{"title":"临床医生对COVID-19问题的看法:综述","authors":"G. Yeryomenko, T. Bezditko, T. Ospanova","doi":"10.35339/ic.8.4.217-225","DOIUrl":null,"url":null,"abstract":"The review article features the peculiarities in the epidemiological and clinical picture of a new coronavirus infection, COVID-19. The purpose of the review was to analyze the issues of the management. Pathogenetic relationships between SARS-CoV-2 virus, COVID-19 and angiotensin-converting enzyme 2 (ACE2) are assessed. Predisposing factors, which result in development of pneumonia and endothelial dysfunction, disorders in microcirculation, vasocon- striction, work of the renin-angiotensin system with subsequent development of ischemia in certain organs, inflammation and edema of tissues, are analyzed. Lung damage causes devel- opment of interstitial pneumonia, activation of the process of formation of fibrosis and de- creased pulmonary function. Accumulation of anti-inflammatory cytokines, which break the blood-brain barrier, in the CNS can cause dysregulation of central structures, autonomic dysfunction and severe asthenic syndrome, which can maintain low-grade inflammation for a long time. Opportune diagnosis and treatment of concomitant diseases in post-COVID-19 patients are of paramount significance for achieving a positive clinical outcome. The plan of rehabilitation treatment should be individualized according to the patient’s needs. In order to assess remote consequences of COVID-19 all patients require further follow-ups.","PeriodicalId":194632,"journal":{"name":"Inter Collegas","volume":"169 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"THE VIEW OF THE CLINICIAN ON THE PROBLEM OF COVID-19: review\",\"authors\":\"G. Yeryomenko, T. Bezditko, T. Ospanova\",\"doi\":\"10.35339/ic.8.4.217-225\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The review article features the peculiarities in the epidemiological and clinical picture of a new coronavirus infection, COVID-19. The purpose of the review was to analyze the issues of the management. Pathogenetic relationships between SARS-CoV-2 virus, COVID-19 and angiotensin-converting enzyme 2 (ACE2) are assessed. Predisposing factors, which result in development of pneumonia and endothelial dysfunction, disorders in microcirculation, vasocon- striction, work of the renin-angiotensin system with subsequent development of ischemia in certain organs, inflammation and edema of tissues, are analyzed. Lung damage causes devel- opment of interstitial pneumonia, activation of the process of formation of fibrosis and de- creased pulmonary function. Accumulation of anti-inflammatory cytokines, which break the blood-brain barrier, in the CNS can cause dysregulation of central structures, autonomic dysfunction and severe asthenic syndrome, which can maintain low-grade inflammation for a long time. Opportune diagnosis and treatment of concomitant diseases in post-COVID-19 patients are of paramount significance for achieving a positive clinical outcome. The plan of rehabilitation treatment should be individualized according to the patient’s needs. In order to assess remote consequences of COVID-19 all patients require further follow-ups.\",\"PeriodicalId\":194632,\"journal\":{\"name\":\"Inter Collegas\",\"volume\":\"169 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Inter Collegas\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.35339/ic.8.4.217-225\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inter Collegas","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35339/ic.8.4.217-225","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
THE VIEW OF THE CLINICIAN ON THE PROBLEM OF COVID-19: review
The review article features the peculiarities in the epidemiological and clinical picture of a new coronavirus infection, COVID-19. The purpose of the review was to analyze the issues of the management. Pathogenetic relationships between SARS-CoV-2 virus, COVID-19 and angiotensin-converting enzyme 2 (ACE2) are assessed. Predisposing factors, which result in development of pneumonia and endothelial dysfunction, disorders in microcirculation, vasocon- striction, work of the renin-angiotensin system with subsequent development of ischemia in certain organs, inflammation and edema of tissues, are analyzed. Lung damage causes devel- opment of interstitial pneumonia, activation of the process of formation of fibrosis and de- creased pulmonary function. Accumulation of anti-inflammatory cytokines, which break the blood-brain barrier, in the CNS can cause dysregulation of central structures, autonomic dysfunction and severe asthenic syndrome, which can maintain low-grade inflammation for a long time. Opportune diagnosis and treatment of concomitant diseases in post-COVID-19 patients are of paramount significance for achieving a positive clinical outcome. The plan of rehabilitation treatment should be individualized according to the patient’s needs. In order to assess remote consequences of COVID-19 all patients require further follow-ups.