Oncologia i radiologia Kazakhstana最新文献

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BURNOUT SYNDROME AMONG MEDICAL PROFESSIONALS: LITERATURE REVIEW 医学专业人员的职业倦怠综合征:文献综述
Oncologia i radiologia Kazakhstana Pub Date : 2022-06-30 DOI: 10.52532/2521-6414-2022-2-64-59-65
Zh. Zhumanbayeva, A. Кrykpaeva, A. Serikbaev, N. Rakhmatullina, G. Aitmurzinova, A. Seitkabylov
{"title":"BURNOUT SYNDROME AMONG MEDICAL PROFESSIONALS: \u0000LITERATURE REVIEW","authors":"Zh. Zhumanbayeva, A. Кrykpaeva, A. Serikbaev, N. Rakhmatullina, G. Aitmurzinova, A. Seitkabylov","doi":"10.52532/2521-6414-2022-2-64-59-65","DOIUrl":"https://doi.org/10.52532/2521-6414-2022-2-64-59-65","url":null,"abstract":"Relevance: Burnout syndrome in medical staff is a sensitive topic of health care, as this condition can directly affect treatment and care, that \u0000is, the patient’s satisfaction with the medical service and the psychological state of the medical staff as a whole. Burnout syndrome includes several \u0000risk factors that can directly affect the spread of this syndrome. Thus, the psychological state of medical personnel and the prevention of burnout \u0000syndrome is an important healthcare aspect. \u0000The purpose of the study was to review the literature on the spread, risk factors, and prevention of burnout syndrome in medical staff. \u0000Methods: The research for papers was made using the PubMed, Cochrane Library, Medscape, CINAHL, and Google Scholar search engines, \u0000e-Library.ru and CyberLeninka electronic libraries. Inclusion criteria: search depth of 10 years (2012-2022), original articles, literature reviews, \u0000meta-analyses and systematic reviews, open-access full-text articles in English and Russian. Exclusion criteria: low-quality articles not meeting the \u0000search criteria or containing unclear information and conclusions, reports, abstracts, and newspaper articles. In total, the review included 47 articles. \u0000Results: The literature review showed that burnout syndrome among medical staff is spreading every year and requires high-quality prevention \u0000methods. \u0000Conclusion: The literature review showed that emotional burnout syndrome among medical workers is a global problem and has become one \u0000of the most noticeable issues in healthcare. From the point of risk factors, professional factors rank first, followed by social, physiological, and \u0000other factors. The reviewed foreign and domestic publications insufficiently study the burnout syndrome prevention measures and their efficacy.","PeriodicalId":19480,"journal":{"name":"Oncologia i radiologia Kazakhstana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74410183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STERNUM TUMOR SURGICAL TREATMENT METHOD: A CLINICAL CASE 胸骨肿瘤手术治疗方法:1例临床
Oncologia i radiologia Kazakhstana Pub Date : 2022-06-30 DOI: 10.52532/2521-6414-2022-2-64-44-48
Z. Pyssanova
{"title":"STERNUM TUMOR SURGICAL TREATMENT METHOD: A CLINICAL CASE","authors":"Z. Pyssanova","doi":"10.52532/2521-6414-2022-2-64-44-48","DOIUrl":"https://doi.org/10.52532/2521-6414-2022-2-64-44-48","url":null,"abstract":"Relevance: Sarcomas are relatively rare. They make up 1% of all malignant neoplasms in adults, of which about 10-15% appear in the chest \u0000wall. Unlike primary tumors, metastatic bone tumors occur 2-4 times more often, while the sternum is affected in 9% of all metastatic bone lesions. \u0000A review of the literature and analysis of patients with chest wall tumors showed that surgical treatment might be the best option for primary tumors \u0000and some secondary chest wall tumors. \u0000Chondrosarcoma (12%) is the most common primary chest bone sarcoma and originates from the anterior segment of the ribs, less often from \u0000the sternum, scapula, or clavicle. \u0000The purpose was to present the outcome of a sternum sarcoma surgical treatment with a simultaneous reconstruction of an extensive postoperative defect at the Kazakh Institute of Oncology and Radiology (Almaty, Kazakhstan). \u0000Methods: The article reviews the literature on the treatment of chest wall tumors and describes a clinical case of a patient with chondrosarcoma of the sternum. After subtotal resection of the sternum 2-3 cm away from the tumor margins, the patient underwent reconstructive plastic \u0000surgery. Synthetic material was used to stabilize the chest wall, prevent paradoxical breathing, and replace the defect. \u0000Result: No recurrence of the main process was registered after radical removal of the sternum tumor with the simultaneous reconstruction of \u0000the defect with synthetic material. Given the prevalence of the tumor, intraoperative suturing of the subclavian vein was performed, which led to \u0000vein thrombosis in the postoperative period. \u0000Conclusions: The key to successful sternum tumor treatment is early recognition and radical removal with adequate margins. Complete excision with broadly negative microscopic margins at the first operation is paramount since local recurrence increases the risk of systemic metastasis \u0000and death. Thus, standard guidelines are required to ensure chest wall sarcomas proper treatment.","PeriodicalId":19480,"journal":{"name":"Oncologia i radiologia Kazakhstana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82574652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AN ANALYSIS OF AN INTEGRATED APPROACH TO CAROTID BODY TUMOR SURGICAL TREATMENT AT THE NATIONAL RESEARCH ONCOLOGY CENTER (NUR-SULTAN, KAZAKHSTAN) 国家肿瘤研究中心(努尔苏丹,哈萨克斯坦)颈动脉体肿瘤手术治疗的综合入路分析
Oncologia i radiologia Kazakhstana Pub Date : 2022-06-30 DOI: 10.52532/2521-6414-2022-2-64-28-32
A. Tulemissov
{"title":"AN ANALYSIS OF AN INTEGRATED APPROACH TO CAROTID BODY TUMOR SURGICAL \u0000TREATMENT AT THE NATIONAL RESEARCH ONCOLOGY CENTER \u0000(NUR-SULTAN, KAZAKHSTAN)","authors":"A. Tulemissov","doi":"10.52532/2521-6414-2022-2-64-28-32","DOIUrl":"https://doi.org/10.52532/2521-6414-2022-2-64-28-32","url":null,"abstract":"Relevance: Carotid body tumors (CBT) account for 0.01% of all head and neck tumors. 5-15% of CBTs are malignant. The expansive growth \u0000of this tumor and its tight attachment to the carotid arteries pose a risk of damage to the main blood vessels and cranial nerves during surgery \u0000that can lead to life-threatening bleeding. Today, preoperative embolization of CBT feeding vessels (PECBT) is used to minimize blood loss during \u0000CBT radical excision. \u0000The study aimed to evaluate the results of preoperative preparation of patients with CBT by PECBT; justification of a CBT incidence multicenter study to determine CBT's current status in Kazakhstan. \u0000Methods: An anamnesis was collected from all patients, and instrumental diagnostic studies (ultrasound, CTA) were performed. We used the \u0000Shamblin (1971) classification of CBT modified by Luna-Ortiz et al. (2006). PECBT was performed to prepare patients for open surgery. CBT \u0000excision tactics were selected depending on the classification of the CBT according to Shamblin. \u0000Results: Out of 9 patients with CBT, seven patients complained mainly of a neck tumor; the others mentioned pain and dysphagia. Four patients had a left-side CBT, and the others had a right-side. One tumor was Shamblin type I, five were Shamblin type II, and three were Shamblin type \u0000III. Eight patients underwent PECBT, and one was operated on without PECBT. In 8 cases, CBT was surgically incised; one patient did not show \u0000up for the second stage of treatment. Arterial reconstruction was required in two cases. An average size tumor was 27.4 cm3. The CBT excision was \u0000controlled without significant bleeding thanks to the presence of an embolic agent. Blood loss averaged 750 ml; reinfusion – 243.3 ml. \u0000Conclusion: The CBT incidence in Kazakhstan has not been studied yet, so a multicenter study is required. Early ultrasound and CT diagnostics support providing patients with up-to-date, efficient surgical treatment. PECBT provides favorable conditions for the tumor resection without \u0000hemodynamically significant blood loss","PeriodicalId":19480,"journal":{"name":"Oncologia i radiologia Kazakhstana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80438386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HPV VACCINATION ROLE IN CERVICAL CANCER ELIMINATION: A LITERATURE REVIEW HPV疫苗接种在消除宫颈癌中的作用:文献综述
Oncologia i radiologia Kazakhstana Pub Date : 2022-06-30 DOI: 10.52532/2521-6414-2022-2-64-79-83
A. Satanova, D. Kaidarova, E. Kukubassov, R. Bolatbekova, O. Bertleuov, D. Kaldybekov
{"title":"HPV VACCINATION ROLE IN CERVICAL CANCER ELIMINATION: \u0000A LITERATURE REVIEW","authors":"A. Satanova, D. Kaidarova, E. Kukubassov, R. Bolatbekova, O. Bertleuov, D. Kaldybekov","doi":"10.52532/2521-6414-2022-2-64-79-83","DOIUrl":"https://doi.org/10.52532/2521-6414-2022-2-64-79-83","url":null,"abstract":"Relevance: Cervical cancer (CC) is a socially significant disease in the development of which the human papillomavirus (HPV) plays a central \u0000role. HPV is the most common sexually transmitted virus, affecting 80% of sexually active men and women by age 45. Since 2017, the World Health \u0000Organization has recommended that all countries implement HPV vaccination programs to reduce and eliminate CC. \u0000The study aimed to examine the role of HPV vaccination in eliminating CC over the past decade. \u0000Methods: The literature search was done in the PUBMED, MEDLINE, and Cochrane databases for the last ten years using the keywords \u0000«cervical cancer,» «vaccination,» and «human papillomavirus.» The review included the results of randomized studies and meta-analyses. \u0000Results: The literature provides evidence of the effectiveness and safety of HPV vaccination in countries that have introduced HPV vaccine \u0000immunization. The compelling evidence for the effectiveness of HPV vaccination in preventing HPV urge to move from control to elimination of \u0000HPV-related diseases. \u0000Conclusion: CC is only cancer that can be prevented by vaccination. The development of HPV vaccines and the introduction of HPV immunization into national vaccination schedules helped many countries reduce HPV prevalence and thus reduce HPV incidence.","PeriodicalId":19480,"journal":{"name":"Oncologia i radiologia Kazakhstana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82704192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TOTAL VAGINECTOMY FOR RECURRENT GYNECOLOGICAL CANCER: A SERIES OF CLINICAL CASES 阴道全切除术治疗复发性妇科肿瘤:一系列临床病例
Oncologia i radiologia Kazakhstana Pub Date : 2022-06-30 DOI: 10.52532/2521-6414-2022-2-64-49-52
A. Satanova, D. Kaidarova, E. Kukubassov, O. Bertleuov, D. Kaldybekov, R. Bolatbekova
{"title":"TOTAL VAGINECTOMY FOR RECURRENT GYNECOLOGICAL CANCER: \u0000A SERIES OF CLINICAL CASES","authors":"A. Satanova, D. Kaidarova, E. Kukubassov, O. Bertleuov, D. Kaldybekov, R. Bolatbekova","doi":"10.52532/2521-6414-2022-2-64-49-52","DOIUrl":"https://doi.org/10.52532/2521-6414-2022-2-64-49-52","url":null,"abstract":"Relevance: Treating vaginal recurrence of gynecological cancer remains a complex clinical problem. Surgery is an effective and relatively \u0000safe strategy for these cases. Vaginectomy is a method of surgical treatment of gynecological cancer local recurrence. Although vaginectomy is \u0000considered an effective treatment for a vaginal recurrence of cervical, ovarian, or endometrial cancers, only a few published reports of vaginal \u0000resections have been found. In most cases, vaginal resections were performed by vaginal and/or/or open access. Several reports on laparoscopic \u0000vaginal resection for recurrence in gynecological cancer were found. \u0000The aim was to study the effectiveness of vaginectomy in recurrent gynecological cancer. \u0000Methods: Clinical cases of seven patients after vaginectomy were analyzed. \u0000Results: The patients age ranged from 42 to 62 years (median 53 years). The duration of the operation varied from 240 to 480 minutes (median \u0000317 min), the volume of blood loss – from 90 to 220 ml (median 140 ml), and resection margins were negative in all cases. An ureteral catheter was \u0000installed in 2 cases. The Foley catheter was removed after 10 days on average (from 1 to 11 days). The patients stayed in the hospital for 7-14 days \u0000(median – 7 days). No intraoperative complications were registered. All patients after vaginectomy are alive. \u0000Conclusion: Vaginal recurrence is the most common local recurrence in gynecological cancer, and there is no consensus regarding its treatment tactics. Although this article is somewhat limited in the number of patients, our results show the efficacy of vaginectomy in recurrent vaginal \u0000gynecological cancer","PeriodicalId":19480,"journal":{"name":"Oncologia i radiologia Kazakhstana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74758654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE IMPACT OF COVID-19 ON THE INCIDENCE OF RECTAL CANCER IN KAZAKHSTAN: RESULTS OF COMPONENT ANALYSIS COVID-19对哈萨克斯坦直肠癌发病率的影响:成分分析结果
Oncologia i radiologia Kazakhstana Pub Date : 2022-06-30 DOI: 10.52532/2521-6414-2022-2-64-4-8
Zhansaya Telmanova, A. Axarin, A. Oralbek, S. Orozbaev, K. Kulayev, N. Shapambayev, Y. Kuandykov, Z. Bilalova, G. Igissinova, K. Rustemova, I. Kudaibergenova, N. Igissinov
{"title":"THE IMPACT OF COVID-19 ON THE INCIDENCE OF RECTAL CANCER IN KAZAKHSTAN: RESULTS OF COMPONENT ANALYSIS","authors":"Zhansaya Telmanova, A. Axarin, A. Oralbek, S. Orozbaev, K. Kulayev, N. Shapambayev, Y. Kuandykov, Z. Bilalova, G. Igissinova, K. Rustemova, I. Kudaibergenova, N. Igissinov","doi":"10.52532/2521-6414-2022-2-64-4-8","DOIUrl":"https://doi.org/10.52532/2521-6414-2022-2-64-4-8","url":null,"abstract":"Relevance: Every year, 732,210 new cases of RC are registered globally, with an incidence of 7.6 per 100,000. The COVID-19 pandemic has affected the screening, case detection, and referral of patients with an asymptomatic cancer diagnosis. \u0000The aim was to assess the trends in rectal cancer incidence in the entire population of Kazakhstan before and during the COVID \u0000pandemics. \u0000Methods: The data obtained from the Ministry of Healthcare of the Republic of Kazakhstan concerning RC (Form no. 7) was retrospectively studied by descriptive and analytical epidemiology methods. The component method was used to analyze RC incidence dynamics \u0000based on the number of cases from 2010 to 2020. \u0000Results: From 2010 to 2020, the risk of getting RC went down. An increase in incidence in 2010-2020 (+24.8%) was lower than in \u0000the preCOVID period of 2010-2019 (+37.2%). We found a sharp decrease in RC incidence from 2019 to 2020. The overall decrease was \u00000.89‰⁰⁰ due to changes in the age structure of the population (∑ΔA=+0.13‰⁰⁰), the risk of getting RC (∑ΔR=−1.02‰⁰⁰), and the combined \u0000impact of age structure and the risk of getting RC (∑ΔAR=−0.002‰⁰⁰). According to the component analysis, 1,662 patients with RC were \u0000expected in 2020; instead, only 1,471 cases were registered. Such a decline in cases was mainly due to a reduced risk of getting RC. \u0000Conclusions: The analysis of RC incidence trends in Kazakhstan shows a negative impact of COVID-19 on cancer care indicators and \u0000effectiveness. All oncological examinations were strengthened with the resumption of work after COVID restrictions. However, the number \u0000of screening visits remains lower than in previous years. Untimely diagnosis can increase the number of cases of late-stage CRC and an \u0000overall loss of years of life due to the lack of proper treatment. However, these forecasts can be mitigated by proper follow-up.","PeriodicalId":19480,"journal":{"name":"Oncologia i radiologia Kazakhstana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91028947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE CURRENT ROLE OF MULTIPARAMETRIC MRI IN PROSTATE CANCER DIAGNOSTICS: A LITERATURE REVIEW 目前多参数mri在前列腺癌诊断中的作用:文献综述
Oncologia i radiologia Kazakhstana Pub Date : 2022-06-30 DOI: 10.52532/2663-4864-2022-2-64-66-72
K. Karakoishin, Z. Zholdybay, A. Aynakulova, D. Toleshbaev, Z. Amankulov, Zh. Zhakenova, A. Beisen, A. Kabidenov, N. Kashaev
{"title":"THE CURRENT ROLE OF MULTIPARAMETRIC MRI IN PROSTATE CANCER DIAGNOSTICS: A LITERATURE REVIEW","authors":"K. Karakoishin, Z. Zholdybay, A. Aynakulova, D. Toleshbaev, Z. Amankulov, Zh. Zhakenova, A. Beisen, A. Kabidenov, N. Kashaev","doi":"10.52532/2663-4864-2022-2-64-66-72","DOIUrl":"https://doi.org/10.52532/2663-4864-2022-2-64-66-72","url":null,"abstract":"","PeriodicalId":19480,"journal":{"name":"Oncologia i radiologia Kazakhstana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75754373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE CURRENT ROLE OF MULTIPARAMETRIC MRI IN THE DIAGNOSIS OF PROSTATE CANCER: A LITERATURE REVIEW 目前多参数mri在前列腺癌诊断中的作用:文献综述
Oncologia i radiologia Kazakhstana Pub Date : 2022-06-30 DOI: 10.52532/2521-6414-2022-2-64-66-72
K. Karakoishin, Z. Zholdybay, A. Aynakulova, D. Toleshbaev, Z. Amankulov, Zh. Zhakenova, A. Beisen, A. Kabidenov, N. Kashaev
{"title":"THE CURRENT ROLE OF MULTIPARAMETRIC MRI IN THE DIAGNOSIS OF PROSTATE CANCER: \u0000A LITERATURE REVIEW","authors":"K. Karakoishin, Z. Zholdybay, A. Aynakulova, D. Toleshbaev, Z. Amankulov, Zh. Zhakenova, A. Beisen, A. Kabidenov, N. Kashaev","doi":"10.52532/2521-6414-2022-2-64-66-72","DOIUrl":"https://doi.org/10.52532/2521-6414-2022-2-64-66-72","url":null,"abstract":"Relevance: Multiparametric MRI (mpMRI) is one of the main methods for diagnosing prostate cancer (PCa). Although mpMRI has been adopted into routine urological and oncological practice in a few short years, there are conflicting views on the timing of mpMRI. \u0000The purpose was to study the diagnostic value and role of mpMRI at the stages of diagnosis of prostate cancer. \u0000Methods: The article reviews the literature on the use of mpMRI in diagnosing prostate cancer in the framework of traditional clinical approaches. \u0000Results: current national guidelines in Europe emphasize the value of mpMRI in diagnosing patients with suspected PCa. The rationale for \u0000using mpMRI in selecting patients with suspected PCa who should and should not be biopsied and selecting areas of the prostate for biopsy is \u0000compelling. The evidence base, including level 1 studies, is overwhelming, as are arguments for patient benefit in avoiding biopsy or overdiagnosis \u0000of clinically insignificant cancer. \u0000Conclusion: Patients considering biopsy start to realize that mpMRI imaging can avoid biopsy in some cases and make it more targeted in \u0000others. For obvious reasons, these patients will seek to avoid the risk of biopsy or minimize the risk with fewer biopsy specimens. Switching from \u0000“standard” SB to TB judiciously and selectively augmented with BD using a two-stage risk assessment offers the best compromise to reduce biopsy \u0000rates and reduce overdiagnosis of cnPCa while minimizing the chances of missing clinically significant cancer. Evidence that it is possible to avoid \u0000SB altogether, even in the era of mpMRI before biopsy, is weak. This provides grounds for searching for new methods for diagnosing clinically \u0000significant cancer using mpMRI","PeriodicalId":19480,"journal":{"name":"Oncologia i radiologia Kazakhstana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78258109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ASSOCIATION OF NATURAL KILLER CELLS ACTIVITY WITH THE INCIDENCE OF COLORECTAL NEOPLASIA AT SCREENING 自然杀伤细胞活性与筛查结直肠癌发病率的关系
Oncologia i radiologia Kazakhstana Pub Date : 2022-06-30 DOI: 10.52532/2521-6414-2022-2-64-14-18
J. Amankulov
{"title":"ASSOCIATION OF NATURAL KILLER CELLS ACTIVITY WITH THE INCIDENCE \u0000OF COLORECTAL NEOPLASIA AT SCREENING","authors":"J. Amankulov","doi":"10.52532/2521-6414-2022-2-64-14-18","DOIUrl":"https://doi.org/10.52532/2521-6414-2022-2-64-14-18","url":null,"abstract":"Relevance: Increased natural killer cells (NK cells) activity is associated with reduced colorectal cancer (CRC) risk. Previously published \u0000studies examined the association of NK cells and CRC prevalence in individuals at high cancer risk. \u0000The purpose was to study the relationship between NK cell activity and the incidence of advanced adenomas (AA) and CRC in a population \u0000with average cancer risk. \u0000Methods: The activity of NK cells was assessed by enzyme immunoassay (ELISA) of blood in participants of average risk with a measurement \u0000range of 25-2500 pg/ml. The level of NK cells below 200 pg/ml was defined as pathological. The informativeness of the diagnostic test for determining NK cell activity was assessed using indicators such as sensitivity, specificity, negative and positive predictive value, and clinical utility index. \u0000The probability coefficient for the development of colorectal cancer was calculated using logistic regression. \u0000Results: The activity of NK cells was assessed in 354 persons of average risk (mean age 59 years; 36% of them men). The diagnostic accuracy \u0000of NK cells determination for CRC and AA was 76% and 72%, respectively, and the negative predictive value was 96%. The NK cell test demonstrated a good negative clinical utility index for CRC and AA (0.66 and 0.74, respectively). Individuals with low levels of NK cells were seven times \u0000more likely to be diagnosed with CRC (95% CI 2.3-20.3; p<0.001). NK cell levels were higher in men compared to women (549 pg/mL vs 500 pg/ \u0000mL) and lower in smokers (412 pg/mL versus 544 pg/mL), non-athletic participants (413 pg/mL versus 654 pg / ml), in people who abuse alcohol \u0000(389 pg/ml versus 476 pg/ml). \u0000Conclusion: Our study shows that a high level of NK cells can potentially exclude CRC and AA in individuals with average cancer risk","PeriodicalId":19480,"journal":{"name":"Oncologia i radiologia Kazakhstana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86337958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THE ROLE OF DIFFERENTIAL MARKERS CD 200, CD103, CD11C IN THE DIAGNOSIS OF CHRONIC B-LYMPHOPROLIFERATIVE DISEASES BY FLOW CYTOMETRY: A LITERATURE REVIEW cd200、cd103、cd11c在流式细胞术诊断慢性b淋巴细胞增生性疾病中的作用:文献综述
Oncologia i radiologia Kazakhstana Pub Date : 2022-06-30 DOI: 10.52532/2521-6414-2022-2-64-53-58
K. Baktikulova, S. Kurmangalieva, V. Toymanova, Kh. Kudabaeva, E. Bazargaliev, N. Sagindykova
{"title":"THE ROLE OF DIFFERENTIAL MARKERS CD 200, CD103, CD11C IN THE DIAGNOSIS \u0000OF CHRONIC B-LYMPHOPROLIFERATIVE DISEASES BY FLOW CYTOMETRY: \u0000A LITERATURE REVIEW","authors":"K. Baktikulova, S. Kurmangalieva, V. Toymanova, Kh. Kudabaeva, E. Bazargaliev, N. Sagindykova","doi":"10.52532/2521-6414-2022-2-64-53-58","DOIUrl":"https://doi.org/10.52532/2521-6414-2022-2-64-53-58","url":null,"abstract":"Relevance: Immunophenotyping with multiparameter flow cytofluorimetry allows differentiating classical variants of chronic B-lymphoproliferative diseases. However, some atypical conditions are hard to interpret; they gave rise to the search for new differential markers. \u0000The study aimed to analyze the predictive value of monoclonal markers CD200, CD103, and CD11c in differential diagnostics of hairy cell \u0000leukemia, splenic marginal zone lymphoma, and splenic mantle zone lymphoma. \u0000Methods: We studied open access articles with a search depth of 10 years using the following databases of scientific publications and specialized search engines: PubMed, Google Scholar, Cochrane Library, Web of Science, Scopus, Сyberleninka, and the eLIBRARY electronic library. As \u0000a result, 30 literary sources were identified, of which eight publications were the basis of the analytical material for this article. Inclusion criteria: \u0000Evidence level A, B publications: meta-analyses, systematic reviews, cohort, and cross-sectional studies. Exclusion criteria: expert opinion in the \u0000form of short messages or promotional articles. \u0000Results: We revealed a different degree of informativeness of some traditional markers in immunophenotypic diagnostics of B-cell lymphoproliferative diseases by flow cytometry; the use of additional differential markers CD200, CD103, and CD11c showed their high informativeness \u0000in differential diagnostics between different variants of B-cell lymphoproliferative diseases with initial immunophenotypic and morphological \u0000characteristics of lymphoid elements. \u0000Conclusion: Analysis of the selected publications gives grounds to improve the multiparametric panel for differential diagnostics of chronic \u0000B-lymphoproliferative diseases.","PeriodicalId":19480,"journal":{"name":"Oncologia i radiologia Kazakhstana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90922304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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