Inter Collegas最新文献

{"title":"NEW MARKERS FOR DIAGNOSIS AND PROGNOSIS OF COGNITIVE IMPAIRMENT IN PATIENTS WITH MULTIPLE SCLEROSIS (review)","authors":"O. Teslenko, O. Tovazhnyanska","doi":"10.35339/ic.9.1.14-18","DOIUrl":"https://doi.org/10.35339/ic.9.1.14-18","url":null,"abstract":"The article presents modern approaches about the diagnosis of brain damage and the development of cognitive impairment in patients with multiple sclerosis. Neurodegenerative changes are considered, which take place in the early stages of the disease and play an important role in the formation of irreversible neurological deficits. Cognitive impairment in patients with multiple sclerosis is quite common, but they are not always noticed, but they significantly reduce patients' quality of life. The article describes the possibilities of neuroimaging methods to identify structural changes in the parts of the brain responsible for cognitive functions. The importance of brain neurotrophic factor (BDNF) as a promising biomarker of multiple sclerosis is presented. Further study of BDNF remains interesting, which will allow to develop algorithms for early diagnosis and prediction of disease progression, that will provide an opportunity to deepen the understanding of the place of BDNF in the pathomorphological chain of nervous system damage in multiple sclerosis.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117090149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL SIGNIFICANCE OF NATRIURETIC PEPTIDES (review)","authors":"L. Zhuravlyova, N. Sokolnikova, Tetyana Rogachova","doi":"10.35339/ic.9.1.5-13","DOIUrl":"https://doi.org/10.35339/ic.9.1.5-13","url":null,"abstract":"Natriuretic peptides are widely known for their protective effects against the development of metabolic syndrome and cardiovascular disease. The important role of determining the levels of natriuretic peptides in the diagnosis, assessment of severity, prognosis and effectiveness of treatment of heart failure has been proven in many studies and noted in clinical guidelines worldwide. Visceral obesity reduces the production and action of natriuretic peptides, increasing the risk of heart failure and diabetes mellitus 2 type. Metabolic syndrome is present in 60% of patients with chronic heart failure, most of its components contribute to the development and progression of chronic heart failure and include obesity, hypertension, dyslipidemia, insulin resistance, impaired glucose tolerance. The prevalence of metabolic syndrome in the general population is 34% and is constantly increasing due to unhealthy diet, sedentary lifestyle and chronic stress. The prevalence of chronic heart failure is increasing rapidly in all industrialized countries, affecting 2% of adults and 10% of the elderly. Therefore, the problem of early diagnosis and treatment of metabolic syndrome and chronic heart failure is very relevant nowadays. The review focuses on the pathophysiological relationships between natriuretic peptides, heart failure and metabolic syndrome, and the approaches to the correction of natriuretic peptides’ metabolism.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129764536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE ANALYSIS OF CLINICAL AND LABORATORY DATA OF LUNG AFFECTION IN PATIENTS WITH COVID-19 WITH THOSE OF PANDEMIC INFLUENZA A/H1N1","authors":"K. Yurko, D. Katsapov, A. Bondarenko, Volodymir Kulchin, O. Chiriukina","doi":"10.35339/ic.9.1.19-23","DOIUrl":"https://doi.org/10.35339/ic.9.1.19-23","url":null,"abstract":"Influenza viruses, in particular A ‒ A(H3N2) and A(H1N1)pdm09, as well as influenza B virus, mainly (98%) of the B/Victoria line, continue to circulate during the current epidemic season. The level of influenza vaccination remains low, about 0.6% of the population of Ukraine, and among occupational and epidemiological risk groups ‒ 22.8%, according to the Public Health Centre of the Ministry of Health of Ukraine. In the COVID-19 pandemic, simultaneous circulation of influenza viruses and SARS-CoV-2 can lead to difficulties in differential diagnosis and treatment. Comparison of clinical and laboratory features of severe influenza complicated by pneumonia caused by pandemic influenza virus A(H1N1)pdm09 in the epidemic season of 2015/2016 Kharkiv RCIDH with COVID-19 on clinical and laboratory data was the aim of the work. Patients and research methods. The analysis of clinical symptoms and laboratory examination data of 19 patients with influenza complicated by community-acquired pneumonia of clinical group IV who were treated at the Kharkiv Regional Hospital and their comparison with those of patients with COVID-19 according to the literature. Results and discussion. Among the studied patients, men predominated ‒ 12 persons (63.2%) aged 50.68±11.95 years. The predominant number had concomitant diseases. At the beginning of the disease, moderate weakness, headache, fever, minor catarrhal phenomena and, as a result, delayed hospitalization prevailed. From 3‒4 days of the disease the condition significantly worsened, shortness of breath and cyanosis joined. Typical initial symptoms of COVID-19 are fever of varying degrees (73%), unproductive cough (59%) and shortness of breath or shortness of breath. Conclusions. In patients with COVID-19 and severe influenza, a more acute onset of the disease was reported, with moderate weakness, headache and fever up to 38°C and symptoms of pharyngitis. Influenza patients often show a delay in seeking medical attention and hospitalization for 6.21±1.46 days of illness. The severity of the disease in influenza is due to the accession of community-acquired pneumonia, in contrast to COVID-19, where the typical features are diffuse, mostly subpleural lung affection. Vaccination of people at risk before the start of the epidemic season is necessary to prevent severe complications of influenza caused by the pandemic virus A(H1N1)pdm09 in the context of the COVID-19 pandemic.\u0000\u0000Keywords: influenza, pneumonia, COVID-19, diagnosis.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133944487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FORENSIC MEDICAL DETERMINATION OF THE SEVERITY OF CHEST INJURIES WITH RIB CAGE TRAUMA","authors":"M. Gubin, V. Olkhovsky, E. Grygorian","doi":"10.35339/ic.9.1.45-49","DOIUrl":"https://doi.org/10.35339/ic.9.1.45-49","url":null,"abstract":"Background. Closed chest trauma with rib fractures is a common injury to the external respiratory system. Victims with such an injury may be subject to forensic examination.\u0000\u0000Purpose. The aim of the study was to determine the severity of injuries in patients with closed chest trauma with violation of the integrity of the costal skeleton, treated in a specialized surgical hospital, to establish additional criteria for forensic diagnosis of such trauma.\u0000\u0000Subjects and Methods. 71 medical cards of inpatients, patients with chest injuries who were treated at the Kharkiv Institute of General and Emergency Surgery named after V.T. Zaitseva. A forensic medical evaluation of closed chest injuries with rib fractures was performed according to the severity of injuries according to clinical observations. Morphological and clinical approach was used to determine the severity of injuries.\u0000\u0000Results. Severe injuries were found in 14 (19.7%) cases of injuries, mainly with the occurrence of a life-threatening phenomenon, namely acute respiratory failure. Moderate injuries were found in 57 (80.3%) cases of chest injuries with rib fractures in the absence of danger to life.\u0000\u0000Conclusions. It is established that in the available scientific and methodological literature there are no diagnostic morpho-clinical signs for qualitative forensic assessment and prediction of the final results of closed chest injuries, there are different views on forensic assessment. It is determined that when applying the morphological and clinical approach of forensic assessment, additional diagnostic criteria for closed chest injuries, should be considered when determining the severity of injuries: dynamics and duration of recovery of post-traumatic morphological and functional changes of injured organs. or the entire respiratory system (lungs), the occurrence of life-threatening phenomena. The ways of further improvement of forensic diagnostics in the assessment of these injuries by the degree of their severity are identified.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132673503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIMULATION OF EPIDEMIC PROCESSES: A REVIEW OF MODERN METHODS, MODELS AND APPROACHES","authors":"T. Chumachenko, D. Chumachenko","doi":"10.35339/ic.9.1.66-75","DOIUrl":"https://doi.org/10.35339/ic.9.1.66-75","url":null,"abstract":"The paper is devoted to an overview of the current state of research on the modeling of epidemic processes. The classification of mathematical and simulation models of epidemic processes is carried out. The disadvantages of classical models are revealed. Specific characteristics inherent in epidemic processes have been determined, which must be taken into account when constructing mathematical and simulation models. A review of deterministic compartment models is carried out. Various methods and approaches to the construction of statistical models of epidemic processes are considered. The types of problems that are solved using machine learning are analyzed.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"79 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133087822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SEX-RELATED DIFFERENCES IN THE LEVELS OF URINE 6-SULFATOXYMELATONIN IN VERY LOW BIRTH WEIGHT INFANTS","authors":"Hanna Kuzienkova","doi":"10.35339/ic.9.1.31-35","DOIUrl":"https://doi.org/10.35339/ic.9.1.31-35","url":null,"abstract":"Background. The sex-related differences of the urinary 6-sulfatoxymelatonin have not been studied in premature infants yet. The purpose of the work was to measure the daily urinary 6-sulfatoxymelatonin in premature infants with a very low birth weight.\u0000\u0000Materials and Methods. Fifty premature infants (28 males and 22 females) with gestational age less than 33 weeks and body weight from 999 g to 1499 g were involved in the study. Urine 6-sulfatoxymelatonin was assessed using urine collection on the 1st day and on the 10th‒14th days of life.\u0000\u0000Results. The level of urine 6-sulfatoxymelatonin on the 1st day of life showed a significant increase in its excretion in females compared to males. The median values in males were 202.0 (95% CI 77.1–390.9) pg/ml and in females 437.0 (279.6–501.0) pg/ml, p=0.0103. Its level on the 10th–14th days of life significantly decreased both in males 57.0 (95 % СІ 45,0–99.7) pg/ml, p=0.0028 and in females 90.0 (51.9–160.7) pg/ml, p=0.0021 without differences in sex-related distribution, p=0.3940.\u0000\u0000Conclusions. The melatonin metabolite as urinary 6-sulfatoxymelatonin in premature infants with a very low birth weight demonstrates sex-related differences with significant increase in females compared to males on the 1st day of life and no sex-related difference on the 10th–14th days of life. The trend of reduced pineal function is a key point in understanding the neuroendocrine reactivity in male preterms. Future investigation of sex-related aspects of urinary 6-sulfatoxymelatonin excretion in children, especially premature infants, is required.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131313057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ROLE OF “MICROBIAL FACTOR” IN THE DEVELOPMENT OF ADENOMYOSIS (review)","authors":"M.A. Shcherbyna, A. Chekhunova","doi":"10.35339/ic.9.1.59-65","DOIUrl":"https://doi.org/10.35339/ic.9.1.59-65","url":null,"abstract":"Endometriosis is a multifactorial disease that affects mainly women of reproductive age. The exact pathogenesis of this disease is still a mystery. The analysis of modern etiology concepts and mechanisms of adenomyosis development were carried out. The review includes data from foreign articles published in the PubMed, UpToDate, eLibrary databases over the past ten years. A number of works presenting studies of the uterus microbiota and its influence on the disease development were analyzed. The possibilities of cultural and molecular genetic diagnostic methods, in particular 16S rRNA, in studying the state of the uterine cavity microbiota are described. The modern paradigm of the development and progression of adenomyosis provides for the presence of endometrium bacterial contamination which, in turn, is a trigger for cell modifications activating a vicious circle of pathology.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126329861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CREATION OF ANTI-INFLAMMATORY PHARMACEUTICAL COMPOSITIONS (review)","authors":"G. Syrova, V. Petiunina, Volodymir Makarov, L. Lukianova, Natalya Сhalenko","doi":"10.35339/ic.9.1.93-101","DOIUrl":"https://doi.org/10.35339/ic.9.1.93-101","url":null,"abstract":"The review article summarizes the date of literature and our own research on the creation of more effective and safe domestic combined drugs with a pronounced anti-inflammatory and analgesic effects. Untimely treatment of inflammatory processes often leads to long-term disability and even disability, so today there is an active search for new effective and safe domestic combination drugs with pronounced anti-inflammatory and analgesic effects. The constant search for innovative drugs causes a significant number of diseases, pathological conditions for which treatment with existing drugs is not effective or causes addiction and a large number of side effects. Because of, inflammatory processes can be accompanied by severe pain, spasms, increased convulsive activity of the brain, other disorders of the body, so non-narcotic analgesics and nonsteroidal anti-inflammatory drugs are combined with other drugs that can cause complementary effects or potentiate each other's effects. Caffeine is a useful adjuvant of nonsteroidal anti-inflammatory drugs of various chemical structures in terms of anti-inflammatory and analgesic effects. The review article presents a literature review of the current state of treatment of inflammation and pain, conducting research to expand the therapeutic capabilities of known pharmaceuticals, the creation of pharmaceutical compositions of nonsteroidal anti-inflammatory drugs with caffeine.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117343186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CURRENT ISSUES OF RESISTANT TUBERCULOSIS AND SMOKING (review)","authors":"T. Butova, A. Tkachenko, D. Butov","doi":"10.35339/ic.9.1.24-30","DOIUrl":"https://doi.org/10.35339/ic.9.1.24-30","url":null,"abstract":"Tuberculosis and smoking are among the most pressing issues in the modern health care system in the world. Tuberculosis patients who smoke are confirmed to have reduced the effectiveness of anti-tuberculosis therapy, unsatisfactory prognosis of a specific disease, higher risk of treatment failure and mortality from this disease. Diseases such as HIV and alcoholism increase ineffective treatment in tobacco smokers. In addition, smoking leads to increased virulence of the causative agent of tuberculosis - Mycobacterium tuberculosis.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130945548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREDICTING THE EFFECTIVENESS OF MYOPIA CONTROL WHEN USING ORTHOKERATOLOGICAL LENSES BASED ON INDIVIDUAL EYE PARAMETERS","authors":"P. Bezdetko, R. Parkhomets","doi":"10.35339/ic.9.1.76-85","DOIUrl":"https://doi.org/10.35339/ic.9.1.76-85","url":null,"abstract":"Introduction. The prevalence and progressive course of myopia is one of the most important medical and social problems worldwide. In recent years, in our country and abroad there is a tendency to increase the incidence of myopia, becoming in some countries an epidemic. In recent years, the most common method of effective control of myopia is the method of refractive therapy with orthokeratological lenses.\u0000\u0000Objective: To develop criteria for predicting the effectiveness of myopia control using orthokeratological lenses based on individual eye parameters.\u0000\u0000Object and methods of research. A total of 60 children (117 eyes) were included in the clinical study, who were selected by OKL of combined design, SkyOptix, licensed by KATT Design Group (Canada). The average age was 11 [10; 13], from 7 to 14 years, of which 37 were females (61.7%), 23 males (38.3%). Ophthalmological examination consisted of visometry without correction and with optical correction, autorefractometry on the narrow pupil and in the state of drug cycloplegia, biomicroscopy, biometry, ophthalmoscopy of the central and peripheral fundus, keratotopography of the horns, pupilometry.\u0000\u0000The results of the research: Among the studied people, the average refractive index at the beginning of the study was -2.25 [-3; -1.5] diopters. The initial diameter of the pupils was determined from 2.78 to 6.30 mm according to the pupilometry performed on the topograph. The average values of eccentricity (Ex) studied in the flat meridian averaged 0.51 [0.47; 0.58], in the steep - 0.53 [0.43; 0.59] at the beginning of the study. In our study, the keratometry of the cornea averaged 43.5 at the beginning of the study [42.7; 44.4].\u0000\u0000As a result of probability analysis (increase in APS for two years), the method of construction of logistic regression models was used. We selected five factor features (X): Initial refraction, Pupil diameter (X2), Keratometry (X3), Peripheral corneal force on the reverse zone ring (X4 and X5), Corneal diameter, and Axial length of the eye (APS) at the time of treatment (initial).\u0000\u0000The equation of logistic regression of the model for predicting the probability of progression of myopia on the background of the use of OKL had the form:\u0000\u0000The classification ability of the model was determined according to the training sample and amounted to 79.5%. The probability of a true positive result (increase in APS less than 0.3) when using this model was 91.9%, and the probability of a true negative result - 38.5%. Evaluation of the quality of the model using ROC-analysis showed the following: the area under the ROC-curve (AUC) was equal to 0.86 (p <0.001), which characterizes the good quality of the classification of traits. The sensitivity of the model was 82.6%, specificity - 73.1%.\u0000\u0000As part of the research and mathematical calculations, an interactive WEB application was also developed, which can be accessed from various types of devices connected to the World Wide Web. Modern solutions a","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116965532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}