CeO2-GO纳米复合材料的合成及其对SOD1蛋白影响的计算研究:分子对接

IF 0.6 Q4 CHEMISTRY, MULTIDISCIPLINARY
S. Chitrarasu, A. Selvam, M. Yogapriya, K. i Boopath, K. Selvapriya
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引用次数: 0

摘要

运动神经元病(MND)已成为与ALS、AD、PD一样,影响全球数百万人的最广泛的神经退行性疾病。其中,ALS疾病在MND中起主要作用。金属氧化物在神经退行性疾病中起重要作用。近年来,氧化铈纳米颗粒由于其氧化还原活性、自由基清除能力、生物膜抑制等特性,作为未来治疗各种疾病的潜在药物受到了广泛关注。我们正在使用分子对接实验来更好地了解过渡金属氧化物(CeO2)与突变和非突变SOD1蛋白的相互作用。通过分子对接研究,研究了氨基酸之间的结构关系、结合能和配体效率。自动对接分析还表明,CeO2纳米颗粒具有显著的结合能。在这项工作中,我们合成了氧化铈/氧化石墨烯复合物,并研究了其对突变型和非突变型SOD1蛋白的影响,以及抗氧化试验(SOD3)、抗微生物活性和CV分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis of CeO2-GO Nano Composite and its Impact on SOD1 Protein Through Computation Study: Molecular Docking
Motor neuron disease (MND) has become the most widespread neurodegenerative disease, like ALS, AD, and PD, affecting millions of human beings worldwide. Among these, ALS disease plays a major role in MND. The metal oxides have an essential role in neurodegenerative diseases. Cerium oxide nanoparticles have received a lot of attention in recent years as a potential future remedy for treating a variety of problems due to their redox activity, free radical scavenging capabilities, biofilm suppression, and other features. We are using molecular docking experiments to better understand the interaction of transition metal oxides (CeO2) with mutated and Non-mutated SOD1 proteins. Through the use of molecular docking studies, the structural relationship between amino acids, binding energy, and ligand efficiency was investigated. Auto-dock analysis also reveals that the CeO2 nanoparticle has significant binding energy. In this work, we synthesize a Cerium oxide/GO composite and examine its impact on mutant and non-mutant SOD1 proteins, as well as antioxidant assays (SOD3), anti-microbial activity, and CV analysis.
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来源期刊
Oriental Journal Of Chemistry
Oriental Journal Of Chemistry CHEMISTRY, MULTIDISCIPLINARY-
自引率
20.00%
发文量
172
期刊介绍: Oriental Journal of Chemistry was started in 1985 with the aim to promote chemistry research. The journal consists of articles which are rigorously peer-reviewed. The journal was indexed in Emerging Science citation index in 2016. The Editorial board member consists of eminent international scientist in all fields of Chemistry. Details of each member and their contact information is mentioned in website. The journal has thorough ethics policies and uses plagiarism detection software(ithenticate) to screen each submission. The journal has recently partnered with publons as a part of making our reviews more transparent. The journal has recently incorporated PlumX for article level matrix. The journal is promoting research on all social and academic platforms mentioned in PlumX guidelines. The journal uses google maps to improve on the geographical distribution of Editorial board members as well as authors.
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