靶向治疗骨肉瘤中的 WNT5B 和 WNT10B。

Q2 Medicine

Oncotarget Pub Date : 2024-08-02 DOI:10.18632/oncotarget.28617

Gustavo A Miranda-Carboni, Susan A Krum

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引用次数: 0

摘要

WNT 信号调节骨肉瘤的增殖。然而，在骨肉瘤领域，关于 WNT 信号转导是促癌还是抗癌还存在争议。对 WNT 靶向治疗药物（包括激活剂和抑制剂）进行了比较。WNT5B是一种不依赖于β-catenin的配体，而WNT10B是一种依赖于β-catenin的WNT配体。此外，WNT10B 和 WNT5B 对不同组织学亚型的骨肉瘤具有调节作用。将 WNT 信号调节剂用作治疗可能取决于 WNT 配体和/或激活的信号通路。

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Targeting WNT5B and WNT10B in osteosarcoma.

WNT signaling regulates osteosarcoma proliferation. However, there is controversy in the field of osteosarcoma as to whether WNT signaling is pro- or anti-tumorigenic. WNT-targeting therapeutics, both activators and inhibitors, are compared. WNT5B, a β-catenin-independent ligand, and WNT10B, a β-catenin-dependent WNT ligand, are each expressed in osteosarcomas, but they are not expressed in the same tumors. Furthermore, WNT10B and WNT5B regulate different histological subtypes of osteosarcomas. Using WNT signaling modulators as therapeutics may depend on the WNT ligand and/or the activated signaling pathway.

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