Organic Chemistry eJournal最新文献

{"title":"Investigation of Antibacterial Activity Against Staphylococcus Aureus Of Ruthenium(II) Complexes Containing Furan-Substituted Ligands","authors":"Xiangwen Liao, Bin Huang, Guangbin Jiang, Guijuan Jiang, Xiaoli Lin, Yanshi Xiong, X. Duan, Jintao Wang","doi":"10.2139/ssrn.3782143","DOIUrl":"https://doi.org/10.2139/ssrn.3782143","url":null,"abstract":"The growing burden of antibiotic resistance worldwide&nbsp;calls for&nbsp;developing new classes of antimicrobial&nbsp;strategy. Recently years, the use of adjuvants&nbsp;that rescue antibiotics identified as&nbsp;a promising combination strategy for overcoming bacterial resistance. In this study, we designed and synthesized&nbsp;of three&nbsp;ruthenium complexes&nbsp;functionalized with furan-substituted ligands: [Ru(phen)₂(CAPIP)](ClO₄)₂ &nbsp;(<b>Ru(II)-1</b>), [Ru(dmp)₂(CAPIP)](ClO₄)₂ &nbsp;(<b>Ru(II)-2</b>) and [Ru(dmb)₂(CAPIP)](ClO₄)₂ &nbsp;(<b>Ru(II)-3</b>) (dmb=4,4′-dimethyl-2,2′-bipyridine,&nbsp;phen=1,10-phenanthroline,&nbsp;dmp=2,9-dimethyl-1,10-phenanthroline, CAPIP=(E)-2- (2-(furan-2-yl)vinyl)-1H-imidazo[4,5-f][1,10]phenanthroline).&nbsp;Their antimicrobial activities against <i>S. aureus</i>&nbsp;were assessed. All complexes show meaningful activity against <i>Staphylococcus aureus</i> with ranging MIC from 0.018-0.050 mg/mL.&nbsp;Importantly, the <b>Ru(II)-2</b> complexes which posses minimum MIC values was further tested against biofilms and toxin secretion. The results clearly indicated <b>Ru(II)-2</b> could effectively inhibit biofilms formation of <i>S. aureus</i> and inhibit the hemolysin toxin secretion as well. In addition, aimed to test whether ruthenium complexes have potent value as antimicrobial adjuvants, the synergism between <b>Ru(II)-2</b> and common antibiotics against <i>S. aureus</i> were&nbsp;investigated using the checkerboard method. Interesting, <b>Ru(II)-2</b> could selectivity increase the susceptibility of <i>S. aureus</i> to some aminoglycoside antibiotics.&nbsp;Finally, &nbsp;murine skin infection model&nbsp;verified <b>Ru(II)-2</b> were highly effective against <i>S. aureus in vivo</i> . Taken together,&nbsp;ruthenium complexes functionalized with furan-substituted ligands&nbsp;prepared here have good antimicrobial activity <i>in vitro</i> and <i>in vivo</i>.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"96 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78558998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and Characterization of Mustard Stalks Derived Carboxymethyl Cellulose and Poly(L-Lactic Acid) Biocomposites","authors":"Md. Hafezur Rahaman, Mahfuja Rahman, S. Alam, M. Sultana, M. S. Parvez, Asadullah Ahmed","doi":"10.2139/ssrn.3899839","DOIUrl":"https://doi.org/10.2139/ssrn.3899839","url":null,"abstract":"The influences of poly ( L- lactic acid) (PLLA) and carboxymethyl cellulose (CMC) derived from mustard stalks content on the morphological and thermal properties of PLLA/CMC biocomposites were investigated. The yield of CMC from microcrystalline cellulose (MCC) of mustard stalks was about 78%. Biocomposites were prepared using the solution casting method, varying PLLA, and CMC ratio. Prepared samples were characterized using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetric, X-ray diffraction, and scanning electron microscopy. The decomposition temperature of CMC was increased and formed excellent biocomposites with PLLA. Composite crystallinity was varied with the percentages of the CMC. The CMC fibers coated with a layer of PLLA suggested that CMC and PLLA have good compatibility.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87142166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strong Dual-Components Bioadhesive Based on Solventless Thiol-Isocyanate Click Chemistry","authors":"Yifan Zhang, Xiaojie Li, Wei Wei, Xiaoya Liu","doi":"10.2139/ssrn.3765751","DOIUrl":"https://doi.org/10.2139/ssrn.3765751","url":null,"abstract":"Isocyanate is an efficient tissue anchor for engineering of strong bioadhesive. However, isocyanate containing adhesives are seldom manufactured, due to their requirement of water-free administration and time-consuming moisture-induced solidification. To address this issue, herein, a solventless dual-component bioadhesive based on thiol-isocyanate crosslinking chemistry is reported. This dual-component bioadhesive consists of a hyperbranched polymer with thiol groups (HBPTE) and an isocyanate modified polyethylene glycol (PEGNCO). HBPTE and PEGNCO are low-viscosity fluids at room temperature and hence could be used directly as adhesive components, in absence of catalyst and solvent. The thiol-isocyanate click chemistry of components provide HBPTE-PEGNCO mixture with a gelation time of 1.5~3 minutes, which makes it acceptable for practical applications. The abundance of isocyanate groups in the adhesive molecule provides strong bonding strength through formation of chemical linkages with reactive groups on the tissue. Moreover, <i>in vitro</i> and <i>in vivo</i> evaluations in mice showed excellent biocompatibility of HBPTE-PEGNCO adhesive. This dual-component bioadhesive based on solventless thiol-isocyanate click chemistry displayed a fast gelation time and excellent bonding performance, providing a pioneering ideal for engineering isocyanate containing bioadhesive.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85505683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catalytic CO 2 Hydrosilylation with [Mn(CO) 5br] Under Mild Reaction Conditions","authors":"T. González, Juventino J. García","doi":"10.2139/ssrn.3804178","DOIUrl":"https://doi.org/10.2139/ssrn.3804178","url":null,"abstract":"Carbon dioxide hydrosilylation with earth-abundant transition-metal catalysts is an attractive alternative for the design of greener and cost-effective synthetic strategies. Herein, simple [Mn(CO)₅Br] is an efficient precatalyst in the hydrosilylation of carbon dioxide with Et₃SiH under mild reaction conditions. Using THF as a solvent, triethylsilylformate Et₃SiCH(O)O was obtained in 67% yield after 1 hour at 50 °C and 4 bar of CO₂ pressure. The selectivity of the reaction was tuned by changing the solvent to a mixture of THF and toluene producing bis(triethylsilyl)acetal (Et₃SiO)₂CH₂ in 86% yield. The CO₂ hydrosilylation was also effective at room temperature and atmospheric pressure using either THF or the mixture THF/toluene as the solvent resulting in high Et3SiH conversion (92% - 99%) but with a decrease in the selectivity. Radical trapping experiments indicated the participation of radical species in the catalytic mechanism. To the best of our knowledge, this is the first report on CO₂ hydrosilylation catalyzed by transition-metal radical intermediates.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85987444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stable Amperometric Sensor Based on Novel Polymeric Zinc Phthalocyanine Film for the Nanomolar Detection of Ammonia","authors":"Lokesh Koodlur Sannegowda, Keshavananda Prabhu Cp, Dr. Shambhulinga Aralekallu, Manjunatha Palanna, Veeresh A Sajjan, Renuka B","doi":"10.2139/ssrn.3782144","DOIUrl":"https://doi.org/10.2139/ssrn.3782144","url":null,"abstract":"Novel zinc tetra [4-[2-(1H-benzimidazol-2-yl) phenoxy]] phthalocyanine (ZnTBImPc) was prepared in a pure state and good yield. The characterization of the ligands and complex were done by combination of techniques like elemental analysis, UV-Visible, FT-IR, Mass, TGA, XRD and electrochemical techniques. The benzimidazole moiety of ZnTBImPc undergoes electropolymerization and the polymeric layer deposits on glassy carbon surface. The polymeric film interface was characterized and used for the voltammetric sensing of ammonia which showed linear characteristics in 0.1 to 1.0 µM range. The LOD was 0.03 µM with sensitivity of 237.25 µAµM-1cm-2. The efficiency and sensitivity of ammonia oxidation at the poly(ZnTBImPc) was compared with the composite hybrid electrode of poly(ZnTBImPc) and carbon nanoparticle (CNP). The amperometric sensing of ammonia showed linear behaviour in the 0.05 to 0.5 µM range. The RDE experiment revealed that the number of electrons involved in the ammonia oxidation is nearly 3. The polymeric electrode was subjected to the interference studies to evaluate the selectivity of the fabricated electrode and found that the co-existing molecules did not show interference during the detection of ammonia.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"2021 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76603327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper Triazine Polycarboxylic Acid Crystalline Framework Materials：Synthesis, Structure and Multifunctional Properties with the Luminescent and Catalytic Reduction of 4-Np","authors":"Li-yan Wang, Xue Han, Zhan Shi, Y. Xing, Li-Xian Sun","doi":"10.1016/j.poly.2020.114966","DOIUrl":"https://doi.org/10.1016/j.poly.2020.114966","url":null,"abstract":"","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88650550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microcrystalline Cellulose from Groundnut Shell as Potential Adsorbent of Crystal Violet and Methylene Blue. Kinetics, Isotherms and Thermodynamics Studies","authors":"Z. Zango, S. Imam","doi":"10.23939/chcht14.04.563","DOIUrl":"https://doi.org/10.23939/chcht14.04.563","url":null,"abstract":"The isolation of microcrystalline cellulose from a groundnut shell is reported. Adsorption experiments were carried out for the removal of cationic crystal violet and methylene blue and it follows Langmuir model. Positive enthalpy and negative free energy changes have shown endothermic and favorable processes. The results reflect good adsorption process.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89260275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dy-DTPA as Supersensitive Shifting and Relaxational Probe for NMR / MRI Control of Local Temperature","authors":"E. Zapolotsky, S. P. Babailov","doi":"10.1016/j.poly.2020.114908","DOIUrl":"https://doi.org/10.1016/j.poly.2020.114908","url":null,"abstract":"","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88901784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observation of a Potential-Dependent Switch of Water Oxidation Mechanism on Co-Oxide-Based Catalysts","authors":"C. Lang, Jingyi Li, Ke R. Yang, Yuanxing Wang, Da He, James E. Thorne, Seth Croslow, Qi Dong, Yanyan Zhao, Gabriela Prostko, G. Brudvig, V. Batista, M. Waegele, Dunwei Wang","doi":"10.2139/ssrn.3732357","DOIUrl":"https://doi.org/10.2139/ssrn.3732357","url":null,"abstract":"O-O bond formation is a key elementary step of the water oxidation reaction. However, it is still unclear how the mechanism of O-O coupling depends on the applied electrode potential. Herein, using water-in-salt electrolytes, we systematically altered the water activity, which enabled us to probe the O-O bond forming mechanism on heterogeneous Co-based catalysts as a function of applied potential. We discovered that the water oxidation mechanism is sensitive to the applied potential: At relatively low driving force, the reaction proceeds through an intramolecular oxygen coupling mechanism, whereas the water nucleophilic attack mechanism prevails at high driving force. The observed mechanistic switch has major implications for the understanding and control of the water oxidation reaction on heterogeneous catalysts.","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79347859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Technology for Preparing the Thermostable Milk Containing Filling and Study of Infrared Spectra of Its Components","authors":"F. Pertsevoy, O. Koshel, S. Sabadash, M. Mashkin, V. Mohutova, Vadym Volokh","doi":"10.15587/1729-4061.2020.214903","DOIUrl":"https://doi.org/10.15587/1729-4061.2020.214903","url":null,"abstract":"Solving the problem of detecting counterfeiting in confectionery requires appropriate identification methods and is of paramount importance in the list of measures aimed at achieving food safety and quality. The following infrared spectra of the samples were studied in this work: – a model system containing xanthan gum and tare gum; – a model system containing xanthan gum, tare gum, and sugar; – a model system containing xanthan gum, tare gum, skimmed milk powder; – a model system containing xanthan gum, tare gum, maltodextrin. Absorption is characteristic of certain groups of atoms, its intensity is directly proportional to their concentration. Thus, the measurement of the absorption intensity makes it possible to calculate the amount of a given component in the sample. A detailed technological scheme for the production of heat-resistant fillings using gelatin has been developed, which allows obtaining a product with new organoleptic and physical and chemical properties. The novelty of the technological scheme is the use of thermostable fillings of gelatin and the enzyme transglutaminase, and a mixture of gums, in the technology. A special feature in the production of these fillings is the operation of structuring at a temperature of 55±5 °C, which distinguishes it from existing technologies. This paper reports the results of the infrared spectroscopic analysis of fillings, which made it possible to argue about the positive effect of gelatin usage in the technology of confectionery. The developed heat-resistant milk-containing filling has a high biological and nutritional value in comparison with the existing technologies of fillings for confectionery. It has been analyzed that polysaccharides, gelatin, skimmed milk powder, and powdered sugar are rich, first of all, in reactive groups. Therefore, the physical and chemical properties of the fillings will be enhanced (adhesion, moisture-binding forms, etc.)","PeriodicalId":19542,"journal":{"name":"Organic Chemistry eJournal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86928964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}