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The use of near-infrared spectroscopy to measure kidney oxygenation in the neonatal intensive care unit. 使用近红外光谱测量新生儿重症监护病房的肾氧合。
IF 2.6 3区 医学
Pediatric Nephrology Pub Date : 2025-12-01 Epub Date: 2025-05-16 DOI: 10.1007/s00467-025-06792-4
Aadil Kakajiwala, Nivedita Kamath, Saudamini Nesargi, Lisa Goto, Suma Bhat Hoffman, Brianna Michelle Liberio, Jennifer A Rumpel, Mona Khattab, Arwa Nada, Christine Stoops, Sofia I Perazzo, Matthew W Harer
{"title":"The use of near-infrared spectroscopy to measure kidney oxygenation in the neonatal intensive care unit.","authors":"Aadil Kakajiwala, Nivedita Kamath, Saudamini Nesargi, Lisa Goto, Suma Bhat Hoffman, Brianna Michelle Liberio, Jennifer A Rumpel, Mona Khattab, Arwa Nada, Christine Stoops, Sofia I Perazzo, Matthew W Harer","doi":"10.1007/s00467-025-06792-4","DOIUrl":"10.1007/s00467-025-06792-4","url":null,"abstract":"<p><p>Near-infrared spectroscopy (NIRS) is a relatively recent technology, first applied in clinical contexts in the early 1970s. Critically ill neonates in the intensive care unit face unique post-natal adaptations that can be challenging when compounded by clinical co-morbidities. Given the size and limited blood volume of these patients, there is a need for non-invasive monitoring methods that go beyond traditional vital signs and laboratory assessments. NIRS offers a potential approach for monitoring regional tissue oxygenation and perfusion of the kidney with a potential for early detection of acute kidney injury in high-risk neonates. However, its application is not without challenges, including inconsistent normative values, technological and technique-related limitations, and uncertainties about its clinical applicability. Despite these challenges, NIRS monitoring of kidney oxygenation shows promise for supporting kidney health and informing clinical care decisions. In this educational review, we aim to outline the basic principles of NIRS as it relates to kidney oxygenation, summarize the current literature on its use for monitoring and clinical decision-making, discuss its limitations and knowledge gaps, and propose investigative approaches with future research directions.</p>","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"3623-3635"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to critical appraisal of "Renal perfusion in dynamic scans: a key predictor of long-term outcomes in posterior urethral valves". 对“动态扫描中的肾灌注：后尿道瓣膜长期预后的关键预测因素”的关键评价的反应。
IF 2.6 3区 医学
Pediatric Nephrology Pub Date : 2025-12-01 Epub Date: 2025-09-08 DOI: 10.1007/s00467-025-06946-4
Mamta Sengar, Niyaz Khan, Ashvin Damdoo
{"title":"Response to critical appraisal of \"Renal perfusion in dynamic scans: a key predictor of long-term outcomes in posterior urethral valves\".","authors":"Mamta Sengar, Niyaz Khan, Ashvin Damdoo","doi":"10.1007/s00467-025-06946-4","DOIUrl":"10.1007/s00467-025-06946-4","url":null,"abstract":"","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"3841"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are the outcomes of critically ill children undergoing pediatric continuous kidney replacement therapy actually modifiable? 危重儿童接受儿科持续肾替代治疗的结果是否可以改变？
IF 2.6 3区 医学
Pediatric Nephrology Pub Date : 2025-12-01 Epub Date: 2025-06-05 DOI: 10.1007/s00467-025-06836-9
Francesco Guzzi, Zaccaria Ricci
{"title":"Are the outcomes of critically ill children undergoing pediatric continuous kidney replacement therapy actually modifiable?","authors":"Francesco Guzzi, Zaccaria Ricci","doi":"10.1007/s00467-025-06836-9","DOIUrl":"10.1007/s00467-025-06836-9","url":null,"abstract":"","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"3601-3603"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on: Erythropoietin resistance among pediatric patients on chronic hemodialysis: A cross-sectional study. 评论：儿童慢性血液透析患者的促红细胞生成素抵抗：一项横断面研究。
IF 2.6 3区 医学
Pediatric Nephrology Pub Date : 2025-12-01 Epub Date: 2025-05-26 DOI: 10.1007/s00467-025-06835-w
Shree Rath
{"title":"Comment on: Erythropoietin resistance among pediatric patients on chronic hemodialysis: A cross-sectional study.","authors":"Shree Rath","doi":"10.1007/s00467-025-06835-w","DOIUrl":"10.1007/s00467-025-06835-w","url":null,"abstract":"","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"3835-3836"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liberation from pediatric continuous kidney replacement therapy: a survey of provider perceptions and practices. 从儿童持续肾脏替代治疗中解放出来：一项对提供者观念和实践的调查。
IF 2.6 3区 医学
Pediatric Nephrology Pub Date : 2025-12-01 Epub Date: 2025-06-16 DOI: 10.1007/s00467-025-06849-4
Evan A Rajadhyaksha, Dana Y Fuhrman, Shina Menon, David T Selewski, Katja M Gist, Michelle C Starr
{"title":"Liberation from pediatric continuous kidney replacement therapy: a survey of provider perceptions and practices.","authors":"Evan A Rajadhyaksha, Dana Y Fuhrman, Shina Menon, David T Selewski, Katja M Gist, Michelle C Starr","doi":"10.1007/s00467-025-06849-4","DOIUrl":"10.1007/s00467-025-06849-4","url":null,"abstract":"","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"3831-3833"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of therapeutic plasma exchange on amoxicillin, clindamycin, midazolam, and morphine pharmacokinetics in a critically ill child. 治疗性血浆置换对危重患儿阿莫西林、克林霉素、咪达唑仑和吗啡药代动力学的影响。
IF 2.6 3区 医学
Pediatric Nephrology Pub Date : 2025-12-01 Epub Date: 2025-07-03 DOI: 10.1007/s00467-025-06873-4
André Yaghyazaryan, Valentina Gracchi, Sybrand W J Zielhuis, Elisabeth H Schölvinck, Daan J Touw, Martin C J Kneyber, Paola Mian
{"title":"Effect of therapeutic plasma exchange on amoxicillin, clindamycin, midazolam, and morphine pharmacokinetics in a critically ill child.","authors":"André Yaghyazaryan, Valentina Gracchi, Sybrand W J Zielhuis, Elisabeth H Schölvinck, Daan J Touw, Martin C J Kneyber, Paola Mian","doi":"10.1007/s00467-025-06873-4","DOIUrl":"10.1007/s00467-025-06873-4","url":null,"abstract":"<p><p>We report a 15-year-old boy with severe septic shock and multiple organ failure, requiring intensive care and extracorporeal therapies, including veno-arterial extracorporeal membrane oxygenation, continuous veno-venous hemodiafiltration, and therapeutic plasma exchange. Given their critical role in the clinical management, pharmacokinetics of amoxicillin, clindamycin, midazolam, and morphine were closely monitored. Drug concentrations were measured before, during, and after therapeutic plasma exchange sessions. Despite theoretical predictions, clinically significant reductions in plasma drug concentrations of amoxicillin, clindamycin, and midazolam were observed following therapeutic plasma exchange. This case report emphasizes the necessity of therapeutic drug monitoring to adjust dosing appropriately and optimize patient outcomes.</p>","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"3659-3662"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Critical appraisal of "Renal perfusion in dynamic scans: a key predictor of long-term outcomes in posterior urethral valves". “动态扫描中的肾灌注：后尿道瓣膜长期预后的关键预测因素”的关键评价。
IF 2.6 3区 医学
Pediatric Nephrology Pub Date : 2025-12-01 Epub Date: 2025-08-04 DOI: 10.1007/s00467-025-06928-6
Ahmad Shabbir, Fatima Shams, Muhammad Asim Agha
{"title":"Critical appraisal of \"Renal perfusion in dynamic scans: a key predictor of long-term outcomes in posterior urethral valves\".","authors":"Ahmad Shabbir, Fatima Shams, Muhammad Asim Agha","doi":"10.1007/s00467-025-06928-6","DOIUrl":"10.1007/s00467-025-06928-6","url":null,"abstract":"","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"3839"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-CD20 monoclonal antibodies for idiopathic nephrotic syndrome: Advances, challenges, and future directions. 抗cd20单克隆抗体治疗特发性肾病综合征：进展、挑战和未来方向
IF 2.6 3区 医学
Pediatric Nephrology Pub Date : 2025-12-01 Epub Date: 2025-05-01 DOI: 10.1007/s00467-025-06738-w
Andrea Angeletti, Gian Marco Ghiggeri
{"title":"Anti-CD20 monoclonal antibodies for idiopathic nephrotic syndrome: Advances, challenges, and future directions.","authors":"Andrea Angeletti, Gian Marco Ghiggeri","doi":"10.1007/s00467-025-06738-w","DOIUrl":"10.1007/s00467-025-06738-w","url":null,"abstract":"","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"3597-3600"},"PeriodicalIF":2.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Critical insights on post-infectious glomerulonephritis among children before and during the COVID-19 pandemic. COVID-19大流行之前和期间儿童感染后肾小球肾炎的重要见解
IF 2.6 3区 医学
Pediatric Nephrology Pub Date : 2025-11-01 Epub Date: 2025-06-30 DOI: 10.1007/s00467-025-06886-z
Sadeeq Khan, Abdur Rehman, Waheed Khan
{"title":"Critical insights on post-infectious glomerulonephritis among children before and during the COVID-19 pandemic.","authors":"Sadeeq Khan, Abdur Rehman, Waheed Khan","doi":"10.1007/s00467-025-06886-z","DOIUrl":"10.1007/s00467-025-06886-z","url":null,"abstract":"","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"3591"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence-based risk stratification for neonatal acute kidney injury: a call to action. 新生儿急性肾损伤的循证风险分层：行动呼吁。
IF 2.6 3区 医学
Pediatric Nephrology Pub Date : 2025-11-01 Epub Date: 2025-03-27 DOI: 10.1007/s00467-025-06752-y
Tahagod Mohamed, Nicole Asdell, Xia Ning, Jason G Newland, Matthew W Harer, Cara L Slagle, Michelle C Starr, John D Spencer, Francis P Wilson, David T Selewski, Jonathan L Slaughter
{"title":"Evidence-based risk stratification for neonatal acute kidney injury: a call to action.","authors":"Tahagod Mohamed, Nicole Asdell, Xia Ning, Jason G Newland, Matthew W Harer, Cara L Slagle, Michelle C Starr, John D Spencer, Francis P Wilson, David T Selewski, Jonathan L Slaughter","doi":"10.1007/s00467-025-06752-y","DOIUrl":"10.1007/s00467-025-06752-y","url":null,"abstract":"","PeriodicalId":19735,"journal":{"name":"Pediatric Nephrology","volume":" ","pages":"3335-3339"},"PeriodicalIF":2.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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