Inter CollegasPub Date : 2022-09-30DOI: 10.35339/ic.9.1.50-58
V. Lazurenko, Y. Y. Bilyi, O. A. Liashchenko, O. B. Ovcharenko, I. Borzenko
{"title":"MODERN VIEW ON CHRONIC RESPIRATORY DISEASES IN PREGNANT (review)","authors":"V. Lazurenko, Y. Y. Bilyi, O. A. Liashchenko, O. B. Ovcharenko, I. Borzenko","doi":"10.35339/ic.9.1.50-58","DOIUrl":"https://doi.org/10.35339/ic.9.1.50-58","url":null,"abstract":"Disorders in the fetoplacental complex of pregnant women with chronic respiratory diseases (CRD) is one of the actual problems of modern obstetrics in medical, economic and social aspects. Respiratory diseases in the context of disorders of the fetoplacental complex (FPC) may be a comorbid process, a background to the pathology of pregnancy, or a premorbid condition that contributes to the development of placental dysfunction (PD) or even initiates it; morphophysiological changes characteristic of pregnancy also affect the state of the respiratory system, moderating the course of bronchoobstructive pathology. The presence of respiratory diseases in women, the impact of its treatment and features of the course and medical support of pregnancy in these conditions affect the condition of both the woman and the fetus, and in the future - the physical and neuropsychological development of the child.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"55 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121457512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inter CollegasPub Date : 2022-05-22DOI: 10.35339/ic.8.4.254-259
Olena Grihoryan, Vоlоdymyr Korobchanskyі
{"title":"ATTENTION AS A CRITERIAL PROPERTY OF PROFESSIONAL FITNESS OF PERSONS WORKING IN HAZARDOUS CONDITIONS","authors":"Olena Grihoryan, Vоlоdymyr Korobchanskyі","doi":"10.35339/ic.8.4.254-259","DOIUrl":"https://doi.org/10.35339/ic.8.4.254-259","url":null,"abstract":"The purpose of the study was to improve methodological approaches to determination of attention as a criterion of professional fitness of persons working in hazardous conditions. To determine attention, we evaluated productivity index of information retrieval by “Numeric Square” method. When analyzing the data obtained during the study of attention (including its switching) on the productivity of information retrieval in persons who perform different types of hazardous work and the difference between the type of work performed. The vast majority of surveyed persons working in hazardous conditions were found to meet professional requirements (70%) by psychophysiological function “attention” (including its switching). The group of “conditionally fit” included (25%) subjects and “unfit” – 5%.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133473995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inter CollegasPub Date : 2022-05-22DOI: 10.35339/ic.8.4.290-297
N. Maryenko, O. Stepanenko
{"title":"FRACTAL DIMENSION IN MORPHOLOGY AND MEDICINE: THEORETICAL BASES AND PRACTICAL APPLICATION: review","authors":"N. Maryenko, O. Stepanenko","doi":"10.35339/ic.8.4.290-297","DOIUrl":"https://doi.org/10.35339/ic.8.4.290-297","url":null,"abstract":"Morphometry is an integral part of most modern morphological studies and the classic morphological morphometric methods and techniques are often borrowed for research in other fields of medicine. The majority of morphometric techniques are derived from Euclidean geometry. In the past decades, the principles, parameters and methods of fractal geometry are increasingly used in morphological studies. The basic parameter of fractal geometry is fractal dimension. Fractal dimension allows you to quantify the degree of filling of space with a certain geometric object and to characterize the complexity of its spatial configuration. There are many anatomical structures with complex irregular shapes that cannot be unambiguously and comprehensively characterized by methods and techniques of traditional geometry and traditional morphometry: irregular linear structures, irregular surfaces of various structures and pathological foci, structures with complex branched, tree-like, reticulated, cellular or porous structure, etc. Fractal dimension is a useful and informative morphometric parameter that can complement existing quantitative parameters to quantify objective characteristics of various anatomical structures and pathological foci. Fractal analysis can qualitatively complement existing morphometric methods and techniques and allow a comprehensive assessment of the spatial configuration complexity degree of irregular anatomical structures. The review describes the basic principles of Euclidean and fractal geometry and their application in morphology and medicine, importance and application of sizes and their derivatives, topological, metric and fractal dimensions, regular and irregular figures in morphology, and practical application of fractal dimension and fractal analysis in the morphological studies and clinical practice.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131624614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inter CollegasPub Date : 2022-05-22DOI: 10.35339/ic.8.4.278-289
A. Tkachenko, A. Onishchenko, D. Butov, M. Tkachenko
{"title":"FLOW CYTOMETRY IN NANOTOXICOLOGY: brief overview","authors":"A. Tkachenko, A. Onishchenko, D. Butov, M. Tkachenko","doi":"10.35339/ic.8.4.278-289","DOIUrl":"https://doi.org/10.35339/ic.8.4.278-289","url":null,"abstract":"The paper deals with the role of flow cytometry in assessing the biocompatibility and safety profiles of nanomaterials. Flow cytometry is a powerful tool to characterize the impact of various exogenous factors on different cell populations due to its ability to register optical and fluorescence characteristics of cells analyzing multiple parameters simultaneously. An overview of flow cytometry application for evaluating the redox state of cells, viability and cell death modes (apoptosis, necrosis, necroptosis, pyroptosis, autophagy), and pro-inflammatory effects of nanoparticles is provided.\u0000\u0000Flow cytometry offers rapid, informative, quite cost-effective and multi-angled analysis of safety profiles of nanomaterials taking into account the key mechanisms of their toxic action. Recent advances in flow cytometry technologies and the availability of commercial automated cell counters make flow cytometry a convenient research tool for in vitro nanotoxicology. However, the field requires the development of standardized flow cytometry protocols for nanotoxicity testing.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116881647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inter CollegasPub Date : 2022-05-22DOI: 10.35339/ic.8.4.260-277
Victor Ohniev, K. Pomohaibo, V. Nesterenko
{"title":"OVERWEIGHT AND OBESITY IN YOUNG PEOPLE: review","authors":"Victor Ohniev, K. Pomohaibo, V. Nesterenko","doi":"10.35339/ic.8.4.260-277","DOIUrl":"https://doi.org/10.35339/ic.8.4.260-277","url":null,"abstract":"Obesity in young people is one of the main problems of modern health care due to its high prevalence, complex adverse health effects, risk of complications and low effectiveness of existing treatments. The urgency of this problem is also increasing in low- and middle-income countries, including Ukraine. The article presents data on the medical and social significance of obesity at a young age, the prevalence of overweight and obesity among children of all ages in the world and in our country, key risk factors for overweight, as well as key WHO strategies and programs for the prevention of food-related diseases. In Ukraine, there is an insufficient level of registration of cases of obesity, which is due to the imperfection of the existing system of prevention of this pathology. Thus, important measures on this issue in our country, according to modern strategy, are the study of the environment where the child is, the lifestyle of families, the health of overweight children, followed by the organization of prevention and treatment.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133070224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inter CollegasPub Date : 2022-05-22DOI: 10.35339/ic.8.4.238-246
I. Kryvoruchko, A. Olefir
{"title":"ADHESIVE OBSTRUCTION OF THE SMALL INTESTINE: FEATURES OF DIAGNOSIS AND TREATMENT IN THE CONTEXT OF MINIMALLY INVASIVE TECHNOLOGIES: review","authors":"I. Kryvoruchko, A. Olefir","doi":"10.35339/ic.8.4.238-246","DOIUrl":"https://doi.org/10.35339/ic.8.4.238-246","url":null,"abstract":"The review presents a modern view on the features of the course and treatment of adhesions of the small intestine, based on modern epidemiological data, accepted guidelines for the diagnosis and nature of the treatment of different categories of patients. It is noted that adhesive intestinal obstruction is a symptom complex due to violation of the movement of contents through the intestines due to the presence of adhesions in the abdominal cavity after operations and injuries. Attention is drawn to the peculiarities of diagnostics of various forms of the disease, which include the leading clinical symptoms, data of X-ray methods (X-ray and CT of the abdominal cavity), MRI, assessment of various biomarkers, indicators of the severity of the patient's condition. It is noted that at present the primary task in solving this problem is to study several controversial issues in this area. The main provisions of measures for the treatment of adhesive obstruction of the small intestine, based on the principles of non-surgical treatment in a certain category of patients, the use of surgical interventions strictly according to indications, especially in patients who need to perform repeated operations, were highlighted. Among them, special attention is paid to the features of open and minimally invasive surgical interventions. It is emphasized that at present, minimally invasive surgical interventions perform the main tasks of surgical treatment for adhesive ileus of the small intestine and significantly reduce surgical trauma in comparison with \"open\" methods of treatment, but these interventions have not widespread in the world yet.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"130 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123133464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inter CollegasPub Date : 2022-05-21DOI: 10.35339/ic.8.4.196-200
V. Kapustnyk, V. Myasoedov, O. Riga, N. Orlova
{"title":"CENTER OF PALLIATIVE MEDICINE AT KHARKIV NATIONAL MEDICAL UNIVERSITY: MODERN CHALLENGES AND DEVELOPMENT STRATEGIES","authors":"V. Kapustnyk, V. Myasoedov, O. Riga, N. Orlova","doi":"10.35339/ic.8.4.196-200","DOIUrl":"https://doi.org/10.35339/ic.8.4.196-200","url":null,"abstract":"In most countries of the world, palliative care is an integral part of quality medical care, which includes comprehensive medical, social, psychological, and spiritual support for critically ill patients and their relatives. According to the WHO, every year about 20 million people worldwide need palliative care at the end of their lives. There are many more who need palliative care until the last year of their lives. Thus, the total number of people who need palliative care annually is about 40 million. It is estimated that of the 20 million people in need of end-of-life palliative care, 78% live in low- and middle-income countries; about 67% are elderly and about 6% are children. However, only 14% of people who need end-of-life palliative care receive it. Palliative care considers the principle of respect for patients' decisions and aims to provide practical support to their family members during illness and in the event of a patient's death to overcome grief over the loss of a loved one. The WHO's global strategy for health care, based on human approach and integration, is to strengthen palliative care programs for patients with various diseases. Despite the fact that some steps have already been taken in Ukraine towards the development of palliative care, there are still some problems: lack of qualified medical staff; lack of relationships between primary and secondary, tertiary care and coordination; imperfect system of informing medical workers about ensuring the right to anesthesia for seriously ill patients; lack of a sufficient number of pharmacies licensed to operate controlled medicines; lack of interagency programs in the field of palliative care.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127252235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inter CollegasPub Date : 2022-05-21DOI: 10.35339/ic.8.4.217-225
G. Yeryomenko, T. Bezditko, T. Ospanova
{"title":"THE VIEW OF THE CLINICIAN ON THE PROBLEM OF COVID-19: review","authors":"G. Yeryomenko, T. Bezditko, T. Ospanova","doi":"10.35339/ic.8.4.217-225","DOIUrl":"https://doi.org/10.35339/ic.8.4.217-225","url":null,"abstract":"The review article features the peculiarities in the epidemiological and clinical picture of a new coronavirus infection, COVID-19. The purpose of the review was to analyze the issues of the management. Pathogenetic relationships between SARS-CoV-2 virus, COVID-19 and angiotensin-converting enzyme 2 (ACE2) are assessed. Predisposing factors, which result in development of pneumonia and endothelial dysfunction, disorders in microcirculation, vasocon- striction, work of the renin-angiotensin system with subsequent development of ischemia in certain organs, inflammation and edema of tissues, are analyzed. Lung damage causes devel- opment of interstitial pneumonia, activation of the process of formation of fibrosis and de- creased pulmonary function. Accumulation of anti-inflammatory cytokines, which break the blood-brain barrier, in the CNS can cause dysregulation of central structures, autonomic dysfunction and severe asthenic syndrome, which can maintain low-grade inflammation for a long time. Opportune diagnosis and treatment of concomitant diseases in post-COVID-19 patients are of paramount significance for achieving a positive clinical outcome. The plan of rehabilitation treatment should be individualized according to the patient’s needs. In order to assess remote consequences of COVID-19 all patients require further follow-ups.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"169 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115754225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inter CollegasPub Date : 2022-05-21DOI: 10.35339/ic.8.4.201-210
A. Shalimova
{"title":"INSUFFICIENT CONTROL OF OUT-OF-OFFICE BLOOD PRESSURE: THE PROBLEM OF MASKED UNCONTROLLED HYPERTENSION: review","authors":"A. Shalimova","doi":"10.35339/ic.8.4.201-210","DOIUrl":"https://doi.org/10.35339/ic.8.4.201-210","url":null,"abstract":"Despite significant advances in the diagnosis and treatment of arterial hypertension (AH), the problem of insufficient blood pressure (BP) control in hypertensive patients is quite acute. According to current guidelines, the effectiveness of antihypertensive therapy is mainly assessed by reaching the target levels of office BP, while masked uncontrolled hypertension (MUCH), which is diagnosed on the basis of insufficient control of out-of-office BP, increases the risk of cardiovascular events. Patients with insufficient out-of-office BP control have an increased risk of cardiovascular events compared to patients with both office and out-of-office BP control, therefore MUCH requires timely diagnosis and correction.\u0000\u0000This mini-review summarizes the understanding of the nature of MUCH. A particular attention is paid to risk factors and ways of influencing the out-of-office BP control. The article also assessed the important contribution of ABPM to the control of out-of-office BP and to determining the overall risk of MUCH.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127148186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inter CollegasPub Date : 2022-05-21DOI: 10.35339/ic.8.4.226-231
N. Zhelezniakova, O. Babak, T. Aleksandrova
{"title":"MODERN METHODS OF DIAGNOSIS AND SCREENING OF NON-ALCOHOLIC FATTY LIVER DISEASE AND ITS STAGES: review","authors":"N. Zhelezniakova, O. Babak, T. Aleksandrova","doi":"10.35339/ic.8.4.226-231","DOIUrl":"https://doi.org/10.35339/ic.8.4.226-231","url":null,"abstract":"The review is devoted to the problem of diagnosing one of the most common pathologies of the modern world – non-alcoholic fatty liver disease (NAFLD). Data from experimental and clinical studies on the importance of various instrumental and biochemical methods of non-invasive diagnosis ofnon-alcoholic steatohepatitis (NASH) and liver fibrosis (LF) are presented. New non-invasive diagnostic methods of NASH and LF are considered.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"128 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134552265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}