Oman Medical Journal最新文献

筛选
英文 中文
Sleep Quality and its Daytime Effects among University Students in the UAE. 阿联酋大学生的睡眠质量及其白天的影响。
Oman Medical Journal Pub Date : 2024-03-31 eCollection Date: 2024-03-01 DOI: 10.5001/omj.2024.61
Nisha Shantakumari, Safielrahman Haitham Sami Elawaddlly, Ahmad Jalal Amir Kanawati, Abdulrahman Salem Abufanas, Abdulilah Dakak, Fathima Manal Ibham, Ibrahim Bani
{"title":"Sleep Quality and its Daytime Effects among University Students in the UAE.","authors":"Nisha Shantakumari, Safielrahman Haitham Sami Elawaddlly, Ahmad Jalal Amir Kanawati, Abdulrahman Salem Abufanas, Abdulilah Dakak, Fathima Manal Ibham, Ibrahim Bani","doi":"10.5001/omj.2024.61","DOIUrl":"10.5001/omj.2024.61","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the irregularity in the sleep schedule among university students in the UAE and determine its correlation with poor sleep quality, daytime sleepiness, and fatigue.</p><p><strong>Methods: </strong>This observational cross-sectional survey was electronically conducted among undergraduate students of Ajman University during the academic year 2022-2023. The participants were selected using a simple random sampling method. The instruments for data collection comprised of sleep schedule questionnaire, Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and Fatigue Severity Scale. Data was subjected to chi-square analysis, Mann-Whitney U test, Wilcoxon rank-sum test, and Spearman's correlation.</p><p><strong>Results: </strong>Of the 537 participants, 353 (65.7%) were female. The majority (57.2%) kept highly irregular bedtimes. The cohort's mean global PSQI score was 8.9±3.0 indicating poor sleep quality. There was a positive correlation between the irregular bedtime frequency and the global PSQI score (r = 0.311; <i>p</i> < 0.010). Most (70.8%) participants had a total high Fatigue Severity Scale score of ≥ 36. The scores of women (41.0±10.5) were significantly higher than those of men (38.5±11.0) (<i>p =</i>0.006). Around 53.0% of the participants had high ESS scores indicating excessive daytime sleepiness. There was also a significant correlation between ESS score and irregular bedtime frequency (r = 0.113; <i>p =</i>0.009).</p><p><strong>Conclusions: </strong>The students at Ajman University had a high prevalence of irregular bedtime and inadequate sleeping hours. This was affecting their sleep quality and causing excessive daytime sleepiness. The students, especially women, were suffering from fatigue, potentially affecting their normal functionality. It is crucial to encourage students to establish regular sleep patterns and improve sleep habits to promote their productivity and general well-being.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"39 2","pages":"e612"},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Complicated Case of Thrombotic Thrombocytopenic Purpura in Pregnancy with Superimposed Preeclampsia. 妊娠合并血栓性血小板减少性紫癜并发子痫前期的复杂病例。
Oman Medical Journal Pub Date : 2024-03-31 eCollection Date: 2024-03-01 DOI: 10.5001/omj.2024.11
Ikram Abdelaziz Shinko, Zenab Yusuf Tambawala, Shabnam Saquib, Saba Al Sayari
{"title":"A Complicated Case of Thrombotic Thrombocytopenic Purpura in Pregnancy with Superimposed Preeclampsia.","authors":"Ikram Abdelaziz Shinko, Zenab Yusuf Tambawala, Shabnam Saquib, Saba Al Sayari","doi":"10.5001/omj.2024.11","DOIUrl":"10.5001/omj.2024.11","url":null,"abstract":"<p><p>A 32-year-old woman at 26 weeks gestation presented with severe unexplained thrombocytopenia with signs and symptoms of severe pregnancy-induced hypertension and what appeared to be hemolysis, elevated liver enzymes, and low platelet count syndrome, leading to a severe diagnostic challenge. The multidisciplinary team identified her condition as thrombotic thrombocytopenic purpura. Timely management decisions and multidisciplinary care ensured a safe delivery.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"1 1","pages":"e619"},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70683669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Venous Thromboembolism Risk and Prophylaxis in the Acute Hospital Care Settings in Oman: A National Multicenter Cross-sectional Study. 阿曼急症医院护理环境中的静脉血栓栓塞风险和预防措施:一项全国多中心横断面研究。
Oman Medical Journal Pub Date : 2024-03-31 eCollection Date: 2024-03-01 DOI: 10.5001/omj.2024.63
Asma Al Jahwari, Bader Al Rawahi
{"title":"Venous Thromboembolism Risk and Prophylaxis in the Acute Hospital Care Settings in Oman: A National Multicenter Cross-sectional Study.","authors":"Asma Al Jahwari, Bader Al Rawahi","doi":"10.5001/omj.2024.63","DOIUrl":"10.5001/omj.2024.63","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the prevalence of risk for venous thromboembolism (VTE) and the proportion of at-risk patients who receive appropriate thromboprophylaxis among inpatients in acute hospital care settings in Oman. A related objective was to evaluate the type and time of initiation of VTE prophylaxis.</p><p><strong>Methods: </strong>This multicenter, cross-sectional study was conducted in three tertiary hospitals in Oman. The study included acutely ill medical and surgical inpatients admitted from August to September 2022. VTE risk assessment and prophylaxis were assessed based on the 2012 recommendations of the American College of Chest Physicians (ACCP).</p><p><strong>Results: </strong>A total of 384 patients were enrolled, 240 were medical patients and 144 were surgical patients. As per the ACCP criteria, 179 (74.6%) of medical and 92 (63.9%) of surgical patients were at risk for VTE and required prophylaxis. Appropriate prophylaxis was received by 142 (79.3%) at-risk medical and 70 (76.1%) at-risk surgical patients. In cases where pharmacological prophylaxis was contraindicated, mechanical prophylaxis was markedly underused. For medical patients, the median day of initiating VTE prophylaxis was day one of admission. For surgical patients, the median day of initiating VTE prophylaxis was postoperative day one.</p><p><strong>Conclusions: </strong>The majority of hospitalized patients in Oman are at risk of VTE. However, a significant minority of patients do not receive the required pharmacological or mechanical prophylaxis. We recommend the development of a national VTE risk assessment and guiding tool with a facility for monitoring compliance.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"39 2","pages":"e614"},"PeriodicalIF":0.0,"publicationDate":"2024-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel PTRH2 Gene Mutation Causing Infantile-onset Multisystem Neurologic, Endocrine, and Pancreatic Disease in a Bahraini Patient. 一名巴林患者的新型 PTRH2 基因突变导致婴儿期发病的多系统神经系统、内分泌和胰腺疾病。
Oman Medical Journal Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI: 10.5001/omj.2024.08
Hasan M Isa, Sara D Khalaf, Sara Janahi, Mohamed M Naser, Noor Al Hamad, Hasan Alhaddar, Maryam Busehail
{"title":"A Novel PTRH2 Gene Mutation Causing Infantile-onset Multisystem Neurologic, Endocrine, and Pancreatic Disease in a Bahraini Patient.","authors":"Hasan M Isa, Sara D Khalaf, Sara Janahi, Mohamed M Naser, Noor Al Hamad, Hasan Alhaddar, Maryam Busehail","doi":"10.5001/omj.2024.08","DOIUrl":"10.5001/omj.2024.08","url":null,"abstract":"<p><p>Infantile-onset multisystem neurologic, endocrine, and pancreatic disease (IMNEPD) is a rare autosomal recessive multisystemic disease with a prevalence of < 1/1 000 000. The wide spectrum of symptoms and associated diseases makes the diagnosis of this disease particularly challenging. Here, we report a 12-year-old Bahraini male who presented with the core clinical features of IMNEPD including intellectual disability, global developmental delay, sensorineural hearing loss, endocrine dysfunction, and exocrine pancreatic insufficiency. The diagnosis was confirmed by genetic testing using whole exome sequencing. This is the first reported case of IMNEPD from Bahrain and was found to have a novel homozygous peptidyl-tRNA hydrolase 2 (PTRH2) gene mutation (NM_001015509.2: c.370del p.(Glu124Lysfs*4)). Moreover, we conducted an extensive literature review with an emphasis on the variable clinical spectrum and genotypes of previously reported patients in comparison to our case.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"1 1","pages":"e599"},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10951560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70683229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ApaI and Fok1 Variants of Vitamin D Receptor Gene Associated with Metabolic Syndrome Among Jordanian Women. 与约旦妇女代谢综合征有关的维生素 D 受体基因 ApaI 和 Fok1 变异。
Oman Medical Journal Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI: 10.5001/omj.2024.47
Manar Fayiz Atoum
{"title":"<i>ApaI</i> and <i>Fok1</i> Variants of Vitamin D Receptor Gene Associated with Metabolic Syndrome Among Jordanian Women.","authors":"Manar Fayiz Atoum","doi":"10.5001/omj.2024.47","DOIUrl":"10.5001/omj.2024.47","url":null,"abstract":"<p><strong>Objectives: </strong>The association between vitamin D receptor (VDR) polymorphisms and metabolic syndrome (MS) remains debatable. The current study aimed to determine the correlation of VDR gene polymorphisms with MS among Jordanian women.</p><p><strong>Methods: </strong>This case-control study enrolled 100 women with MS and 100 age-matched women as control at Al-Hikma Modern Hospital in Jordan between January 2019 and January 2020. The levels of glycated hemoglobin, fasting glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and 25-hydroxy vitamin D (25(OH)D) were determined from serum samples of all participants. DNA was extracted from whole blood samples, and VDR gene polymorphisms <i>Apa1</i>, <i>Taq1</i>, <i>Bsm1</i>, and <i>Fok1</i> were analyzed by polymerase chain reaction and restriction fragment length polymorphism.</p><p><strong>Results: </strong>There was a significant difference between MS patients and control in terms of body mass index (34.3±3.1 vs. 28.1±2.5), glycated hemoglobin (5.9±1.1 vs. 4.6±1.2), fasting blood glucose (6.4±1.6 vs. 5.2±1.4), and total cholesterol (6.5±1.2 vs. 5.3±1.8). The results also demonstrated a statistical difference in the number of MS patients and control with 25(OH)D deficiency (69.0 vs. 33.0), 25(OH)D insufficiency (25.0 vs. 42.0), and 25(OH)D sufficiency (6.0 vs. 25.0) (<i>p</i> < 0.001). MS was significantly associated with VDR polymorphisms among <i>Apa1</i> and <i>Fok1</i> genes. The genotype distribution for CC (47.0% vs. 53.0%; <i>p</i> = 0.002) and CA (37.0% vs. 45.0%; <i>p</i> = 0.001) genotypes among Apa1 VDR polymorphism, as well as among TT genotype (38.0% vs. 20.0%; <i>p</i> = 0.025) among <i>Fok1</i> VDR gene polymorphism significantly differed between MS patients and healthy individuals. However, no associations were detected among <i>Taq1</i> and <i>Bsm1</i> VDR genotypes.</p><p><strong>Conclusions: </strong>VDR gene polymorphism of <i>Apa1</i> and <i>Fok1</i> variants may increase the risk of metabolic syndrome among Jordanian women.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"1 1","pages":"e591"},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11077276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70685506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Time to Positivity of Blood Culture as a Predictor of Causative Pathogens and Survival in Neonatal Sepsis: A Retrospective Cohort Study from Indonesia. 血液培养阳性时间作为新生儿败血症致病病原体和存活率的预测指标:印度尼西亚的一项回顾性队列研究。
Oman Medical Journal Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI: 10.5001/omj.2024.43
Agung Dwi Wahyu Widodo, Putu Bagus Dharma Permana, Arina Setyaningtyas, Manik Retno Wahyunitisari
{"title":"Time to Positivity of Blood Culture as a Predictor of Causative Pathogens and Survival in Neonatal Sepsis: A Retrospective Cohort Study from Indonesia.","authors":"Agung Dwi Wahyu Widodo, Putu Bagus Dharma Permana, Arina Setyaningtyas, Manik Retno Wahyunitisari","doi":"10.5001/omj.2024.43","DOIUrl":"10.5001/omj.2024.43","url":null,"abstract":"<p><strong>Objectives: </strong>In the blood culture procedure for neonatal sepsis, time to positivity (TTP) reflects the pathogenic bacterial load and the time required for empirical antibiotic regimen administration prior to definitive treatment. This study aims to identify the differences in TTP among causative pathogens and its predictive value for the overall survival of neonates with sepsis at a tertiary healthcare center in Indonesia.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted from January 2020 to August 2022 at Dr. Soetomo General Hospital, Surabaya, Indonesia. Neonates with blood culture-proven neonatal sepsis were included in the analysis. TTP was defined as the time between the acceptance of a blood culture specimen from the neonatal intensive care unit and reports of positive culture growth by the laboratory.</p><p><strong>Results: </strong>Across 125 cases, the median TTP was 58.1 hours (IQR = 24.48). Blood cultures were positive within 48 hours for 41.6% of cases, 72 hours for 86.4%, and 96 hours for 98.4%. A significantly shorter TTP was exhibited by the three major gram-negative organisms (<i>Klebsiella pneumoniae,Acinetobacter baumannii,Enterobacter cloacae</i>) compared to coagulase-negative Staphylococci. The neonatal sepsis mortality rate was 49.6% during the study period. In the Cox multivariate regression model, a shorter TTP was an independently predicted mortality in the entire cohort (hazard ratio (HR) = 0.985, 95% CI: 0.973-0.998) and the gram-negative sepsis cohort group (HR = 0.983, 95% CI: 0.968-0.999).</p><p><strong>Conclusions: </strong>TTP predicts different causative pathogens and the overall survival of neonatal sepsis cases at a tertiary healthcare facility in Indonesia.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"1 1","pages":"e588"},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11231517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70685611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Diabetic Retinopathy Among Individuals with Diabetes in Gulf Cooperation Council countries: A Systematic Review and 
Meta-analysis. 海湾合作委员会国家糖尿病患者中糖尿病视网膜病变的患病率:系统回顾与元分析》。
Oman Medical Journal Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI: 10.5001/omj.2024.77
Zoelfigar Mohamed, Malek Al-Natour, Hilal Al Rahbi
{"title":"Prevalence of Diabetic Retinopathy Among Individuals with Diabetes in Gulf Cooperation Council countries: A Systematic Review and \u2028Meta-analysis.","authors":"Zoelfigar Mohamed, Malek Al-Natour, Hilal Al Rahbi","doi":"10.5001/omj.2024.77","DOIUrl":"https://doi.org/10.5001/omj.2024.77","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the proportion of diabetic retinopathy (DR) among individuals with diabetes mellitus in the Gulf Cooperation Council (GCC) countries.</p><p><strong>Methods: </strong>This study was executed in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines. Online databases including Scopus, Web of Sciences, PubMed, Index Medicus for the eastern Mediterranean region, Medline, and ProQuest, were utilized to retrieve studies on the prevalence of DR in GCC countries that were conducted from 2003 to 2019.</p><p><strong>Results: </strong>Twenty articles were included in the meta-analysis, involving 61 855 patients. The prevalence of DR was 20.5% (95% CI: 20.212-20.850). The highest prevalence rate was observed in Saudi Arabia (69.8%; 95% CI: 64.989-74.216) and the lowest in the UAE (6.0%; 95% CI: 2.780-11.084). There was a significant heterogeneity between the reviewed studies (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>The prevalence of DR was high in the GCC countries. Our findings provide crucial information for the public healthcare systems in these countries to actively educate the public and screen at-risk populations for undiagnosed cases of diabetes, detect early stages of retinopathy, and provide required care to minimize the number of untreated cases.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"39 1","pages":"e585"},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11033453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pituitary Adenoma Prevalence and Characteristics of Omani Patients: A Single Center Experience. 阿曼垂体腺瘤发病率和患者特征:单中心经验。
Oman Medical Journal Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI: 10.5001/omj.2024.44
Abdullah M Al Futaisi, Asma M Al Marzouqi, Mohammed A Al Abri, Maha Z Al Riyami
{"title":"Pituitary Adenoma Prevalence and Characteristics of Omani Patients: A Single Center Experience.","authors":"Abdullah M Al Futaisi, Asma M Al Marzouqi, Mohammed A Al Abri, Maha Z Al Riyami","doi":"10.5001/omj.2024.44","DOIUrl":"10.5001/omj.2024.44","url":null,"abstract":"<p><strong>Objectives: </strong>To estimate the incidence of pituitary adenomas (PA) in adult Omani patients and describe its epidemiological, clinical, and radiological characteristics.</p><p><strong>Methods: </strong>In this longitudinal, descriptive study, we reviewed the records of all PA patients from January 2015 to January 2020 who presented at the endocrinology facilities at Sultan Qaboos University Hospital, Muscat.</p><p><strong>Results: </strong>The participants comprised of 112 Omani patients with PA. The incidence of PA among all adult patients at Sultan Qaboos University Hospital (inpatient and outpatient) over five years (2015-2020) was 0.23%. The cohort had a mean age of 41.0±15.0 years. Of the 112 patients included in this study, 79 (70.5%) were women. Nearly half (51; 45.5%) of adenomas were prolactinomas while 46 (41.1%) were non-functioning adenomas, and seven (6.3%) were growth hormone-secreting adenomas while six (5.4%) were adrenocorticotropic hormone secreting adenomas. Headache was present in 67 (59.8%) patients, followed by visual field defects (40; 35.7%), galactorrhea (26; 23.2%), and fatigue (19; 17.0%). The majority of women (45/79; 57.0%) presented with menstrual cycle abnormalities. Radiological appearances were nearly equally distributed between micro- and macroadenomas. Most cases (58/112; 52.0%) of PA were treated medically by cabergoline, octreotide, and replacement therapies such as hydrocortisone and thyroxin, 38 (33.9%) were treated surgically (mainly by trans-sphenoidal pituitary resection), and the remaining 10 (8.9%) cases were subjected to radiotherapy. Medical treatment combined with surgery was employed for 15 (13.4%) patients.</p><p><strong>Conclusions: </strong>In our investigation, PA was primarily prevalent among Omani female patients, and the most common subtype of pituitary tumors was prolactinomas. The most common presentation symptom was headaches; most female patients had menstrual irregularities. Medical treatment was the primary approach for the applicable types of PAs, while surgery and radiotherapy were found to be secondary and tertiary treatment options, respectively.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"1 1","pages":"e589"},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70685617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IDH1 and IDH2 Gene Mutations in Omani Patients with Acute Myeloid Leukemia: Prognostic Significance and Clinic-pathologic Features. 阿曼急性髓性白血病患者的 IDH1 和 IDH2 基因突变:预后意义和临床病理特征。
Oman Medical Journal Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI: 10.5001/omj.2023.126
Yusra Al Abri, Mohammed Al Huneini, Shoaib Al Zadjali, Mohammed Al Rawahi
{"title":"<i>IDH1</i> and <i>IDH2</i> Gene Mutations in Omani Patients with Acute Myeloid Leukemia: Prognostic Significance and Clinic-pathologic Features.","authors":"Yusra Al Abri, Mohammed Al Huneini, Shoaib Al Zadjali, Mohammed Al Rawahi","doi":"10.5001/omj.2023.126","DOIUrl":"10.5001/omj.2023.126","url":null,"abstract":"<p><strong>Objectives: </strong>We sought to define the prevalence of isocitrate dehydrogenase (IDH) mutations, evaluate the clinicopathologic impact of IDH mutations, assess the effect of IDH mutations on the response to the currently offered treatment for acute myeloid leukemia (AML) cases, and determine the impact of other common concurrent mutations with IDH.</p><p><strong>Methods: </strong>A single-center retrospective cohort study was conducted at Sultan Qaboos University Hospital (SQUH) from October 2009 to October 2019. We included all Omani patients (pediatric and adult) treated at SQUH with the standard therapy, for whom DNA extraction was performed at diagnosis. The target mutations in both IDH1 and IDH2 genes were screened using the direct polymerase chain reaction product sequencing method. Statistical analysis was conducted using SPSS software. Survival differences were estimated using the log-rank test. Continuous variables were presented as median (IQRs), while categorical variables were presented as frequency.</p><p><strong>Results: </strong>A total of 61 patients treated, for whom DNA extraction was performed at diagnosis were evaluated. The median age was 40 (range = 25.5-65.5). The prevalence of IDH1 R132, IDH2 R140, and IDH2 R172 mutations among the study group was 6.6%, 3.3%, and 1.6%, respectively. Clinicopathologic characteristics associated with IDH mutations at diagnosis included older age, lower white blood cell count, higher median platelet counts, normal karyotype AML, and cytogenetics intermediate-risk group. The overall survival (OS) in patients harboring IDH mutations was poor, with a median OS of nine months. This analysis confirms that the response rate and OS for both IDH-mutated and IDH wild-type AML patients were comparable. This will provide contemporary data to be used for comparison with the results of novel investigational (e.g., selective IDH inhibitor) strategies.</p><p><strong>Conclusions: </strong>The current study results were consistent with the other international studies of IDH mutations in AML and demonstrate the poor prognosis associated with IDH mutations. Clinicopathologic features associated with IDH mutations included older age, lower white blood cell count, higher median platelet counts, normal karyotype AML, and cytogenetics intermediate-risk group.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"1 1","pages":"e592"},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11270159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70683138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Quality of Life of Urban Omani People During the COVID-19 Pandemic in A'Seeb Wilayat: A Cross-sectional Study. A'Seeb Wilayat 地区 COVID-19 大流行期间阿曼城市居民的生活质量:横断面研究。
Oman Medical Journal Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI: 10.5001/omj.2024.51
Mohammed Al Hinai, Zalikha Issa Al Belushi, Asma Said Al Shidhani, Maisa Hamed Al Kiyumi
{"title":"The Quality of Life of Urban Omani People During the COVID-19 Pandemic in A'Seeb Wilayat: A Cross-sectional Study.","authors":"Mohammed Al Hinai, Zalikha Issa Al Belushi, Asma Said Al Shidhani, Maisa Hamed Al Kiyumi","doi":"10.5001/omj.2024.51","DOIUrl":"10.5001/omj.2024.51","url":null,"abstract":"<p><strong>Objectives: </strong>COVID-19 is an emergent disease with significant global concern, which might have a negative effect on quality of life. This study aimed to determine the impact of the COVID-19 pandemic on the quality of life of people (with or without COVID-19) attending primary health centers in A'Seeb Wilayat in Muscat, Oman.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in four randomly selected primary health centers in A'Seeb Wilayat from 17 July 2021 to 31 January 2022. All Omani men and women, aged ≥ 18 years, regardless of their COVID-19 infection status, who were able to read and use online questionnaire, were included. The consecutive sampling method was applied. An online self-administered and validated Arabic version of the Short Form-12 was used to determine the impact of the COVID-19 pandemic on mental and physical quality of life.</p><p><strong>Results: </strong>A total of 701 participants were included with a mean age of 25.3 years. Two-thirds of the participants (n = 473, 67.5%) reported being physically affected by the COVID-19 pandemic (score of ≤ 50) and more than half (n = 392, 55.9%) had been mentally affected (score of ≤ 42). Univariate analysis revealed a significant association between physical impact and educational level, low family income, chronic diseases, and alcohol consumption. Gender, young age, being single, low income, and chronic diseases were significant risk factors for mental impact.</p><p><strong>Conclusions: </strong>Physical and mental impacts are very common during the COVID-19 pandemic. Several risk factors were identified. Public health programs need to be implemented to mitigate the negative impact of COVID-19 on quality of life.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"1 1","pages":"e594"},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70693439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信