Oncotarget最新文献_第5页

Retraction: In vivo and in vitro effects of microRNA-27a on proliferation, migration and invasion of breast cancer cells through targeting of SFRP1 gene via Wnt/β-catenin signaling pathway. 撤回：microRNA-27a通过Wnt/β-catenin信号通路靶向SFRP1基因对乳腺癌细胞增殖、迁移和侵袭的体内和体外影响

Oncotarget Pub Date : 2024-08-14 DOI: 10.18632/oncotarget.28616

Ling-Yu Kong, Mei Xue, Qing-Cai Zhang, Chuan-Fu Su

引用次数: 0

The gut barrier as a gatekeeper in colorectal cancer treatment. 肠道屏障是结直肠癌治疗的守门员。

Oncotarget Pub Date : 2024-08-14 DOI: 10.18632/oncotarget.28634

Roy Hajjar, Carole Richard, Manuela M Santos

引用次数: 0

Retraction: IGF-1 induces the epithelial-mesenchymal transition via Stat5 in hepatocellular carcinoma. 撤回：IGF-1通过Stat5诱导肝细胞癌的上皮-间质转化

Oncotarget Pub Date : 2024-08-05 DOI: 10.18632/oncotarget.28573

Chuanzong Zhao, Qian Wang, Ben Wang, Qi Sun, Zhaobin He, Jianguo Hong, Florian Kuehn, Enyu Liu, Zongli Zhang

引用次数: 0

Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival. 肿瘤居民、T 细胞受体 CDR3 和肾酶-1 的化学互补性与黑色素瘤存活率的提高有关。

Oncotarget Pub Date : 2024-08-05 DOI: 10.18632/oncotarget.28633

Saif Zaman, Fred S Gorelick, Andrea Chrobrutskiy, Boris I Chobrutskiy, Gary V Desir, George Blanck

{"title":"Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival.","authors":"Saif Zaman, Fred S Gorelick, Andrea Chrobrutskiy, Boris I Chobrutskiy, Gary V Desir, George Blanck","doi":"10.18632/oncotarget.28633","DOIUrl":"10.18632/oncotarget.28633","url":null,"abstract":"Overexpression of the secretory protein renalase-1 negatively impacts the survival of melanoma and pancreatic cancer patients, while inhibition of renalase-1 signaling drives tumor rejection by promoting T-cell activation. Thus, we investigated the chemical complementarity between melanoma-resident, T-cell receptor (TCR) complementarity-determining region 3 (CDR3) amino acid sequences (AAs) and the renalase-1 protein. Increasing complementarity of TCR CDR3s to renalase-1 AAs, as assessed by a chemical complementarity scoring algorithm, was associated with improved overall survival (OS) in melanoma patients. The expression levels of several immune signature genes were significantly, positively correlated with increasing TCR CDR3-renalase-1 complementarity scores. Additionally, the survival association observed with high complementarity of TCR CDR3s to renalase-1 AAs was more robust in cases with low renalase-1 gene expression levels. Mapping of TCR CDR3-renalase-1 in silico interaction sites identified major epitope candidates including RP220, the signaling module of the renalase-1 protein, consistent with the fact that a monoclonal antibody to RP220 is a potent inhibitor of melanoma growth. These findings indicate that renalase-1 is a potential antigen for TCR recognition in melanoma and could be considered as a target for immunotherapy.","PeriodicalId":19499,"journal":{"name":"Oncotarget","volume":"15 ","pages":"550-561"},"PeriodicalIF":0.0,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction: CUL4B promotes bladder cancer metastasis and induces epithelial-to-mesenchymal transition by activating the Wnt/β-catenin signaling pathway. 撤回：CUL4B通过激活Wnt/β-catenin信号通路促进膀胱癌转移并诱导上皮细胞向间质转化。

Oncotarget Pub Date : 2024-08-05 DOI: 10.18632/oncotarget.28407

Xia-Wa Mao, Jia-Quan Xiao, Gang Xu, Zhong-Yi Li, Hui-Feng Wu, Yi Li, Yi-Chun Zheng, Nan Zhang

引用次数: 0

Retraction: Berberine and cinnamaldehyde together prevent lung carcinogenesis. 撤回：小檗碱和肉桂醛共同防止肺癌发生

Oncotarget Pub Date : 2024-08-05 DOI: 10.18632/oncotarget.28577

Mingjing Meng, Shengnan Geng, Zhenhua Du, Jingjing Yao, Yaqiu Zheng, Zibo Li, Zhenzhen Zhang, Jiahuan Li, Yongjian Duan, Gangjun Du

引用次数: 0

Next-generation vaccines are showing promise against glioblastoma. 下一代疫苗有望对抗胶质母细胞瘤。

Oncotarget Pub Date : 2024-08-05 DOI: 10.18632/oncotarget.28636

Robert O Dillman, Daniela A Bota

引用次数: 0

Targeting WNT5B and WNT10B in osteosarcoma. 靶向治疗骨肉瘤中的 WNT5B 和 WNT10B。

Oncotarget Pub Date : 2024-08-02 DOI: 10.18632/oncotarget.28617

Gustavo A Miranda-Carboni, Susan A Krum

引用次数: 0

Beyond pixels: Graph filtration learning unveils new dimensions in hepatocellular carcinoma imaging. 超越像素：图形过滤学习揭示肝癌成像的新维度。

Oncotarget Pub Date : 2024-07-24 DOI: 10.18632/oncotarget.28635

Yashbir Singh

引用次数: 0

Prevalence and impact of the KIT M541L variant in patients with mastocytosis. 肥大细胞增多症患者中 KIT M541L 变异的患病率和影响。

Oncotarget Pub Date : 2024-07-22 DOI: 10.18632/oncotarget.28614

Luisa N Dominguez Aldama, Eric Karlins, Xiaoping Sun, Daniel Veltri, Hirsh D Komarow, Irina Maric, Dean D Metcalfe, Melody C Carter

{"title":"Prevalence and impact of the KIT M541L variant in patients with mastocytosis.","authors":"Luisa N Dominguez Aldama, Eric Karlins, Xiaoping Sun, Daniel Veltri, Hirsh D Komarow, Irina Maric, Dean D Metcalfe, Melody C Carter","doi":"10.18632/oncotarget.28614","DOIUrl":"10.18632/oncotarget.28614","url":null,"abstract":"Activating mutations in KIT, particularly D816V, have been associated with mastocytosis. Additionally, expression of heterozygous KIT M541L has been primarily reported in patients with pediatric mastocytosis. We thus examined the prevalence of this variant in pediatric and adult patients with mastocytosis (n = 100) compared to ancestry-matched 1000 genomes controls (n = 500) and patients with idiopathic anaphylaxis (n = 23). We then compared clinical symptoms and laboratory data on patients with systemic and cutaneous mastocytosis and bone marrow histopathology on a matched cohort with and without the KIT M541L variant. Overall, the KIT M541L variant was identified in 19 individuals; the majority were diagnosed with systemic mastocytosis (89.4%) with an associated KIT D816V mutation. There were no significant differences in peripheral blood parameters between groups. Patients with mastocytosis carrying the KIT M541L variant did not demonstrate significant differences in symptomatology compared to a matched reference cohort (n = 13/81) without KIT M541L. In patients with idiopathic anaphylaxis, no significant associations were observed. This study uniquely examines the prevalence and impact of the KIT M541L variant in both adult and pediatric patients with mastocytosis further stratified by disease variant. To our knowledge, this is the first case/control study to show a significant genetic association with mastocytosis at the KIT M541L locus.","PeriodicalId":19499,"journal":{"name":"Oncotarget","volume":"15 ","pages":"521-531"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0