Neurology India最新文献_第2页

Doctor, Will My Aneurysm Rupture?

IF 0.9 3区医学

Neurology India Pub Date : 2025-03-01 Epub Date: 2025-04-03 DOI: 10.4103/neurol-india.Neurol-India-D-25-00139

B Jayanand Sudhir, Azhaganmaadevi K Alagan, G B Akhilesh Gowda, B S V Patnaik

引用次数: 0

Giant Superior Sagittal Sinus Thrombosis with Persistent Falcine Sinus.

IF 0.9 3区医学

Neurology India Pub Date : 2025-03-01 Epub Date: 2024-11-29 DOI: 10.4103/neurol-india.Neurol-India-D-24-00303

Cheng Zhou Zhang, Ping Wang, Jun Li

引用次数: 0

Syncopal Seizure: A Rare Manifestation of Takayasu Arteritis. 晕厥发作：高须动脉炎的一种罕见表现。

IF 0.9 3区医学

Neurology India Pub Date : 2025-03-01 Epub Date: 2024-11-29 DOI: 10.4103/neurol-india.Neurol-India-D-24-00424

Anand Kumar, Ibrahim Hussain, Deepika Joshi, Varun Kumar Singh

引用次数: 0

Development of a New Animal Model for Non-Cystic Periventricular Leukomalacia.

IF 0.9 3区医学

Neurology India Pub Date : 2025-03-01 Epub Date: 2025-04-03 DOI: 10.4103/neurol-india.Neurol-India-D-23-00580

Thangaraj Abiramalatha, Prakash Amboiram, Ananda Kumar Ponnala, Yogeshkumar V Murkunde, Alan Mathew Punnoose, Aravindhan Vivekanandhan, Shonam Tamrakar, Lawrence D Cruze, Anita Mahadevan

{"title":"Development of a New Animal Model for Non-Cystic Periventricular Leukomalacia.","authors":"Thangaraj Abiramalatha, Prakash Amboiram, Ananda Kumar Ponnala, Yogeshkumar V Murkunde, Alan Mathew Punnoose, Aravindhan Vivekanandhan, Shonam Tamrakar, Lawrence D Cruze, Anita Mahadevan","doi":"10.4103/neurol-india.Neurol-India-D-23-00580","DOIUrl":"10.4103/neurol-india.Neurol-India-D-23-00580","url":null,"abstract":"Periventricular leukomalacia (PVL) is a major cause of cerebral palsy in preterm neonates. Though many interventions are being explored as therapeutic options in PVL, all these therapies are still in preclinical phase. This emphasizes the need for the development of robust animal models for PVL. We aimed to develop a new animal (rat) model for PVL using natural pattern of perinatal insults as in humans. The animal model was developed using a combination of three insults: prenatal inflammation, prenatal near total ischemia and postnatal recurrent hypoxia. Pathological and immunohistochemical analysis of pup brains was performed on day 28. We had 33 pups in experimental (inflammation, ischemia and hypoxia, LIH) group and 34 normal pups as controls. Histopathological analysis and immunohistochemistry with anti myelin basic protein (MBP) antibody showed myelin loss in corpus callosum or periventricular white matter in all pups in LIH group. Nissl's stain showed focal to generalized cortical disorganization. On functional assessment, LIH pups had prolonged escape latency in morris water maze test suggestive of cognitive/memory impairment. To conclude, we have developed a new animal model for PVL in rat, using a similar pattern of perinatal insults as in human preterm neonates. The model resembles non-cystic PVL in both pathological and functional analysis.","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 2","pages":"320-324"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

I-Beam Sign in Progressive Supranuclear Palsy.

IF 0.9 3区医学

Neurology India Pub Date : 2025-03-01 Epub Date: 2025-04-03 DOI: 10.4103/neurol-india.Neurol-India-D-24-00101

Sandhya Manorenj, Shashanka Chillapuram

引用次数: 0

Dural Arteriovenous Fistulas in Spontaneous Intracranial Hypotension.

IF 0.9 3区医学

Neurology India Pub Date : 2025-03-01 Epub Date: 2025-04-03 DOI: 10.4103/neurol-india.Neurol-India-D-23-00575

Enrico Ferrant, Michele Trimboli, Cristina Erminio, Luca Quilici, Oreste Marsico, Mirko Maria Ferrante

{"title":"Dural Arteriovenous Fistulas in Spontaneous Intracranial Hypotension.","authors":"Enrico Ferrant, Michele Trimboli, Cristina Erminio, Luca Quilici, Oreste Marsico, Mirko Maria Ferrante","doi":"10.4103/neurol-india.Neurol-India-D-23-00575","DOIUrl":"10.4103/neurol-india.Neurol-India-D-23-00575","url":null,"abstract":"The occurrence of dural arteriovenous fistulas (DAVFs) in patients with spontaneous intracranial hypotension (SIH) is exceptionally rare. While DAVF is a known complication of cerebral venous thrombosis (CVT), the role of CVT as one of the early events in the genesis of DAVFs is still debated. This is because only a small number of patients with CVT develop DAVFs, and not all DAVFs are associated with CVT. Although several hypotheses have been proposed to explain the link between CVT and DAVFs, the relationship between DAVFs and SIH in the absence of CVT remains unclear. To delineate the association between DAVFs and SIH. We reviewed the medical records of 460 SIH patients who were observed and treated over the past several years, looking specifically for cases of SIH complicated by DAVFs. We also reviewed all published case reports reporting patients with SIH and DAVFs. Of the 460 SIH patients reviewed, two (0.4%) were also diagnosed with DAVFs. Both patients had orthostatic headache, diffuse pachymeningeal enhancement, and brain sagging on brain magnetic resonance imaging, which are typical neuroimaging findings of SIH. Patient n.1 reported DAVF caused by left transverse/sigmoid sinus thrombosis, while patient n.2 presented DAVF as a complication of SIH in the absence of CVT. We speculate that SIH, even without CVT, might represent the start of a cascade of events leading to DAVFs. The pathogenic mechanism involved in DAVF formation in SIH patients could be explained by the opening of preexisting microscopic vascular channels within the dura mater, secondary to extreme venodilation related to SIH.","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 2","pages":"332-338"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spontaneous Angiographic Disappearance of an Intracranial Aneurysm: A Systematic Review of Cases in the Last Ten Years and Two Cases from Our Institution. 颅内动脉瘤血管造影自发消失：对过去十年中病例的系统回顾以及本院的两例病例。

IF 0.9 3区医学

Neurology India Pub Date : 2025-03-01 Epub Date: 2025-04-03 DOI: 10.4103/neurol-india.Neurol-India-D-24-00119

Jun Ha Hwang, Hong Bum Kim, Su Hee Cho, Kuhyun Yang

{"title":"Spontaneous Angiographic Disappearance of an Intracranial Aneurysm: A Systematic Review of Cases in the Last Ten Years and Two Cases from Our Institution.","authors":"Jun Ha Hwang, Hong Bum Kim, Su Hee Cho, Kuhyun Yang","doi":"10.4103/neurol-india.Neurol-India-D-24-00119","DOIUrl":"10.4103/neurol-india.Neurol-India-D-24-00119","url":null,"abstract":"Spontaneous disappearances of intracranial aneurysms have been reported previously, but because of their rarity, discussing their pathophysiology has been difficult. This study aims to investigate cases of spontaneous angiographic disappearance of intracranial aneurysms over the past 10 years, including two additional cases from our hospital, and determine their clinical significance. PubMed was searched for articles on the spontaneous disappearance of intracranial aneurysms published within the last ten years. Data on patient demographics, characteristics of the aneurysms (ruptured or unruptured, location, size, and shape), and the time to the disappearance, recurrence, with or without vasospasm, and treatment were collected. Additionally, two cases from our hospital (Cases A and B) were analyzed. In total, 11 articles with 12 cases of spontaneous aneurysm disappearance were chosen for analysis. Of these cases, 10 occurred in females, and the age of the affected patients ranged from 7 months to 72 years. Eight cases involved unruptured aneurysms, which were larger and took longer to disappear. Three patients experienced a recurrence during the observation period. Several differences were found between the characteristics of the previous cases and those of our case XIII in Table 1 (Case A). In conclusion, spontaneous angiographic disappearance involves complex interactions between thrombosis, vasospasm, and endothelial remodeling. Exceptions were noted, emphasizing the need for nuanced considerations in elucidating the mechanisms behind aneurysm disappearance. The recurrence of aneurysms that had disappeared highlights the importance of the following treatment, if clinically indicated, urgent neurosurgical intervention should be considered; otherwise, thorough angiographic monitoring at least.","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 2","pages":"238-243"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of Diffusion Tensor Imaging in Predicting Outcomes Following Surgical Treatment of Degenerative Cervical Myelopathy.

IF 0.9 3区医学

Neurology India Pub Date : 2025-03-01 Epub Date: 2025-04-03 DOI: 10.4103/neurol-india.Neurol-India-D-24-00271

Selvin Prabhakar, Pratyush Shahi, Md Tosaddeque Hussain, Mona Tiwari, Christopher Gerber, Anindya Basu

{"title":"Utility of Diffusion Tensor Imaging in Predicting Outcomes Following Surgical Treatment of Degenerative Cervical Myelopathy.","authors":"Selvin Prabhakar, Pratyush Shahi, Md Tosaddeque Hussain, Mona Tiwari, Christopher Gerber, Anindya Basu","doi":"10.4103/neurol-india.Neurol-India-D-24-00271","DOIUrl":"10.4103/neurol-india.Neurol-India-D-24-00271","url":null,"abstract":"Background: The utility of diffusion tensor imaging (DTI) in predicting surgical outcomes in degenerative cervical myelopathy (DTI) remains controversial.Objective: To identify the preoperative clinical and radiological factors associated with poor outcomes following surgical treatment of DCM.Methods and material: This prospective cohort study included patients who underwent surgery for DCM. MRI parameters (compression ratio, CR; transverse area, TA; signal-intensity ratio, SIR) and DTI parameters (fractional anisotropy, FA; apparent diffusion coefficient, ADC; relative anisotropy, RA; volume ratio, VR) were assessed preoperatively. Demographic and operative data were collected. Based on the improvement in modified Japanese Orthopaedic Association (mJOA) score at 4 months, patients were categorized as group A (good surgical outcome) and group B (poor surgical outcome). Univariate and regression analyses were performed to identify risk factors and predictors, respectively, of poor surgical outcome.Results: Sixty-six patients were included. Thirty-eight patients belonged to group A (good outcome) and 28 patients belonged to group B (poor outcome). There was no significant difference between the two groups in demographic and operative variables. FA was found to be significantly less in group B compared to group A (550 vs. 610, P = 0.04). No significant difference was seen in RA, CR, TA, SIR, ADC, and VR between the two groups. On regression analysis, no independent predictor of poor outcome could be identified.Conclusions: Preoperative FA was found to be significantly lower in patients with poor outcome following surgical treatment for DCM.","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 2","pages":"292-297"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined Susceptibility-Weighted Imaging and Vessel Wall Imaging of Unruptured Intracranial Aneurysms Presenting with Sentinel Headache. 出现前哨头痛的未破裂颅内动脉瘤的联合感度加权成像和血管壁成像。

IF 0.9 3区医学

Neurology India Pub Date : 2025-03-01 Epub Date: 2025-04-03 DOI: 10.4103/neurol-india.Neurol-India-D-24-00290

Pooja Gupta, Santhosh K Kannath, Bejoy Thomas, Kesavadas Chandrasekharan, Gurpreet Singh

{"title":"Combined Susceptibility-Weighted Imaging and Vessel Wall Imaging of Unruptured Intracranial Aneurysms Presenting with Sentinel Headache.","authors":"Pooja Gupta, Santhosh K Kannath, Bejoy Thomas, Kesavadas Chandrasekharan, Gurpreet Singh","doi":"10.4103/neurol-india.Neurol-India-D-24-00290","DOIUrl":"10.4103/neurol-india.Neurol-India-D-24-00290","url":null,"abstract":"Background: The combinational assessment of susceptibility-weighted imaging and vessel wall imaging on magnetic resonance imaging (MRI) in patients of unruptured intracranial aneurysms presenting with sentinel headache can show microbleeds and inflammatory changes in the wall of the aneurysms and thus predict the future risk of rupture of the aneurysm. In this pilot study, we hypothesized that combination of vessel wall imaging and susceptibility-weighted imaging would be more informative to assess the changes in the wall of aneurysm in patients with sentinel headache.Materials and methods: Fifteen patients of intracranial aneurysms with history of sentinel headache underwent advanced MRI. Susceptibility-weighted imaging images were evaluated for presence of any hypointensity suggestive of microbleeds along the wall of the aneurysm. The postcontrast vessel wall images were evaluated for presence of any wall enhancement.Results: Susceptibility foci suggestive of microbleeds on susceptibility-weighted imaging in the wall of the aneurysms were seen in 14 intracranial aneurysms. Vessel wall imaging showed enhancement of wall in 10 cases and nonenhancement in five cases. Enhancement of the wall on MRI was observed more in aneurysms imaged early after the onset of symptoms (<45 days) than in those imaged late (>45 days).Conclusion: Our observations might be indicative of temporally evolving pathologic changes in the aneurysmal wall in unruptured aneurysms with sentinel headache. Combining advanced magnetic resonance sequences can help in elucidation of the wall pathology and rupture risk assessment of unruptured aneurysms, and these observations could be incorporated in future studies.","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 2","pages":"251-256"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Evaluation of Telephone versus Face-to-Face Administration of the Indian Stroke Scale in Clinical Practice.

IF 0.9 3区医学

Neurology India Pub Date : 2025-03-01 Epub Date: 2025-04-03 DOI: 10.4103/neurol-india.Neurol-India-D-24-00166

Sneha M Prajapati, Sweni A Shah, V Prakash

{"title":"Comparative Evaluation of Telephone versus Face-to-Face Administration of the Indian Stroke Scale in Clinical Practice.","authors":"Sneha M Prajapati, Sweni A Shah, V Prakash","doi":"10.4103/neurol-india.Neurol-India-D-24-00166","DOIUrl":"10.4103/neurol-india.Neurol-India-D-24-00166","url":null,"abstract":"The Indian Stroke Scale (ISS) measures limitations in everyday activities experienced by stroke patients in India. However, routine use of the ISS faces challenges, especially in remote areas, due to follow-up and accessibility issues, including logistical difficulties in arranging in-person visits, patient mobility issues, and the increased time and resources required for in-person assessments. We aimed to investigate whether the ISS produced equivalent scores when administered via telephone mode compared with face-to-face within clinical stroke rehabilitation settings. We administered the ISS face-to-face and by telephone to 104 stroke patients within a week. The order in which the modes of administration were administered was randomized. We evaluated the equivalence of modes of administration by calculating the intraclass correlation coefficient (ICC), the standard error of measurement (SEM), the minimal detectable change (MDC), and the limits of agreement using the Bland-Altman plot. Both modes of administration produced similar results. There was excellent reliability for total scores (ICC 2,1 = 0.95; 95% CI, 0.92 to 0.96); SEM was 1.45 and MDC was 4. The limits of agreement were narrow (-8.8 and 8.5) and within acceptable limits: 10 points. The ISS produced similar results when administered face-to-face and via telephone among patients with stroke. The study findings can benefit stroke rehabilitation researchers in recruiting patients living in geographically dispersed regions and remote locations who are often underrepresented in clinical trials and clinicians in conducting routine follow-up evaluations.","PeriodicalId":19429,"journal":{"name":"Neurology India","volume":"73 2","pages":"339-342"},"PeriodicalIF":0.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0