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SCREEN: SCatteREr ENabled optical asymmetry. 屏幕:散射启用光学不对称。
IF 8.5 1区 物理与天体物理
Optica Pub Date : 2025-06-20 Epub Date: 2025-05-27 DOI: 10.1364/optica.549587
Yongyi Zhao, Sean M Farrell, Christian R Jacobson, A J Yates, Andrew McClung, Urcan Guler, Naomi J Halas, Peter Nordlander, Ashok Veeraraghavan
{"title":"SCREEN: SCatteREr ENabled optical asymmetry.","authors":"Yongyi Zhao, Sean M Farrell, Christian R Jacobson, A J Yates, Andrew McClung, Urcan Guler, Naomi J Halas, Peter Nordlander, Ashok Veeraraghavan","doi":"10.1364/optica.549587","DOIUrl":"https://doi.org/10.1364/optica.549587","url":null,"abstract":"<p><p>Optics that allow us to see clearly along one viewing direction while obscuring others' view of us are useful in numerous settings, including privacy-preserving window screens and one-way mirrors for psychological studies. Additionally, due to the rise of cameras that are able to see outside the visible spectrum, there is a need for optics that can also provide one-way visibility at these wavelengths. This is particularly challenging for thermal (i.e., infrared) imaging because most existing methods require precise control of scene illumination, which is difficult to achieve in the infrared. To address this challenge, we demonstrate broadband, passive one-way visibility by precisely tuning the position and optical parameters of a single optical scatterer. We show the benefits of our approach in both a simulated and an experimental testbed. With experimental data, we demonstrate a 5.22× and 5.23× improvement in the degree of asymmetry for midwave infrared (MWIR) and visible (VIS) wavelengths, respectively. Ultimately, our method introduces a robust, passive one-way visibility system at midwave infrared (MWIR), which can aid in numerous privacy preservation applications.</p>","PeriodicalId":19515,"journal":{"name":"Optica","volume":"12 6","pages":"753-768"},"PeriodicalIF":8.5,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144963376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational imaging with meta-optics 元光学计算成像
IF 10.4 1区 物理与天体物理
Optica Pub Date : 2025-05-30 DOI: 10.1364/optica.546382
Johannes E. Fröch, Shane Colburn, David J. Brady, Felix Heide, Ashok Veeraraghavan, Arka Majumdar
{"title":"Computational imaging with meta-optics","authors":"Johannes E. Fröch, Shane Colburn, David J. Brady, Felix Heide, Ashok Veeraraghavan, Arka Majumdar","doi":"10.1364/optica.546382","DOIUrl":"https://doi.org/10.1364/optica.546382","url":null,"abstract":"Sub-wavelength diffractive meta-optics have emerged as a versatile platform to manipulate light fields at will, due to their ultra-small form factor and flexible multifunctionalities. However, miniaturization and multimodality are typically compromised by a reduction in imaging performance; thus, meta-optics often yield lower resolution and stronger aberration compared to traditional refractive optics. Concurrently, computational approaches have become popular to improve the image quality of traditional cameras and exceed limitations posed by refractive lenses. This in turn often comes at the expense of higher power and latency, and such systems are typically limited by the availability of certain refractive optics. Limitations in both fields have thus sparked cross-disciplinary efforts to not only overcome these roadblocks but also to go beyond and provide synergistic meta-optical–digital solutions that surpass the potential of the individual components. For instance, an application-specific meta-optical frontend can preprocess the light field of a scene and focus it onto the sensor with a desired encoding, which can either ease the computational load on the digital backend or can intentionally alleviate certain meta-optical aberrations. In this review, we introduce the fundamentals, summarize the development of meta-optical computational imaging, focus on latest advancements that redefine the current state of the art, and give a perspective on research directions that leverage the full potential of sub-wavelength photonic platforms in imaging and sensing applications. The current advancement of meta-optics and recent investments by foundries and technology partners have the potential to provide synergistic future solutions for highly efficient, compact, and low-power imaging systems.","PeriodicalId":19515,"journal":{"name":"Optica","volume":"1 1","pages":"774"},"PeriodicalIF":10.4,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-speed 4D fluorescence light field tomography of whole freely moving organisms. 整个自由活动生物体的高速四维荧光场断层扫描。
IF 8.5 1区 物理与天体物理
Optica Pub Date : 2025-05-20 Epub Date: 2025-05-05 DOI: 10.1364/optica.549707
Kevin C Zhou, Clare Cook, Archan Chakraborty, Jennifer Bagwell, Joakim Jönsson, Kyung Chul Lee, Xi Yang, Shiqi Xu, Ramana Balla, Kushal Kolar, Caitlin Lewis, Mark Harfouche, Donald T Fox, Michel Bagnat, Roarke Horstmeyer
{"title":"High-speed 4D fluorescence light field tomography of whole freely moving organisms.","authors":"Kevin C Zhou, Clare Cook, Archan Chakraborty, Jennifer Bagwell, Joakim Jönsson, Kyung Chul Lee, Xi Yang, Shiqi Xu, Ramana Balla, Kushal Kolar, Caitlin Lewis, Mark Harfouche, Donald T Fox, Michel Bagnat, Roarke Horstmeyer","doi":"10.1364/optica.549707","DOIUrl":"10.1364/optica.549707","url":null,"abstract":"<p><p>Volumetric fluorescence imaging techniques, such as confocal, multiphoton, light sheet, and light field microscopy, have become indispensable tools across a wide range of cellular, developmental, and neurobiological applications. However, it is difficult to scale such techniques to the large 3D fields of view (FOV), volume rates, and synchronicity requirements for high-resolution 4D imaging of freely behaving organisms. Here, we present reflective Fourier light field computed tomography (ReFLeCT), a high-speed volumetric fluorescence computational imaging technique. ReFLeCT synchronously captures entire tomograms of multiple unrestrained, unanesthetized model organisms across multi-millimeter 3D FOVs at 120 volumes per second. In particular, we applied ReFLeCT to reconstruct 4D videos of fluorescently labeled zebrafish and <i>Drosophila</i> larvae, enabling us to study their heartbeat, fin and tail motion, gaze, jaw motion, and muscle contractions with nearly isotropic 3D resolution while they are freely moving. To our knowledge, as a novel approach for snapshot tomographic capture, ReFLeCT is a major advance toward bridging the gap between current volumetric fluorescence microscopy techniques and macroscopic behavioral imaging.</p>","PeriodicalId":19515,"journal":{"name":"Optica","volume":"12 5","pages":"674-684"},"PeriodicalIF":8.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wide-field bond-selective fluorescence imaging: from single-molecule to cellular imaging beyond video rate. 宽视场键选择荧光成像:从单分子到超越视频速率的细胞成像。
IF 8.5 1区 物理与天体物理
Optica Pub Date : 2025-02-20 Epub Date: 2025-01-31 DOI: 10.1364/optica.545195
Dongkwan Lee, Haomin Wang, Philip A Kocheril, Xiaotian Bi, Noor Naji, Lu Wei
{"title":"Wide-field bond-selective fluorescence imaging: from single-molecule to cellular imaging beyond video rate.","authors":"Dongkwan Lee, Haomin Wang, Philip A Kocheril, Xiaotian Bi, Noor Naji, Lu Wei","doi":"10.1364/optica.545195","DOIUrl":"10.1364/optica.545195","url":null,"abstract":"<p><p>Wide-field (WF) imaging is pivotal for observing dynamic biological events. While WF chemical microscopy offers high molecular specificity, it lacks the sensitivity for single-molecule detection. In contrast, WF fluorescence microscopy provides live-cell dynamic mapping but fails to leverage the rich chemical information necessary for functional interpretations. To address these limitations, we introduce Wide-Field Bond-selective Fluorescence-detected Infrared-Excited (WF-BonFIRE) spectro-microscopy. This technique combines rationally optimized imaging speed and field-of-view (FOV) to achieve single-molecule sensitivity with bond-selective contrast. We demonstrate WF-BonFIRE's capabilities in imaging single molecules, cells, astrocytes, and live neurons, capturing single FOVs up to 50 μm × 50 μm, with further expansion via multi-FOV mosaicking. Additionally, we have implemented a new temporal-delay modulation scheme that allows real-time kilohertz WF-BonFIRE imaging with speeds up to 1500 Hz. We showcase the millisecond temporal resolution through monitoring the random motion of live Escherichia coli. Leveraging its ability to distinguish molecules through distinct narrow-band BonFIRE signals, we further demonstrate multicolor real-time <i>E. coli</i> tracking. WF-BonFIRE should significantly broaden the boundary for chemical imaging, enabling high-speed observations at unparalleled sensitivity levels.</p>","PeriodicalId":19515,"journal":{"name":"Optica","volume":"12 2","pages":"148-157"},"PeriodicalIF":8.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced biochemical sensing with high-Q transmission resonances in free-standing membrane metasurfaces. 独立膜超表面的高q透射共振增强生化传感。
IF 8.4 1区 物理与天体物理
Optica Pub Date : 2025-02-20 Epub Date: 2025-02-05 DOI: 10.1364/optica.549393
Samir Rosas, Wihan Adi, Aidana Beisenova, Shovasis Kumar Biswas, Furkan Kuruoglu, Hongyan Mei, Mikhail A Kats, David A Czaplewski, Yuri S Kivshar, Filiz Yesilkoy
{"title":"Enhanced biochemical sensing with high-Q transmission resonances in free-standing membrane metasurfaces.","authors":"Samir Rosas, Wihan Adi, Aidana Beisenova, Shovasis Kumar Biswas, Furkan Kuruoglu, Hongyan Mei, Mikhail A Kats, David A Czaplewski, Yuri S Kivshar, Filiz Yesilkoy","doi":"10.1364/optica.549393","DOIUrl":"https://doi.org/10.1364/optica.549393","url":null,"abstract":"<p><p>Optical metasurfaces provide novel solutions to label-free biochemical sensing by localizing light resonantly beyond the diffraction limit, thereby selectively enhancing light-matter interactions for improved analytical performance. However, high-Q resonances in metasurfaces are usually achieved in the reflection mode, which impedes metasurface integration into compact imaging systems. Here, we demonstrate a novel metasurface platform for advanced biochemical sensing based on the physics of the bound states in the continuum (BIC) and electromagnetically induced transparency (EIT) modes, which arise when two interfering resonances from a periodic pattern of tilted elliptic holes overlap both spectrally and spatially, creating a narrow transparency window in the mid-infrared spectrum. We experimentally measure these resonant peaks observed in transmission mode (Q~734 @ <i>λ</i>~8.8 μ<i>m</i>) in free-standing silicon membranes and confirm their tunability through geometric scaling. We also demonstrate the strong coupling of the BIC-EIT modes with a thinly coated PMMA film on the metasurface, characterized by a large Rabi splitting (32 cm<sup>-1</sup>) and biosensing of protein monolayers in transmission mode. Our new photonic platform can facilitate the integration of metasurface biochemical sensors into compact and monolithic optical systems while being compatible with scalable manufacturing, thereby clearing the way for on-site biochemical sensing in everyday applications.</p>","PeriodicalId":19515,"journal":{"name":"Optica","volume":"12 2","pages":"178-189"},"PeriodicalIF":8.4,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11999634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Celebrating the Tenth Anniversary of Optica: editorial 庆祝Optica成立十周年:社论
IF 10.4 1区 物理与天体物理
Optica Pub Date : 2024-12-17 DOI: 10.1364/optica.553433
Prem Kumar
{"title":"Celebrating the Tenth Anniversary of Optica: editorial","authors":"Prem Kumar","doi":"10.1364/optica.553433","DOIUrl":"https://doi.org/10.1364/optica.553433","url":null,"abstract":"<jats:italic toggle=\"yes\">Optica</jats:italic> Editor-in-Chief Prem Kumar reviews the first ten years of the Journal.","PeriodicalId":19515,"journal":{"name":"Optica","volume":"20 1","pages":""},"PeriodicalIF":10.4,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hybrid dark-field and attenuation contrast retrieval for laboratory-based X-ray tomography. 基于实验室的x射线断层成像的混合暗场和衰减对比度检索。
IF 8.4 1区 物理与天体物理
Optica Pub Date : 2024-11-25 eCollection Date: 2024-12-20 DOI: 10.1364/OPTICA.525760
Adam Doherty, Ian Buchanan, Oriol Roche I Morgó, Alberto Astolfo, Savvas Savvidis, Mattia F M Gerli, Antonio Citro, Alessandro Olivo, Marco Endrizzi
{"title":"Hybrid dark-field and attenuation contrast retrieval for laboratory-based X-ray tomography.","authors":"Adam Doherty, Ian Buchanan, Oriol Roche I Morgó, Alberto Astolfo, Savvas Savvidis, Mattia F M Gerli, Antonio Citro, Alessandro Olivo, Marco Endrizzi","doi":"10.1364/OPTICA.525760","DOIUrl":"10.1364/OPTICA.525760","url":null,"abstract":"<p><p>X-ray dark-field imaging highlights sample structures through contrast generated by sub-resolution features within the inspected volume. Quantifying dark-field signals generally involves multiple exposures for phase retrieval, separating contributions from scattering, refraction, and attenuation. Here, we introduce an approach for non-interferometric X-ray dark-field imaging that presents a single-parameter representation of the sample. This fuses attenuation and dark-field signals, enabling the reconstruction of a unified three-dimensional volume. Notably, our method can obtain dark-field contrast from a single exposure and employs conventional back projection algorithms for reconstruction. Our approach is based on the assumption of a macroscopically homogeneous material, which we validate through experiments on phantoms and on biological tissue samples. The methodology is implemented on a laboratory-based, rotating anode X-ray tube system without the need for coherent radiation or a high-resolution detector. Utilizing this system with streamlined data acquisition enables expedited scanning while maximizing dose efficiency. These attributes are crucial in time- and dose-sensitive medical imaging applications and unlock the ability of dark-field contrast with high-throughput lab-based tomography. We believe that the proposed approach can be extended across X-ray dark-field imaging implementations beyond tomography, spanning fast radiography, directional dark-field imaging, and compatibility with pulsed X-ray sources.</p>","PeriodicalId":19515,"journal":{"name":"Optica","volume":"11 12","pages":"1603-1613"},"PeriodicalIF":8.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11674740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated chirped photonic-crystal cavities in gallium phosphide for broadband soliton generation 用于产生宽带孤子的磷化镓集成啁啾光子晶体空腔
IF 10.4 1区 物理与天体物理
Optica Pub Date : 2024-10-16 DOI: 10.1364/optica.530247
Alberto Nardi, Alisa Davydova, Nikolai Kuznetsov, Miles H. Anderson, Charles Möhl, Johann Riemensberger, Tobias J. Kippenberg, Paul Seidler
{"title":"Integrated chirped photonic-crystal cavities in gallium phosphide for broadband soliton generation","authors":"Alberto Nardi, Alisa Davydova, Nikolai Kuznetsov, Miles H. Anderson, Charles Möhl, Johann Riemensberger, Tobias J. Kippenberg, Paul Seidler","doi":"10.1364/optica.530247","DOIUrl":"https://doi.org/10.1364/optica.530247","url":null,"abstract":"Chirped mirrors have underpinned advances in ultra-fast lasers based on bulk optics but have yet to be fully exploited in integrated photonics, where they could provide a means to engineer otherwise unattainable dispersion profiles for a range of nonlinear optical applications, including soliton frequency comb generation. The vast majority of integrated resonators for frequency combs make use of microring geometries, in which only waveguide width and height are varied to engineer dispersion. Here, we present an integrated photonic-crystal Fabry–Pérot resonator made of gallium phosphide (GaP), a material exhibiting a Kerr nonlinearity 200 times larger than that of silicon nitride and a high refractive index that permits the creation of strongly chirped photonic-crystal mirrors. Leveraging the additional degrees of freedom provided by integrated chirped mirrors, we disentangle optical losses from dispersion. We obtain an overall dispersion that is more anomalous than that achievable in both silicon nitride and gallium phosphide ring resonators with the same free-spectral range (FSR), while simultaneously obtaining higher quality factors than those of GaP ring resonators. With subharmonic pulsed pumping at an average power of 23.6 mW, we are able to access stable dissipative Kerr frequency combs in a device with a FSR of 55.9 GHz. We demonstrate soliton formation with a 3-dB bandwidth of 3.0 THz, corresponding to a pulse duration of 60 fs. This approach to cavity design based on photonic-crystal reflectors offers nearly arbitrary dispersion engineering over the optical transparency window of the nonlinear material.","PeriodicalId":19515,"journal":{"name":"Optica","volume":"22 1","pages":""},"PeriodicalIF":10.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photonic and electrochemical biosensors for near-patient tests-a critical comparison. 近病人试验的光子和电化学生物传感器——一个关键的比较。
IF 8.4 1区 物理与天体物理
Optica Pub Date : 2024-10-04 eCollection Date: 2024-10-20 DOI: 10.1364/OPTICA.530068
Thomas F Krauss, Lisa Miller, Christoph Wälti, Steven Johnson
{"title":"Photonic and electrochemical biosensors for near-patient tests-a critical comparison.","authors":"Thomas F Krauss, Lisa Miller, Christoph Wälti, Steven Johnson","doi":"10.1364/OPTICA.530068","DOIUrl":"10.1364/OPTICA.530068","url":null,"abstract":"<p><p>Research into diagnostic biosensors is a vibrant field that combines scientific challenge with translational opportunities; innovation in healthcare is of great societal interest and is an essential element of future healthcare provision. Photonic and electrochemical biosensors are the dominant modalities, both scientifically and commercially, yet the two scientific communities largely remain separated and siloed. It seems astute to better understand what the two fields can learn from one another so as to progress the key scientific, translational, and commercial challenges. Here, we provide an analysis of the fundamental operational characteristics of photonic and electrochemical biosensors using a classification based on energy transfer; in photonics, this separates refractive index sensors from fluorescence and vibrational spectroscopy, while in electrochemistry, it distinguishes Faradaic from non-Faradaic processes. This classification allows us to understand some of the key performance characteristics, such as the susceptibility to fouling and dependence on the clinical matrix that is being analyzed. We discuss the use of labels and the ultimate performance limits, and some of the unique advantages of photonics, such as multicolor operation and fingerprinting, and critically evaluate the requirements for translation of these technologies for clinical use. We trust that this critical review will inform future research in biosensors and support both scientific and commercial developments.</p>","PeriodicalId":19515,"journal":{"name":"Optica","volume":"11 10","pages":"1408-1418"},"PeriodicalIF":8.4,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asynchronous, semi-reverberant elastography. 异步,半混响弹性成像。
IF 8.4 1区 物理与天体物理
Optica Pub Date : 2024-09-20 Epub Date: 2024-09-10 DOI: 10.1364/optica.528507
Ginger Schmidt, Brett E Bouma, Néstor Uribe-Patarroyo
{"title":"Asynchronous, semi-reverberant elastography.","authors":"Ginger Schmidt, Brett E Bouma, Néstor Uribe-Patarroyo","doi":"10.1364/optica.528507","DOIUrl":"10.1364/optica.528507","url":null,"abstract":"<p><p>Optical coherence elastography measures elasticity-a property correlated with pathologies such as tumors due to fibrosis, atherosclerosis due to heterogeneous plaque composition, and ocular diseases such as keratoconus and glaucoma. Wave-based elastography, including reverberant elastography, leverages the properties of shear waves traveling through tissue primarily to infer shear modulus. These methods have already seen significant development over the past decade. However, existing implementations in OCT require robust synchronization of shear wave excitation with imaging, complicating widespread clinical adoption. We present a method for complete recovery of the harmonic shear wave field in an asynchronous, conventional frame-rate, raster-scanning OCT system by modeling raster-scanning as an amplitude modulation of the displacement field. This technique recovers the entire spatially and temporally coherent complex valued shear wave field from just two B-scans, while reducing the time scale for sensitivity to motion from minutes to tens of milliseconds. To the best of our knowledge, this work represents the first successful demonstration of reverberant elastography on a human subject <i>in vivo</i> with a conventional frame-rate, raster-scanning OCT system, greatly expanding opportunity for widespread translation.</p>","PeriodicalId":19515,"journal":{"name":"Optica","volume":"11 9","pages":"1285-1294"},"PeriodicalIF":8.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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