Hellenic Journal of Obstetrics and Gynecology最新文献

{"title":"Periodontal disease of the mother and incidence of preeclampsia","authors":"Thrasyvoulos-Marios Smyrlis, S. Stavros, D. Loutradis, P. Drakakis","doi":"10.33574/hjog.1866","DOIUrl":"https://doi.org/10.33574/hjog.1866","url":null,"abstract":"","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129084626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PI3K/PDK1/Akt pathways and their fundamental role in Gynecological Cancer","authors":"S. Stavros, K. Pappa, P. Drakakis","doi":"10.33574/hjog.1851","DOIUrl":"https://doi.org/10.33574/hjog.1851","url":null,"abstract":"The PI3K/PDK1/Akt pathway can regulate a large variety of cellular processes such as cell growth, proliferation and survival. Moreover, it is one of the most frequently altered networks in cancer though. The dysregulation of these pathways has been reported in several human cancers, as well as in diabetes, neurological diseases and cardiovascular diseases. Cervical carcinogenesis seems to be associated with increased levels of activated AKT kinase. Moreover, PTEN inactivation is the most common genetic alteration in type1 endometrial cancer. In addition, the PI3K /AKT pathway is related to ovarian carcinomas cell motility and adhesion. This pathway plays an imperative role in cell survival and except for that, it may lead to metastatic and invasive phenotypes of a large variety of malignant cells. A battery of cancerous types has been associated with PI3K/AKT hyperactivation; inhibition of this pathway has been described as a treatment option of malignancy. The role of PI3K-PDK-AKT signaling pathway in gynecological malignancy seems to play a pivotal role, but it necessitates further investigation, which could lead to novel therapeutic strategies of eventual robust advantages to many cancer patients. The aim of that review is to highlight and underline the role of those pathways paving the way of gynecological malignancy.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133059377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Kifc1, Kchn5 and miRNA-302 on in vitro development in 8-cell, morula and blastocyst stage of mouse embryos","authors":"K. Ntzeros, D. Mavrogianni, A. Koutsi, Antonia Kandaraki, Anastasios Papadelas, S. Stavros, P. Drakakis, D. Loutradis","doi":"10.33574/hjog.1768","DOIUrl":"https://doi.org/10.33574/hjog.1768","url":null,"abstract":"Introduction: Embryo development is characterized by lack of cell cycle check-points and overexpression of core circadian oscillators. On previous report we have identified several genes over-and under-detected at human embryo blastomeres. In this study, we investigated the expression profile of Kcnh5, KIFC1 and miRNA-302 genes at three pre-implantation stages of mouse embryo development. Material and methods: Total RNA was extracted from mouse embyos at 8-cell, morula and blastocyst stage. The expression profile of Kcnh5, KIFC1 and miRNA-302 was assessed by RT-PCR and the results were normalized with G6pdh expression levels. Results: Kcnh5 showed absence of expression at all stages, indicating novel mechanisms of cell cycle control during blastomeres divisions. KIFC1 showed positive expression at all stages, with decreasing levels as the embryogenesis progresses. This finding indicates that KIFC1 may have more important role at early events. miRNA-302 showed increased levels of expression at all stages, with morula having the highest levels. Therefore, miRNA-302 might play an important role at the events that happen during morula stage such as compaction. Conclusions: Cell cycle control of blastomeres at early embryogenesis might be based on different mechanisms compared to somatic cells and more research is needed in order to reveal crucial cycling elements.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121871157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Campomelic dysplasia: an overview of a rare genetic disorder","authors":"N. Antonakopoulos, D. Vrachnis, N. Loukas, Chryssi Christodoulaki, Z. Iliodromiti, N. Vrachnis","doi":"10.33574/hjog.1767","DOIUrl":"https://doi.org/10.33574/hjog.1767","url":null,"abstract":"Campomelic dysplasia is a rare and severe genetic condition that is characterized by shortening and bowing of the long bones, abnormal face, multiple congenital anomalies, and ambiguous genitalia. Having conducted a review of the existing literature on this rare genetic disorder, we herein present the most pertinent and essential data on the condition viewed from the clinical perspective. In the majority of cases when the neonate survives the condition, since the underlying cause is more often than not a de novo mutation of the SOX9 gene, there is no increased risk of recurrence. Diagnosis is tentatively made based on skeletal findings during routine prenatal ultrasound; it may subsequently be confirmed via either prenatal or postnatal molecular genetic testing or else radiologic evaluation. In general, the condition is considered to be lethal in the neonatal period, there is no prenatal treatment and pregnancy termination is an option.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131752182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liquid biopsy and ovarian cancer; Where do we stand?","authors":"C. Theofanakis, N. Thomakos, D. Haidopoulos, A. Rodolakis","doi":"10.33574/hjog.1779","DOIUrl":"https://doi.org/10.33574/hjog.1779","url":null,"abstract":"","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133921572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pemphigusvulgaris in pregnancy. A rare case report","authors":"Ioannis Kokolakis, Fanis Makrigiannakis, Sabine Kruger, K. Krasagakis, A. Makrigiannakis","doi":"10.33574/hjog.1771","DOIUrl":"https://doi.org/10.33574/hjog.1771","url":null,"abstract":"Pemphigus vulgaris (PV) is an autoimmune, bullous, mucocutaneous and potentially life-threatening disease. During pregnancy the occurrence of PV is exceedingly rare and its condition will become more complicated due to different mother’s hormone level and the effect of treatment on both mother and her fetus. PV may be associated with an adverse outcome, such as fetal growth restriction and preterm births. We report a case of a 33-year-old woman who was firstly diagnosed with PV during pregnancy. Treatment of highdoses systemic corticosteroids was instituted to control the disease. She delivered a healthy live preterm baby, appropriate for gestational age with no skin or mucosal lesions or other apparent complications.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133108351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of gynaecological and general history parameters inpregnant women in long term refugee camps in Greece: results from a pilot program","authors":"V. Pergialiotis, C. Botsi, Ioanna Papari, Stavroula Gkritziou, K. Mellou, S. Pappas, A. Terzidis, T. Rosenberg","doi":"10.33574/hjog.1769","DOIUrl":"https://doi.org/10.33574/hjog.1769","url":null,"abstract":"Objective:The purpose of the present article is to present preliminary data related to the gynecological history and current health status of pregnant refugees that reside in long-term refugee camps in Greece. Materials and Methods: The study was funded by the European program “PHILOS – Emergency health response to refugee crisis” of the Greek Ministry of Health, implemented by the Hellenic Center for Disease Control and Prevention (HCDCP), funded by the Asylum, Migration and Integration Fund (AMIF) of EU’s DG Migration and Home Affairs.Refugee pregnant women who resided in long-stay refugee camps of the mainland in Greece in 2017 were recruited. Results: Overall, 456 pregnant women were enrolled in the present study with a mean age of 27.5±6.9 years (median 27, range 17-48 years). 182 women (39.8%) were primigravidae. Mean gravidity was 2.4 (median 2, range 1-11). Among them 105 had a previous delivery, 75 women had 2 previous deliveries, 50 women had 3 previous deliveries and 14 had four previous deliveries. Of those, only six women had access to prenatal screening.Twenty-three women (5%) reported that had at least an artificial abortion performed (median 1, range 1-4) and 87 women (19.0%) had at least one spontaneous abortion (median 1, range 1-6).Two hundred and three women (44.5%) reported the use of a contraceptive method. Among them withdrawal (pull-out method) was the most prevalent accounting for almost half cases (36.9%), by followed by condom, intrauterine devices (IUD) and oral contraceptives. No differences were observed after checking the potential differences among the different age groups (p=.234). Conclusions: Refugee women that reside in long term refugee camps have limited access to national healthcare systems concerning their gynecological and obstetrical assessment. Future studies, should specifically target these problems to help structure specific healthcare plans that will ensure maternal and fetal well-being.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129034512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycogen storage disease type iv: a case with histologic findings in placental tissue from first trimester miscarriage","authors":"A. Papakonstantinou, K. Zacharis, S. Kravvaritis, Theodoros Charitos, Eleni Chrysafopoulou, Anastasia Fouka","doi":"10.33574/hjog.1772","DOIUrl":"https://doi.org/10.33574/hjog.1772","url":null,"abstract":"Glycogen storage disease Type IV is a rare hereditary autosomal recessive disorder caused by deficient enzymatic activity of glycogen branching enzyme (GBE) which is encoded by GBE1 gene. We hereby report the case of a 32-year-old woman presented with a first-trimester miscarriage. The histologic findings of the placental tissue included intracytoplasmic inclusion vacuoles suggested GSD‐IV. The diagnosis was confirmed by the genetic analysis of the parents, in which mother was found to be carrier of a GBE1 mutation. This variable disorder can be diagnosed by histopathology of the placenta but for its confirmation and prevention in subsequent pregnancies, genetic analysis is needed.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"25 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132604444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Extensive” T4 breast tumors: Considerations regarding local management.","authors":"Ioannidis Charilaos","doi":"10.33574/hjog.1770","DOIUrl":"https://doi.org/10.33574/hjog.1770","url":null,"abstract":"“Extensive” T4 malignant breast tumors are not uncommon and can be either primary or recurrent. Theycan present without or be accompanied by distant metastases at the time of initial presentation. They share one or more of the following symptoms: mass effect, pain, malodor, esthetic distress, exudation, pruritus, bleeding, and crusting. The aim of their treatment is therapeutic, when possible, or palliative, which is quite often the case. A small case series of three female patients with “extensive” T4 breast cancer is presented. The various surgical options for excision of the tumor and reconstruction of the resulting defect are discussed. Methods of management of odor, infection control, and pain, especially when surgery or radiotherapy is contraindicated, is also discussed.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134286345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications and Management of Asymptomatic Patients with Measles Infection During Pregnancy","authors":"Z. Fasoulakis, G. Galazios, V. Liberis, E. Kontomanolis","doi":"10.33574/hjog.1726","DOIUrl":"https://doi.org/10.33574/hjog.1726","url":null,"abstract":"Measles virus is a member of the family Paramyxoviridae that causes an epidemic disease with worldwide distribution, with the main symptom of this systematic disease being a prodrome of fever and a pathognomonic enanthema (Koplik spots), followed by a maculopapular rash. The rash usually appears about 14 days after the patient’s exposure and even though vaccination has led the virus to be limited to preschool children and young adults, measles infection can cause severe and even fatal complications in adults, pregnant women and immunocomprised patients. The aim of this article is to highlight the dangers of measles outbreak during a possible crucial and hazardous period for both the mother and the fetus, and to suggest possible management and treatment options during gestation.","PeriodicalId":194739,"journal":{"name":"Hellenic Journal of Obstetrics and Gynecology","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121554411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}