S. Chitrarasu, A. Selvam, M. Yogapriya, K. i Boopath, K. Selvapriya
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Synthesis of CeO2-GO Nano Composite and its Impact on SOD1 Protein Through Computation Study: Molecular Docking
Motor neuron disease (MND) has become the most widespread neurodegenerative disease, like ALS, AD, and PD, affecting millions of human beings worldwide. Among these, ALS disease plays a major role in MND. The metal oxides have an essential role in neurodegenerative diseases. Cerium oxide nanoparticles have received a lot of attention in recent years as a potential future remedy for treating a variety of problems due to their redox activity, free radical scavenging capabilities, biofilm suppression, and other features. We are using molecular docking experiments to better understand the interaction of transition metal oxides (CeO2) with mutated and Non-mutated SOD1 proteins. Through the use of molecular docking studies, the structural relationship between amino acids, binding energy, and ligand efficiency was investigated. Auto-dock analysis also reveals that the CeO2 nanoparticle has significant binding energy. In this work, we synthesize a Cerium oxide/GO composite and examine its impact on mutant and non-mutant SOD1 proteins, as well as antioxidant assays (SOD3), anti-microbial activity, and CV analysis.
期刊介绍:
Oriental Journal of Chemistry was started in 1985 with the aim to promote chemistry research. The journal consists of articles which are rigorously peer-reviewed. The journal was indexed in Emerging Science citation index in 2016. The Editorial board member consists of eminent international scientist in all fields of Chemistry. Details of each member and their contact information is mentioned in website. The journal has thorough ethics policies and uses plagiarism detection software(ithenticate) to screen each submission. The journal has recently partnered with publons as a part of making our reviews more transparent. The journal has recently incorporated PlumX for article level matrix. The journal is promoting research on all social and academic platforms mentioned in PlumX guidelines. The journal uses google maps to improve on the geographical distribution of Editorial board members as well as authors.