Oral Therapeutics and Pharmacology最新文献_第10页

Effect of diclofenac sodium on osteoclast formation 双氯芬酸钠对破骨细胞形成的影响

Oral Therapeutics and Pharmacology Pub Date : 2001-12-01 DOI: 10.11263/JSOTP1982.20.196

M. Nobukawa, S. Yamada, H. Amano

引用次数: 2

A Literatue Study of Oral Therapeutics and Pharmacology 口腔治疗学与药理学文献研究

Oral Therapeutics and Pharmacology Pub Date : 2001-08-01 DOI: 10.11263/JSOTP1982.20.110

Yoshio Saito, Miyuki Ikeda, Hidemi Tanaka, J. Iijima, K. Sakata

引用次数: 1

Pharmacokinetic study of one dose of 750mg of Amoxicillin 单剂量750mg阿莫西林的药代动力学研究

Oral Therapeutics and Pharmacology Pub Date : 2001-08-01 DOI: 10.11263/JSOTP1982.20.78

M. Otsuru, A. Kaneko, Yusuke Mori, N. Nakatogawa, J. Sasaki, N. Yamane, Hiroshi Takanohashi, I. Kobayashi

引用次数: 1

In vitroantimicrobial activity of ampicillin, panipenem, and ofloxacin against oral Streptococci adherent to solid phase 氨苄西林、帕尼培南和氧氟沙星对口服链球菌的体外抗菌活性粘附于固相

Oral Therapeutics and Pharmacology Pub Date : 2001-08-01 DOI: 10.11263/JSOTP1982.20.82

Ayumi Yoshioka, T. Yoshii, I. Takenono, T. Komori

引用次数: 0

The choice of antimicrobial agents based on prompt Gram's staining 基于提示革兰氏染色的抗菌药物的选择

Oral Therapeutics and Pharmacology Pub Date : 2001-08-01 DOI: 10.11263/JSOTP1982.20.92

J. Sasaki, Yusuke Mori, Hiroshi Takanohashi

引用次数: 0

Effects of Cevimeline hydrochloride on salivary secretion in streptozotocin-induced diabetic Balb/ cA mice 盐酸西维米林对链脲佐菌素诱导的糖尿病Balb/ cA小鼠唾液分泌的影响

Oral Therapeutics and Pharmacology Pub Date : 2001-08-01 DOI: 10.11263/JSOTP1982.20.86

H. Ishii, Y. Nakagawa, Takayuki Shiga, T. Shimizu, M. Sakai, K. Asada, K. Ishibashi

引用次数: 0

Effects of chronic administration of pilocarpine on saliva secretion in streptozotocin-induced diabetic mice 长期服用匹罗卡品对链脲佐菌素诱导的糖尿病小鼠唾液分泌的影响

Oral Therapeutics and Pharmacology Pub Date : 2001-08-01 DOI: 10.11263/JSOTP1982.20.96

Y. Nakagawa, H. Ishii, Takashi Saito, Takahiro Wakui, Taketomo Sato, Katsunori Ishibashii, M. Humphreys-Beher

{"title":"Effects of chronic administration of pilocarpine on saliva secretion in streptozotocin-induced diabetic mice","authors":"Y. Nakagawa, H. Ishii, Takashi Saito, Takahiro Wakui, Taketomo Sato, Katsunori Ishibashii, M. Humphreys-Beher","doi":"10.11263/JSOTP1982.20.96","DOIUrl":"https://doi.org/10.11263/JSOTP1982.20.96","url":null,"abstract":"Pilocarpine is a parasympathomimetic agonist and one of the most extensively studied salivary stimulants. Salivary hypofunction patients require long-term administration of secretagogues, but little is known about the effects of chronic administration of pilocarpine on saliva secretion. Hence, in the present study, we evaluated the effects of chronic administration of pilocarpine on saliva secretion in streptozotocin (STZ)-induced diabetic mice. Four weeks after induction of diabetes, saliva flow rate, protein concentration, and amylase activity were measured, by collecting saliva from the oral cavity over 30 min following an injection of pilocarpine. The effects of 7 days of pilocarpine administration were compared with the effects of a single injection. Saliva flow following a single intraperitoneal pilocarpine injection was significantly lower in the STZ diabetic mice than the control mice (buffer injection). With chronic administration of pilocarpine, the rate of saliva release increased significantly in the first 10-min period following injection, both in the diabetic and control mice, compared with the single pilocarpine injection results. The total amylase secretion over 30 min induced by a single injection of pilocarpine was not reduced in diabetic mice, despite a decrease in total salivary protein secretion. After chronic administration of pilocarpine, protein secretion increased both in the diabetic and control mice, compared with single injection levels. Chronic administration tended to increase total amylase activity in the control mice, but not the diabetic mice. The present study has clarified the effects of chronic administration of pilocarpine, and suggests that pilocarpine may be beneficial for patients with salivary gland dysfunction.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"20 1","pages":"96-103"},"PeriodicalIF":0.0,"publicationDate":"2001-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63817739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Clinical Trial of SBJ-PRO2 for Dental Plaque Removal SBJ-PRO2用于牙菌斑清除的临床研究

Oral Therapeutics and Pharmacology Pub Date : 2001-04-01 DOI: 10.11263/JSOTP1982.20.23

Koichi Ito, N. Yoshinuma, N. Sugano, Shuichi Sato, T. Nishida, M. Matsue, H. Masunaga, K. Hozumi, Fumihiko Ymanouchi, Akihiko Gunji, A. Fujii

引用次数: 0

A pharmacological and immunopharmacological study on allergic reaction induced by rosin 松香致敏反应的药理学和免疫药理学研究

Oral Therapeutics and Pharmacology Pub Date : 2001-04-01 DOI: 10.11263/JSOTP1982.20.11

Takafumi Katuta, T. Ohsumi

{"title":"A pharmacological and immunopharmacological study on allergic reaction induced by rosin","authors":"Takafumi Katuta, T. Ohsumi","doi":"10.11263/JSOTP1982.20.11","DOIUrl":"https://doi.org/10.11263/JSOTP1982.20.11","url":null,"abstract":"Dental drugs and dental materials induce several allergic reactions, but our knowledge about the causal substances and the mechanism of allergic reactions is still limited. In this study, we conducted pharmacological and immunopharmacological examinations of rosin, which is included in many preparations, such as pulp capping agents and root canal filling agents. First, we used the adjuvant and patch test in guinea pigs. Twenty-four hours after challenge, erythema was noted in all 3 animals to which we applied 25, 12.5, and 5 % rosin and edema was also noted in one of the animals to which we applied 25% rosin, second, to examine places where rosin causes type IV allergic reactions, the ear swelling test in mice was conducted. At 5 % rosin, the difference was significant ; at 25% rosin, the swelling rate was as high as 55%. From the above two examinations, the results indicated that contact dermatitis, which is type N allergy, may be induced by dental drugs and dental materials containing rosin, and the induction of allergy depended on the concentration of rosin. Third, the kinetics of immunocytes was examined in mice to which we applied 25% rosin in the ear swelling test. The distribution of immunocytes in the ears and lymph nodes was immunohistochemically examined by the indirect enzyme-labeled antibody method. Thy-1.2, CD4, interleukin-2 receptor (IL-2R), IL-4R and CD8-positive cells were detected by light microscopy. The number of IL-4R and CD8-positive cells was increased in the effector phase. It is suggested that Th-2 rather than Th-1 was involved in allergy induced by rosin, and clarified that CD8 positive cells were involved.","PeriodicalId":19590,"journal":{"name":"Oral Therapeutics and Pharmacology","volume":"20 1","pages":"11-22"},"PeriodicalIF":0.0,"publicationDate":"2001-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63817069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Development of a Clinical pathway for Radiotherapy 放射治疗临床途径的发展

Oral Therapeutics and Pharmacology Pub Date : 2001-04-01 DOI: 10.11263/JSOTP1982.20.32

Sachiko Harada, Kumiko Kasashi, I. Wada, Konami Watanabe, M. Saeki, Y. Yamazaki, M. Ono, K. Tei, K. Ohmori, Masayo Kakinuma, H. Fukuda, Y. Totsuka

引用次数: 0