Ophthalmic Plastic and Reconstructive Surgery最新文献

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Thyroid Eye Disease Research From 2010 to 2024: An Analysis of Social Media Impact Versus Traditional Citation Metrics. 甲状腺眼病研究从2010年到2024年:社会媒体影响与传统引用指标的分析
IF 1.3 4区 医学
Ophthalmic Plastic and Reconstructive Surgery Pub Date : 2025-09-11 DOI: 10.1097/IOP.0000000000003072
Aaron T Zhao, William R Katowitz
{"title":"Thyroid Eye Disease Research From 2010 to 2024: An Analysis of Social Media Impact Versus Traditional Citation Metrics.","authors":"Aaron T Zhao, William R Katowitz","doi":"10.1097/IOP.0000000000003072","DOIUrl":"https://doi.org/10.1097/IOP.0000000000003072","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the relationship between traditional bibliometric measures and Altmetric Scores for articles on thyroid eye disease, examining their scientific and social media impact from 2010 to 2024.</p><p><strong>Methods: </strong>We analyzed the 100 most-cited articles on thyroid eye disease from the Web of Science Core Collection, comparing traditional citation metrics with Altmetric Attention Scores. Statistical analyses included Spearman correlation, temporal trend analysis, and comparison of impact patterns across journals and publication years.</p><p><strong>Results: </strong>Among the top 100 cited articles, we found a moderate positive correlation between citations and Altmetric Scores (r = 0.350, p = 0.002). Only 8% of articles achieved high impact in both metrics (>Q3). The median citation count was 40 (interquartile range: 32-59; range: 26-531), while the median Altmetric Score was 3 (interquartile range: 1-10; range: 1-546). Recent articles (2020-2024) showed significantly higher Altmetric Scores compared with earlier periods (median: 11 vs. 1, p < 0.0001). Open access articles demonstrated higher impact in both metrics compared with subscription-based articles.</p><p><strong>Conclusion: </strong>Traditional citation metrics and social media impact measures capture different aspects of research influence in thyroid eye disease literature. The emergence of high-impact therapeutic studies, particularly regarding teprotumumab, demonstrates how breakthrough research can achieve substantial impact across both traditional and alternative metrics. Given the increasing role of social media in research dissemination and patient education, clinicians should consider both traditional and alternative metrics when evaluating research impact and should be prepared to discuss studies that achieve high social media engagement with patients.</p>","PeriodicalId":19588,"journal":{"name":"Ophthalmic Plastic and Reconstructive Surgery","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transorbital Endoscopic Approach to the Orbital Apex Via the Superior Lid Crease: A Clinical Series. 经上睑折痕经眶内内镜入路眶尖:临床系列。
IF 1.3 4区 医学
Ophthalmic Plastic and Reconstructive Surgery Pub Date : 2025-09-11 DOI: 10.1097/IOP.0000000000003022
Jessica Y Tong, James Slattery, Dinesh Selva
{"title":"Transorbital Endoscopic Approach to the Orbital Apex Via the Superior Lid Crease: A Clinical Series.","authors":"Jessica Y Tong, James Slattery, Dinesh Selva","doi":"10.1097/IOP.0000000000003022","DOIUrl":"https://doi.org/10.1097/IOP.0000000000003022","url":null,"abstract":"<p><p>A retrospective case series was performed to describe a transorbital endoscopic approach to the superior orbital apex. The surgical technique involved an extended lid crease incision and subperiosteal dissection along the orbital roof. Three patients were identified for inclusion (a 9-year-old male, a 21-year-old male, and a 55-year-old female). Follow-up time ranged from 10 months to 2 years. Procedural indications included biopsy or debulking of orbital and/or dural tissue for antineutrophilic cytoplasmic antibody vasculitis with hypertrophic pachymeningitis, orbital myxoma, and Langerhans cell histiocytosis. No intraoperative complications were encountered. All patients developed postoperative ptosis and upgaze limitation, which persisted in 1 patient at 12-month follow-up. There were no instances of a permanent sensory deficit or cerebrospinal fluid leak. The transorbital approach to the superior apex under endoscopic guidance represents a reasonable alternative to a lateral orbitotomy or craniotomy for the biopsy of orbital masses.</p>","PeriodicalId":19588,"journal":{"name":"Ophthalmic Plastic and Reconstructive Surgery","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Technique in One-Staged Reconstruction of Large Lower Eyelid Defects: Orbicularis Oculi Myoperiosteal Flap. 下眼睑大面积缺损一期重建的新技术:眼轮匝肌骨膜瓣。
IF 1.3 4区 医学
Ophthalmic Plastic and Reconstructive Surgery Pub Date : 2025-09-11 DOI: 10.1097/IOP.0000000000003019
Murat Kara
{"title":"A Novel Technique in One-Staged Reconstruction of Large Lower Eyelid Defects: Orbicularis Oculi Myoperiosteal Flap.","authors":"Murat Kara","doi":"10.1097/IOP.0000000000003019","DOIUrl":"https://doi.org/10.1097/IOP.0000000000003019","url":null,"abstract":"<p><p>Proper reconstruction of the lower eyelids is essential to preserve their function and aesthetic integrity. However, there are limited studies on lower eyelid reconstruction in specific patient populations without available donor sites, such as pediatric patients and those with common skin lesions, severe facial scars, and recurrent lower eyelid tumors. This study aims to analyze the results of a novel technique, the orbicularis oculi myoperiosteal flap, in a challenging case: a pediatric patient with xeroderma pigmentosum who lacks skin laxity and has limited tissue availability. Based on this single case, the proposed orbicularis oculi myoperiosteal flap appears to be a promising technique for lower eyelid reconstruction in challenging scenarios, offering proper lid function and acceptable aesthetic results without significant donor-site morbidity in a single stage. Therefore, the orbicularis oculi myoperiosteal flap should be considered an essential technique in the armamentarium of reconstructive surgeons.</p>","PeriodicalId":19588,"journal":{"name":"Ophthalmic Plastic and Reconstructive Surgery","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Superficial Temporal Artery Biopsy Incision Optimization: An Anatomical Study. 颞浅动脉活检切口优化:解剖学研究。
IF 1.3 4区 医学
Ophthalmic Plastic and Reconstructive Surgery Pub Date : 2025-09-11 DOI: 10.1097/IOP.0000000000003012
Alexander R Engelmann, Nicole P Rebollo, Suraj Bala, Catherine J Hwang, Julian D Perry
{"title":"Superficial Temporal Artery Biopsy Incision Optimization: An Anatomical Study.","authors":"Alexander R Engelmann, Nicole P Rebollo, Suraj Bala, Catherine J Hwang, Julian D Perry","doi":"10.1097/IOP.0000000000003012","DOIUrl":"https://doi.org/10.1097/IOP.0000000000003012","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the course of the superficial temporal artery (STA) and identify the optimal location for temporal artery biopsy when a pulse cannot be reliably palpated.</p><p><strong>Methods: </strong>In this anatomical study, the arterial systems of 12 fresh adult cadaver heads were filled with red neoprene latex to highlight the STA. Coronal incisions starting at the root of the auricular helix and extended 80 mm superiorly were made bilaterally. The primary outcome was the probability of the STA being encountered at each location on a standardized, superimposed 50 × 50 mm grid. Secondary outcomes included degree of declination from the incision line, distance at which the vessel crossed the incision, presence of frontal/parietal bifurcation, presence of branches, visibility of the temporal branch of the facial nerve, and vessel caliber. Means, standard deviations, and ranges were used to describe the data.</p><p><strong>Results: </strong>In all specimens analyzed, the STA crossed the coronal incision line within 45 mm of the helix root. The STA was found within the same 5 × 5 mm location, 10 to 15 mm cranial to the root of the helix, and 5 to 10 mm anterior to the incision in 68.4% of specimens. In the remaining specimens, a portion of the STA was found within 7 mm of this location.</p><p><strong>Conclusion: </strong>Especially in cases where the STA is nonpalpable, care must be taken to avoid iatrogenic injury to the facial nerve during temporal artery biopsy. Surgeons should recognize that the STA can be reliably encountered with an incision beginning 5 mm anterior and 5 mm cranial to the helix root, carried 40 mm in the posterior and cranial direction, 30 degrees declined from the coronal plane.</p>","PeriodicalId":19588,"journal":{"name":"Ophthalmic Plastic and Reconstructive Surgery","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Probable Ciliary Nerve Within Capsule of an Orbital Cavernous Venous Malformation. 眶海绵状静脉畸形囊内可能的睫状神经。
IF 1.3 4区 医学
Ophthalmic Plastic and Reconstructive Surgery Pub Date : 2025-09-11 DOI: 10.1097/IOP.0000000000003025
Yaroslav Grusha, Kaveh Vahdani, Dmitri Konovalov, Geoffrey E Rose
{"title":"Probable Ciliary Nerve Within Capsule of an Orbital Cavernous Venous Malformation.","authors":"Yaroslav Grusha, Kaveh Vahdani, Dmitri Konovalov, Geoffrey E Rose","doi":"10.1097/IOP.0000000000003025","DOIUrl":"https://doi.org/10.1097/IOP.0000000000003025","url":null,"abstract":"<p><p>Removal of an orbital cavernous venous malformation in a 39-year-old white female resulted in a significant intraoperative sectoral mydriasis. White fascicles were recorded as running into the mass at surgery, and one of these was confirmed histologically to be peripheral nerve within the capsule of a markedly fibrous orbital cavernous venous malformation. Most efferent pupillary anomalies after orbital surgery are probably due to ischemic or tractional neuropraxia, but the resected nerve raises the possibility of unplanned excision of a few fascicles of the postganglionic (parasympathetic) short ciliary nerves.</p>","PeriodicalId":19588,"journal":{"name":"Ophthalmic Plastic and Reconstructive Surgery","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Topical Chemotherapy in Ocular Adnexal Sebaceous Carcinoma. 局部化疗治疗眼附件皮脂腺癌的疗效观察。
IF 1.3 4区 医学
Ophthalmic Plastic and Reconstructive Surgery Pub Date : 2025-09-09 DOI: 10.1097/IOP.0000000000003053
Andrew J Rong, Matthew Camacho, Sander R Dubovy, Ryan A Gallo, Carol L Karp, Nathan W Blessing
{"title":"Efficacy of Topical Chemotherapy in Ocular Adnexal Sebaceous Carcinoma.","authors":"Andrew J Rong, Matthew Camacho, Sander R Dubovy, Ryan A Gallo, Carol L Karp, Nathan W Blessing","doi":"10.1097/IOP.0000000000003053","DOIUrl":"https://doi.org/10.1097/IOP.0000000000003053","url":null,"abstract":"<p><p>This study aimed to report clinical outcomes of topical chemotherapy for ocular adnexal sebaceous carcinoma (OaSC) with intraepithelial spread. A retrospective chart review of patients with OaSC treated at the Bascom Palmer Eye Institute between 2000 and 2023 was conducted. Patient inclusion criteria included: (1) biopsy-proven diagnosis of OaSC, (2) intraepithelial pagetoid involvement confirmed by conjunctival map biopsy, (3) implementation of topical chemotherapy for tumor control, and (4) repeat conjunctival map biopsy following cessation of topical chemotherapy. We reviewed 120 patients with OaSC and 10 patients met the inclusion criteria (n = 10). Topical chemotherapy agents were utilized via monotherapy or in combination and included mitomycin C (MMC) 0.02% or 0.04% (8 cases), 5-fluorouracil 1% (3 cases), and interferon alpha-2a 1 million units/ml (2 cases). Inadequate control of intraepithelial disease was observed in 8 (8/10, 80%) of cases. Resolution of pagetoid disease was achieved in 2 patients (2/10, 20%) with MMC monotherapy. Seven patients (7/10, 70%) experienced adverse effects from topical chemotherapy, with MMC accounting for 6 cases and 5-fluorouracil accounting for 1 case. Topical chemotherapy was ineffective in controlling the majority of OaSC patients with pagetoid involvement. Both patients who achieved local conjunctival tumor control were treated with MMC for at least 3 total weeks of therapy, although residual disease within the eyelid was still identifiable on pathology following surgical resection. Topical MMC may be used in the neoadjuvant setting for OaSC with pagetoid spread; however, additional studies are needed to determine the optimal dosing and treatment duration to minimize adverse effects and reduce ocular surface comorbidity.</p>","PeriodicalId":19588,"journal":{"name":"Ophthalmic Plastic and Reconstructive Surgery","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic Transorbital Approach for Endovascular Access to the Cavernous Sinus in Carotid-Cavernous Fistula: A Case Report. 经鼻内窥镜经眶入路进入颈动脉-海绵窦瘘的海绵窦:1例报告。
IF 1.3 4区 医学
Ophthalmic Plastic and Reconstructive Surgery Pub Date : 2025-09-09 DOI: 10.1097/IOP.0000000000003062
Lewis Hains, Khizar Rana, Clare Quigley, Abhiram Hiwase, Alistair Dukes, Dinesh Selva
{"title":"Endoscopic Transorbital Approach for Endovascular Access to the Cavernous Sinus in Carotid-Cavernous Fistula: A Case Report.","authors":"Lewis Hains, Khizar Rana, Clare Quigley, Abhiram Hiwase, Alistair Dukes, Dinesh Selva","doi":"10.1097/IOP.0000000000003062","DOIUrl":"https://doi.org/10.1097/IOP.0000000000003062","url":null,"abstract":"<p><p>Carotid-cavernous fistulas (CCF) are indirect or direct vascular shunts between vessels of the cavernous sinus and the carotid artery. While indirect CCFs have high rates of spontaneous resolution, direct CCF cases can result in significant orbital and neurological sequelae. This case describes a 75-year-old male patient presenting with acute subarachnoid hemorrhage secondary to a Barrow type-D CCF. Digital subtraction angiography revealed dual arterial supply of the CCF from both the left and right internal carotid artery. Transvenous access for coiling could not be achieved due to vessel tortuosity. Thus, we used an endoscopic transorbital approach to directly puncture the cavernous sinus through the superior orbital fissure. This approach allowed for direct visualization of the lateral cavernous sinus and enabled endovascular maneuvrability and coiling. There was a reduction but residual flow post CCF coiling due to microcatheter kickback preventing posterior embolization. Persistent CCF necessitated a craniotomy to allow sufficient access for complete obliteration. At 6-week postcoiling, there was resolution of proptosis and full extraocular movements. This approach has been described in cadaveric studies, with our case demonstrating the first application of this technique in vivo for CCF.</p>","PeriodicalId":19588,"journal":{"name":"Ophthalmic Plastic and Reconstructive Surgery","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiation Therapy for Solitary Fibrous Tumor of the Orbit. 眼眶孤立性纤维性肿瘤的放射治疗。
IF 1.3 4区 医学
Ophthalmic Plastic and Reconstructive Surgery Pub Date : 2025-09-09 DOI: 10.1097/IOP.0000000000003023
Agni Kakouri, Kaveh Vahdani, Matthew J Debnam, Ashleigh B Guadagnolo, Geoffrey E Rose, David Verity, Tracy Lu, Bita Esmaeli
{"title":"Radiation Therapy for Solitary Fibrous Tumor of the Orbit.","authors":"Agni Kakouri, Kaveh Vahdani, Matthew J Debnam, Ashleigh B Guadagnolo, Geoffrey E Rose, David Verity, Tracy Lu, Bita Esmaeli","doi":"10.1097/IOP.0000000000003023","DOIUrl":"https://doi.org/10.1097/IOP.0000000000003023","url":null,"abstract":"<p><p>Solitary fibrous tumor, formerly also referred to as hemangiopericytoma, is a fibroblastic mesenchymal neoplasm of the orbit that rarely metastasizes but has a propensity for local recurrence. We describe 5 cases of orbital solitary fibrous tumors that were treated with radiation. In 3 patients, radiation therapy was given in the neoadjuvant setting prior to surgery. In the remaining 2 patients, radiation was used palliatively in patients who declined surgery. In 4 of 5 cases, a measurable reduction in the size of the orbital mass was observed in response to radiation therapy; however, long-term adverse effects of radiation may not yet be evident, given the relatively short follow-up period for some of the patients in this report.</p>","PeriodicalId":19588,"journal":{"name":"Ophthalmic Plastic and Reconstructive Surgery","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Position of Lower Marginal Arterial Arcade in Relation to Lower Tarsal Plate. 下边缘动脉拱廊相对于下跗骨板的位置。
IF 1.3 4区 医学
Ophthalmic Plastic and Reconstructive Surgery Pub Date : 2025-09-09 DOI: 10.1097/IOP.0000000000003055
Hirohiko Kakizaki, Deepak P Edward, Yasuhiro Takahashi
{"title":"Position of Lower Marginal Arterial Arcade in Relation to Lower Tarsal Plate.","authors":"Hirohiko Kakizaki, Deepak P Edward, Yasuhiro Takahashi","doi":"10.1097/IOP.0000000000003055","DOIUrl":"https://doi.org/10.1097/IOP.0000000000003055","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the position of the lower marginal arterial arcade (LMA) along the lower tarsal plate in microscopic specimens, particularly its relationship to anatomical landmarks.</p><p><strong>Methods: </strong>Central sagittal sections of 27 lower eyelids (12 right, 10 left) from 15 Japanese cadavers (8 males, 7 females; aged 38-88 years, mean 70.5 years) were histologically examined. Specimens were fixed in 10% formalin and stained with Masson's trichrome. Measurements included the height of the lower tarsal plate and the distance from the lower tarsal edge and the lower eyelid margin to the LMA. Differences related to age (younger group: 38-61 years; older group: 73-88 years), gender, and laterality were analyzed.</p><p><strong>Results: </strong>Lower tarsal height was significantly greater in females and tended to be larger on the left side. The distance from the lower tarsal edge to the LMA showed no significant differences by age, gender, or laterality. The distance from the lower eyelid margin to the LMA was similar across age and gender groups, but was significantly greater on the left side.</p><p><strong>Conclusion: </strong>The position of the LMA relative to the lower tarsal edge and the lower eyelid margin was established. When the lower edge of the tarsal plate is visible, the LMA is estimated to be approximately 1.5 mm superior; conversely, when the LMA is identified, the eyelid margin can be assumed to be about 3-4 mm superior to the LMA. These findings describe the LMA location and will assist in safe and reliable lower eyelid surgery.</p>","PeriodicalId":19588,"journal":{"name":"Ophthalmic Plastic and Reconstructive Surgery","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Efficacy and Safety of Teprotumumab in Geriatrics Patients: A Multicenter Study. Teprotumumab在老年患者中的疗效和安全性:一项多中心研究。
IF 1.3 4区 医学
Ophthalmic Plastic and Reconstructive Surgery Pub Date : 2025-09-09 DOI: 10.1097/IOP.0000000000003024
Shreya Ashish Shah, Patcharaporn Chandraparnik, Suyoung Choi, Linus Amarikwa, Ridhima Guniganti, Hannah L Walsh, Raul Hernandez Rubio, Taylor Linaburg, Evan Meyer, Karmouta Reem, Connie Sears, Melissa Goldin, Benyam Kinde, Chrysoula Dosiou, Amina Malik, Louise Mawn, Roman Shinder, Sara Wester, Daniel Rootman, Kimberly Cockerham, Madhura Tamhankar, Steven Couch, Andrew Harrison, Andrea Lora Kossler
{"title":"The Efficacy and Safety of Teprotumumab in Geriatrics Patients: A Multicenter Study.","authors":"Shreya Ashish Shah, Patcharaporn Chandraparnik, Suyoung Choi, Linus Amarikwa, Ridhima Guniganti, Hannah L Walsh, Raul Hernandez Rubio, Taylor Linaburg, Evan Meyer, Karmouta Reem, Connie Sears, Melissa Goldin, Benyam Kinde, Chrysoula Dosiou, Amina Malik, Louise Mawn, Roman Shinder, Sara Wester, Daniel Rootman, Kimberly Cockerham, Madhura Tamhankar, Steven Couch, Andrew Harrison, Andrea Lora Kossler","doi":"10.1097/IOP.0000000000003024","DOIUrl":"https://doi.org/10.1097/IOP.0000000000003024","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy and safety of teprotumumab for the treatment of thyroid eye disease in geriatric patients.</p><p><strong>Methods: </strong>This was a multicenter cohort study of patients aged 75 and older, treated between February 2020 and September 2023 across 10 tertiary institutions. Patients were included if they had moderate-to-severe thyroid eye disease and at least 1 infusion of teprotumumab. Efficacy outcome measures included improvement in clinical activity score, proptosis, and Gorman diplopia score. Safety outcome measures included teprotumumab-related adverse event (TAE) incidence, onset, and severity.</p><p><strong>Results: </strong>Fifty patients (40 females, 10 males), average age of 79.2 years, were evaluated. Patients received an average of 6.9 infusions, with 34.0% (17/50) discontinuing treatment due to TAEs. Mean baseline clinical activity score was 4.0 ± 1.6, with a mean reduction of 4.0 ± 1.1. Proptosis improved by ≥2 mm in 86.0% (43/50) of patients, with a mean reduction of 4.24 mm. Of patients with baseline diplopia, 42.9% (18/42) experienced an improvement in Gorman diplopia score. Proptosis regression occurred in 62.5% (15/24) of patients at 2.5 years, and 27.9% (12/43) experienced thyroid eye disease reactivation on average 49.8 weeks posttreatment completion. TAEs were reported by 78.0% (39/50) of patients, with 30% (15/46) experiencing moderate TAEs and 14% (7/50) severe TAEs. The most common TAEs were muscle cramps (42.0%, 21/50), hearing impairment (38.0%, 19/46), and hyperglycemia (36.0%, 18/46).</p><p><strong>Conclusions: </strong>Teprotumumab is effective in reducing clinical activity score and proptosis in geriatric thyroid eye disease patients with short-term follow-up; however, high rates of adverse events, reactivation, and proptosis regression over time warrant extreme caution and selective use in this population.</p>","PeriodicalId":19588,"journal":{"name":"Ophthalmic Plastic and Reconstructive Surgery","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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