OECD Series on Testing and Assessment最新文献

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Good Cell Culture Practice (GCCP) 良好细胞培养规范(GCCP)
OECD Series on Testing and Assessment Pub Date : 2018-12-14 DOI: 10.1787/9789264304796-16-en
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引用次数: 0
Performance of the method 方法性能
OECD Series on Testing and Assessment Pub Date : 2018-12-14 DOI: 10.1787/9789264304796-13-en
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引用次数: 0
Guidance Document on Good In Vitro Method Practices (GIVIMP) 良好体外方法规范指导文件(GIVIMP)
OECD Series on Testing and Assessment Pub Date : 2018-12-10 DOI: 10.1787/9789264304796-en
Emma Pedersen, Kristina Fant
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引用次数: 105
Annexes 附件
OECD Series on Testing and Assessment Pub Date : 2018-12-10 DOI: 10.1787/g2836fccb6-en
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引用次数: 0
Considerations for Assessing the Risks of Combined Exposure to Multiple Chemicals 评估多重化学品联合暴露风险的考虑
OECD Series on Testing and Assessment Pub Date : 2018-12-06 DOI: 10.1787/ceca15a9-en
{"title":"Considerations for Assessing the Risks of Combined Exposure to Multiple Chemicals","authors":"","doi":"10.1787/ceca15a9-en","DOIUrl":"https://doi.org/10.1787/ceca15a9-en","url":null,"abstract":"","PeriodicalId":19458,"journal":{"name":"OECD Series on Testing and Assessment","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85983605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 58
Developmental Neurotoxicity Study (OECD TG 426) 发育神经毒性研究(OECD TG 426)
OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI: 10.1787/9789264304741-27-en
{"title":"Developmental Neurotoxicity Study (OECD TG 426)","authors":"","doi":"10.1787/9789264304741-27-en","DOIUrl":"https://doi.org/10.1787/9789264304741-27-en","url":null,"abstract":"","PeriodicalId":19458,"journal":{"name":"OECD Series on Testing and Assessment","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88118965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Larval Amphibian Growth and Development Assay (LAGDA) (OECD TG 241) 两栖动物幼虫生长发育测定(LAGDA) (OECD TG 241)
OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI: 10.1787/9789264304741-15-en
Tg
{"title":"Larval Amphibian Growth and Development Assay (LAGDA) (OECD TG 241)","authors":"Tg","doi":"10.1787/9789264304741-15-en","DOIUrl":"https://doi.org/10.1787/9789264304741-15-en","url":null,"abstract":"422. Modality detected/endpoints: OECD TG 241 has three endpoints indicating generalised toxicity (mortality, abnormal behaviour and growth), and several providing specific information about endocrine disruption or impaired reproduction (histopathology of thyroid, gonads, kidney and liver, time to metamorphosis [NF stage 62]; secondary sex characteristics (nuptial pads); vitellogenin (optional); genetic and phenotypic sex ratio). Most of these specific endocrine endpoints are likely to respond to interference with the hypothalamic/pituitary/gonadal (HPG) axis, while thyroid histopathology and time to metamorphosis may respond to interference with the hypothalamic/pituitary/thyroid axis (as may the “generalised toxicity” indicator, growth).","PeriodicalId":19458,"journal":{"name":"OECD Series on Testing and Assessment","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88622439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
OECD in vitro screens (Conceptual Framework Level 2) OECD体外筛选(概念框架2级)
OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI: 10.1787/9789264304741-4-en
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引用次数: 1
Combined Chronic Toxicity/Carcinogenicity Studies (OECD TG 451-3) 慢性毒性/致癌性联合研究(OECD TG 451-3)
OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI: 10.1787/9789264304741-24-en
Tg
{"title":"Combined Chronic Toxicity/Carcinogenicity Studies (OECD TG 451-3)","authors":"Tg","doi":"10.1787/9789264304741-24-en","DOIUrl":"https://doi.org/10.1787/9789264304741-24-en","url":null,"abstract":"745. These assays determine the general toxicity (OECD TG 452 and TG 453) and carcinogenicity (OECD TG 451 and TG 453) of chemicals in laboratory animals after exposure for a period lasting most of the lifespan. Route of administration may be oral, dermal or inhalation, although oral via diet is the most common. OECD TG 453 was revised in September 2009 and replaced OECD TG 451 (older studies may have used OECD TG 451). General toxicity studies usually have a duration of 12 months whilst carcinogenicity studies usually have a duration of 18 or 24 months depending on the species tested. They provide information on major toxic effects, target organ toxicity and carcinogenicity. Although they have not been validated for the detection of endocrine disruptors (EDs), they contain many endpoints that are suitable for the determination of endocrine effects. Organ weights are not always included in the carcinogenicity phases of these studies as neoplastic changes may confound them, but they are generally determined at 12 months. A comparison can be made with validation of the OECD TG 407 (28-Day Oral Toxicity Study) for endocrine endpoints (OECD, 2006) where substances that were moderate and strong EDs for (anti)estrogenicity and (anti)androgenicity (e.g. ethinylestradiol and flutamide) and weak and strong modulators of thyroid hormone-related effects (e.g. propylthiouracil, T4 and methyl testosterone) were detected. Steroidogenesis inhibition was also detected although only one (potent) chemical was used in the validation study (CGS 18320B). OECD TG 453 and TG 452 are likely to be more sensitive than OECD TG 407 because of the extended dosing period and the larger number of animals per group (20 or 50 rodents per sex per group for chronic or carcinogenicity studies respectively compared with 5 in OECD TG 407). OECD TG 453 and TG 452, however, do not contain some sensitive endpoints (e.g. thyroid hormones, estrous cyclicity) that may be included in OECD TG 407.","PeriodicalId":19458,"journal":{"name":"OECD Series on Testing and Assessment","volume":"83 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82867505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
21-Day Fish Assay (OECD TG 230) 21天鱼类化验(OECD TG 230)
OECD Series on Testing and Assessment Pub Date : 2018-09-03 DOI: 10.1787/9789264304741-7-en
{"title":"21-Day Fish Assay (OECD TG 230)","authors":"","doi":"10.1787/9789264304741-7-en","DOIUrl":"https://doi.org/10.1787/9789264304741-7-en","url":null,"abstract":"","PeriodicalId":19458,"journal":{"name":"OECD Series on Testing and Assessment","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88043853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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