Osteoarthritis and Cartilage最新文献

{"title":"Associations between deep learning-derived infrapatellar fat pad volume on MRI with knee cartilage thickness and imaging features of knee osteoarthritis: Data from the Osteoarthritis Initiative.","authors":"Adrian A Marth, Felix Liu, Gabby B Joseph, Romy Zwerin, Sharmila Majumdar, John A Lynch, Nancy E Lane, Michael C Nevitt, Charles E McCulloch, Thomas M Link","doi":"10.1016/j.joca.2026.08.001","DOIUrl":"10.1016/j.joca.2026.08.001","url":null,"abstract":"<p><strong>Objective: </strong>To investigate associations between infrapatellar fat pad volume (IPFP_Vol) measured on MRI with knee cartilage thickness and imaging features of knee osteoarthritis.</p><p><strong>Design: </strong>This cross-sectional study used baseline data from the Osteoarthritis Initiative. IPFP_Vol was quantified using a deep learning algorithm for automatic volumetric IPFP segmentation. Outcomes by subregion included knee cartilage thickness in the lateral tibia (LT), medial tibia (MT), lateral femur (LF), medial femur (MF), and patella, along with Whole-Organ Magnetic Resonance Imaging Score (WORMS) scores for cartilage, bone marrow edema-like lesions (BMELL), and menisci across the same subregions and the trochlea. Linear regression models included an interaction term between IPFP_Vol and subregion. When interactions were significant, subregion-specific associations were estimated. Models were adjusted for relevant confounders.</p><p><strong>Results: </strong>A total of 4257 participants were included in the final analysis. Significant interactions between IPFP_Vol and subregion were observed for cartilage thickness and WORMS scores (all p<0.001). Larger IPFP_Vol was associated with greater cartilage thickness in the patella (β = 0.011 mm per cm³; 95% CI, 0.006-0.016) and LT (β = 0.015 mm per cm³; 95% CI, 0.010-0.019). For WORMS, larger IPFP_Vol was associated with lower cartilage lesion scores in the patella (β = -0.036 points per cm³; 95% CI, -0.061 to -0.010), LF (β = -0.058 points per cm³; 95% CI, -0.076 to -0.039), and LT (β = -0.079 points per cm³; 95% CI, -0.099 to -0.060), along with lower BMELL scores in the LT (β = -0.027 points per cm³; 95% CI, -0.036 to -0.018) and lower lateral meniscus scores (β = -0.054 points per cm³; 95% CI, -0.070 to -0.037).</p><p><strong>Conclusions: </strong>Larger IPFP_Vol was associated with greater patellofemoral cartilage thickness and less severe osteoarthritis features in the patellofemoral and lateral tibiofemoral joint. These findings highlight the subregion-specific relationship between IPFP volume, knee cartilage thickness and imaging features of osteoarthritis.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective sleep characteristics and incident osteoarthritis risk: A prospective analysis of the UK biobank cohort.","authors":"Guosheng Wang, Zhenyu Hu, Wanjun Fan, Qian Wang, Jing Zhang, Nan Zhang, Minjie Cao, Ruiyan Liu, Xueying Yu, Tao Zhang, Guoqi Cai, Faming Pan","doi":"10.1016/j.joca.2026.07.012","DOIUrl":"10.1016/j.joca.2026.07.012","url":null,"abstract":"<p><strong>Objective: </strong>Sleep is a modifiable lifestyle factor potentially related to osteoarthritis (OA), but previous studies have mainly relied on self-reported sleep duration or quality. Using accelerometer-derived data, we examined associations of multidimensional objective sleep characteristics with incident OA.</p><p><strong>Method: </strong>We included 61,904 UK Biobank participants who were free of OA at baseline and had accelerometer data. Six objective sleep metrics across five dimensions were derived: sleep quantity (average sleep duration), sleep quality (sleep efficiency), sleep regularity (sleep regularity index and sleep duration variability), sleep timing (sleep midpoint), and circadian rhythm strength (relative amplitude). Cox models examined associations with incident OA. Restricted cubic splines (RCS) and interaction analyses were conducted.</p><p><strong>Results: </strong>Longer average sleep duration (HR 0.93, 95% CI 0.91-0.95), higher sleep efficiency (HR 0.95, 95% CI 0.92-0.97), and stronger relative amplitude (HR 0.93, 95% CI 0.90-0.95) were associated with lower OA risk, whereas delayed sleep midpoint was associated with higher risk (HR 1.08, 95% CI 1.05-1.11; all FDR < 0.001). RCS analyses indicated significant non-linear associations for these four metrics except sleep efficiency. Stronger circadian rhythmicity may attenuate the OA risk associated with delayed sleep midpoint. Associations were broadly consistent for weight-bearing joint OA (hip and knee), but not non-weight-bearing joint (hand) OA.</p><p><strong>Conclusions: </strong>Delayed sleep timing and weaker circadian rhythm strength were associated with higher incident OA risk, with particularly higher risk observed when delayed sleep timing was accompanied by weaker circadian rhythmicity, extending previous evidence on sleep duration and quality by highlighting sleep timing and circadian rhythmicity.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148649239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does fat mass contribute to knee osteoarthritis risk beyond weight itself? Data from the Multicenter Osteoarthritis Study.","authors":"K Godziuk, S Tilley, M LaValley, D P Kiel, M C Nevitt, C E Lewis, J C Torner, T Neogi","doi":"10.1016/j.joca.2026.07.007","DOIUrl":"10.1016/j.joca.2026.07.007","url":null,"abstract":"<p><strong>Objective: </strong>We examined the extent to which fat mass may contribute to the risk of incident radiographic knee osteoarthritis (ROA) beyond body weight alone.</p><p><strong>Methods: </strong>Participants from the Multicenter Osteoarthritis (MOST) Study with DXA body composition and no ROA in ≥1 knee at baseline were included. Incident ROA (KL grade ≥2 or knee replacement) was assessed at 7 years. We created sex-specific weight categories (<70,70-79.9,80-89.9, ≥90 kg in females, <90,90-99.9, ≥100 kg in males), computed % fat mass quartiles, and then evaluated the relation between quartiles (lowest as referent) to risk of ROA in each weight category. We then scaled and standardized % fat mass in a combined model to assess the overall relationship between relative fat mass and ROA risk.</p><p><strong>Results: </strong>We included 1611 individuals (60% female, mean age 61.7 years, BMI 29.6 kg/m², 2646 knees). Incident ROA developed in 27.6% of knees after 7 years. In females only, risk for ROA increased in those with the highest % fat mass relative to lowest in their weight category (Q4 vs Q1, RR 1.29, 95% CI 1.02, 1.64). Spline analyses identified a J- or U-shaped pattern of % fat mass on incident ROA in females and males, with predicted probabilities only differing by 10-20% across the fat mass percentiles.</p><p><strong>Conclusions: </strong>A higher relative fat mass did not influence increased risk of incident ROA in males, but there was a potential threshold effect in females. Overall, total body mass (weight) appears to be driving risk for ROA rather than a distinct influence of relative fat mass.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INTENSIVE DIET OR KNEE ARTHROPLASTY FOR SEVERE KNEE OSTEOARTHRITIS: THE INKA RANDOMISED TRIAL.","authors":"Marius Henriksen,Robin Christensen,Asbjørn Seenithamby Poulsen,Kristine Ifigenia Bunyoz,Saber Muthanna Aljuboori,Camilla Toft Nielsen,Tobias Haugegaard,Henrik Gudbergsen,Kirill Gromov,Anna Døssing,Anthony Leeds,Søren Overgaard,Anders Troelsen,Henning Bliddal","doi":"10.1016/j.joca.2026.07.004","DOIUrl":"https://doi.org/10.1016/j.joca.2026.07.004","url":null,"abstract":"OBJECTIVETo test whether an intensive dietary weight loss program (IN) yields non-inferior symptom improvement vs. knee arthroplasty (KA) in people with knee osteoarthritis eligible for knee arthroplasty.DESIGNA non-inferiority, randomised, comparative effectiveness trial involving participants with obesity (body mass index of ≥30 kg/m2) and knee osteoarthritis eligible for knee arthroplasty. After randomisation a 12 week wait list was installed, after which IN participants were offered a 12-week low-calorie meal replacement program with weekly group sessions focusing on behaviour and education supervised by a dietitian and the KA participants were offered surgical insertion of a knee arthroplasty. We aimed to recruit 200 participants. The primary outcome was knee pain and function assessed by the Oxford Knee Score (0-48 score; higher better) 6 months after treatment start, with a prespecified non-inferiority margin of 4 points. Secondary outcomes included change in body weight.RESULTSRecruitment target was not reached. 92 participants were randomly assigned to IN (n=45) or KA (n=47). 6 months after treatment start the Oxford Knee Score was 28.2 with IN and 36.5 with KA, with a between-group difference of -8.2 (95%CI, -11.5 to -5.0) favouring KA; the 95% CI did not include the noninferiority margin of 4 points. The mean change in body weight was -11.0 kg (-10.4%) in the IN group and -1.3 kg (-1.2%) in the KA group. The adverse event incidence was similar in the two groups.CONCLUSIONAmong people with obesity and severe knee osteoarthritis eligible for knee arthroplasty a 12-week supervised intensive weight loss program was not non-inferior to knee arthroplasty, shown as clinically inferior improvements in patient reported knee pain and function after 6 months.TRIAL REGISTRATIONClinicalTrials.gov number, NCT05172843.","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"147 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148416109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient receptor potential melastatin 3 ion channel expressed in sensory neurons mediates osteoarthritis pain in mice.","authors":"Robson da Costa, Suelen Pereira, Clive Gentry, Fabiana C Dias, Bianca de Lima Almeida, Margot Maurer, Laura I Primicheru, Lio Moreira, Stefanie Mannebach, Petra Weissgerber, Stephan E Philipp, David A Andersson, Stuart Bevan","doi":"10.1016/j.joca.2026.04.015","DOIUrl":"10.1016/j.joca.2026.04.015","url":null,"abstract":"<p><strong>Objective: </strong>Osteoarthritis (OA) is a degenerative joint disease characterized by chronic pain. We investigated whether the ion channel transient receptor potential melastatin 3 (TRPM3), expressed in sensory neurons, mediates OA pain.</p><p><strong>Design: </strong>We used genetically modified mice, pharmacological tools, and behavioural assessments to evaluate the role of TRPM3 in OA pain induced by monosodium iodoacetate (MIA) or partial medial meniscectomy (PMM). Mice with global Trpm3 knockout (Trpm3^-/-) and conditional deletion in sensory neurons (Advillin-Cre/Trpm3^fl/fl) were compared with control mice. Selective TRPM3 antagonists (ononetin and isosakuranetin) were tested for their ability to reverse established pain. Histological analyses were performed to assess cartilage damage.</p><p><strong>Results: </strong>Global deletion of Trpm3 prevented the development of pain behaviours in both MIA (mean difference [MD] = -7.8, 95% CI: -13.6 to -2.1) and PMM (MD = -13.6, 95% CI: -22.3 to -4.9) models without inhibiting structural cartilage damage. Sensory neuron-specific Trpm3 deletion replicated this effect in PMM mice (MD = -9.0, 95% CI: -15.0 to -3.1), demonstrating a neuronal contribution. Furthermore, pharmacological inhibition of TRPM3 with ononetin (MIA: MD = -2.8, 95% CI: -4.4 to -1.4; PMM: MD = -1.5, 95% CI: -2.2 to -0.7) or isosakuranetin (MIA: MD = -3.0, 95% CI: -4.4 to -1.6; PMM: MD = -1.5, 95% CI: -2.2 to -0.8) reversed established mechanical hypersensitivity in OA mice.</p><p><strong>Conclusions: </strong>TRPM3 expressed in sensory neurons is a critical mediator of OA pain in mice. Selective TRPM3 antagonism effectively alleviates established pain, supporting this channel as a potential therapeutic target for chronic pain associated with OA.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147875198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory and anabolic effects of liraglutide on 3D inflammatory osteoarthritic spheroid and scaffold models of human chondrocytes.","authors":"Eda Ciftci, Sophie C Eberlein, Sibylle Grad, Mauro Alini, Francis Berenbaum, Zhen Li","doi":"10.1016/j.joca.2026.04.018","DOIUrl":"10.1016/j.joca.2026.04.018","url":null,"abstract":"<p><strong>Objective: </strong>Osteoarthritis (OA) is a prevalent age-related joint disease characterized by low-grade inflammation and progressive cartilage degeneration. Liraglutide, a glucagon-like peptide-1 receptor agonist approved for diabetes and obesity, has shown anti-inflammatory and chondroprotective effects in preclinical OA models, but its effects in human 3D chondrocyte systems remain unclear.</p><p><strong>Materials and methods: </strong>Human articular chondrocytes were cultured as 3D spheroid pellets or seeded into porous polyurethane scaffolds. OA-like inflammation was induced using interleukin-1β (IL-1β, 1 ng/mL), followed by liraglutide treatment. Scaffold constructs were subjected to physiological cyclic mechanical loading (1 h/day for 7 days). Inflammatory mediators, anabolic gene expression, and extracellular matrix features were assessed using biochemical, molecular, and histological analyses.</p><p><strong>Results: </strong>In pellet cultures, liraglutide reduced IL-8 levels (877.8 ± 155.3 ng at 0.5 µM) compared with IL-1β treated controls (3127.0 ± 1140.5 ng) at day 14, with a smaller reduction observed for IL-6 (863.6 ± 63.1 ng at 0.5 µM vs 1055.0 ± 74.4 ng in IL-1β group). Liraglutide increased ACAN expression at lower concentrations (1.297 ± 0.820 vs 0.260 ± 0.323-fold in IL-1β group), whereas PRG4 expression was higher at day 14 at increased concentrations (0.713 ± 0.07 vs 0.338 ± 0.11-fold in IL-1β group). In scaffold cultures under mechanical loading, liraglutide reduced IL-8 protein release during early time points (3.782 ± 1.505 vs 10.44 ± 6.524-fold in IL-1β group) and was associated with donor-dependent modulation of ACAN expression (1.09 ± 0.84 vs 0.45 ± 0.13-fold in IL-1β group). Histological analyses indicated preservation of proteoglycan- and type II collagen-rich matrix in liraglutide-treated conditions.</p><p><strong>Conclusion: </strong>Physiological mechanical loading is essential for establishing scaffold-based human OA models. Liraglutide modulates inflammatory and matrix-related responses in human 3D chondrocyte systems in a context- and donor-dependent manner, supporting its relevance for translational investigation for OA treatment.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147869172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing early-stage symptomatic knee osteoarthritis (EsSKOA): A strategic lens for trial design","authors":"Armaghan Mahmoudian ,&nbsp;Lauren K King ,&nbsp;Jean W Liew ,&nbsp;Qiuke Wang ,&nbsp;Francis Berenbaum ,&nbsp;Siddharth Das ,&nbsp;Changhai Ding ,&nbsp;Carolyn A Emery ,&nbsp;Stephanie R Filbay ,&nbsp;Marc C Hochberg ,&nbsp;Muneaki Ishijima ,&nbsp;Margreet Kloppenburg ,&nbsp;Nancy E Lane ,&nbsp;Elena Losina ,&nbsp;Ali Mobasheri ,&nbsp;C Thomas Appleton ,&nbsp;Martin Englund ,&nbsp;L Stefan Lohmander ,&nbsp;Jos Runhaar ,&nbsp;Aleksandra Turkiewicz ,&nbsp;Ida K Haugen","doi":"10.1016/j.joca.2025.12.016","DOIUrl":"10.1016/j.joca.2025.12.016","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 5","pages":"Pages 647-651"},"PeriodicalIF":9.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145796092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoarthritis — A call to action","authors":"David J. Hunter,&nbsp;Virginia B. Kraus","doi":"10.1016/j.joca.2026.02.003","DOIUrl":"10.1016/j.joca.2026.02.003","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 5","pages":"Pages 652-653"},"PeriodicalIF":9.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why is there no treatment for osteoarthritis – Opportunity for AI based big data analytics to advance the field","authors":"F. Saxer ,&nbsp;G. Jansen ,&nbsp;S.M.A. Bierma-Zeinstra ,&nbsp;B. Holzhauer ,&nbsp;D. Demanse ,&nbsp;J. Melnick ,&nbsp;D. Vukadinovic Greetham ,&nbsp;T. Rall ,&nbsp;P. Mesenbrink ,&nbsp;M. Schieker","doi":"10.1016/j.joca.2025.12.021","DOIUrl":"10.1016/j.joca.2025.12.021","url":null,"abstract":"<div><h3>Background</h3><div>Osteoarthritis (OA) has long been researched but insights have not translated into novel treatments for OA. One reason may be the heterogeneity of patients suffering from OA. Developments in machine-learning (ML) especially privacy-preserving, federated approaches could help to detect patterns of patient characteristics that allow better segmentation of patient populations, generate prognostic insights on disease progression, and define regulatory acceptable pathways towards patient-relevant surrogate endpoints.</div></div><div><h3>Opportunity</h3><div>The article describes the vision of a collaborative inter-professional, inter-institutional and public-private activity leveraging the wealth of rich yet fragmented datasets to achieve this goal. We summarize the underlying assumptions, challenges and potential applications of such an ML-based approach.</div></div><div><h3>Use cases</h3><div>Employing federated training algorithms locally has the advantage of preserving privacy. The application of novel ML techniques to divers sets of multidimensional health care data such as registries, real-world evidence, trial data etc. allows not only prognostic and predictive inferences but can also overcome issues with incompleteness of variables, heterogeneity in database structures and multidimensionality of variables. This exploration of data can form the foundation for the development of covariates, digital twins, synthetic control groups and form a potential basis for trial emulation. In addition, the approach will enable the development of novel (surrogate) endpoints and inform enrichment strategies.</div></div><div><h3>Conclusion</h3><div>Leveraging ML in a federated framework, the richness of data on OA and the expertise from various areas including patients, providers, ethicists and regulators has the potential to revolutionize trial designs in OA and finally meet the needs of patients suffering from OA.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 5","pages":"Pages 657-666"},"PeriodicalIF":9.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do rates of femorotibial cartilage loss in Kellgren-Lawrence 2 and 3 knees differ between those with mild-moderate vs. severe patellofemoral structural damage? – Data from the FNIH and IMI-APPROACH cohorts","authors":"Frank W. Roemer ,&nbsp;Mylène Jansen ,&nbsp;Susanne Maschek ,&nbsp;Simon Mastbergen ,&nbsp;Anna Wisser ,&nbsp;Harrie H. Weinans ,&nbsp;Francisco J. Blanco ,&nbsp;Francis Berenbaum ,&nbsp;Margreet Kloppenburg ,&nbsp;Ida K. Haugen ,&nbsp;David J. Hunter ,&nbsp;Ali Guermazi ,&nbsp;Wolfgang Wirth","doi":"10.1016/j.joca.2025.10.003","DOIUrl":"10.1016/j.joca.2025.10.003","url":null,"abstract":"<div><h3>Background</h3><div>The aim was to assess whether rates of quantitative femorotibial (FT) cartilage loss are increased for knees with semiquantitatively (sq)-defined severe patellofemoral (PF) cartilage damage and/or large bone marrow lesions (BMLs) vs. those without over a period of 24 months.</div></div><div><h3>Methods</h3><div>626 knees with Kellgren-Lawrence 2 and 3 from the FNIH and IMI-APPROACH studies were included. MRI assessment was performed using the MRI Osteoarthritis Knee Score (MOAKS) instrument. Baseline FT cartilage damage severity was defined as mild, moderate, or severe. PF cartilage damage was defined as mild-moderate vs. severe. A 2nd definition was based on the presence or absence of large BMLs. Quantitative cartilage thickness loss (defined as the difference from baseline to follow-up in mean cartilage thickness in the medial and in the lateral femorotibial joint, which were computed by summing the cartilage thickness measures observed in the respective cartilage plates) was derived from baseline and 24-month manual segmentations. Between-group comparisons were performed using analysis of covariance (ANCOVA) adjusting for age, sex and body mass index.</div></div><div><h3>Results</h3><div>410 (65%) knees were categorized as mild, 92 (15%) as moderate, and 124 (20%) as severe medial FT cartilage damage. For almost all categories of FT cartilage damage, the difference in quantitative medial FT cartilage loss was not statistically significant. Only for the category of knees with moderate medial FT cartilage damage, statistically higher rates of FT cartilage loss were observed for those with large PF BMLs compared to those without (mean adjusted difference −0.128 mm, 95% confidence interval [-0.238, −0.018], p=0.023).</div></div><div><h3>Conclusions</h3><div>Screening for PF cartilage damage and BMLs does not appear to be required in a disease-modifying OA drug trial.</div></div>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"34 5","pages":"Pages 672-678"},"PeriodicalIF":9.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145288264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}