Sajeev Wagle, Julie Anne Lee, H. P. Vasantha Rupasinghe
{"title":"Synergistic Cytotoxicity of Extracts of Chaga Mushroom and Microalgae against Mammalian Cancer Cells In Vitro","authors":"Sajeev Wagle, Julie Anne Lee, H. P. Vasantha Rupasinghe","doi":"10.1155/2024/7944378","DOIUrl":"https://doi.org/10.1155/2024/7944378","url":null,"abstract":"Chaga mushroom (<i>Inonotus obliquus</i>) contains bioactive metabolites and has been used to treat various ailments, including cancer. Similarly, marine microalgae are considered a sustainable food supplement with anticancer and antioxidant properties. This study investigated the cytotoxicity of different extracts prepared from <i>I. obliquus</i> and microalgae using cultured human and canine cancer cell lines (MCF-7, HepG2, HOS, D-17, and DH-82). MTS cell viability assay was used to study the cytotoxicity of <i>I. obliquus</i> and microalgae extracts, and a synergy matrix effect was used to study the combined effect of the extracts. Isobologram analysis and the highest single agent synergy model were applied to study and validate the synergy between the extracts from <i>I. obliquus</i> and microalgae. Ethanol-based extraction and supercritical water extract significantly inhibited the growth of various mammalian cancer cells compared to aqueous extracts. Osteosarcoma cells were more susceptible to the supercritical extracts of <i>I. obliquus</i> and chlorophyll-free and sugar-free ethanol extracts of microalgae. A combination of ethanol-based <i>I. obliquus</i> extract and chlorophyll-free microalgae extract resulted in a synergistic interaction with various tested cancer cells. This study provides experimental evidence supporting the potential therapeutic application of <i>I. obliquus</i> and microalgae extracts with a synergistic effect to inhibit the growth of various mammalian cancer cells. Additional in vivo studies are required to fully explore possible therapeutic applications of these unique mixtures to be used in treating cancers.","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139483002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retracted: Rhodiola Rosea Extract Counteracts Stress in an Adaptogenic Response Curve Manner via Elimination of ROS and Induction of Neurite Outgrowth","authors":"Oxidative Medicine and Cellular Longevity","doi":"10.1155/2024/9782834","DOIUrl":"https://doi.org/10.1155/2024/9782834","url":null,"abstract":"<jats:p />","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139441370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retracted: Pinosylvin Extract Retinari™ Sustains Electrophysiological Function, Prevents Thinning of Retina, and Enhances Cellular Response to Oxidative Stress in NFE2L2 Knockout Mice","authors":"Oxidative Medicine and Cellular Longevity","doi":"10.1155/2024/9835864","DOIUrl":"https://doi.org/10.1155/2024/9835864","url":null,"abstract":"<jats:p />","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"60 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139441489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retracted: Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects","authors":"Oxidative Medicine and Cellular Longevity","doi":"10.1155/2024/9849584","DOIUrl":"https://doi.org/10.1155/2024/9849584","url":null,"abstract":"<jats:p />","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"42 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retracted: Progress of Statin Therapy in the Treatment of Idiopathic Pulmonary Fibrosis","authors":"Oxidative Medicine and Cellular Longevity","doi":"10.1155/2024/9830469","DOIUrl":"https://doi.org/10.1155/2024/9830469","url":null,"abstract":"<jats:p />","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"40 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retracted: Black Truffle Extract Exerts Antidiabetic Effects through Inhibition of Inflammation and Lipid Metabolism Regulation","authors":"Oxidative Medicine and Cellular Longevity","doi":"10.1155/2024/9765609","DOIUrl":"https://doi.org/10.1155/2024/9765609","url":null,"abstract":"<jats:p />","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"35 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retracted: Theaflavin Chemistry and Its Health Benefits","authors":"Oxidative Medicine and Cellular Longevity","doi":"10.1155/2024/9893267","DOIUrl":"https://doi.org/10.1155/2024/9893267","url":null,"abstract":"<jats:p />","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"35 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retracted: The Protective Role of Brain CYP2J in Parkinson’s Disease Models","authors":"Oxidative Medicine and Cellular Longevity","doi":"10.1155/2024/9765745","DOIUrl":"https://doi.org/10.1155/2024/9765745","url":null,"abstract":"<jats:p />","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"24 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139443131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retracted: Influence Factors and Predictive Models for the Outcome of Patients with Ischemic Stroke after Intravenous Thrombolysis: A Multicenter Retrospective Cohort Study","authors":"Oxidative Medicine and Cellular Longevity","doi":"10.1155/2024/9813785","DOIUrl":"https://doi.org/10.1155/2024/9813785","url":null,"abstract":"<jats:p />","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"27 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139443411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retracted: Quercetin Prevents Radiation-Induced Oral Mucositis by Upregulating BMI-1","authors":"Oxidative Medicine and Cellular Longevity","doi":"10.1155/2024/9790182","DOIUrl":"https://doi.org/10.1155/2024/9790182","url":null,"abstract":"<jats:p />","PeriodicalId":19657,"journal":{"name":"Oxidative Medicine and Cellular Longevity","volume":"18 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139443980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}