Obesity Science & Practice最新文献

{"title":"Device-Specific Sex- and Age-Stratified Distributions of Phase Angle and Skeletal Muscle Mass in a Routine Outpatient Multifrequency Bioelectrical Impedance Cohort.","authors":"D E Cortés Sierra, J M Mora-Méndez, R Rosero-Revelo","doi":"10.1002/osp4.70166","DOIUrl":"10.1002/osp4.70166","url":null,"abstract":"<p><strong>Background: </strong>Large population-based studies have demonstrated age- and sex-related differences in phase angle (PhA). However, multifrequency bioelectrical impedance analysis (BIA) systems remain highly device-specific due to proprietary algorithms and prediction equations. This limits comparability across platforms, making descriptive distributions from single-device cohorts essential for routine clinical interpretation.</p><p><strong>Objective: </strong>To describe sex- and age-specific distributions of PhA and skeletal muscle mass using a single multifrequency BIA platform in an outpatient cohort, and to explore relationships with other device-derived body composition estimates.</p><p><strong>Methods: </strong>A retrospective cross-sectional analysis was conducted on adults in an outpatient program using the SECA mBCA 514 platform. PhA and skeletal muscle mass data were available for 1849 and 1870 participants, respectively. Sex- and age-stratified percentiles were generated. Fat-to-muscle ratio (FMR) was calculated, and its associations with PhA and device-estimated visceral adiposity were evaluated using Spearman correlation.</p><p><strong>Results: </strong>Men demonstrated higher PhA and skeletal muscle mass values than women; both measures declined across age strata in both sexes. Women exhibited higher FMR values. Higher FMR was moderately associated with lower PhA (rho = -0.467, <i>p</i> < 0.001), while its association with device-estimated visceral adiposity was weak (rho = 0.104, <i>p</i> < 0.001). Since all measurements originated from the same platform, these associations are descriptive rather than mechanistic.</p><p><strong>Conclusions: </strong>Device-specific, stratified distributions derived from routine multifrequency BIA assessments assist the clinical contextual interpretation of outpatient body composition measurements. The observed relationships between FMR and PhA are hypothesis-generating and require further validation using independent gold-standard reference methods such as MRI, DXA, or CT.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 3","pages":"e70166"},"PeriodicalIF":2.5,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13291798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148331513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Memory Performance in Adolescents Living With Obesity: Brain Activation During Encoding and Retrieval in a Case-Control Study.","authors":"Anaïs Emmie Bouvier, Bixente Dilharreguy, Ernesto Sanz-Arigita, Pascal Barat, Sylvie Berthoz, Elodie Barse, Aline Marighetto, Guillaume Ferreira, Gwenaëlle Catheline","doi":"10.1002/osp4.70147","DOIUrl":"10.1002/osp4.70147","url":null,"abstract":"<p><strong>Objective: </strong>Effects of obesity on brain health have been revealed in adults, including mental health effects and cognitive impairment. Regarding cognition, obesity-related memory impairment has been specifically described. While this effect could have a major impact on learning abilities during adolescence, few studies have considered this critical period.</p><p><strong>Methods: </strong>In this present study, a new fMRI memory task based on paired encoding of faces and backgrounds and subsequent face recognition was presented to male adolescents living with obesity (<i>N</i> = 11) and their lean counterparts (<i>N</i> = 15).</p><p><strong>Results: </strong>Our study shows that adolescents living with obesity exhibited significantly lower face recognition memory performances (F_(1,72) = 9.84, <i>p</i> = 0.002) than their lean counterparts coupled with altered functional cerebral activation patterns during the encoding and retrieval phases of the task. More specifically, during the encoding of the task, a hypoactivation of the right hippocampus and the parahippocampal gyrus was identified in adolescents living with obesity and during the retrieval a hyperactivation of the precuneus (<i>Z</i> > 2.3, cluster-corrected <i>p</i> = 0.05).</p><p><strong>Conclusions: </strong>These results suggest that obesity during adolescence is associated with neurocognitive impairment. Future studies should consider adolescence more carefully since this memory impairment could contribute to academic learning difficulties faced by adolescents living with obesity.</p><p><strong>Trial registration: </strong>CHUBX 2017/19; CPP number: 2017-3A02533-50.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 3","pages":"e70147"},"PeriodicalIF":2.5,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13288255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148318088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of an Online Weight Loss Program for Mexican Adults: Findings From a Randomized Controlled Trial.","authors":"Alma Lorena Ruelas Yanes, Teresita de Jesús Martínez-Contreras, Maria Del Carmen Candia-Plata, Julián Esparza-Romero, Ana Lourdes Mata-Pineda, Arelly Ornelas-Vargas, Rolando Giovanni Díaz-Zavala, Michelle M Haby","doi":"10.1002/osp4.70165","DOIUrl":"10.1002/osp4.70165","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a major public health crisis in Mexico. With internet usage rapidly increasing, digital health interventions present a clear opportunity for treating obesity. This study addressed a key gap in research by evaluating a web-based Intensive Lifestyle Modification intervention adapted from the Diabetes Prevention Program for weight loss (DPP-web) in this population.</p><p><strong>Methods: </strong>To evaluate the efficacy of the DPP-web in Mexican adults with overweight or obesity at 3 and 6 months compared with a wait-list control group, a randomized controlled trial (<i>n</i> = 62) with two groups was conducted. The primary outcome was the change in weight at 3 months, with secondary outcomes including changes in anthropometric parameters, quality of life and depressive symptoms at three and 6 months, and biochemical measures at 3 months.</p><p><strong>Results: </strong>Participants, predominantly women (81%), with an average age of 31.5 ± 8.6 years and BMI of 33.4 ± 4.85 kg/m², had retention rates of 77% at 3 months and 60% at 6 months. The treatment effect by intention-to-treat analysis was -3.65 kg (95% CI -5.41, -1.89, <i>p</i> < 0.01) at 3 months and -5.50 kg (95% CI -7.58, -3.41) at 6 months, favoring the DPP-group.</p><p><strong>Conclusions: </strong>The DPP-web was effective for weight loss in the Mexican population at three and 6 months and could help to improve access to an effective obesity treatment in Spanish-speaking countries, including Mexico.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 3","pages":"e70165"},"PeriodicalIF":2.5,"publicationDate":"2026-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13280466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions of Obesity and Treatment Decision-Making Among Hispanic-Latino Adults: Barriers to Metabolic and Bariatric Surgery.","authors":"Viviane Fornasaro-Donahue, Ceren Gunsoy, Kathleen J Melanson","doi":"10.1002/osp4.70156","DOIUrl":"10.1002/osp4.70156","url":null,"abstract":"<p><strong>Objective: </strong>Metabolic and Bariatric Surgery (MBS) is underutilized among Hispanic-Latino adults despite higher obesity rates and related comorbidities. Although barriers such as cost, language, and limited provider referrals are documented, sociocultural and psychological perceptions about obesity and obesity care remain less understood. This study aimed to explore the beliefs, experiences, and information sources influencing perceptions of obesity, obesity treatment, and patient-provider communication, and how these factors relate to MBS decision-making in this population.</p><p><strong>Methods: </strong>Semi-structured, in-depth interviews were conducted with 14 Hispanic-Latino adults in Rhode Island who met the eligibility criteria for MBS. Interviews were transcribed, reviewed, and thematically analyzed using an inductive approach to identify patterns in obesity perceptions, treatment beliefs, and healthcare communication.</p><p><strong>Results: </strong>Participants expressed fear, skepticism, and misinformation about MBS, shaped by stigma, cultural values, and personal beliefs. Many viewed MBS as a last resort and cited concerns about complications or long-term effects. Participants often relied on informal sources-such as family and friends-for obesity treatment information rather than healthcare providers. Communication with providers about obesity treatment options was often limited or non-specific.</p><p><strong>Conclusion: </strong>Findings highlight the need for culturally tailored bilingual education and improved patient-provider communication to increase MBS awareness and trust. Addressing these gaps may help reduce disparities in obesity care access among Hispanic-Latino adults.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 3","pages":"e70156"},"PeriodicalIF":2.5,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13277397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148295813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Optimization of Risk for Stroke With Abdominal Obesity Patients: Insights From NHANES 2005-2018.","authors":"Lei Zhou, Mengyang He, Feng Xiao, Qixing Liu, Xuezhen Li, Binghua He, Xiangang Tan","doi":"10.1002/osp4.70154","DOIUrl":"10.1002/osp4.70154","url":null,"abstract":"<p><strong>Objective: </strong>Stroke is the leading cause of disability worldwide, and it is now estimated that one in four individuals may experience a stroke during their lifetime. Early detection and rapid access to treatment can save lives and improve recovery. This study aimed to identify and characterize the potential influencing factors in patients with obesity who have had strokes.</p><p><strong>Methods: </strong>The research screened the 2005-2018 NHANES database and analyzed potential risk factors in eligible stroke patients with abdominal obesity using 10 machine model learning. Multivariable-adjusted least absolute shrinkage and selection operator (LASSO) regression, restricted cubic spline (RCS) analysis, and Shapley Additive Explanations (SHAP) plots were used to identify important risk factors for obese individuals who have experienced strokes.</p><p><strong>Results: </strong>The 8764 eligible individuals were divided into training set (6,134) and validation set (2,630) for predictive model development. In addition, the random forest model achieved the highest performance in predicting stroke incidence (area under the curve: 0.823) and all-cause mortality (area under the curve: 0.741). The SHAP values showed that age was the highest predictor followed by hypertension, diabetes, heart failure, smoking history, alcohol use, total cholesterol (TC), TyG-BMI, and cardiovascular artery disease (CDAI).</p><p><strong>Conclusions: </strong>TyG-BMI, CDAI, and TC are innovative and clinically viable predictive biomarkers for stroke in patients with abdominal obesity, exhibiting age- and gender-specific effects that are particularly pronounced in elderly females. These findings provide an evidence-based basis for personalized stroke risk assessment and targeted prevention strategies in the growing abdominally obese population.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 3","pages":"e70154"},"PeriodicalIF":2.5,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13273839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148278242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Predictors of Weight-Related Outcomes With Fixed-Dose, Extended-Release Naltrexone and Bupropion Among Treatment-Adherent Patients in Phase 3 COR Trials: A Treatment Target Analysis.","authors":"Donna H Ryan, Angela Fitch, Robert F Kushner, Jena S Tronieri, Christopher D Still, Caroline M Apovian","doi":"10.1002/osp4.70159","DOIUrl":"10.1002/osp4.70159","url":null,"abstract":"<p><strong>Objective: </strong>As patient response to obesity medication can vary, it is crucial to identify both those likely and unlikely to respond to treatment. This post hoc analysis aimed to examine predictive characteristics in patients who achieved weight-related targets with fixed-dose, extended-release combination of naltrexone and bupropion (NB-ER).</p><p><strong>Methods: </strong>This pooled analysis included patients from three Phase 3, placebo-controlled COR trials (NCT00532779, NCT00567255, NCT00456521). The impact of baseline characteristics in predicting changes in weight-related anthropometric targets at 56 weeks in those who completed treatment and were ≥ 90% adherent to NB-ER was evaluated with univariable and multivariable analyses.</p><p><strong>Results: </strong>Of the 1692 patients analyzed, similar proportions of patients receiving NB-ER versus placebo were female and White. Among patients treated with NB-ER with ≥ 90% adherence, 73.2% achieved ≥ 5% body weight (BW) reduction, 47.6% achieved ≥ 10% BW reduction, 27.8% achieved ≥ 15% BW reduction, 33.7% achieved target body mass index, and 23.7% achieved target waist circumference thresholds. Among the baseline characteristics assessed, female sex and White race most consistently predicted the likelihood of achieving the target outcomes.</p><p><strong>Conclusion: </strong>Adherence to NB-ER was associated with achieving anthropometric targets; however, the ability to predict a successful response in advance of NB-ER treatment is still limited.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 3","pages":"e70159"},"PeriodicalIF":2.5,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13270069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148272416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare Provider Awareness and Perspectives on Obesity: A Survey Across Medical Specialties.","authors":"Fatheya Alawadi, Rahila Bhatti, Khadija Hafidh, Barbara McGowan, Soniya Rai, Alice Koechlin, Amir Mohseni, Fatih Tangi, Rachel Batterham, Sara G I Suliman","doi":"10.1002/osp4.70152","DOIUrl":"10.1002/osp4.70152","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a complex, chronic disease requiring multifactorial management; however, gaps remain between clinical guidelines and real-world practice. Given the high prevalence of obesity in the Gulf region, understanding Healthcare Providers' (HCPs) awareness and perceived barriers is essential for better, tailored regional treatment strategies.</p><p><strong>Objective: </strong>This study aimed to address the existing knowledge gaps through exploring HCP awareness, perspectives and expectations on the complexities of obesity management across various medical specialties and seeking to refine management strategies.</p><p><strong>Methods: </strong>A cross-sectional electronic survey was conducted among HCPs attending the joint 21st International Congress of Endocrinology (ICE 2024) and 14th Emirates Diabetes and Endocrinology Congress (EDEC) held in Dubai, United Arab Emirates (UAE). Thirteen multiple-choice questions assessed HCPs' views on the contributing factors, barriers to effective management, and expectations for future care of obesity.</p><p><strong>Results: </strong>Of approximately 3200 attendees, 565 participated (17.7% response rate). Confidence in diagnosing obesity was high (85.1%). Body Mass Index (BMI) was used as the sole diagnostic tool by 43.9% of the respondents. The rising prevalence of obesity was attributed primarily to inappropriate dietary habits and sedentary lifestyles (60.4%). Key barriers to effective obesity management reported were the cost of treatment (52.3%) and lack of patient awareness (35.5%).To enhance the quality of obesity care, HCPs emphasized the need for improved understanding of obesity pathophysiology (64.9%) and advocated for individualized treatment approaches (49.6%).</p><p><strong>Conclusion: </strong>Addressing barriers to obesity care and enhancing HCP education are important steps toward more effective and patient-centered obesity management.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 3","pages":"e70152"},"PeriodicalIF":2.5,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13260700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Income Preschool Children's Free Sugar Consumption and Its Association With the Home Environment.","authors":"Maryam Yuhas, Katherine M Kidwell, Xeuzhu Hua, Lynn S Brann","doi":"10.1002/osp4.70161","DOIUrl":"10.1002/osp4.70161","url":null,"abstract":"<p><strong>Background: </strong>High consumption of sugary foods and beverages by young children has negative health effects; however, few studies have examined multiple domains of the home environment simultaneously or included sugars from 100% fruit juice. This study hypothesized that less favorable socio-cultural, built, and economic home environments would be associated with higher free sugar intake among low-income preschool children.</p><p><strong>Methods: </strong>Caregivers (<i>n</i> = 170) of 3-5-year-old children enrolled in Head Start programs completed questionnaires assessing food and drink intake, home environment, and food parenting practices. Statistical analyses included bivariate and multivariable linear regression with sensitivity analyses.</p><p><strong>Results: </strong>Children consumed an average of 4.05 (SD = 3.12) sugary foods/drinks per day, while caregivers consumed 3.78 (SD = 3.49); intake was strongly correlated (<i>r</i> = 0.67, <i>p</i> < 0.001). In bivariate analyses, higher child intake was associated with parental intake, permissive food parenting practices, number of caregivers, home availability, and lowest household income. In the adjusted regression model, parental intake (<i>β</i> = 0.333, <i>p</i> < 0.001), allowing sugary foods on a \"bad day\" (<i>β</i> = 0.397, <i>p</i> = 0.030), and home availability (<i>β</i> = 1.872, <i>p</i> < 0.001) remained significant predictors.</p><p><strong>Conclusions: </strong>Children and caregivers exceeded national and global recommendations for free sugar intake. Findings highlight the importance of multilevel interventions addressing caregiver intake, permissive parenting practices, home availability, and socioeconomic barriers.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 3","pages":"e70161"},"PeriodicalIF":2.5,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13254234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Atrial Fibrillation-Related Mortality Among Adults With Obesity in the United States From 1999 to 2024.","authors":"Aymen Ahmed, Ruqiat Masooma Batool, Saad Ahmed Waqas, Hasan Fareed Siddiqui, Muhammad Sameer Arshad, Neha Saleem Paryani, Izza Shahid, Hasibullah Aminpoor, Ali Mithani, Muhammad Talha Ayub","doi":"10.1002/osp4.70160","DOIUrl":"10.1002/osp4.70160","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with increased mortality, particularly among individuals with obesity. This study examined trends in AF-related mortality in adults with obesity in the United States from 1999 to 2024.</p><p><strong>Methods: </strong>Trends in AF-related mortality in adults with obesity aged ≥ 25 years with obesity were analyzed using the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database. AF and obesity were considered as multiple causes of death. Age-adjusted mortality rates (AAMRs) per 1,000,000 were analyzed using Joinpoint regression to identify trends and calculate average annual percentage change (AAPC) stratified by gender, race, and region.</p><p><strong>Results: </strong>A total of 63,853 deaths were identified. From 1999 to 2024, AF-related mortality rates increased from 1.9 in 1999 to 20.8 in 2024 (AAPC: 11.4 [95% CI: 10.4, 12.2]). Males recorded higher AAMRs than females. White individuals exhibited higher AAMRs than Blacks. Nonmetropolitan areas (9.6) had higher AAMR than metropolitan areas (7.4). The Midwest recorded the highest AAMR while the South reported the steepest rise. States in the top 90th percentile of AAMR were Vermont, Oklahoma, Oregon, Minnesota, and Wyoming.</p><p><strong>Conclusion: </strong>AF- and obesity-related mortality has increased overall from 1999 to 2024, with higher mortality rates observed in men, White individuals, nonmetropolitan areas, and the Southern US region. These findings highlight the need for continued surveillance and targeted prevention efforts in this population.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 3","pages":"e70160"},"PeriodicalIF":2.5,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13250834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148227199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Obesity on Systemic Treatment Outcomes in Metastatic Urological Malignancies.","authors":"A Handke, M Silberg, C Orf, C Loeffelholz, P Bach, S Berg, F Roghmann, K H Tully","doi":"10.1002/osp4.70164","DOIUrl":"10.1002/osp4.70164","url":null,"abstract":"<p><strong>Introduction: </strong>Obesity increasingly influences treatment outcomes in urological malignancies (metastatic bladder cancer (BC), renal cell cancer (RCC), and prostate cancer (PC)). This study evaluated the impact of obesity on survival in patients with major metastatic urological cancers receiving systemic therapy.</p><p><strong>Materials and methods: </strong>Patients with metastatic BC, RCC, and PC treated at a high-volume center from 2017 to 2025 were retrospectively analyzed. In total, 387 patients were included (BC: <i>n</i> = 166; RCC: <i>n</i> = 63; PC: <i>n</i> = 158) and stratified by the body mass index [BMI]. Overall survival was assessed using restricted mean survival time (RMST) at predefined landmarks (24 months for BC and RCC; 36 months for PC).</p><p><strong>Results: </strong>Overall, 23.5% of the patients had obesity, with the highest prevalence in RCC (44.4%). In metastatic BC, obesity was not associated with differences in RMST at 24 months. In RCC, patients with obesity showed a numerical improvement in RMST and a significantly longer duration of systemic therapy. In contrast, patients with obesity with metastatic PC demonstrated significantly shorter RMST at 36 months than patients without obesity.</p><p><strong>Conclusion: </strong>The prognostic impact of obesity differs across metastatic urological malignancies. While the present findings support an obesity paradox in RCC, obesity was associated with worse survival in metastatic PC but showed no impact on survival in BC. These results highlight the need for tumor-specific biological interpretation of BMI-related outcomes.</p>","PeriodicalId":19448,"journal":{"name":"Obesity Science & Practice","volume":"12 3","pages":"e70164"},"PeriodicalIF":2.5,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13238925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}