Orthopedic Reviews最新文献

{"title":"State of the Nonunion: A review of the latest literature.","authors":"Wendy Ghanem, Hady Ezzeddine, Rita Saad, Elyssa Kiwan, Raymonde Dahdouh, Omar Fakih, Georges Sakhat, Elie Alam, Joseph Najjar, Fouad Assaf, Moro Chahine, Nabil Dib, Rabih Kortbawi, Mohammad Badra, Ramzi Moucharafieh","doi":"10.52965/001c.129085","DOIUrl":"10.52965/001c.129085","url":null,"abstract":"<p><p>The distinction between prolonged bone healing and nonunion in long bone fracture remains a historical challenge in the field of orthopedics. Despite numerous proposed definitions and scoring systems, a consensus remains elusive, thereby complicating both diagnosis and treatment. An accurate diagnosis is necessary, facilitated by a range of imaging modalities. Bone nonunion management encompasses surgical and non-surgical options, including external or internal fixation, and bone grafting, tailored to the nonunion type. This review discusses the pathophysiology of nonunion, risk factors, diagnosis and treatment. It particularly addresses early detection and the impacts of nonunion on the patient. The aim of this review is to obtain a global and updated point of view regarding nonunion of the bone as well as to reflect on the potential use of untraditional methods in their treatment such as orthobiologics, along with emerging and non-invasive technologies including shockwave therapy, gene therapy, tissue engineering, regenerative medicine and 3D printing.</p>","PeriodicalId":19669,"journal":{"name":"Orthopedic Reviews","volume":"17 ","pages":"129085"},"PeriodicalIF":1.4,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11807701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Return to work after proximal humeral fractures: a single center study comparing conservative versus operative treatment.","authors":"Amber Hameleers, Jasper Most, Martijn Schotanus, Nina Wijnands, Martijn Dremmen, Raoul van Vugt, Bert Boonen","doi":"10.52965/001c.128106","DOIUrl":"10.52965/001c.128106","url":null,"abstract":"<p><strong>Background: </strong>Adequate treatment of proximal humeral fractures (PHF) is essential for restoring shoulder function and expediting return-to-work (RTW). This study aims to assess the impact of conservative and operative treatments on RTW and PHF recovery.</p><p><strong>Objective & methods: </strong>In a retrospective case-control study, 858 patients (aged 18-68) treated for PHF between 2018 and 2021 were included. Questionnaires were sent to 342 operatively treated patients (Operative group (OG)) and 191 conservatively treated matched controls (Conservative group (CG)). Assessments covered RTW, functional outcomes (DASH, ASES), and quality of life (EQ-5D). A Kaplan-Meier analysis explored RTW in weeks.</p><p><strong>Results: </strong>With a 61% response rate, 73 eligible participants (40 OG, 33 CG) contributed. Of respondents, 67.1% were female, and 60% were employed pre-trauma. Almost 70% of employed patients RTW, with no significant difference between groups (log rank, p=0.36). Among those returning to work, OG tended to resume 4 weeks later than CG (OG 10.5, IQR 22 vs. CG 6.00, IQR 8 weeks, p=0.07). DASH, ASES, and quality of life VAS scores showed no statistical difference between groups (p=0.542, p=0.257, p=0.530, respectively).</p><p><strong>Conclusion: </strong>The RTW proportion did not differ between operatively and conservatively treated PHF patients, though the former tended to return 4 weeks later. Functional outcomes demonstrated no significant differences. Further adequately powered studies are necessary to establish a standardized aftercare protocol for PHF, enhancing patient care and minimizing work disability.</p>","PeriodicalId":19669,"journal":{"name":"Orthopedic Reviews","volume":"17 ","pages":"128106"},"PeriodicalIF":1.4,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11779521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Percutaneous Peripheral Nerve Stimulation for the Treatment of Occipital Neuralgia.","authors":"Kayla Valenti, Christopher L Robinson, Vwaire Orhurhu, Syed Mahmood, Jamal Hasoon","doi":"10.52965/001c.128100","DOIUrl":"10.52965/001c.128100","url":null,"abstract":"<p><p>Headaches are among the most prevalent medical complaints globally. Occipital neuralgia is a chronic headache disorder characterized by unilateral or bilateral severe pain originating in the neck or skull base and radiating up along the occipital nerve distribution. Effective treatment options for occipital neuralgia can be challenging and some patients may prove to be refractory to conventional medical and interventional therapies. We present a case report on a patient with severe occipital neuralgia that was refectory to conventional therapies that responded to percutaneous peripheral nerve stimulation.</p>","PeriodicalId":19669,"journal":{"name":"Orthopedic Reviews","volume":"17 ","pages":"128100"},"PeriodicalIF":1.4,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11741895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Treatment and Monitoring of Osteoporosis using Bone Turnover Markers.","authors":"Nikhil Patel, Latha Ganti","doi":"10.52965/001c.127772","DOIUrl":"10.52965/001c.127772","url":null,"abstract":"<p><p>Osteoporosis is a degenerative bone disease that causes the weakening of bone structure. Since bone structure is dynamic throughout a person's lifespan, bones are under constant growth and destruction in a process known as bone turnover or bone remodeling. Osteoporosis involves the disruption of this growth/destruction equilibrium towards the destructive side. An increase in bone turnover leads to a lower bone density and therefore a greater risk of fracture or injury of higher severity. Bone turnover markers serve as indicators of the process of bone turnover. These markers are split into two groups: formation (building up) markers and resorption (breaking down) markers. Using biochemical techniques and assays, these markers can be measured to monitor the activity of the markers as well as determine treatment options and efficacy based on this activity. The use of biomarkers in osteoporosis can pave the way for their use in other diseases such as cancer.</p>","PeriodicalId":19669,"journal":{"name":"Orthopedic Reviews","volume":"17 ","pages":"127772"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11710883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the use of sublingual sufentanil in patients with buprenorphine treatment who are undergoing ambulatory surgery: A Prospective Case Report.","authors":"Kateryna Slinchenkova, Elilary Montilla Medrano, Adam S Yedlin, Preeti Anand, Karina Gritsenko, Sofia Steinberg, Kathryn Breidenbach, Sarang Koushik, Jagun Raghavan, Omar Viswanath, Naum Shaparin","doi":"10.52965/001c.124776","DOIUrl":"10.52965/001c.124776","url":null,"abstract":"<p><strong>Introduction: </strong>Opioid use disorder is a chronic illness with significant morbidity and mortality. Opioid agonists, like buprenorphine, are commonly used to prevent relapse. Recent changes in buprenorphine legislation are expected to increase prescription and guidelines recommend its continuation during the perioperative period for many patients. However, buprenorphine's strong affinity for mu receptors can complicate perioperative pain management, requiring high doses of analgesics and increasing risks like respiratory depression. A newly FDA-approved sublingual sufentanil system, with higher mu receptor affinity, may offer a solution.</p><p><strong>Case presentation: </strong>A series of three cases with patients undergoing outpatient surgery procedures while continuing buprenorphine treatment are presented.</p><p><strong>Management and outcomes: </strong>Sublingual sufentanil was effective in lowering pain with no adverse effects for the buprenorphine patients undergoing surgery with general anesthesia without a missed dose.</p><p><strong>Conclusion: </strong>Further research is needed to make conclusive remarks on the efficacy of this treatment, but the quick onset and effective treatment make this route worthwhile to consider.</p>","PeriodicalId":19669,"journal":{"name":"Orthopedic Reviews","volume":"16 ","pages":"124776"},"PeriodicalIF":1.4,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary total knee arthroplasty in a patient with a chronic total patellectomy using femoral condyle autograft for patellar reconstruction and resurfacing: New technique: A case report.","authors":"Thana Bamroongshawgasame","doi":"10.52965/001c.126709","DOIUrl":"10.52965/001c.126709","url":null,"abstract":"<p><strong>Introduction: </strong>Undertaking a primary total knee arthroplasty for chronic complete patellectomy knees is an infrequent and complex scenario. The technical demands are high, often leading to suboptimal outcomes. However, our innovative approach, which involves a patellar autograft from an intraoperatively cut femoral condyle placed into the extensor mechanism following cement resurfacing, has shown promising results.</p><p><strong>Case presentation: </strong>A 74-year-old man had been living with the consequences of a road accident that occurred 40 years ago. This incident led to an open knee injury in his right knee and a thorough patellectomy. He arrived at Ratchaburi Hospital in 2017 with pain in both knees and had been using crutches for 40 years.</p><p><strong>Management and outcomes: </strong>His left knee had primary total knee arthroplasty in December 2017, and his right knee was scheduled for 2019; but, because of the COVID-19 pandemic, his procedure was postponed and performed as of February 2022. Our patient's knee function significantly improved after using an unconstrained posterior stabilized prosthesis on both knees and the right knee using the patient's patellar autograft from an intraoperatively cut femoral condyle. At 12 weeks postoperatively, the Oxford Knee Society Scores increased from 12 to 45, while the Feller Patellar Scores increased from 8 to 26.</p><p><strong>Conclusion: </strong>These successful outcomes at 12 weeks postoperatively and even more so after two years demonstrate the significant potential of this new technique, instilling hope for improved outcomes in similar cases.</p>","PeriodicalId":19669,"journal":{"name":"Orthopedic Reviews","volume":"16 ","pages":"126709"},"PeriodicalIF":1.4,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142838469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infrapatellar Fat Pad-Derived Non-Cellular Products in Therapy for Musculoskeletal Diseases: A Scoping Review.","authors":"Aditya Fuad Robby Triangga, Widya Asmara, Rahadyan Magetsari, Indra Bachtiar, Dandy Ardhan Fazatamma, Paramita Ayu Saraswati, A Faiz Huwaidi, Yohanes Widodo Wirohadidjojo","doi":"10.52965/001c.125841","DOIUrl":"10.52965/001c.125841","url":null,"abstract":"<p><strong>Background: </strong>The complex nature of musculoskeletal diseases and the limitations of existing treatments have driven researchers to explore innovative solutions, particularly those involving stem cells and their derivatives. The utilization of the IPFP as a source of MSC-derived non-cellular products for the treatment of musculoskeletal diseases has gained recognition in recent years. This study aimed to identify the progress of IPFP-derived acellular biologics use in the treatment of orthopedic conditions such as osteoarthritis and ligament and/or tendon injuries.</p><p><strong>Methods: </strong>A literature search was conducted through PubMed, Scopus and Google Scholar databases including studies over the past 10 years. This scoping review includes studies discussing the development of intercellular messenger signaling molecules (non-cellular products) in the form of exosomes, secretomes, and conditioned medium derived from the IPFP in the management of musculoskeletal diseases. The PRISMA-ScR guidelines were utilized in this review.</p><p><strong>Results: </strong>Six studies met the inclusion criteria. Most studies reported the beneficial anti-inflammatory effects of IPFP-derived noncellular products in musculoskeletal conditions. The effects of IPFP-derived exosomes, secretomes, and conditioned medium administration are mostly reported in microscopic changes through cellular and matrix changes. Additionally, quantitative analyses involved assessing levels of anti-inflammatory and pro-inflammatory markers, proteins, fatty acids, and gene expression.</p><p><strong>Conclusions: </strong>The use of IPFP-derived non-cellular products has shown significant promise in the regenerative therapy for musculoskeletal diseases. These agents have demonstrated beneficial effects, particularly in reducing inflammation, promoting cellular changes, and enhancing tissue regeneration. However, further research is needed to fully understand the characteristics and explore the potential applications of IPFP-derived non-cellular products in musculoskeletal cases.</p>","PeriodicalId":19669,"journal":{"name":"Orthopedic Reviews","volume":"16 ","pages":"125841"},"PeriodicalIF":1.4,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142838364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-sensitive injuries for the sports medicine surgeon - \"Sports Medicine Trauma\", Part 1: Upper Extremity.","authors":"Reece M Rosenthal, Joseph Featherall, Robert M Putko, Patrick J McGlone, Scott M Feeley, Nicholas M Panarello, Brendan M Lilley, Sarah Rabin, Daniel C Lewis, Chad W Parkes, Rebecca L Sanderson, Robert A Waltz, Justin J Ernat","doi":"10.52965/001c.126704","DOIUrl":"10.52965/001c.126704","url":null,"abstract":"<p><p>Skeletal fractures are traumatic injuries that are widely accepted as requiring acute treatment to avoid long-term disability and dysfunction. There are a number of soft-tissue injuries or non-traditional fractures, frequently treated by sports medicine surgeons, which additionally require treatment in an expedited fashion in order to optimize healing and function. Sports medicine injuries of the lower extremity requiring acute treatment include, but are not limited to, irreducible shoulder dislocations, acute traumatic rotator cuff tears, posterior sternoclavicular joint dislocations, high grade acromioclavicular joint dislocations, pectoralis major tendon ruptures, distal biceps tendon ruptures, and triceps tendon ruptures. The purpose of this manuscript is to review the sports medicine injuries of the upper extremity which require acute/urgent management to facilitate optimal treatment.</p>","PeriodicalId":19669,"journal":{"name":"Orthopedic Reviews","volume":"16 ","pages":"126704"},"PeriodicalIF":1.4,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-Sensitive Injuries for the Sports Medicine Surgeon - \"Sports Medicine Trauma\", Part 2: Lower Extremity.","authors":"Reece M Rosenthal, Joseph Featherall, Daniel C Lewis, Chad W Parkes, Rebecca L Sanderson, Robert M Putko, Patrick J McGlone, Scott M Feeley, Nicholas M Panarello, Brendan M Lilley, Sarah Rabin, Robert A Waltz, Justin J Ernat","doi":"10.52965/001c.126707","DOIUrl":"10.52965/001c.126707","url":null,"abstract":"<p><p>Skeletal fractures are traumatic injuries that are widely accepted as requiring acute treatment to avoid long-term disability and dysfunction. There are a number of soft-tissue injuries or non-traditional fractures, frequently treated by sports medicine surgeons, which additionally require treatment in an expedited fashion in order to optimize healing and function. Sports medicine injuries of the lower extremity requiring acute treatment include, but are not limited to, multiligamentous knee injuries, proximal hamstring ruptures, quadriceps tendon ruptures, patellar sleeve avulsions, patellar tendon ruptures, tibial spine avulsions, posterior cruciate ligament avulsions, bucket handle meniscus tears, and achilles tendon ruptures. The purpose of this manuscript is to review the sports medicine injuries of the lower extremity which require acute/urgent management to facilitate optimal treatment.</p>","PeriodicalId":19669,"journal":{"name":"Orthopedic Reviews","volume":"16 ","pages":"126707"},"PeriodicalIF":1.4,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biophysics of ACL Injuries.","authors":"Bartłomiej Kacprzak, Mikołaj Stańczak, Jakub Surmacz, Magdalena Hagner-Derengowska","doi":"10.52965/001c.126041","DOIUrl":"10.52965/001c.126041","url":null,"abstract":"<p><p>Anterior Cruciate Ligament (ACL) injuries rank among the most prevalent and severe types of injuries, significantly impacting both athletes and non-athletes alike. These injuries not only result in immediate physical impairment, such as intense pain, substantial swelling, and a marked loss of mobility, but also carry long-term health consequences that can alter a person's quality of life. Chronic pain, persistent instability, and an increased risk of developing osteoarthritis are among the lasting effects that can follow an ACL injury. An in-depth understanding of the biophysics behind ACL injuries is paramount for devising effective prevention and treatment protocols. Biophysics, which combines principles from physics with biological systems, provides crucial insights into the mechanical and structural integrity of the ACL and its susceptibility to injury under various conditions. This systematic review aims to collate and synthesize the current knowledge surrounding the biophysical mechanisms that underlie ACL injuries.</p>","PeriodicalId":19669,"journal":{"name":"Orthopedic Reviews","volume":"16 ","pages":"126041"},"PeriodicalIF":1.4,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}