抗炎药物组合物的创建(综述)

G. Syrova, V. Petiunina, Volodymir Makarov, L. Lukianova, Natalya Сhalenko
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摘要

本文综述了文献资料和我们自己的研究,以创造更有效、安全、具有明显抗炎和镇痛作用的国产联合药物。对炎症过程的不及时治疗往往会导致长期残疾甚至残疾,因此目前人们正在积极寻找新的有效和安全的、具有明显抗炎和镇痛作用的国产联合药物。对创新药物的不断探索导致了大量现有药物治疗无效或导致成瘾的疾病和病理状况,以及大量的副作用。因为,炎症过程可能伴随着剧烈的疼痛、痉挛、大脑痉挛活动的增加,以及身体的其他紊乱,所以非麻醉性镇痛药和非甾体抗炎药与其他药物联合使用,可以产生互补作用或相互增强作用。咖啡因是各种化学结构的非甾体类抗炎药的有效辅助剂,具有抗炎和镇痛作用。这篇综述文章介绍了目前治疗炎症和疼痛的文献综述,开展研究以扩大已知药物的治疗能力,创造含有咖啡因的非甾体抗炎药的药物组合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CREATION OF ANTI-INFLAMMATORY PHARMACEUTICAL COMPOSITIONS (review)
The review article summarizes the date of literature and our own research on the creation of more effective and safe domestic combined drugs with a pronounced anti-inflammatory and analgesic effects. Untimely treatment of inflammatory processes often leads to long-term disability and even disability, so today there is an active search for new effective and safe domestic combination drugs with pronounced anti-inflammatory and analgesic effects. The constant search for innovative drugs causes a significant number of diseases, pathological conditions for which treatment with existing drugs is not effective or causes addiction and a large number of side effects. Because of, inflammatory processes can be accompanied by severe pain, spasms, increased convulsive activity of the brain, other disorders of the body, so non-narcotic analgesics and nonsteroidal anti-inflammatory drugs are combined with other drugs that can cause complementary effects or potentiate each other's effects. Caffeine is a useful adjuvant of nonsteroidal anti-inflammatory drugs of various chemical structures in terms of anti-inflammatory and analgesic effects. The review article presents a literature review of the current state of treatment of inflammation and pain, conducting research to expand the therapeutic capabilities of known pharmaceuticals, the creation of pharmaceutical compositions of nonsteroidal anti-inflammatory drugs with caffeine.
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