Osteoarthritis and Cartilage最新文献

{"title":"Alcohol consumption and incident osteoarthritis: A nationwide population-based longitudinal study.","authors":"Seoyeon Cho, Sangmin Yong, Eunhee Ha, Jin-Hong Kim, Yi-Jun Kim","doi":"10.1016/j.joca.2026.09.005","DOIUrl":"10.1016/j.joca.2026.09.005","url":null,"abstract":"<p><strong>Objective: </strong>To examine the association between alcohol consumption and incident osteoarthritis (OA) and whether it persists after restriction for liver-related and weight-related factors.</p><p><strong>Design: </strong>We analyzed South Korean National Health Insurance Service data for adults aged ≥40 years who underwent health screening in 2009-2011 and had no recorded OA at baseline. Alcohol consumption was assessed by self-reported drinking frequency and estimated daily ethanol intake. Participants were followed until first claims-based OA diagnosis (ICD-10 M15-M19, excluding traumatic OA), death, or December 31, 2023. Multivariable Cox models estimated adjusted hazard ratios (HRs). Prespecified restricted analyses were conducted in participants with normal liver function and no liver disease history and in participants with normal weight and no obesity history.</p><p><strong>Results: </strong>Among 1,233,179 participants with drinking-amount data (mean age, 50.8 years), the mean follow-up period was 9.9 years, during which 571,077 cases of OA occurred. Compared with non-drinkers, the light-drinking group had an adjusted HR of 1.037 (95% CI, 1.030-1.045), the moderate-drinking group had an adjusted HR of 1.081 (95% CI, 1.072-1.091), and the heavy-drinking group had an adjusted HR of 1.186 (95% CI, 1.174-1.197). A similar dose-response pattern was observed for drinking frequency and across sensitivity analyses. The pattern also persisted in the normal liver function and normal weight cohorts, and women showed elevated OA risk at lower levels of alcohol consumption than men.</p><p><strong>Conclusions: </strong>Alcohol consumption was associated with incident OA in a dose-dependent manner that persisted after liver-related and weight-related restrictions, suggesting that this association is unlikely to be explained solely by hepatic dysfunction or obesity. These findings identify alcohol consumption as a factor associated with incident OA, warranting further investigation as a potentially modifiable contributor to OA risk.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to stepped care for the management of knee osteoarthritis in the Netherlands.","authors":"Walter van der Weegen, Michiel Siebelt, Anke Kornuijt, Judith Olde Heuvel, Keetie Kremers, Rintje Agricola","doi":"10.1016/j.joca.2026.08.014","DOIUrl":"10.1016/j.joca.2026.08.014","url":null,"abstract":"<p><strong>Objectives: </strong>To gain insight in Stepped Care (SC) adherence prior to orthopedic consultation in patients 55 years of age or older with a symptomatic knee, in treatment choices following orthopedic consultation and in factors associated with arthroplasty as preferred treatment.</p><p><strong>Methods: </strong>Prospectively collected Computer-Assisted History Taking data from three hospitals was used to allocate included patients (n=7874, average age 66.8 years (SD: ±8.2), 54% female) into a full SC (three steps: non anti-inflammatory analgesics, anti-inflammatory drugs, exercises), a partial SC (missing 1 or 2 steps) or a no SC group (no steps applied). Regression analyses were used to evaluate how clinical features, SC adherence and radiographic severity were associated with arthroplasty as a treatment choice following orthopedic consultation.</p><p><strong>Results: </strong>Prior to orthopedic consultation, full SC adherence was 12%, partial SC 66.3% and no SC 21.7%. For the majority of patients (71.6%), treatment following orthopedic consultation consisted of non-operative OA management options. Increasing age, higher BMI, longer symptom duration, greater pain during activity, reduced walking ability, and full adherence to SC were all associated with higher odds of arthroplasty, with a highest Odds Ratio of 4.4 (95% Confidence Interval: 3.7-5.3) for symptom duration.</p><p><strong>Conclusions: </strong>Despite clinical guidelines outlining a SC approach to manage knee OA, only a small proportion of patients of 55 years of age or older with knee complaints have utilized all non-surgical treatment options before being referred for orthopedic consultation in the Netherlands. Most patients consulting an orthopedic surgeon receive conservative treatment modalities, also included in the Dutch clinical guideline on knee symptoms for GPs.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of care delivery models for knee osteoarthritis in primary healthcare settings: A systematic review and meta-analysis of randomized controlled trials.","authors":"Hugo Pak-Yiu Fong, Shuqi Wang, Chunyi Wen, David Rabago, Christian Mallen, Regina Wing-Shan Sit","doi":"10.1016/j.joca.2026.09.001","DOIUrl":"10.1016/j.joca.2026.09.001","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate care delivery models for knee osteoarthritis (OA) versus usual care in primary health care settings and explore effects by delivery arrangement subcategory.</p><p><strong>Method: </strong>Systematic review and meta-analysis of randomized controlled trials (RCTs). We searched PubMed, Embase, CENTRAL and trial registries from 1 January 2010-28 June 2026. Delivery differences were mapped using the Cochrane Effective Practice and Organisation of Care (EPOC) Delivery Arrangements taxonomy. Outcomes were pain, function and health-related quality of life (HRQoL). Risk of bias and certainty were assessed using RoB 2 and GRADE respectively.</p><p><strong>Results: </strong>Fifteen RCTs (n=2944) were included. Compared with usual care, care delivery models improved pain (SMD -0.40, 95% CI -0.63 to -0.16) and function (SMD -0.26, 95% CI -0.39 to -0.14), with little to no difference in HRQoL (SMD 0.00, -0.10 to 0.09). Back-translated effects did not reach prespecified minimal clinically important differences (MCIDs) for pain (0.68 vs 2 NRS points) or function (4.2 vs 12 WOMAC Function points). Certainty was moderate for pain and function, and high for HRQoL. Exploratory subgroups incorporating information and communication technology (ICT) suggested benefit, but each included only two or three trials.</p><p><strong>Conclusion: </strong>Care delivery models produced small improvements in pain and function, but these did not reach prespecified MCIDs. There was little to no difference in HRQoL. Only 15 trials were included, and findings from subgroups of two or three trials should be interpreted cautiously. ICT-supported delivery, particularly when combined with care coordination, warrants evaluation in larger pragmatic trials with longer follow-up.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148892255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoarthritis Year in Review 2026: Genetics, genomics and epigenetics","authors":"Utsav Das,Sarah J Rice","doi":"10.1016/j.joca.2026.09.004","DOIUrl":"https://doi.org/10.1016/j.joca.2026.09.004","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"12 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of knee radiographic and symptomatic osteoarthritis and ultrasound features across sex and body mass index groups: The Johnston County Health Study.","authors":"Maya Patel, Carolina Alvarez, Todd A Schwartz, Tessa Walker, Serena Savage-Guin, Jordan B Renner, Jonathan Samuels, Janice Lin, Minna Kohler, Catherine Bakewell, Katherine A Yates, Yvonne M Golightly, Amanda E Nelson","doi":"10.1016/j.joca.2026.08.012","DOIUrl":"10.1016/j.joca.2026.08.012","url":null,"abstract":"<p><strong>Objective: </strong>To quantify general population prevalence, and differences by sex and BMI, in ultrasound (US) features of knee osteoarthritis (KOA), patient-reported knee symptoms (Ksx), radiographic KOA (rKOA), and symptomatic KOA (sxKOA).</p><p><strong>Methods: </strong>Participants from the Johnston County Health Study (2019-2024; n=902) provided demographic, clinical, and imaging data. Ksx was defined as self-reported pain, aching or stiffness on most days of any one month in the past 12 months. rKOA was defined as Kellgren-Lawrence grade ≥2 (or total knee replacement (TKR)), severe rKOA as grades 3-4 (or TKR), and sxKOA as rKOA and Ksx in the same knee. Standardized US scoring was performed as previously reported. Weighted prevalence estimates and 95% confidence intervals (CI) for Ksx, rKOA, sxKOA, severe rKOA, and US features were calculated overall and by sex and BMI category.</p><p><strong>Results: </strong>Among 902 participants (67% female; 66% non-Hispanic white, mean age 55 years, and BMI 33 kg/m²), the weighted prevalence of Ksx, rKOA, sxKOA, and severe rKOA were 61%, 36%, 27%, and 21%, respectively, all higher (based on non-overlapping CIs) than baseline estimates from the Johnston County Osteoarthritis Project and other cohorts. Ksx, rKOA, sxKOA, and severe rKOA were higher among females and those with obesity. Compared to females with obesity, those with severe obesity had higher prevalence of all radiographic outcomes at moderate and severe grades with non-overlapping CI. US effusion and synovitis were more prevalent in males, whereas medial and lateral cartilage damage were more common in females. With increasing obesity, osteophytes and medial cartilage damage were more prevalent, while gryescale effusion was actually less frequent.</p><p><strong>Conclusion: </strong>KOA prevalence continues to increase in the population. Sex and BMI differences in KOA prevalence and US features were most pronounced among females with severe obesity. Distinguishing between sexes and by obesity levels may improve understanding of KOA mechanisms and guide tailored prevention and treatment strategies.</p>","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":" ","pages":""},"PeriodicalIF":9.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of bias in network meta-analyses of interventions for knee and hip osteoarthritis published in leading general medical and specialty journals: A methodological study using the RoB NMA tool","authors":"Tim Schleimer,Svenja Kaczorowski,Florian Teichert,Sofia Dias,Katja Ehrenbrusthoff,Melanie Holden,Carole Lunny,Tobias Saueressig,Marius Henriksen,Daniel L Belavy","doi":"10.1016/j.joca.2026.09.002","DOIUrl":"https://doi.org/10.1016/j.joca.2026.09.002","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"176 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148893937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fundamentals of Osteoarthritis 2026: Imaging","authors":"Frank W. Roemer,Ali Guermazi,Shadpour Demehri,Wolfgang Wirth,Felix Eckstein,Richard Kijowski","doi":"10.1016/j.joca.2026.09.003","DOIUrl":"https://doi.org/10.1016/j.joca.2026.09.003","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"56 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148923262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lubricin (PRG4) in Articular Cartilage and Intervertebral Disc: Comparative Biology and Therapeutic Potential","authors":"Ying Zhang,Cunxin Zhang,Xinzhou Xie,Xiaodong Wang,Chenghu Xie,Chaoliang Lv,Ming Pei","doi":"10.1016/j.joca.2026.09.014","DOIUrl":"https://doi.org/10.1016/j.joca.2026.09.014","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"30 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoarthritis service delivery model: regional care networks","authors":"Joost Dekker","doi":"10.1016/j.joca.2026.09.009","DOIUrl":"https://doi.org/10.1016/j.joca.2026.09.009","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"6 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149020084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overall and specific treatment effects of pharmacological interventions for hand osteoarthritis: a systematic review and meta-analysis of randomized controlled trials","authors":"Zeqin Wen,Ziqi Chen,Hongyi He,Weiya Zhang,Michael Doherty,Yuqing Zhang,Guanghua Lei,Jie Wei,Chao Zeng","doi":"10.1016/j.joca.2026.09.012","DOIUrl":"https://doi.org/10.1016/j.joca.2026.09.012","url":null,"abstract":"","PeriodicalId":19654,"journal":{"name":"Osteoarthritis and Cartilage","volume":"31 1","pages":""},"PeriodicalIF":7.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149049104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}