Oman Medical JournalPub Date : 2023-11-30eCollection Date: 2023-11-01DOI: 10.5001/omj.2023.113
Fatma Al Farsi, Khuloud Al Maamari, Fatma Ba Alawi, Murtadha Al-Khabori, David Dennison, Abdullah Al Busaidi, Iman Al Manthari
{"title":"Cytomegalovirus Infection Post-hematopoietic Stem Cell Transplant: Incidence, Risk Factors, and Outcome in an Omani Cohort.","authors":"Fatma Al Farsi, Khuloud Al Maamari, Fatma Ba Alawi, Murtadha Al-Khabori, David Dennison, Abdullah Al Busaidi, Iman Al Manthari","doi":"10.5001/omj.2023.113","DOIUrl":"10.5001/omj.2023.113","url":null,"abstract":"<p><strong>Objectives: </strong>To estimate the incidence, risk factors, and outcome of cytomegalovirus (CMV) infection during the first year following hematopoietic stem cell transplant (HSCT) among Omani patients.</p><p><strong>Methods: </strong>This retrospective study included allogenic HSCT recipients between January 2006 and December 2018. We investigated the possible factors associated with CMV infection and CMV impact on one-year mortality.</p><p><strong>Results: </strong>Among 556 recipients of allogenic HSCT, 308 (55.4%) were male, the median age was 12 years, and 366 (65.8%) had benign conditions. One-year after transplants, the prevalence of CMV infection was 59.4%, and that of CMV disease was 1.8%. Multivariate analyses revealed significant relationships between CMV infection and haploidentical transplant (<i>p =</i> 0.006), graft versus host disease (<i>p =</i> 0.013), myeloablative conditioning (<i>p =</i> 0.001), and patient age ≥ 12 years (<i>p</i> < 0.001). CMV infection was associated with an increased risk of one-year mortality (<i>p =</i> 0.001). One-year overall mortality was 8.3%.</p><p><strong>Conclusions: </strong>The incidence of CMV infection in this Omani cohort was comparable with earlier findings, but the disease incidence and overall mortality were lower. Older age, haploidentical transplant, myeloablative conditioning, and graft versus host disease were significantly associated with a higher risk of CMV infection. In addition, CMV infection was associated with an increased risk of overall mortality in the first year post-transplant. Our findings support early initiation of preemptive therapy at low-level CMV viremia.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"38 6","pages":"e567"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10822133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oman Medical JournalPub Date : 2023-11-30eCollection Date: 2023-11-01DOI: 10.5001/omj.2024.01
Iman Al Hatmi, Huda Al Maqbali, Ahmed Al Waily, Ayida Al Khalili, Asim Qureshi
{"title":"Pityriasis Rosea and Pityriasis Rosea-like Eruption Following COVID-19 Vaccinations: Case Series from Oman.","authors":"Iman Al Hatmi, Huda Al Maqbali, Ahmed Al Waily, Ayida Al Khalili, Asim Qureshi","doi":"10.5001/omj.2024.01","DOIUrl":"10.5001/omj.2024.01","url":null,"abstract":"<p><p>To mitigate the impact of the COVID-19 pandemic, several vaccines have been developed and administered to the public since 2021. A spectrum of cutaneous reactions has been reported among some of the vaccinated individuals. In this case series, we describe three cases of pityriasis rosea and pityriasis rosea-like eruption that manifested after COVID-19 vaccinations, which might suggest the vaccines as a possible trigger.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"1 1","pages":"e579"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10801697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70683345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oman Medical JournalPub Date : 2023-11-30eCollection Date: 2023-11-01DOI: 10.5001/omj.2023.131
Abdul Rahman Al Farsi
{"title":"Cesarean Scar Pregnancy: Time to Initiate Universal Screening.","authors":"Abdul Rahman Al Farsi","doi":"10.5001/omj.2023.131","DOIUrl":"10.5001/omj.2023.131","url":null,"abstract":"","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"38 6","pages":"e564"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10822124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139571252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oman Medical JournalPub Date : 2023-11-30eCollection Date: 2023-11-01DOI: 10.5001/omj.2023.110
Bayan Muhannad Al Abd, Juhaina Salim Al-Maqbali, Ibrahim Al-Zakwani
{"title":"Impact of Clinical Pharmacists-driven Bundled Activities from Admission to Discharge on 90-day Hospital Readmissions and Emergency Department Visits.","authors":"Bayan Muhannad Al Abd, Juhaina Salim Al-Maqbali, Ibrahim Al-Zakwani","doi":"10.5001/omj.2023.110","DOIUrl":"10.5001/omj.2023.110","url":null,"abstract":"<p><strong>Objectives: </strong>Patient-centered clinical pharmacists' activities play a major role in improving clinical outcomes by optimizing the efficacy of drug therapies and minimizing associated toxicities during hospitalization, at the transition of care, and upon discharge. We aimed to compare the impact of comprehensive versus partial clinical pharmacists-driven bundled of care services on the rate of 90-day hospital readmissions and emergency department (ED) visits.</p><p><strong>Methods: </strong>This retrospective study included all admitted patients who received a comprehensive or partial bundle of clinical pharmacy services (medication history, interventions, counseling, and discharge prescription review) from 1 January 2021 to 30 June 2021 at Sultan Qaboos University Hospital. The comprehensive bundle of care included the four services, while the partial bundle of care included one, two, or three services only. Analyses were performed using univariate and multivariate statistical techniques.</p><p><strong>Results: </strong>The study included 430 patients with a mean age of 56.021.0 years, and 43.7% (n = 188) were male. Of the patients, 12.1% (n = 52) received a comprehensive bundle of care. Compared with the partial bundle of care group, the comprehensive bundle of care group had significantly more patients with diabetes (65.4% vs. 42.9%; <i>p =</i>0.002), % 3 comorbidities (50.0% vs. 29.4%; <i>p =</i>0.003), and polypharmacy (% 5 medications) (73.1% vs. 46.0%; <i>p</i> < 0.001). The comprehensive bundle of care group was significantly associated with a lower 90-day readmission rate (adjusted odds ratio (aOR) = 0.27, 95% CI: 0.90?\"0.82; <i>p =</i>0.021) but not with ED visits (aOR = 0.57, 95% CI: 0.13?\"2.57; <i>p =</i>0.461).</p><p><strong>Conclusions: </strong>This study demonstrated a significant reduction in the 90-day readmission rate for patients on a comprehensive bundle of care but not ED visits. These findings emphasize the importance of the comprehensive services provided by clinical pharmacists on the healthcare resources use and clinical outcomes.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"1 1","pages":"e566"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10800745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70682286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oman Medical JournalPub Date : 2023-11-30eCollection Date: 2023-11-01DOI: 10.5001/omj.2023.115
Noor Al Wahaibi, Rahma Al Kindi, Mustafa Al Hinai
{"title":"Quality of Life Among Postgraduate Medical Residents in Oman: A Cross-sectional Survey.","authors":"Noor Al Wahaibi, Rahma Al Kindi, Mustafa Al Hinai","doi":"10.5001/omj.2023.115","DOIUrl":"10.5001/omj.2023.115","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the quality of life (QoL) of medical residents enrolled in the various postgraduate programs of the Oman Medical Specialty Board (OMSB).</p><p><strong>Methods: </strong>The data for this cross-sectional study was collected from January to June 2022. All postgraduate residents who were enrolled in all 19 OMSB training programs were targeted. An online English version of the validated 36-Item Short Form Health Survey (SF-36) was used to assess the participants' self-reported QoL.</p><p><strong>Results: </strong>The participants were 425 OMSB residents (mean age = 29.6±2.2 years), of whom 289 (68.0%) were female, 259 (60.9%) were married, and 295 (69.4%) were enrolled in medical specialties. Overall, female residents reported significantly poorer QoL than male residents in all subscales of SF-36 (<i>p =</i>0.001). Married residents reported lower bodily pain scores than unmarried residents (<i>p =</i>0.005), although the latter endorsed better physical functioning, general health, and mental health. Residents in laboratory specialties had higher scores than those in medical and surgical specialties in most QoL dimensions including physical health, role functioning, energy/fatigue, emotional well-being, bodily pain, and general health (<i>p</i> ≤ 0.003). Psychiatry residents reported the lowest overall QoL.</p><p><strong>Conclusions: </strong>Postgraduate medical residents in Oman reported significant variations in QoL based on specialization, gender, and marital status. These findings underscore the need for targeted interventions to tackle health inequalities and improve the QoL of this population.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"1 1","pages":"e568"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70682436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oman Medical JournalPub Date : 2023-11-30eCollection Date: 2023-11-01DOI: 10.5001/omj.2023.117
Dawood Al Riyami, Saja Mohammed, Issa Al Salmi, AbdelMasiah Metry, Naifain Al Kalbani, Fathyia Almurshadi, Samira Al Rasbi, Faisal Al Ismaili, Alan Hola, Suad Hannawi
{"title":"Epidemiology, Management, and Outcome of Atypical Hemolytic Uremic Syndrome in an Omani Cohort.","authors":"Dawood Al Riyami, Saja Mohammed, Issa Al Salmi, AbdelMasiah Metry, Naifain Al Kalbani, Fathyia Almurshadi, Samira Al Rasbi, Faisal Al Ismaili, Alan Hola, Suad Hannawi","doi":"10.5001/omj.2023.117","DOIUrl":"10.5001/omj.2023.117","url":null,"abstract":"<p><strong>Objectives: </strong>Atypical hemolytic uremic syndrome (aHUS) is a rare, life-threatening disease of chronic uncontrolled complement pathway activation that leads to thrombotic-microangiopathy, along with severe organ damage, including end-stage kidney disease. This study aimed to evaluate the epidemiology, management, and outcome of aHUS in an Omani population.</p><p><strong>Methods: </strong>This retrospective descriptive cohort study assessed all cases of aHUS diagnosed and followed up at two tertiary care centers in Oman from January 2008 to December 2019, based on clinical features, complement pathway assays, histopathological, and genetic testing.</p><p><strong>Results: </strong>The study accrued 19 patients who fulfilled the inclusion criteria, of whom 11 (57.9%) were male. The participants' median age was 25.0 years (range = 0.1-69.0). Most (15; 78.9%) patients presented in the acute phase of the disease. The triad of hemolytic anemia, acute kidney injury, and thrombocytopenia was present in all patients. A trigger factor (e.g., infection) was identified in 68.4% of cases. Of the 14 (73.7%) patients who underwent kidney biopsy, 10 (71.4%) were found to have aHUS in native kidneys and three in grafted kidneys. Of the 11 (57.9%) patients who underwent genetic analysis, five (45.5%) were found to have a known pathogenic variant in their aHUS susceptibility genes. Plasma exchange followed by eculizumab was the treatment method in 11 (57.9%) cases. Complete renal recovery was achieved in seven (36.8%) patients, while four (21.1%) passed away during the study period.</p><p><strong>Conclusions: </strong>The wide spectrum and multiple expressions of aHUS make it a challenge to diagnose and consequently may delay the commencement of the targeted treatment. Eculizumab is considered the first-line therapy and should be commenced as early as possible.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"1 1","pages":"e569"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10839635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70682648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oman Medical JournalPub Date : 2023-11-30eCollection Date: 2023-11-01DOI: 10.5001/omj.2023.125
Sally Al Harrasi, Issa Al Salmi, Nasser Al Busaidi
{"title":"Acute Pulmonary Embolism in Oman: A Situational Analysis.","authors":"Sally Al Harrasi, Issa Al Salmi, Nasser Al Busaidi","doi":"10.5001/omj.2023.125","DOIUrl":"10.5001/omj.2023.125","url":null,"abstract":"<p><strong>Objectives: </strong>Pulmonary embolism (PE) is increasingly prevalent in Oman. The aim of this situational analysis of PE among Omani patients was to study its predisposing factors, diagnostic issues, and optimal management.</p><p><strong>Methods: </strong>In this retrospective cross-sectional situational analysis, the subjects were Omani patients who were diagnosed with acute PE using computed tomography pulmonary angiogram from 2010-2021. The required data was collected from the hospital database and statistically analyzed.</p><p><strong>Results: </strong>The subjects were 438 patients diagnosed with PE, with a mean age of 53.3±18.5 years and mean body mass index of 29.7±7.3 kg/m<sup>2</sup>. Males were in a slight majority (223; 50.9%) and were older (55.0±18.5 years) than females (51.5±18.3 years). Two-thirds of the PE patients had hypertension and one-third had diabetes mellitus. Most patients presented with dyspnea and chest pain. Syncope was more common in females compared to males who mostly presented with hemoptysis. Nearly half of the patients had abnormal echocardiogram, and males had lower mean ejection fraction compared to females. Different modalities of management were used to treat patients' PE. Heparin was the most used anticoagulant followed by warfarin and direct oral anticoagulants. Out of the 122 PE patients who died during the study period, PE was the direct cause of death of 68 patients. The mortality was higher in males than in females.</p><p><strong>Conclusions: </strong>The incidence of acute PE was similar among both male and female Omani patients. However, there were sex differences in risk factors, symptoms, investigations, and management of PE. Females presented with more severe PE, but mortality was higher in males.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"1 1","pages":"e574"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10858989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70682732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oman Medical JournalPub Date : 2023-11-30eCollection Date: 2023-11-01DOI: 10.5001/omj.2023.121
Zhilin Jin, Ruijie Yin, Eric Christopher Brown, Bhavarth Shukla, Brandon Hochahn Lee, Safaa Abdulaziz-Alkhawaja, Tahera Anwar Magray, Hala Mounir Agha, Amal El-Sisi, Amani Ali El-Kholy, Victor Bayani, Mohammad Abdellatif Daboor, Majeda Afeef Al Ruzzieh, Ertugrul Guclu, Esra Olmez-Gazioglu, Oguz Dursun, Tuğçe Tural Kara, Iftihar Koksal, Ahmet Eroglu, Merve Havan, Tanıl Kendirli, Suna Secil Ozturk Deniz, Gizem Aktas, Dincer Yildizdas, Ozden Ozgur Horoz, Emel Okulu, Yasemin Ezgi Kostekci, Abeer Aly Omar, Ziad A Memish, Victor Daniel Rosenthal
{"title":"Prospective Cohort Study of Incidence and Risk Factors for Catheter-associated Urinary Tract Infections in 212 Intensive Care Units of Nine Middle Eastern Countries.","authors":"Zhilin Jin, Ruijie Yin, Eric Christopher Brown, Bhavarth Shukla, Brandon Hochahn Lee, Safaa Abdulaziz-Alkhawaja, Tahera Anwar Magray, Hala Mounir Agha, Amal El-Sisi, Amani Ali El-Kholy, Victor Bayani, Mohammad Abdellatif Daboor, Majeda Afeef Al Ruzzieh, Ertugrul Guclu, Esra Olmez-Gazioglu, Oguz Dursun, Tuğçe Tural Kara, Iftihar Koksal, Ahmet Eroglu, Merve Havan, Tanıl Kendirli, Suna Secil Ozturk Deniz, Gizem Aktas, Dincer Yildizdas, Ozden Ozgur Horoz, Emel Okulu, Yasemin Ezgi Kostekci, Abeer Aly Omar, Ziad A Memish, Victor Daniel Rosenthal","doi":"10.5001/omj.2023.121","DOIUrl":"10.5001/omj.2023.121","url":null,"abstract":"<p><strong>Objectives: </strong>To identify urinary catheter (UC)-associated urinary tract infections (CAUTI) incidence and risk factors (RF) in nine Middle Eastern countries.</p><p><strong>Methods: </strong>We conducted a prospective cohort study between 1 January 2014 and 2 December 2022 in 212 intensive care units (ICUs) of 67 hospitals in 38 cities in nine Middle Eastern countries (Bahrain, Egypt, Jordan, Kuwait, Lebanon, Morocco, Saudi Arabia, Turkey, and the UAE). To estimate CAUTI incidence, we used the number of UC days as denominator and the number of CAUTIs as numerator. To estimate CAUTI RFs, we analyzed the following 10 variables using multiple logistic regression: patient sex, age, length of stay (LOS) before CAUTI acquisition, UC-days before CAUTI acquisition, UC-device utilization (DU) ratio, hospitalization type, ICU type, facility-ownership, country income level classified by World Bank, and time period.</p><p><strong>Results: </strong>Among 50 637 patients hospitalized for 434 523 patient days, there were 580 cases of acquired CAUTIs. The pooled CAUTI rate per 1000 UC days was 1.84. The following variables were independently associated with CAUTI: age, rising risk 1.0% yearly (adjusted odds ratio [aOR] = 1.01, 95% CI: 1.01-1.02; <i>p</i> < 0.0001); female sex (aOR = 1.31, 95% CI: 1.09-1.56; <i>p</i> < 0.0001); LOS before CAUTI acquisition, rising risk 6.0% daily (aOR = 1.06, 95% CI: 1.05-1.06; <i>p</i> < 0.0001); and UC/DU ratio (aOR = 1.11, 95% CI: 1.06-1.14; <i>p</i> < 0.0001). Patients from lower-middle-income countries (aOR = 4.11, 95% CI: 2.49-6.76; <i>p</i> < 0.0001) had a similar CAUTI risk to the upper-middle countries (aOR = 3.75, 95% CI: 1.83-7.68; <i>p</i> < 0.0001). The type of ICU with the highest risk for CAUTI was neurologic ICU (aOR = 27.35, 95% CI: 23.03-33.12; <i>p</i> < 0.0001), followed by medical ICU (aOR = 6.18, 95% CI: 2.07-18.53; <i>p</i> < 0.0001) when compared to cardiothoracic ICU. The periods 2014-2016 (aOR = 7.36, 95% CI: 5.48-23.96; <i>p</i> < 0.001) and 2017-2019 (aOR = 1.15, 95% CI: 3.46-15.61; <i>p</i> < 0.001) had a similar risk to each other, but a higher risk compared to 2020-2022.</p><p><strong>Conclusions: </strong>The following CAUTI RFs are unlikely to change: age, sex, ICU type, and country income level. Based on these findings, it is suggested to focus on reducing LOS, UC/DU ratio, and implementing evidence-based CAUTI prevention recommendations.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"1 1","pages":"e571"},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10822129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70682421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oman Medical JournalPub Date : 2023-09-28eCollection Date: 2023-09-01DOI: 10.5001/omj.2023.102
Muhammad Umer Asghar, Kabeer Haneef, Fizza Fatima, Aisha Asghar, Noor Ul Ain
{"title":"Investigating Oxidative Stress Levels in Pregnant Patients Infected with Hepatitis C Virus and Bacterial Vaginosis for Better Treatment Option.","authors":"Muhammad Umer Asghar, Kabeer Haneef, Fizza Fatima, Aisha Asghar, Noor Ul Ain","doi":"10.5001/omj.2023.102","DOIUrl":"10.5001/omj.2023.102","url":null,"abstract":"<p><strong>Objectives: </strong>Hepatitis C virus (HCV) and bacterial vaginosis (BV) coinfection generate sustained inflammation with bulk production of reactive oxygen species. They have the potency to cause hepatocellular carcinoma, vaginal apoptosis, disturb pregnancy, and influence drug treatment and follow-up. This case-control study aimed to compare the redox status in HCV and BV coinfection with respect to BV mono-infection among pregnant females (PFs).</p><p><strong>Methods: </strong>Blood samples and vaginal secretions were drawn from 75 PFs divided into three groups: coinfection (n = 25), monoinfection (n = 25), and control PFs (n = 25) who are presumed healthy subjects. Blood samples were analyzed for HCV detection based on conserved 5' untranslated region via real-time polymerase chain reaction and hematological parameters. Markers of oxidative stress (malondialdehyde and peroxidase) and antioxidants (catalase and superoxide dismutase) were checked in plasma as well as vaginal secretions of patients among all three groups.</p><p><strong>Results: </strong>Hematological analysis reveals that hemoglobin levels, platelets, and lymphocytes decreased significantly (<i>p</i> < 0.050) among the coinfection followed by mono-infection group compared to the control group. Moreover, the higher isolation frequency of pathogenic bacteria (<i>Acinetobacter</i> spp.) and Nugent score trend was observed among the coinfection group. Antioxidant levels were significantly lower (<i>p</i> < 0.050) among the vaginal secretions and blood plasma of patients having coinfection with respect to the mono-infection and control groups. While oxidative stress marker was significantly highest (<i>p</i> < 0.050) among vaginal secretions and blood plasma of coinfection followed by mono-infection and control group. These results validate that overall redox severity was more among the coinfection compared to the mono-infection and control groups.</p><p><strong>Conclusions: </strong>Redox indexes should be considered in early diagnosis and treatment of HCV and BV coinfection which may also facilitate the better treatment of hepatocellular carcinoma and vaginal apoptosis.</p>","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"1 1","pages":"e549"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10800022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70682624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oman Medical JournalPub Date : 2023-09-28eCollection Date: 2023-09-01DOI: 10.5001/omj.2023.114
Mahmood Dhahir Al-Mendalawi
{"title":"Impact of Intimate Partner Violence on Iranian Children's Growth and Development: A Descriptive-analytical Study.","authors":"Mahmood Dhahir Al-Mendalawi","doi":"10.5001/omj.2023.114","DOIUrl":"https://doi.org/10.5001/omj.2023.114","url":null,"abstract":"","PeriodicalId":19667,"journal":{"name":"Oman Medical Journal","volume":"38 5","pages":"e562"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522887/pdf/OMJ-38-05-2300273.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}