Aresty Rutgers Undergraduate Research Journal最新文献_第2页

Is It All in Our Heads? An Investigation into American and Historical Legacies of Racism and Social Frameworks that Perpetuate Racial Inequalities in Twenty-First Century Healthcare Systems 一切都在我们的头脑中吗?调查美国和历史遗产的种族主义和社会框架，延续种族不平等在二十一世纪的医疗保健系统

Aresty Rutgers Undergraduate Research Journal Pub Date : 2022-12-01 DOI: 10.14713/arestyrurj.v1i4.212

Meghana Nampally

{"title":"Is It All in Our Heads? An Investigation into American and Historical Legacies of Racism and Social Frameworks that Perpetuate Racial Inequalities in Twenty-First Century Healthcare Systems","authors":"Meghana Nampally","doi":"10.14713/arestyrurj.v1i4.212","DOIUrl":"https://doi.org/10.14713/arestyrurj.v1i4.212","url":null,"abstract":"Racial bias in the healthcare system, originating from the eminent founders of science and medicine, has numerous adverse effects on black populations and continues to have harmful consequences today (Byrd and Clayton, 2001). From poor clinical decision-making to preventing people of color from entering prominent fields in medicine, racism is ubiquitous in medicine and healthcare (Byrd and Clayton, 2001). The impact of racial bias on patient care is of great interest with many studies illustrating the detrimental impacts of bias on minority groups, specifically in black communities. However, there is additional research that concludes racial bias does not play a role in patient care or in medicine (Dehon et al., 2017). The lack of acknowledgment within academia concerning racial disparities in healthcare and science further oppresses black voices. With my research, I investigate the extent to which various biased social frameworks in healthcare, medicine, and science negatively impact black individuals. I also address major historical events during the creation of the modern-day healthcare system and how these events perpetuate racism today. Focusing on the twenty-first century, I demonstrate that systemic historical and social events during this period eternalize racism in the modern-day American healthcare system.","PeriodicalId":196784,"journal":{"name":"Aresty Rutgers Undergraduate Research Journal","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121650875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rilke in Translation: Uncovering the Panther in the English Language 翻译中的里尔克:揭露英语中的黑豹

Aresty Rutgers Undergraduate Research Journal Pub Date : 2022-12-01 DOI: 10.14713/arestyrurj.v1i4.210

Serena Luckhoff

{"title":"Rilke in Translation: Uncovering the Panther in the English Language","authors":"Serena Luckhoff","doi":"10.14713/arestyrurj.v1i4.210","DOIUrl":"https://doi.org/10.14713/arestyrurj.v1i4.210","url":null,"abstract":"Walter Benjamin’s influential essay, The Task of the Translator, reflects on how translation can be used to create new works of art and literature instead of attempting to create exact replicas of original works. Rather than translating by searching for words in the target language that are most equivalent to words in the original language, Benjamin encourages the practice of translation as a process which lets two languages influence and change one another. Using Benjamin as a guide, I attempt to create an English translation of Rainer Maria Rilke’s German language poem “Der Panther” that distributes the meaning of the original work throughout the entire translation. To do this, I shift my focus away from translating words and phrases in isolation to reflect on how the effects of seemingly small translation choices reverberate through the work as a whole. I will also compare my translation to the historically important translations of “Der Panther” by Stephen Mitchell, Robert Bly, and C. F. MacIntyre, and argue how mine allows for analyses of themes such as stillness, the panther’s mental state, and the panther’s mind-body relation which more closely emulate Rilke’s original work.","PeriodicalId":196784,"journal":{"name":"Aresty Rutgers Undergraduate Research Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114482125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Observing Winter Carbonate Chemistry Dynamics Throughout the Mid-Atlantic Bight Shelf Using Novel Glider Technology 利用新型滑翔机技术观察整个大西洋中部大陆架冬季碳酸盐化学动力学

Aresty Rutgers Undergraduate Research Journal Pub Date : 2022-12-01 DOI: 10.14713/arestyrurj.v1i4.203

Marissa Guzik, G. Saba, E. Wright‐Fairbanks

{"title":"Observing Winter Carbonate Chemistry Dynamics Throughout the Mid-Atlantic Bight Shelf Using Novel Glider Technology","authors":"Marissa Guzik, G. Saba, E. Wright‐Fairbanks","doi":"10.14713/arestyrurj.v1i4.203","DOIUrl":"https://doi.org/10.14713/arestyrurj.v1i4.203","url":null,"abstract":"Increased atmospheric carbon dioxide (CO2) has led to global climate change and ocean acidification (OA) via the absorption of atmospheric CO2 by the ocean. Coastal shelves are also affected by various processes that influence the acidity of seawater, causing acidity to vary over time and space. These variations in ocean acidity can negatively impact marine species, especially calcifying organisms such as surfclams and sea scallops. In the Mid-Atlantic Bight (MAB), a subsection of the U.S. Northeast Shelf (NES), this variation in acidity generates ecological and economic concerns as the MAB is home to some of the nation’s most productive and profitable estuaries and fisheries. In this study, Rutgers University (southern MAB) and Stony Brook University (northern MAB, Hudson Canyon) deployed two gliders equipped with sensors measur-ing depth, temperature, salinity, pH, dissolved oxygen, and chlorophyll to monitor winter 2021 carbonate chemistry conditions on the shelf as well as in slope waters of the MAB. For both deployments, measured pH and calculated aragonite saturation state (Ωarag) showed opposing patterns, with high pH and low Ωarag in shelf/nearshore and low pH and high Ωarag in slope waters. These trends were attributed to different driving factors whereas pH was more influenced by biological processes (i.e. photo-synthesis) and Ωarag was influenced mostly by thermodynamics and chemical factors (i.e. temperature, total alkalinity). The results of this study underscore the importance of monitoring coastal acidity to understand potential impacts on important species.","PeriodicalId":196784,"journal":{"name":"Aresty Rutgers Undergraduate Research Journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124821460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico Studies of Compounds Present in Azadirachta Indica (Neem) and Their Ability to Bind Hiv Integrase Protein 印楝化合物及其结合Hiv整合酶蛋白能力的计算机研究

Aresty Rutgers Undergraduate Research Journal Pub Date : 2022-12-01 DOI: 10.14713/arestyrurj.v1i4.206

Zhongrui Zhang, Yin Hei Lau, S. Arora

{"title":"In Silico Studies of Compounds Present in Azadirachta Indica (Neem) and Their Ability to Bind Hiv Integrase Protein","authors":"Zhongrui Zhang, Yin Hei Lau, S. Arora","doi":"10.14713/arestyrurj.v1i4.206","DOIUrl":"https://doi.org/10.14713/arestyrurj.v1i4.206","url":null,"abstract":"Azadirachta indica (Neem) is an evergreen tree that belongs to the Meliaceae family. It is native to the Indian subcontinent and grows worldwide. It is also known as the \"village pharmacy\" in India for its wide range of therapeutic and pharmacological properties. An in vitro study indicated that A. indica showed anti-HIV properties. However, the exact mechanism for the supposed anti-HIV properties remains unknown. This study aimed to construct an in-silico database of the compounds present in A. in-dica and propose a computational analysis of these compounds against HIV integrase. We performed a thorough literature search to gather relevant information on the plant compounds, including chemical structure, location within the plant, extraction method, and percent yield of each compound found in the plant. We took a comprehensive ap-proach to closely study the binding pockets of HIV integrase and performed molecular docking on A. indica compounds using Molecular Operating Envi-ronment. A deductive analysis of the docking energies of these compounds revealed thirty potential binders against HIV integrase proteins. We further validated these binders by comparing the ligand in-teractions to known inhibitors using Ligplot+, which identified the presence of numerous hydrogen bonds and hydrophobic interactions at the protein binding pocket. In conclusion, we propose an un-derlying binding potential for several A. indica compounds with HIV integrase, yielding a potential mechanism for the anti-HIV activity of A. indica.","PeriodicalId":196784,"journal":{"name":"Aresty Rutgers Undergraduate Research Journal","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121863016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Epithelial Communication to the Mesenchyme and Its Impact on the Expression of Genes Related to Tumorigenesis 探讨上皮细胞与间质间质的通讯及其对肿瘤发生相关基因表达的影响

Aresty Rutgers Undergraduate Research Journal Pub Date : 2022-12-01 DOI: 10.14713/arestyrurj.v1i4.207

Jay Patel, M. Verzi

引用次数: 0

Privacy Paradox or Privacy Apathy? Exploring the Relationship between Social Media Usage and Public Opinion on Government Usage of Data Collection Programs 隐私悖论还是隐私冷漠?探讨社会媒体使用与公众舆论对政府数据收集计划使用的关系

Aresty Rutgers Undergraduate Research Journal Pub Date : 2022-12-01 DOI: 10.14713/arestyrurj.v1i4.213

Robert Wargaski

引用次数: 0

Differential Gene Expression Analysis and Gene Ontology in Triploid and Diploid Pocillopora Acuta 三倍体和二倍体针叶鱼差异基因表达分析及基因本体

Aresty Rutgers Undergraduate Research Journal Pub Date : 2022-12-01 DOI: 10.14713/arestyrurj.v1i4.208

Deeksha Misri, E. Chille, Timothy G. Stephens, D. Bhattacharya

{"title":"Differential Gene Expression Analysis and Gene Ontology in Triploid and Diploid Pocillopora Acuta","authors":"Deeksha Misri, E. Chille, Timothy G. Stephens, D. Bhattacharya","doi":"10.14713/arestyrurj.v1i4.208","DOIUrl":"https://doi.org/10.14713/arestyrurj.v1i4.208","url":null,"abstract":"Corals are marine invertebrates that are facing life-threatening environmental stressors due to climate change. Polyploidy can, in such cases, be an important source of variation and adaptation in corals and other species. Polyploidy is the genomic condition wherein the cells of a normally diploid organism have more than one pair of chromosomes. Pocillopora acuta, also known as the cauliflower coral, is a brooding coral that can also reproduce asexually. It is a stress-sensitive coral, which means it shows clear physiological changes in response to environmental stressors like temperature, salinity, and pH. In this study, about 60% of the stony coral Pocillopora acuta samples collected from Kāneʻohe Bay, Oahu, HI, were triploid. The aim of this study was to identify the differences in gene expression patterns between triploid cluster 1 (T1), triploid cluster 2 (T2), and diploid samples (D) of P. acuta. Pairwise comparisons were carried out between all categories: T1 vs. D, T2 vs. D, and T1 vs. T2. While there were a large number of genes exhibiting similar expression patterns in both triploid clusters, many genes were differentially regulated in T1 when compared to T2. This result provides evidence suggesting that the two triploid lineages originated from separate triploidization events in Kāneʻohe Bay. The differentially expressed genes shared between these two triploid lineages, when compared to the diploid coral lineage, suggests changes in cellular physiology as a result of polyploidization. Functional analysis of the P. acuta genes can provide deeper insight into the specific, differentially regulated molecular functions and biological processes in triploids when compared to diploid P. acuta. Future studies involving comparative functional enrichment analysis with more triploid and diploid samples of P. acuta will provide more insight into events that caused triploidization and the coral’s response to environmental stressors.","PeriodicalId":196784,"journal":{"name":"Aresty Rutgers Undergraduate Research Journal","volume":"31 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121656106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cystinuria: Genetic Aspects and Novel Pharmacotherapeutics 胱氨酸尿:遗传方面和新的药物治疗

Aresty Rutgers Undergraduate Research Journal Pub Date : 2022-12-01 DOI: 10.14713/arestyrurj.v1i4.205

Diana Stachula, A. Sahota

{"title":"Cystinuria: Genetic Aspects and Novel Pharmacotherapeutics","authors":"Diana Stachula, A. Sahota","doi":"10.14713/arestyrurj.v1i4.205","DOIUrl":"https://doi.org/10.14713/arestyrurj.v1i4.205","url":null,"abstract":"This review provides an overview of the genetic aspects of cystinuria, as well as the novel pharmacotherapeutics that could potentially be used to treat the disease. Cystinuria is an inherited disorder characterized by the formation of painful stones in the kidneys, bladder, and other parts of the renal system. Currently, mutations responsible for cystinuria have been identified in two genes (SLC3A1 and SLC7A9 ), and cystinuria patients are categorized based on their genotypes - which versions, or alleles, of these genes they have (mutated or wild-type). Regardless of genotype, however, current treatments for all cystinuria patients have significant limitations. This has led researchers to search for more promising therapeutics. One potential treatment uses cystine analogs—compounds that are structurally similar to cystine, which is the naturally occurring chemical substance from which the stones are formed. These compounds have demonstrated the ability to inhibit stone formation by stunting cystine crystallization – the process by which cystine crystals aggregate to form stones. Gene therapy may also be used to treat cystinuria in the future by replacing mutated copies of SLC3A1 and SLC7A9 with healthy ones. Technological advancements and an improvement of our understanding of how gene therapy functions in the renal system could reveal even more treatment possibilities.","PeriodicalId":196784,"journal":{"name":"Aresty Rutgers Undergraduate Research Journal","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129847936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Socializing at the Shopping Mall: A Review of Literature to Reassess the Social Value of the American Mall 购物中心的社交:重新评估美国购物中心社会价值的文献综述

Aresty Rutgers Undergraduate Research Journal Pub Date : 2022-12-01 DOI: 10.14713/arestyrurj.v1i4.211

Elizabeth Peterson, A. Urban

引用次数: 0

Identification of Anti-Inflammatory Compounds Present in Nigella Sativa and Analyzing Their Effects on the Inflammation Pathway Using In Silico Techniques 黑草抗炎化合物的鉴定及其对炎症通路的影响

Aresty Rutgers Undergraduate Research Journal Pub Date : 2022-12-01 DOI: 10.14713/arestyrurj.v1i4.204

Habiba Abdelhalim

{"title":"Identification of Anti-Inflammatory Compounds Present in Nigella Sativa and Analyzing Their Effects on the Inflammation Pathway Using In Silico Techniques","authors":"Habiba Abdelhalim","doi":"10.14713/arestyrurj.v1i4.204","DOIUrl":"https://doi.org/10.14713/arestyrurj.v1i4.204","url":null,"abstract":"Nigella sativa, also known as black cumin, is an herb native to Asia, the Middle East, and the Mediterranean. The chemical constituents found in Nigella sativa seeds have been known to have a wide array of pharmacological actions. Previous studies have primarily focused on identifying the structures of these compounds and their medicinal properties based on physiochemical analysis. There have been few studies that explain how these compounds interact with enzymes found in the human body. Hence, the objective of this study was to identify anti-inflammatory compounds present in Nigella sativa from previous literature and see if these compounds can be used to target the cyclooxygenase-2 inflammatory pathway. We compiled a list of twenty-three chemical compounds present in Nigella sativa and then constructed a comprehensive molecular database of their three-dimensional structures using chemical modeling approaches. We then docked these compounds into two different cyclooxygenase-2 molecules, using in silico techniques, to observe their conformation as well as binding affinity. Furthermore, we analyzed the inter-action patterns of the five most stable compounds to understand their effects on the cyclooxygenase binding pocket. In conclusion, using structural bioinformatics approaches, we have identified novel compounds derived from Nigella sativa that can be used as possible agents to target inflammation.","PeriodicalId":196784,"journal":{"name":"Aresty Rutgers Undergraduate Research Journal","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126256147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0