基于无溶剂硫醇-异氰酸酯化学的强双组分生物粘合剂

Yifan Zhang, Xiaojie Li, Wei Wei, Xiaoya Liu
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引用次数: 0

摘要

异氰酸酯是一种高效的强生物黏合剂工程组织锚。然而,含有异氰酸酯的胶粘剂很少生产,因为它们要求无水给药和耗时的湿致凝固。为了解决这一问题,本文报道了一种基于巯基异氰酸酯交联化学的无溶剂双组分生物粘合剂。这种双组分生物粘合剂由带有巯基的超支化聚合物(HBPTE)和异氰酸酯改性聚乙二醇(PEGNCO)组成。HBPTE和PEGNCO在室温下是低粘度流体,因此可以直接用作粘合剂组分,不需要催化剂和溶剂。组分的巯基异氰酸酯点击化学提供HBPTE-PEGNCO混合物的凝胶时间为1.5~3分钟,这使得它在实际应用中是可以接受的。黏合剂分子中丰富的异氰酸酯基团通过与组织上的反应基团形成化学键,提供了很强的键合强度。此外,HBPTE-PEGNCO胶粘剂的体外和体内实验表明,该胶粘剂具有良好的生物相容性。这种基于无溶剂硫醇-异氰酸酯点击化学的双组分生物粘合剂具有快速的凝胶时间和优异的粘合性能,为工程中含有异氰酸酯的生物粘合剂提供了开创性的理想。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Strong Dual-Components Bioadhesive Based on Solventless Thiol-Isocyanate Click Chemistry
Isocyanate is an efficient tissue anchor for engineering of strong bioadhesive. However, isocyanate containing adhesives are seldom manufactured, due to their requirement of water-free administration and time-consuming moisture-induced solidification. To address this issue, herein, a solventless dual-component bioadhesive based on thiol-isocyanate crosslinking chemistry is reported. This dual-component bioadhesive consists of a hyperbranched polymer with thiol groups (HBPTE) and an isocyanate modified polyethylene glycol (PEGNCO). HBPTE and PEGNCO are low-viscosity fluids at room temperature and hence could be used directly as adhesive components, in absence of catalyst and solvent. The thiol-isocyanate click chemistry of components provide HBPTE-PEGNCO mixture with a gelation time of 1.5~3 minutes, which makes it acceptable for practical applications. The abundance of isocyanate groups in the adhesive molecule provides strong bonding strength through formation of chemical linkages with reactive groups on the tissue. Moreover, in vitro and in vivo evaluations in mice showed excellent biocompatibility of HBPTE-PEGNCO adhesive. This dual-component bioadhesive based on solventless thiol-isocyanate click chemistry displayed a fast gelation time and excellent bonding performance, providing a pioneering ideal for engineering isocyanate containing bioadhesive.
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