Oriental Journal Of Chemistry最新文献_第7页

Synthesis of CeO2-GO Nano Composite and its Impact on SOD1 Protein Through Computation Study: Molecular Docking CeO2-GO纳米复合材料的合成及其对SOD1蛋白影响的计算研究:分子对接

Oriental Journal Of Chemistry Pub Date : 2023-10-30 DOI: 10.13005/ojc/390523

S. Chitrarasu, A. Selvam, M. Yogapriya, K. i Boopath, K. Selvapriya

{"title":"Synthesis of CeO2-GO Nano Composite and its Impact on SOD1 Protein Through Computation Study: Molecular Docking","authors":"S. Chitrarasu, A. Selvam, M. Yogapriya, K. i Boopath, K. Selvapriya","doi":"10.13005/ojc/390523","DOIUrl":"https://doi.org/10.13005/ojc/390523","url":null,"abstract":"Motor neuron disease (MND) has become the most widespread neurodegenerative disease, like ALS, AD, and PD, affecting millions of human beings worldwide. Among these, ALS disease plays a major role in MND. The metal oxides have an essential role in neurodegenerative diseases. Cerium oxide nanoparticles have received a lot of attention in recent years as a potential future remedy for treating a variety of problems due to their redox activity, free radical scavenging capabilities, biofilm suppression, and other features. We are using molecular docking experiments to better understand the interaction of transition metal oxides (CeO2) with mutated and Non-mutated SOD1 proteins. Through the use of molecular docking studies, the structural relationship between amino acids, binding energy, and ligand efficiency was investigated. Auto-dock analysis also reveals that the CeO2 nanoparticle has significant binding energy. In this work, we synthesize a Cerium oxide/GO composite and examine its impact on mutant and non-mutant SOD1 proteins, as well as antioxidant assays (SOD3), anti-microbial activity, and CV analysis.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"38 20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136068033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Search for New Inhibitors of Human Aromatase Enzyme (Cyp450) from Bioactive Compounds of Citrus species 从柑橘类生物活性化合物中寻找新的人芳香酶抑制剂(Cyp450

Oriental Journal Of Chemistry Pub Date : 2023-10-30 DOI: 10.13005/ojc/390517

Moumita Saha, Sirshendu Chatterjee

{"title":"Search for New Inhibitors of Human Aromatase Enzyme (Cyp450) from Bioactive Compounds of Citrus species","authors":"Moumita Saha, Sirshendu Chatterjee","doi":"10.13005/ojc/390517","DOIUrl":"https://doi.org/10.13005/ojc/390517","url":null,"abstract":"Oestrogen synthesis pathway is one of the bottom line steps for breast cancer advancement; involving, aromatase enzyme (Cyp450), which transform androgens to oestrogens. Thus endocrine-based therapies comprising of human aromatase blockage is the most necessary way in order to decrease the oestrogen levels and thereafter prohibiting the chances of breast cancer commencement. In recent years, limelight on drug discovery from green sources has been growing for their less toxicity and cost effectiveness. Our present course of study aims at searching of new antagonist/s from a common dietary source “Citrus species”. Molecular docking along with in-silico evaluation their pharmacokinetics (ADME) properties and toxicity were employed to fulfill the aim. Result shows that, all the five Citrus compounds have reasonable affinity towards cytochrome p450. However, Hesperidin shows highest affinity towards its target receptor protein i.e. -9.7 kcal/ mol, followed by Chalcone that shows the lowest affinity towards its target protein i.e. -7.4 kcal/ mol. Hence, bioactive components of Citrus species can be green alternatives for breast cancer therapy.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"64 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136068904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Characterization, Molecular docking and Anti-anxiety Evaluation of Some Novel Phenothiazine Derivatives 一些新型吩噻嗪衍生物的合成、表征、分子对接及抗焦虑评价

Oriental Journal Of Chemistry Pub Date : 2023-10-30 DOI: 10.13005/ojc/390516

Pooja Saini, Sushil Kumar

{"title":"Synthesis, Characterization, Molecular docking and Anti-anxiety Evaluation of Some Novel Phenothiazine Derivatives","authors":"Pooja Saini, Sushil Kumar","doi":"10.13005/ojc/390516","DOIUrl":"https://doi.org/10.13005/ojc/390516","url":null,"abstract":"The phenothiazine derivatives 1-(10H-phenothiazin-10-yl)-2-(4-(1-(phenylimino)ethyl)phenoxy)ethan-1-one (4a-4j) are produced from 2-(4-acetylphenoxy)-1-(10H-phenothiazin-10-yl)ethan-1-one (3) and after that, condensing them with various carbonyl compounds. Acetonitrile was used as solvent. The purity of the analogues and reaction progress were identified through their retention factor value and melting point. Characterization of the prepared analogues was completed via performing their Infra-red, proton-nuclear magnetic resonance spectroscopy with their elemental analysis. The set of molecular docking parameters of the compounds were assessed to check to their potentiality. Autodock Vina 1.2.0 was used to dock the derivatives and the docking score of all the synthesized derivatives ranges from -8.7 to -10.2. Investigation of anti-anxiety activity on albino wistar rat, was executed for all the prepared phenothiazine analogues. EPM model was approached for performing anti-anxiety study, taking Diazepam as standard drug. The compounds 2-(4-(1-((3-nitrophenyl) imino)ethyl)phenoxy)-1-(10H-phenothiazin-10-yl)ethan-1-one (4e) and 2-(4-(1-((3,4-dinitrophenyl)imino)ethyl)phenoxy)-1-(10H-phenothiazin-10-yl)ethan-1-one (4g) were showed maximum potency among all the prepared derivatives as compared to Diazepam.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"28 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136068905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis and Anticancer Properties of Novel Hydrazino-Fused Pyrimidines 新型肼合嘧啶的设计、合成及抗癌性能研究

Oriental Journal Of Chemistry Pub Date : 2023-10-30 DOI: 10.13005/ojc/390503

Sathish Kumar Mittapalli, Iffath Rizwana, Ch. Hari Prasad Murthy, Nimisha Jain, Sagar Pamu, Pawan Kumar Gupta

{"title":"Design, Synthesis and Anticancer Properties of Novel Hydrazino-Fused Pyrimidines","authors":"Sathish Kumar Mittapalli, Iffath Rizwana, Ch. Hari Prasad Murthy, Nimisha Jain, Sagar Pamu, Pawan Kumar Gupta","doi":"10.13005/ojc/390503","DOIUrl":"https://doi.org/10.13005/ojc/390503","url":null,"abstract":"The Pyrimidine system has received great attention and a vital component of genetic material emerged has fundamental source to fight against cancer. The pyrazolo(1,5-a) pyrimidines (5a-5j) were designed based on the structural features of antitumor antimetabolites, synthesized and chemical structures were confirmed using spectroscopic methods such as IR, 1H NMR, 13C NMR, Mass Spectral and elemental analysis. The cytotoxic activity was evaluated by DPPH free radical scavenging assay against standard ascorbic acid and MTT assay against MCF-7, HepG-2, and imatinib as standard. The DPPH assay indicated 5b, 5c, 5e, 5h and 5j were efficient antioxidants, while the MTT assay discloses potent cytotoxicity of 5b, 5d against MCF-7 with 16.61, 19.67µg/ml and 5c, 5h against HepG-2 with 14.32 and 19.24µg/ml compared to 5-FU. The ligands 5c and 5h demonstrated promising towards tyrosine kinase and cyclin dependent kinase 2, respectively and the bonding energy is similar as doxorubicin. Concluding that the compounds had reasonable cytotoxic potential and good association observed between in vitro and in silico studies.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"63 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136068899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Frying and Reheating Processes on the Fatty Acids and Antioxidants of Commonly Used Cooking Oils in the Arabian Region: A Comparative Study 油炸和再加热对阿拉伯地区常用食用油脂肪酸和抗氧化剂影响的比较研究

Oriental Journal Of Chemistry Pub Date : 2023-10-30 DOI: 10.13005/ojc/390513

Noha Omer, Suhair A. Atta, Rasha Jame, Fatimah A. Alotaibi, Jozaa. N. Al –Tweher, Hatem A. Al-Aoh, Zahra E. Suliman, Syed Khalid Mustafa

{"title":"Effect of Frying and Reheating Processes on the Fatty Acids and Antioxidants of Commonly Used Cooking Oils in the Arabian Region: A Comparative Study","authors":"Noha Omer, Suhair A. Atta, Rasha Jame, Fatimah A. Alotaibi, Jozaa. N. Al –Tweher, Hatem A. Al-Aoh, Zahra E. Suliman, Syed Khalid Mustafa","doi":"10.13005/ojc/390513","DOIUrl":"https://doi.org/10.13005/ojc/390513","url":null,"abstract":"Vegetable oils like extra virgin olive oil, Moringa oleifera oil, sunflower, and corn oils are regularly used for cooking purposes in the Arabian region. Additionally, the consumption of fried food is becoming increasingly popular in this region. The current study is to find out how temperature affects oils without using food of any kind. The fatty acid and antioxidant profiles of these four vegetable oils (extra virgin olive oil, Moringa oleifera oil, sunflower oil, and corn oil) have been investigated in terms of temperature during deep-frying and re-heating. In this process, an electric fryer is used for deep-frying and reheating oil without adding any kind of food. The collected vegetable oil samples were heated for six hours on five different time periods to a temperature of up to 175 ± 5 °C, and the fatty acid profiles were analysed before and after each cycle by using gas chromatography and were characterized by means of UV and FTIR techniques as well. The composition of oil fatty acids is more affected by re-heating than by deep-frying, as the results indicated. The antioxidant activity of the different oils was assessed using the diphenyl-1-picrylhydrazyl (DPPH) scan; the findings revealed that, whereas antioxidant activity dropped sharply in re-heated oils, it did so gradually for deep-frying samples.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"21 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136069413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Linagliptin – Human Serum Albumin Complex formation using Spectroscopic Analysis and Molecular Docking 利格列汀-人血清白蛋白复合物形成的光谱分析和分子对接研究

Oriental Journal Of Chemistry Pub Date : 2023-10-30 DOI: 10.13005/ojc/390524

D. Usha Rani, Shaheen Begum, S. Nithya, Mohamed El Fadili

{"title":"Investigation of Linagliptin – Human Serum Albumin Complex formation using Spectroscopic Analysis and Molecular Docking","authors":"D. Usha Rani, Shaheen Begum, S. Nithya, Mohamed El Fadili","doi":"10.13005/ojc/390524","DOIUrl":"https://doi.org/10.13005/ojc/390524","url":null,"abstract":"When human serum albumin binds firmly with a drug molecule, the impact will be greater on its half-life and other important pharmacokinetic properties. Linagliptin is an antidiabetic drug candidate with a good safety profile. The interaction mechanism of linagliptin with HSA is not reported so far. In the present study, various spectroscopic investigations (UV, fluorescence, FTIR and CD) and molecular docking were performed to determine the binding constant and the other binding characteristics of the interaction between HSA and drug molecule. The binding constant obtained from the UV-spectroscopic results (0.98 x 103 M-1), revealed weak binding between the protein and linagliptin structure. Fluorescence spectroscopy results showed quenching of intrinsic fluorescence of HSA through static quenching. The binding constant value was Ksv = 1.26×10-4 M-1. In the FTIR and circular dichroism spectra minor changes were observed in peak positions and peak intensities. Molecular docking revealed that linagliptin was stabilized at site-I primarily with Pi-Pi stacking and the binding mode was similar that of R- warfarin.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"452 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136067507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photocatalytic Degradation of Azo Dyes by Zinc Oxide Nanoparticles Fabricated using Aqueous Flower Extract of Cassia alata 决明子花提取物制备氧化锌纳米颗粒光催化降解偶氮染料

Oriental Journal Of Chemistry Pub Date : 2023-10-30 DOI: 10.13005/ojc/390519

S. Karthika, N. Mani, B. Latha Maheswari, N. Kavikala, K. Annaidasan

{"title":"Photocatalytic Degradation of Azo Dyes by Zinc Oxide Nanoparticles Fabricated using Aqueous Flower Extract of Cassia alata","authors":"S. Karthika, N. Mani, B. Latha Maheswari, N. Kavikala, K. Annaidasan","doi":"10.13005/ojc/390519","DOIUrl":"https://doi.org/10.13005/ojc/390519","url":null,"abstract":"The industrial revolution and the rapid increase in population growth have led to water pollution. Among the various types of pollutants, industrial dyes pose a serious threat to public health. Hence, remediation of these toxic dyes from water sources has become highly essential in terms of public health. The present study focused on the use of nanoparticles synthesized using plant sources for the remediation of azo dyes such as Methyl orange (MO) Congo red (CR), Malachite Green (MG), Eriochrome Black T (EBT) under direct solar radiation. The fabrication of Zinc oxide nanoparticles (ZnO-NPs) was mediated by aqueous flower extract of Cassia alata. The synthesized nanoparticles exhibited a surface plasmon resonance (SPR) vibration at wavelength 372 nm. The FTIR analysis revealed aromatic amines and alcohols coating the surface of ZnO-NPs. The XRD analysis showed that the synthesized nanoparticles are highly crystalline and possess hexagonal wurtzite structures. The particle size measured with maximum diffraction peak using Scherrer’s equation was 9.93 nm. The SEM images showed spherical morphology. The particle size determined with Dynamic Light Scattering (DLS) was 78.18 nm and the zeta potential analysis showed that the ZnO-NPs was -14.6 mV, indicating good dispersion and stability. The C.alata mediated ZnO-NPs exhibited excellent Photocatalytic degradation of azo dyes. Degradation efficiency of Methyl orange, Malachite green and Eriochrome black T are 76.65%, 65.07%, 60% respectively at 150 min. But Congo red is 72.76% at 120 min, because the Congo red was completely degraded at 120min. The study shows that green mediated ZnO-NPs could be effectively used as an eco-friendly alternative for the remediation of chemical pollutants from water.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"64 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136068724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of Novel Thiohydantoin Derivatives and Exploration their Physico-Chemical Parameters 新型硫代海因衍生物的设计及其理化参数的探索

Oriental Journal Of Chemistry Pub Date : 2023-10-30 DOI: 10.13005/ojc/390520

Prashant A. Gotmare, Sanjay V. Kolhe

引用次数: 0

A Comprehensive Review on the Techniques and Indexes Used for the Analysis of Fluorosis in Humans and Cattle 人、牛氟中毒分析技术与指标综述

Oriental Journal Of Chemistry Pub Date : 2023-10-30 DOI: 10.13005/ojc/390505

Pradeep Khyalia, Himani Jugiani, Jyoti Dangi, Jitender Singh Laura, Meenakshi Nandal

{"title":"A Comprehensive Review on the Techniques and Indexes Used for the Analysis of Fluorosis in Humans and Cattle","authors":"Pradeep Khyalia, Himani Jugiani, Jyoti Dangi, Jitender Singh Laura, Meenakshi Nandal","doi":"10.13005/ojc/390505","DOIUrl":"https://doi.org/10.13005/ojc/390505","url":null,"abstract":"Fluoride is known to play a significant role in dental formation. High fluoride intake leads to different symptoms one of them is dental fluorosis, which is chronic dental toxicity. Various indexes have been introduced to measure the intensity and severity of dental fluorosis. Some of these indexes are fluoride specific, such as Dean’s index, Thylstrup and Fejerskov index, the Tooth Surface Index of Fluorosis index, ICMR index. While others are non-fluoride descriptive indexes such as the Developmental Defects of enamel index. Dental fluorosis is most commonly assessed by clinical examination by experts in these indexes, but nowadays, technical assistance such as photographs is used for diagnosis. Recent advancements have also witnessed the development of Visual analog scales and quantitative light fluorescence methods for dental fluorosis assessments. This review article focuses on important techniques and indexes used in the evaluation and characterization of dental fluorosis. A comparative review analysis of available indexes and the scope of future advancements have also been compiled.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"155 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136069414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tunable Paramagnetism in Mn co-doped N:CdS Composite Nanoparticles Mn共掺杂N:CdS复合纳米颗粒的可调顺磁性

Oriental Journal Of Chemistry Pub Date : 2023-10-30 DOI: 10.13005/ojc/390511

Surya Sekhar Reddy M

{"title":"Tunable Paramagnetism in Mn co-doped N:CdS Composite Nanoparticles","authors":"Surya Sekhar Reddy M","doi":"10.13005/ojc/390511","DOIUrl":"https://doi.org/10.13005/ojc/390511","url":null,"abstract":"Manganese-co-doped N:CdS composite nanoparticles (CNps) have been prepared by using the co-precipitation method. 2-Mercaptoethonal is used as a surfactant to control the size of nanoparticles. X-ray diffraction (XRD) studies confirm the size of the particles in the nanorange. The Rietveld refinement with X'-pert high-score software studies show multiphase existence in as-prepared composite nanoparticles. The energy dispersive analyses of X-ray studies (EDAX) confirm the presence of doped Mn and nitrogen elements in CdS. The Fourier transform infrared spectroscopy (FTIR) studies confirm the presence of surfactant. The ultraviolet-visible spectroscopy studies (UV-VIS) show a clear blue shift in the band gap, which is an indication of the quantum confinement effect. The photoluminescence studies (PL) attribute the emission of a characteristically strong peak at λ = 632 nm, corresponding to the (4T1→6A1) transition, to the inclusion of Mn2+ in the core of the CdS lattice. The electron paramagnetic spectroscopy (EPR) studies show paramagnetic behavior. The hyperfine splitting constant (A) values around 7 mT from EPR confirms the inclusion of Mn2+ and N3- in the tetrahedral sites of the CdS core. The variation in optical and magnetic properties of as-prepared composite nanoparticles has the potential for optoelectric and magnetoluminescence devices.","PeriodicalId":19599,"journal":{"name":"Oriental Journal Of Chemistry","volume":"29 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136070343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0