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Comprehensive transcriptomic profiling of liver cancer identifies that histone and PTEN are major regulators of SCU‑induced antitumor activity. 肝癌的全面转录组分析表明，组蛋白和 PTEN 是 SCU 诱导抗肿瘤活性的主要调节因子。
IF 2.5 4区 医学
Oncology Letters Pub Date : 2024-01-11 eCollection Date: 2024-03-01 DOI: 10.3892/ol.2024.14227
Sang Eun Ha, Anjugam Paramanantham, Hun Hwan Kim, Pritam Bhagwan Bhosale, Min Yeong Park, Abuyaseer Abusaliya, Jeong Doo Heo, Won Sup Lee, Gon Sup Kim
{"title":"Comprehensive transcriptomic profiling of liver cancer identifies that histone and PTEN are major regulators of SCU‑induced antitumor activity.","authors":"Sang Eun Ha, Anjugam Paramanantham, Hun Hwan Kim, Pritam Bhagwan Bhosale, Min Yeong Park, Abuyaseer Abusaliya, Jeong Doo Heo, Won Sup Lee, Gon Sup Kim","doi":"10.3892/ol.2024.14227","DOIUrl":"10.3892/ol.2024.14227","url":null,"abstract":"<p><p>Worldwide, liver cancer is the most frequent fatal malignancy. Liver cancer prognosis is poor because patients frequently receive advanced-stage diagnoses. The current study aimed to establish the potential pharmacological targets and the biological networks of scutellarein (SCU) in liver cancer, a natural product known to have low toxicity and side effects. To identify the differentially expressed genes between SCU-treated and SCU-untreated HepG2 cells, RNA sequencing (RNA-seq) was carried out. A total of 463 genes were revealed to have differential expression, of which 288 were upregulated and 175 were downregulated in the group that had received SCU treatment compared with a control group. Gene Ontology (GO) enrichment analysis of associated biological process terms revealed they were mostly involved in the regulation of protein heterodimerization activity and nucleosomes. Interaction of protein-protein network analysis using Search Tool for the Retrieval of Interacting Genes/Proteins resulted in two crucial interacting hub targets; namely, histone H1-4 and protein tyrosine phosphatase receptor type C. Additionally, the crucial targets were validated using western blotting. Overall, the present study demonstrated that the use of RNA-seq data, with bioinformatics tools, can provide a valuable resource to identify the pharmacological targets that could have important biological roles in liver cancer.</p>","PeriodicalId":19503,"journal":{"name":"Oncology Letters","volume":"27 3","pages":"94"},"PeriodicalIF":2.5,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10823307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139576105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Corrigendum] Resveratrol reverses P‑glycoprotein‑mediated multidrug resistance of U2OS/ADR cells by suppressing the activation of the NF‑κB and p38 MAPK signaling pathways [更正]白藜芦醇通过抑制NF-κB和p38 MAPK信号通路的激活，逆转P-糖蛋白介导的U2OS/ADR细胞的多药耐药性
IF 2.9 4区 医学
Oncology Letters Pub Date : 2024-01-10 DOI: 10.3892/ol.2024.14225
Rui Zhang, Ming Lu, Zhen Zhang, Xiliang Tian, Shouyu Wang, Decheng Lv
{"title":"[Corrigendum] Resveratrol reverses P‑glycoprotein‑mediated multidrug resistance of U2OS/ADR cells by suppressing the activation of the NF‑κB and p38 MAPK signaling pathways","authors":"Rui Zhang, Ming Lu, Zhen Zhang, Xiliang Tian, Shouyu Wang, Decheng Lv","doi":"10.3892/ol.2024.14225","DOIUrl":"https://doi.org/10.3892/ol.2024.14225","url":null,"abstract":"","PeriodicalId":19503,"journal":{"name":"Oncology Letters","volume":"3 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combination treatment with paclitaxel, carboplatin and cetuximab in maxillary sinus cancer: A case report 紫杉醇、卡铂和西妥昔单抗联合治疗上颌窦癌：病例报告
IF 2.9 4区 医学
Oncology Letters Pub Date : 2024-01-10 DOI: 10.3892/ol.2024.14226
Masahiro Morimoto, Masashi Takano, Takehiko Sato, Shujiroh Makino
{"title":"Combination treatment with paclitaxel, carboplatin and cetuximab in maxillary sinus cancer: A case report","authors":"Masahiro Morimoto, Masashi Takano, Takehiko Sato, Shujiroh Makino","doi":"10.3892/ol.2024.14226","DOIUrl":"https://doi.org/10.3892/ol.2024.14226","url":null,"abstract":"","PeriodicalId":19503,"journal":{"name":"Oncology Letters","volume":"87 21","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139440512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Negative impact of sarcopenia on survival in elderly patients with colorectal cancer receiving surgery: A propensity‑score matched analysis 肌肉疏松症对接受手术的老年结直肠癌患者生存期的负面影响：倾向分数匹配分析
IF 2.9 4区 医学
Oncology Letters Pub Date : 2024-01-08 DOI: 10.3892/ol.2024.14224
Takeshi Nishikawa, Tetsuro Taira, Nao Kakizawa, Riki Ohno, Toshiya Nagasaki
{"title":"Negative impact of sarcopenia on survival in elderly patients with colorectal cancer receiving surgery: A propensity‑score matched analysis","authors":"Takeshi Nishikawa, Tetsuro Taira, Nao Kakizawa, Riki Ohno, Toshiya Nagasaki","doi":"10.3892/ol.2024.14224","DOIUrl":"https://doi.org/10.3892/ol.2024.14224","url":null,"abstract":"","PeriodicalId":19503,"journal":{"name":"Oncology Letters","volume":"44 19","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139447919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promoter DNA methylation patterns in oral, laryngeal and oropharyngeal anatomical regions are associated with tumor differentiation, nodal involvement and survival 口腔、喉和口咽解剖区域的启动子 DNA 甲基化模式与肿瘤分化、结节受累和存活率有关
IF 2.9 4区 医学
Oncology Letters Pub Date : 2024-01-08 DOI: 10.3892/ol.2024.14223
B. Rivera-Peña, Oluwasina Folawiyo, Nitesh Turaga, R. Rodríguez-Benítez, Marco E. Felici, Jaime A Aponte-Ortiz, Francesca Pirini, Sebastian Rodriguez-Torres, R. Vázquez, Ricardo López, D. Sidransky, Rafael Guerrero-Preston, Adriana Báez
{"title":"Promoter DNA methylation patterns in oral, laryngeal and oropharyngeal anatomical regions are associated with tumor differentiation, nodal involvement and survival","authors":"B. Rivera-Peña, Oluwasina Folawiyo, Nitesh Turaga, R. Rodríguez-Benítez, Marco E. Felici, Jaime A Aponte-Ortiz, Francesca Pirini, Sebastian Rodriguez-Torres, R. Vázquez, Ricardo López, D. Sidransky, Rafael Guerrero-Preston, Adriana Báez","doi":"10.3892/ol.2024.14223","DOIUrl":"https://doi.org/10.3892/ol.2024.14223","url":null,"abstract":"","PeriodicalId":19503,"journal":{"name":"Oncology Letters","volume":"26 11","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139446915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare axillary cancer of unknown primary originating from the breast of a 64‑year‑old male patient: A case report and literature review 一名 64 岁男性患者的乳房中发现了原发灶不明的罕见腋窝癌：病例报告和文献综述
IF 2.9 4区 医学
Oncology Letters Pub Date : 2024-01-05 DOI: 10.3892/ol.2024.14220
S. Parisi, C. Gambardella, Roberto Ruggiero, Salvatore Tolone, Francesco Iovino, F. Lucido, Francesca Fisone, Mariachiara Volpe, Giovanni Cozzolino, F. Mongardini, L. Brusciano, Ronchi Andrea, L. Docimo
{"title":"Rare axillary cancer of unknown primary originating from the breast of a 64‑year‑old male patient: A case report and literature review","authors":"S. Parisi, C. Gambardella, Roberto Ruggiero, Salvatore Tolone, Francesco Iovino, F. Lucido, Francesca Fisone, Mariachiara Volpe, Giovanni Cozzolino, F. Mongardini, L. Brusciano, Ronchi Andrea, L. Docimo","doi":"10.3892/ol.2024.14220","DOIUrl":"https://doi.org/10.3892/ol.2024.14220","url":null,"abstract":"","PeriodicalId":19503,"journal":{"name":"Oncology Letters","volume":"48 47","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139382118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cross‑talk between lymphangiogenesis and malignant melanoma cells: New opinions on tumour drainage and immunization (Review) 淋巴管生成与恶性黑色素瘤细胞之间的交叉对话：关于肿瘤引流和免疫的新观点（综述）
IF 2.9 4区 医学
Oncology Letters Pub Date : 2024-01-05 DOI: 10.3892/ol.2024.14215
Wei Ju, Hong-Hua Cai, Wei Zheng, De-Ming Li, Wei Zhang, Xi-Hu Yang, Zhi-Xin Yan
{"title":"Cross‑talk between lymphangiogenesis and malignant melanoma cells: New opinions on tumour drainage and immunization (Review)","authors":"Wei Ju, Hong-Hua Cai, Wei Zheng, De-Ming Li, Wei Zhang, Xi-Hu Yang, Zhi-Xin Yan","doi":"10.3892/ol.2024.14215","DOIUrl":"https://doi.org/10.3892/ol.2024.14215","url":null,"abstract":"","PeriodicalId":19503,"journal":{"name":"Oncology Letters","volume":"47 18","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139384297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut microbiota influences the efficiency of immune checkpoint inhibitors by modulating the immune system (Review) 肠道微生物群通过调节免疫系统影响免疫检查点抑制剂的效率（综述）
IF 2.9 4区 医学
Oncology Letters Pub Date : 2024-01-05 DOI: 10.3892/ol.2024.14221
Haihong Jiang, Qinlu Zhang
{"title":"Gut microbiota influences the efficiency of immune checkpoint inhibitors by modulating the immune system (Review)","authors":"Haihong Jiang, Qinlu Zhang","doi":"10.3892/ol.2024.14221","DOIUrl":"https://doi.org/10.3892/ol.2024.14221","url":null,"abstract":"","PeriodicalId":19503,"journal":{"name":"Oncology Letters","volume":"100 7","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139383623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification and validation of prognostic genes and immune landscape signatures based on a fatty acid oxidation‑related risk score model in glioma 基于脂肪酸氧化相关风险评分模型的胶质瘤预后基因和免疫景观特征的鉴定与验证
IF 2.9 4区 医学
Oncology Letters Pub Date : 2024-01-05 DOI: 10.3892/ol.2024.14222
Fangzhou Guo, Guoyuan Ling, Zhenzhu Zhai, Yi Lei, Ligen Mo, Haozhe Piao
{"title":"Identification and validation of prognostic genes and immune landscape signatures based on a fatty acid oxidation‑related risk score model in glioma","authors":"Fangzhou Guo, Guoyuan Ling, Zhenzhu Zhai, Yi Lei, Ligen Mo, Haozhe Piao","doi":"10.3892/ol.2024.14222","DOIUrl":"https://doi.org/10.3892/ol.2024.14222","url":null,"abstract":"","PeriodicalId":19503,"journal":{"name":"Oncology Letters","volume":"22 2","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139382037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heparanase inhibitor OGT 2115 induces prostate cancer cell apoptosis via the downregulation of MCL‑1 肝素酶抑制剂 OGT 2115 通过下调 MCL-1 诱导前列腺癌细胞凋亡
IF 2.9 4区 医学
Oncology Letters Pub Date : 2024-01-05 DOI: 10.3892/ol.2024.14217
Xin Li, Shuai-Jun Xu, Bin Jin, Hong-Sheng Lu, Shan-Kun Zhao, Xiao-Fei Ding, Ling-Long Xu, Hai-Jun Li, Shuang-Chun Liu, Jie Chen, Guang Chen
{"title":"Heparanase inhibitor OGT 2115 induces prostate cancer cell apoptosis via the downregulation of MCL‑1","authors":"Xin Li, Shuai-Jun Xu, Bin Jin, Hong-Sheng Lu, Shan-Kun Zhao, Xiao-Fei Ding, Ling-Long Xu, Hai-Jun Li, Shuang-Chun Liu, Jie Chen, Guang Chen","doi":"10.3892/ol.2024.14217","DOIUrl":"https://doi.org/10.3892/ol.2024.14217","url":null,"abstract":"","PeriodicalId":19503,"journal":{"name":"Oncology Letters","volume":"12 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139383326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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