Nigerian Postgraduate Medical Journal最新文献

筛选
英文 中文
Comparison of Serum Prolactin Level with Child-Pugh Scoring System in Predicting the Complications of Cirrhosis of Liver: A Cross-sectional Study. 血清催乳素水平与Child-Pugh评分系统预测肝硬化并发症的比较:一项横断面研究
IF 1.2
Nigerian Postgraduate Medical Journal Pub Date : 2026-05-01 DOI: 10.4103/npmj.npmj_469_25
Allu Ravi Kishor, Manne Lakshmi Narasimha Sandeep, Keerthi Reddy, Janardhanan Subramonia Kumar, Siva Prakash Sethupathi
{"title":"Comparison of Serum Prolactin Level with Child-Pugh Scoring System in Predicting the Complications of Cirrhosis of Liver: A Cross-sectional Study.","authors":"Allu Ravi Kishor, Manne Lakshmi Narasimha Sandeep, Keerthi Reddy, Janardhanan Subramonia Kumar, Siva Prakash Sethupathi","doi":"10.4103/npmj.npmj_469_25","DOIUrl":"10.4103/npmj.npmj_469_25","url":null,"abstract":"<p><strong>Background: </strong>Cirrhosis of the liver is a chronic condition characterised by scar tissue replacing healthy liver tissue, leading to impaired liver function and endocrine disturbances. Hyperprolactinemia in cirrhosis results from reduced dopamine inhibition due to elevated circulating oestrogens.</p><p><strong>Aims: </strong>This study assessed the relationship between serum prolactin levels and the Child-Pugh scoring system in predicting complications in liver cirrhosis.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted on 70 cirrhotic patients over 12 months at a tertiary care center. Inclusion criteria included patients aged ≥18 years with diagnosed cirrhosis. Serum prolactin levels were measured using radioimmunoassay. Disease severity was evaluated using the Child-Pugh scoring system. Statistical analysis was performed to assess correlations between prolactin levels, Child-Pugh scores and clinical complications.</p><p><strong>Results: </strong>Serum prolactin levels showed a strong positive correlation with the Child-Pugh score ( r = 0.641, P < 0.001). Elevated prolactin levels were associated with complications such as ascites, portal hypertension, hepatic encephalopathy and oesophageal varices ( P < 0.001). Patients with higher prolactin levels demonstrated significantly increased 6-month mortality ( P < 0.0001). Receiver operating characteristic curve analysis (area under the curve = 0.98) highlighted prolactin's predictive value for mortality.</p><p><strong>Conclusion: </strong>Serum prolactin is a reliable biomarker for assessing cirrhosis severity and predicting complications. It complements the Child-Pugh scoring system and may guide early interventions in high-risk patients.</p>","PeriodicalId":19720,"journal":{"name":"Nigerian Postgraduate Medical Journal","volume":"33 3","pages":"322-327"},"PeriodicalIF":1.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender-specific Causal Relationship between Sex Hormones and Carpal Tunnel Syndrome: A Mendelian Randomisation Study. 性激素与腕管综合征的性别因果关系:一项孟德尔随机研究。
IF 1.2
Nigerian Postgraduate Medical Journal Pub Date : 2026-05-01 DOI: 10.4103/npmj.npmj_125_25
Xianqin Zeng, Zeming Li, Benzong Luo, Rufu Zheng, Donglei Wei, Shenxian Lao
{"title":"Gender-specific Causal Relationship between Sex Hormones and Carpal Tunnel Syndrome: A Mendelian Randomisation Study.","authors":"Xianqin Zeng, Zeming Li, Benzong Luo, Rufu Zheng, Donglei Wei, Shenxian Lao","doi":"10.4103/npmj.npmj_125_25","DOIUrl":"10.4103/npmj.npmj_125_25","url":null,"abstract":"<p><strong>Background: </strong>Observational studies have shown a correlation between sex hormones and the risk of developing carpal tunnel syndrome (CTS), but it remains unclear whether these associations are causal.</p><p><strong>Aims: </strong>We aimed to investigate the potential causal relationships between a range of sex hormones and the risk of CTS using a Mendelian randomisation (MR) approach.</p><p><strong>Methods: </strong>We selected exposure-related genetic instruments from genome-wide association studies summary data using significance thresholds. The CTS summary data were obtained from two sources: the UK Biobank (UKB) (12,887 cases and 443,461 controls) and the FinnGen consortium (17,198 cases and 273,097 controls). The random-effects inverse variance-weighted method was used as the primary approach for causal analysis, along with complementary weighted median, MR-Egger and MR-PRESSO tests for sensitivity analysis. Fixed-effect model was used to meta-analyse the results from the UKB and FinnGen.</p><p><strong>Results: </strong>The meta-analysis of the MR results from FinnGen and UKB identified potential risk factors that may increase the risk of CTS. These factors include lower sex hormone-binding globulin (SHBG) levels (both: odds ratio [OR] =0.628, P < 0.0001; female: OR = 0.601, P < 0.0001; male: OR = 0.717, P < 0.0001) and lower body mass index-adjusted SHBG levels (both: OR = 0.748, P < 0.0001; female: OR = 0.718, P < 0.0001; male: OR = 0.753, P < 0.0001). In males, higher total testosterone (TT) levels (OR = 0.912, P = 0.0052) may decrease the risk of CTS, whereas higher bioavailable testosterone (BAT) levels (OR = 1.370, P < 0.0001) may increase the risk of CTS in females. Oestradiol (E2), progesterone, the ratio of testosterone to oestradiol, androstendione, aldosterone and 17-hydroxyprogesterone showed no significant causal relationship with CTS risk.</p><p><strong>Conclusion: </strong>This MR study provides insights into the potential role of SHBG, TT and BAT in the development of CTS, highlighting the importance of conducting gender-specific genetic analyses.</p>","PeriodicalId":19720,"journal":{"name":"Nigerian Postgraduate Medical Journal","volume":"33 3","pages":"341-352"},"PeriodicalIF":1.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive Utility of Atherogenic Index of Plasma in Carcinoma Breast Cases in Correlation with Oxidative Stress, Immuno-biomarkers and Body Mass Index. 乳腺癌患者血浆动脉粥样硬化指数与氧化应激、免疫生物标志物和体重指数相关的预测应用
IF 1.2
Nigerian Postgraduate Medical Journal Pub Date : 2026-05-01 DOI: 10.4103/npmj.npmj_279_25
Abhishek Pant, Ashish Anjankar
{"title":"Predictive Utility of Atherogenic Index of Plasma in Carcinoma Breast Cases in Correlation with Oxidative Stress, Immuno-biomarkers and Body Mass Index.","authors":"Abhishek Pant, Ashish Anjankar","doi":"10.4103/npmj.npmj_279_25","DOIUrl":"10.4103/npmj.npmj_279_25","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer remains the most prevalent malignancy among women worldwide, contributing significantly to global cancer-related morbidity and mortality. It is responsible for nearly 15% of all female cancer fatalities. It has a higher prevalence in developed nations.</p><p><strong>Aims: </strong>The present study aimed to assess the predictive utility of Atherogenic index of plasma (AIP) in carcinoma breast cases in correlation with oxidative stress, immuno-biomarkers and body mass index (BMI).</p><p><strong>Subjects and methods: </strong>Prospective interventional study. The Prospective Interventional Study was conducted in the Department of Biochemistry, Jawaharlal Nehru Medical College and the Histopathology and Radiology division of the Department of Pathology, JNMC, in collaboration with the Department of Surgery, JNMC and Acharya Vinoba Bhave Rural Hospital, Wardha, for the duration of 3 years. Total 81 samples were recruited for the study. The patient's history was taken, and a proper medical examination was carried out. The SPSS program for Windows, version 26.0 (SPSS, Chicago, Illinois, USA), was employed to conduct the statistical analysis. Categorical variables were analysed using either the Chi-square test or Fisher's exact test, while continuous variables were compared using the unpaired t -testing method. P ≤0.05 was deemed to be statistically significant.</p><p><strong>Results: </strong>A significant positive correlations between AIP and various parameters, including BMI ( r = 0.591, P < 0.001), superoxide dismutase ( r = 0.407, P < 0.001), high-sensitivity C-reactive protein ( r = 0.507, P < 0.001), Interleukin-10 (IL-10) ( r = 0.706, P < 0.001) and IL-18 ( r = 0.652, P < 0.001). Furthermore, a strong positive correlation with lipid profile was observed.</p><p><strong>Conclusions: </strong>AIP could serve as a useful surrogate marker to assess not only lipid imbalance but also broader systemic changes that accompany breast cancer.</p>","PeriodicalId":19720,"journal":{"name":"Nigerian Postgraduate Medical Journal","volume":"33 3","pages":"353-357"},"PeriodicalIF":1.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abdominal Pregnancy at Advanced Gestational Age in Lagos, Nigeria. 在尼日利亚拉各斯的高龄孕龄腹部妊娠。
IF 1.2
Nigerian Postgraduate Medical Journal Pub Date : 2026-05-01 DOI: 10.4103/npmj.npmj_260_25
Naheem Akinwumi Oseni, Okechukwu Uche Ofoegbu
{"title":"Abdominal Pregnancy at Advanced Gestational Age in Lagos, Nigeria.","authors":"Naheem Akinwumi Oseni, Okechukwu Uche Ofoegbu","doi":"10.4103/npmj.npmj_260_25","DOIUrl":"10.4103/npmj.npmj_260_25","url":null,"abstract":"<p><p>Abdominal ectopic pregnancy is an uncommon form of ectopic pregnancy with few cases reported in Nigeria. We present a case report of abdominal ectopic pregnancy with haemoperitoneum in an unbooked multipara at advanced gestational age. She subsequently had an emergency exploratory laparotomy and right salpingectomy. Diagnosis of this condition can be challenging due to non-specific clinical symptoms, while definitive management can also pose a challenge due to the site of placental attachment.</p>","PeriodicalId":19720,"journal":{"name":"Nigerian Postgraduate Medical Journal","volume":"33 3","pages":"378-380"},"PeriodicalIF":1.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of an Instructional Module on Awareness of the Side Effects of Cosmetic Products among Teenage Girls. 一个教学模块对少女化妆品副作用认知的效果。
IF 1.2
Nigerian Postgraduate Medical Journal Pub Date : 2026-05-01 DOI: 10.4103/npmj.npmj_349_25
Pratiksha K Munjewar, Ranjana P Sharma, Savita B Pohekar, Pratibha Wankhede, Swity D Jawade
{"title":"Efficacy of an Instructional Module on Awareness of the Side Effects of Cosmetic Products among Teenage Girls.","authors":"Pratiksha K Munjewar, Ranjana P Sharma, Savita B Pohekar, Pratibha Wankhede, Swity D Jawade","doi":"10.4103/npmj.npmj_349_25","DOIUrl":"10.4103/npmj.npmj_349_25","url":null,"abstract":"<p><strong>Background: </strong>Cosmetic product is widely used by teenage girls as part of their daily routine. However, certain ingredients in these products may cause adverse effects such as acne, dermatitis, allergic reactions and even long-term health risks. Awareness regarding these side effects remains limited among adolescents.</p><p><strong>Aims: </strong>To assess the efficacy of an instructional module in enhancing the knowledge of teenage girls about the side effects of cosmetic products and to identify the association between demographic variables and knowledge scores.</p><p><strong>Materials and methods: </strong>This cross-sectional study aimed to evaluate the efficacy of an instructional module on improving the knowledge of teenage girls regarding the side effects of cosmetic products. The demographic variable of the study participants was also analysed to determine their association with knowledge scores. The study included 100 teenage girls aged 12-19 from central rural India.</p><p><strong>Results: </strong>The results of the study showed that 48% of the participants had poor knowledge before the intervention, and 52% had average knowledge regarding the side effects of cosmetic products. However, after the intervention, the knowledge scores significantly improved, with 60% of the participants having good knowledge and 30% having very good knowledge.</p><p><strong>Conclusions: </strong>The instruction module effectively enhances knowledge regarding cosmetic side effects among teenage girls. Educational intervention should be integrated into school health programs to promote safer cosmetic use and informed decision-making.</p>","PeriodicalId":19720,"journal":{"name":"Nigerian Postgraduate Medical Journal","volume":"33 3","pages":"374-377"},"PeriodicalIF":1.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Bone Mineral Density and Insulin Resistance in Polycystic Ovarian Syndrome - A Case-control Observational Study. 多囊卵巢综合征患者骨密度与胰岛素抵抗的关系——一项病例对照观察性研究。
IF 1.2
Nigerian Postgraduate Medical Journal Pub Date : 2026-05-01 DOI: 10.4103/npmj.npmj_579_25
Anushri Sridharan, Arun Guddeti, Sanjay Kumar, Sayyad Aleem, Sai Ramya Vasamsetti, Sravanthi Mashetty, Lalitha A V Alekya, K V S Hari Kumar
{"title":"Association between Bone Mineral Density and Insulin Resistance in Polycystic Ovarian Syndrome - A Case-control Observational Study.","authors":"Anushri Sridharan, Arun Guddeti, Sanjay Kumar, Sayyad Aleem, Sai Ramya Vasamsetti, Sravanthi Mashetty, Lalitha A V Alekya, K V S Hari Kumar","doi":"10.4103/npmj.npmj_579_25","DOIUrl":"10.4103/npmj.npmj_579_25","url":null,"abstract":"<p><strong>Background: </strong>Polycystic ovarian syndrome (PCOS) has bidirectional effects on the skeleton due to hormonal dysfunction and insulin resistance (IR).</p><p><strong>Aims: </strong>We examined bone mineral density (BMD) and its relationship with IR using the homeostasis model of assessment (HOMA) in patients with PCOS and matched controls.</p><p><strong>Materials and methods: </strong>In this case-control observational study, we included 74 patients newly diagnosed with PCOS and a similar number of age-and weight-matched healthy women as controls. Haematological, biochemical and hormonal parameters were measured in a fasting blood sample during the follicular phase, and the BMD Z score was calculated using dual energy X-ray absorptiometry. The results were analysed using relevant statistical methods, and P < 0.05 was considered significant.</p><p><strong>Results: </strong>The study participants ( n = 148) had a mean age of 23.6 ± 3.7 years and a body mass index (BMI) of 25.2 ± 3.2 kg/m 2 . Among the PCOS patients, 25 (34%) had a normal BMI and 49 (66%) were obese. The BMD at the femoral neck ( P = 0.4313) and lumbar spine ( P = 0.1410) was comparable between the PCOS and control groups. Correlation analysis showed a positive correlation of BMD with testosterone and 17-hydroxy progesterone (17OHP) ( P < 0.001). None of the BMD parameters correlated with HOMA in either group.</p><p><strong>Conclusion: </strong>BMD at the lumbar spine and femoral neck was similar between patients with PCOS and controls. Further studies with a larger sample size, longer follow-up periods and fracture data are needed to confirm our findings.</p>","PeriodicalId":19720,"journal":{"name":"Nigerian Postgraduate Medical Journal","volume":"33 3","pages":"306-310"},"PeriodicalIF":1.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Undernutrition among Tuberculosis Patients in Southern Afghanistan: Prevalence and Determinants. 阿富汗南部结核病患者营养不良:患病率和决定因素。
IF 1.2
Nigerian Postgraduate Medical Journal Pub Date : 2026-03-01 Epub Date: 2026-03-02 DOI: 10.4103/npmj.npmj_405_25
Muhammad Haroon Stanikzai, Hazratullah Bariz, Zabihullah Anwary, Khalid Ahmad Stanikzai
{"title":"Undernutrition among Tuberculosis Patients in Southern Afghanistan: Prevalence and Determinants.","authors":"Muhammad Haroon Stanikzai, Hazratullah Bariz, Zabihullah Anwary, Khalid Ahmad Stanikzai","doi":"10.4103/npmj.npmj_405_25","DOIUrl":"10.4103/npmj.npmj_405_25","url":null,"abstract":"<p><strong>Background: </strong>Poor nutritional status among tuberculosis (TB) patients contributes to treatment failure and poor prognosis. However, no study has provided information on the nutritional conditions of Afghan TB patients. Using data from five TB care facilities in southern Afghanistan, this study aimed to determine the extent of undernutrition and examine its determinants in TB patients.</p><p><strong>Methods: </strong>This was a cross-sectional study that utilised data from five TB care centres in four southern Afghan provinces. Data were collected between May and July 2025. Patients with TB who were aged ≥18 years were included in the analysis. Heights and weights were measured in metres (m) and kilograms (kg), respectively. Patients with a body mass index <18.5 kg/m2 were considered undernourished. Binary logistic regression was used to identify factors associated with undernutrition in TB patients.</p><p><strong>Results: </strong>Of the 431 patients, 40.4% were undernourished. In adjusted models, odds of undernutrition were higher among females (adjusted odds ratio [AOR] 4.12; 95% confidence interval [CI] 2.41-7.04), rural residents (AOR 3.85; 95% CI 2.11-7.02), currently unmarried (AOR 1.86; 95% CI 1.11-3.13), smokers (AOR 11.06; 95% CI 5.27-23.21), patients with severe disease (AOR 2.23; 95% CI 1.16-4.28) and those with medical comorbidity (AOR 2.34; 95% CI 1.32-4.17).</p><p><strong>Conclusion: </strong>In conclusion, the prevalence of undernutrition is alarmingly high in Afghan TB patients. Therefore, nutrition-focused education and support should be considered key elements of TB care in Afghanistan.</p>","PeriodicalId":19720,"journal":{"name":"Nigerian Postgraduate Medical Journal","volume":"33 2","pages":"213-218"},"PeriodicalIF":1.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seroprevalence of Hepatitis B Viral Infections in Ondo State, Nigeria. 尼日利亚翁多州乙型肝炎病毒感染的血清流行率
IF 1.2
Nigerian Postgraduate Medical Journal Pub Date : 2026-03-01 Epub Date: 2026-03-02 DOI: 10.4103/npmj.npmj_283_25
Michael Simidele Odimayo, Pius Abimbola Okiki, Abiodun Oyeneyin, Adejoke Olukayode Obajuluwa, Dolani Zechariah Dolani
{"title":"Seroprevalence of Hepatitis B Viral Infections in Ondo State, Nigeria.","authors":"Michael Simidele Odimayo, Pius Abimbola Okiki, Abiodun Oyeneyin, Adejoke Olukayode Obajuluwa, Dolani Zechariah Dolani","doi":"10.4103/npmj.npmj_283_25","DOIUrl":"10.4103/npmj.npmj_283_25","url":null,"abstract":"<p><strong>Background: </strong>Hepatitis B virus (HBV) is a major cause of liver-associated morbidity and mortality worldwide, accounting for over 354 million cases with high morbidity and fatalities. About 90% of infected people are unaware of their status. Efforts at significant reduction and elimination have come a long way; yet, more concerted efforts are still needed.</p><p><strong>Objective: </strong>The objective of the study was to determine the prevalence of hepatitis B viral infections in Ondo State Nigeria.</p><p><strong>Materials and methods: </strong>We conducted this study from May to December 2024 across the 3 senatorial districts in Ondo State, using a stratified random sampling technique. Subjects ranging from 20 years and above were randomly selected. After a brief health education at each location, 5 ml of fresh blood was aseptically collected from each subject who accepted screening. Double screening for hepatitis B surface antigen was done for each subject using rapid diagnostic kits. Each positive sample and 1 in every 10 negative subjects were also tested using hepatitis B enzyme linked immuno-sorbent assay antigen detection.</p><p><strong>Results: </strong>Amongst the 1979 subjects recruited, 139 were positive for HBV, giving a prevalence rate of 7.02%, with a male-to-female prevalence ratio of 2:1. Male gender, monogamous marriage and singles had higher risks of HBV infection. Alignment with health education as personal prevention efforts significantly reduced HBV among the subjects. Inversely, lifestyles such as habitual alcohol intake and smoking were significant predictors of hepatitis B infection.</p><p><strong>Conclusion: </strong>This study provides valuable insights into the epidemiology of HBV in Ondo State, Nigeria. Highlighting the need for more coordinated efforts towards the prevention and control of the spread of HBV as we move towards the elimination of viral Hepatitis.</p>","PeriodicalId":19720,"journal":{"name":"Nigerian Postgraduate Medical Journal","volume":"33 2","pages":"180-186"},"PeriodicalIF":1.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147327026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Morning versus Bedtime Telmisartan on Ambulatory Blood Pressure and Exercise Response in Diabetic Hypertensive Patients: A Randomised Cross-over Trial. 替米沙坦对糖尿病高血压患者动态血压和运动反应的影响:一项随机交叉试验。
IF 1.2
Nigerian Postgraduate Medical Journal Pub Date : 2026-03-01 Epub Date: 2026-03-02 DOI: 10.4103/npmj.npmj_420_25
Nalabothula Ravi Teja, Taruguvandla Sandhya Rani, Keerthi Reddy Karra, Janardhana Subramonia Kumar, Nanda Kumar
{"title":"Effect of Morning versus Bedtime Telmisartan on Ambulatory Blood Pressure and Exercise Response in Diabetic Hypertensive Patients: A Randomised Cross-over Trial.","authors":"Nalabothula Ravi Teja, Taruguvandla Sandhya Rani, Keerthi Reddy Karra, Janardhana Subramonia Kumar, Nanda Kumar","doi":"10.4103/npmj.npmj_420_25","DOIUrl":"10.4103/npmj.npmj_420_25","url":null,"abstract":"<p><strong>Background: </strong>Chronotherapy optimises the management of hypertension by synchronising medication with circadian rhythms. When taken in accordance with biological patterns, the long-acting angiotensin II receptor blocker telmisartan may provide extra advantages, particularly for patients with diabetes mellitus who have hypertension.</p><p><strong>Objective: </strong>The purpose of this study is to compare the effects of telmisartan 40 mg taken in the morning versus at bedtime on the mean blood pressure (BP) during the day and at night, as well as the BP response to exercise, in patients with diabetes mellitus.</p><p><strong>Methods: </strong>Forty diabetic hypertensive patients were given telmisartan either in the morning or at bedtime for 8 weeks, followed by a 1-week washout and cross-over in a cross-over randomised controlled trial. In addition to treadmill exercise testing (Bruce protocol), ambulatory BP was measured.</p><p><strong>Results: </strong>Bedtime dosing considerably reduced the systolic and diastolic BP at night when compared to morning dosing. Morning dosing was especially successful in lowering BP increases brought on by exercise. No noteworthy adverse events were observed.</p><p><strong>Conclusion: </strong>Bedtime telmisartan dosage improves nocturnal BP control, but morning dosage more successfully lowers exercise-induced BP spikes. Individualised chronotherapy may improve outcomes and control hypertension in diabetic patients.</p>","PeriodicalId":19720,"journal":{"name":"Nigerian Postgraduate Medical Journal","volume":"33 2","pages":"199-206"},"PeriodicalIF":1.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perception of Medical Speciality Professors towards Including Artificial Intelligence in their Curricula. 医学专业教授对将人工智能纳入课程的看法
IF 1.2
Nigerian Postgraduate Medical Journal Pub Date : 2026-03-01 Epub Date: 2026-03-02 DOI: 10.4103/npmj.npmj_389_25
Hid Felizardo Cordero-Franco, Joahannah Mynervah Carrillo-García, Miguel Angel Romero-García, Francisco Javier Guzmán-de la Garza
{"title":"Perception of Medical Speciality Professors towards Including Artificial Intelligence in their Curricula.","authors":"Hid Felizardo Cordero-Franco, Joahannah Mynervah Carrillo-García, Miguel Angel Romero-García, Francisco Javier Guzmán-de la Garza","doi":"10.4103/npmj.npmj_389_25","DOIUrl":"10.4103/npmj.npmj_389_25","url":null,"abstract":"<p><strong>Background: </strong>Medical residents have shown interest in artificial intelligence (AI) for their clinical and academic activities; however, research on the perception of speciality professors regarding AI is lacking.</p><p><strong>Aims: </strong>To estimate the proportion of medical professors who perceive it necessary to include AI in the curricula of their specialities, along with their self-efficacy, perceived benefits and identified barriers to AI tools.</p><p><strong>Subjects and methods: </strong>Cross-sectional study of 108 medical speciality professors in Monterrey, Mexico, in June 2024. We sent them a self-administered questionnaire that included questions about the professors' perceptions of the need to incorporate AI in the specialities' curricula, their self-efficacy, benefits, barriers to AI and other variables. We estimated relative frequencies, 95% confidence intervals (CI), measures of central tendency and dispersion. Self-efficacy, benefits and barriers scores were compared by interest variables using the Mann-Whitney or Student's t-tests. P < 0.05 was significant.</p><p><strong>Results: </strong>Ninety-eight professors (90.7%, 95% CI: 85.3-96.2) considered it necessary to incorporate AI into their academic programmes. Self-efficacy scores were higher among those working in the private sector and those with a course, workshop or diploma in AI. In addition, those with a master's degree or a doctorate, who had completed a course, workshop or diploma, showed higher benefits scores.</p><p><strong>Conclusions: </strong>Nine out of ten professors of medical specialities believe it is necessary to include AI in their curricula, with a high perception of its self-efficacy and benefits. Academic authorities in medical specialisation should examine the growing integration of AI in modern educational environments.</p>","PeriodicalId":19720,"journal":{"name":"Nigerian Postgraduate Medical Journal","volume":"33 2","pages":"232-238"},"PeriodicalIF":1.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信
小红书