne Schaefer, Franz Schaefer

{"title":"Health-related quality of life, mental health and caregiver burden in children with autosomal recessive polycystic kidney disease.","authors":"Charlotte Gimpel, Susanne Schaefer, Franz Schaefer","doi":"10.1007/s00467-025-06795-1","DOIUrl":"10.1007/s00467-025-06795-1","url":null,"abstract":"Background: Pediatric chronic kidney disease (CKD) causes significantly impaired health-related quality of life (hrQOL) and caregiver burden, but no studies focus specifically on autosomal recessive polycystic kidney disease (ARPKD).Methods: This prospective case-control study assessed hrQOL (using PedsQL®ESRD) and screened for psychosocial problems (strength and difficulties questionnaire (SDQ)) in 43 children with ARPKD. Fifty-eight caregivers reported on the disease's impact on family (FaBel) and their own QOL (Ulm inventory of parental caregiver QOL (ULQIE)). As controls, we questioned 36 matched healthy children and 57 parents under similar pandemic restrictions and used published historical controls (healthy and with advanced CKD).Results: Patients were aged 9.0 ± 4.8 years with CKD stage G1-4 (45%), on dialysis (14%) or after kidney transplantation (26%). Nine patients had developmental delay secondary to medical complications. PedsQL®ESRD total scores correlated significantly to kidney function, but could not capture liver-specific symptoms. All 4 measures showed significant differences between treatment modalities with best scores in patients during CKD stages G1-4 and worst on dialysis, except SDQ, which was worst after transplantation. The most significant extra-renal risk factor for all 4 scores was developmental delay of the child. SDQ scores were elevated in contemporary vs. historical controls, but even further in ARPKD especially for peer relationship problems.Conclusion: In summary, ARPKD causes significantly impaired hrQOL, psychosocial problems and caregiver burden, which were equal to, if not greater than, that of controls with more advanced kidney failure. Treatment modality and developmental delay were the most important risk factors.Trial registration: Trial registered 06/2020 DRKS S00021059.","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"135-150"},"PeriodicalIF":2.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12686003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145081216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood pressure variability and cardiovascular risk in pediatric hypertension. 儿童高血压的血压变异性和心血管风险。

IF 2.6 3区医学

Pediatric Nephrology Pub Date : 2026-12-01 Epub Date: 2025-07-01 DOI: 10.1007/s00467-025-06874-3

Kleo Evripidou, Athanasia Chainoglou, Stella Stabouli

引用次数: 0