Nutrition and Metabolic Insights最新文献

{"title":"Examining Second Graders' Healthy Food Choices: Through Literacy and Active Learning.","authors":"Elsie Lindy Olan, Laurie O Campbell, Shiva Jahani","doi":"10.1177/1178638819839063","DOIUrl":"10.1177/1178638819839063","url":null,"abstract":"<p><p>The purpose of this study was to investigate the implementation of a nutrition module and activities (<i>Go, Slow, Whoa</i>) in a literacy environment through an active learning approach. Second graders (N = 85) from diverse socioeconomic status (SES) areas completed the 12-week program. The participants' perceptions of healthy food choices were measured both pre- and post-intervention. Students met for 30 minutes twice a week, to complete 5-lessons from a Coordinated Approach to Child Health (<i>CATCH</i>) nutrition module and activities (<i>Go, Slow, Whoa</i>). Measures were taken both pre- and post-intervention (<i>Food Fury</i> Quiz) to distinguishing between healthy and unhealthy foods (images). There was a statistically significant improvement (<i>t</i> = 12.16, <i>df</i> =84, <i>P</i> = .000) from pretest (<i>M</i> = 19.06, SD = 3.13) and posttest (<i>M</i> = 23.34, SD = 0.48) scores. Administering a healthy food choice curriculum through literacy and active learning provides an alternative approach to improving health knowledge among second grade students.</p>","PeriodicalId":19396,"journal":{"name":"Nutrition and Metabolic Insights","volume":"12 ","pages":"1178638819839063"},"PeriodicalIF":2.3,"publicationDate":"2019-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/55/91/10.1177_1178638819839063.PMC6501495.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37254013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Mechanisms Influencing the Inverse Relationship Between Cannabis and Nonalcoholic Fatty Liver Disease: A Commentary","authors":"Pratima Dibba, Andrew A. Li, G. Cholankeril, M. Ali Khan, Donghee Kim, Aijaz Ahmed","doi":"10.1177/1178638819847480","DOIUrl":"https://doi.org/10.1177/1178638819847480","url":null,"abstract":"Nonalcoholic fatty liver disease (NAFLD) develops when the liver is unable to oxidize or export excess free fatty acids generated by adipose tissue lipolysis, de novo lipogenesis, or dietary intake. Although treatment has generally been centered on reversing metabolic risk factors that increase the likelihood of NAFLD by influencing lifestyle modifications, therapeutic modalities are being studied at the cellular and molecular level. The endocannabinoid system has been of recent focus. The agonism and antagonism of cannabinoid receptors play roles in biochemical mechanisms involved in the development or regression of NAFLD. Exocannabinoids and endocannabinoids, the ligands which bind cannabinoid receptors, have been studied in this regard. Exocannabinoids found in cannabis (marijuana) may have a therapeutic benefit. Our recent study demonstrated an inverse association between marijuana use and NAFLD among adults in the United States. This commentary combines knowledge on the role of the endocannabinoid system in the setting of NAFLD with the findings in our article to hypothesize different potential mechanisms that may influence the inverse relationship between cannabis and NAFLD.","PeriodicalId":19396,"journal":{"name":"Nutrition and Metabolic Insights","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2019-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1178638819847480","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47261722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Part 1: A Novel Model for Three-Dimensional Culture of 3T3-L1 Preadipocytes Stimulates Spontaneous Cell Differentiation Independent of Chemical Induction Typically Required in Monolayer.","authors":"Amy L Aulthouse, Ellen Freeh, Sabrina Newstead, Amy L Stockert","doi":"10.1177/1178638819841399","DOIUrl":"10.1177/1178638819841399","url":null,"abstract":"<p><p>Differences in monolayer and three-dimensional (3D) culture systems have been recognized for several years. Despite the recognized importance of 3D systems, low cost and convenience of monolayer culture are still readily used for metabolic and nutritional studies. Here, we present part 1 of a 2-part series that will highlight (1) a novel and cost-effective model for culturing 3T3-L1 preadipocytes in 3D agarose as well as (2) an initial study showing the successful use of this 3D model for experimental analysis of these cells treated with cinnamon extract while suspended in agarose. In part 1, we provide a full characterization of the model system for the 3T3-L1 cells that demonstrate the functionality and convenience of this system. Importantly, we note spontaneous differentiation to adipocytes while cultured under these methods, independent of chemical induction. We present a 2.5-week time course with rounded cells forming vacuoles as early as 24 hours and accumulation of lipid detectable by Oil Red O stain at 0.5 weeks. Serum selection, lipid volume determination, and cell size are characterized. We conclusively demonstrate adipogenesis based on a peroxisome proliferator-activated receptor γ (PPARγ) detection using immunohistochemistry (IHC) of sections from these 3D cultures. Methods, materials and recommendations are described as well as proposed benefits to the use of this culture system for 3T3-L1 cells.</p>","PeriodicalId":19396,"journal":{"name":"Nutrition and Metabolic Insights","volume":"12 ","pages":"1178638819841399"},"PeriodicalIF":2.3,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/79/47/10.1177_1178638819841399.PMC6454649.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37165813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Better Together: A Pilot Study on <i>Cooking Matters</i> for Adults With Developmental Disabilities and Direct Support Professionals.","authors":"Wesley R Barnhart,&nbsp;Susan M Havercamp,&nbsp;Allison Lorenz,&nbsp;Emily A Yang","doi":"10.1177/1178638819840036","DOIUrl":"https://doi.org/10.1177/1178638819840036","url":null,"abstract":"<p><p>Adults with developmental disabilities face barriers to making healthy lifestyle choices that mirror the barriers faced by the direct support professionals who serve them. These two populations, direct support professionals and adults with developmental disabilities, are likely to lead inactive lifestyles, eat unhealthy diets, and be obese. Moreover, direct support professionals influence the nutrition knowledge, attitudes, and health behaviors of the adults with developmental disabilities whom they serve. We piloted a cooking-based nutrition education program, <i>Cooking Matters for Adults</i>, to dyads of adults with developmental disabilities (n = 8) and direct support professionals (n = 7). Team-taught by a volunteer chef and nutrition educator, <i>Cooking Matters for Adults</i> uses an active learning approach to teach food preparation safety skills and nutrition knowledge to inform healthy food and beverage choices. We assessed healthy food preparation, intake of a balanced diet, healthy food and beverage choices, and cooking confidence and barriers at pre-test, post-test, and 6-months after the intervention. Among both adults with developmental disabilities and direct support professionals, positive trends in healthy food preparation, eating a balanced diet, and reduction in cooking barriers were observed at post-test and 6-months. We also qualitatively assessed knowledge of and attitudes toward healthy eating, frequency of food and beverage intake, knowledge about kitchen skills and safety, as well as overall satisfaction, cooking confidence, and acceptability of the dyad approach. Participants with developmental disabilities and direct support professionals reported that they learned about healthy food and beverage choices and various cooking skills. Participants reported confidence in skills learned and were satisfied with the intervention and approach of including adults with developmental disabilities and direct support professionals in the intervention together.</p>","PeriodicalId":19396,"journal":{"name":"Nutrition and Metabolic Insights","volume":"12 ","pages":"1178638819840036"},"PeriodicalIF":1.7,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1178638819840036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37165900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Pubertal Status and Inflammation on the Use of Ferritin to Define Iron Deficiency in Children With Overweight or Obesity.","authors":"Maria Luz Muzzio,&nbsp;Ezequiel S Lozano Chiappe,&nbsp;Laura Kabakian,&nbsp;Florencia Ferraro,&nbsp;Ines Landó,&nbsp;Elizabeth Alonso,&nbsp;Jorgelina Fernández,&nbsp;Soledad Peredo,&nbsp;Lucrecia Brovarone,&nbsp;Maria Pia Santucci,&nbsp;Tomás Meroño","doi":"10.1177/1178638819839064","DOIUrl":"https://doi.org/10.1177/1178638819839064","url":null,"abstract":"<p><strong>Background and aims: </strong>A worldwide increase in childhood overweight (OW) and obesity (OB) has been reported. OB is an inflammatory state which affects iron metabolism and the sensibility of the tests to detect iron deficiency (ID). Our aim was to evaluate the adequacy of current ferritin cut-offs to define ID in children with OW/OB.</p><p><strong>Methods: </strong>This cross-sectional study included 152 children (54% girls) aged (median [Q1-Q3]) 11 (8-13) years with OW/OB. Complete blood count and iron metabolism were evaluated. Low ferritin, transferrin saturation (TSat), and anemia were defined by age- and sex-specific cut-offs recommended by National Guidelines. Iron intake was assessed in a subgroup (n = 80) by a 24-hour dietary recall. Analyses were made according to pubertal development and ferritin tertiles.</p><p><strong>Results: </strong>The overall prevalence of low ferritin, TSat, and anemia was 2.6%, 23.8%, and 5.2%, respectively. Among pre-pubertal children (n = 87), the frequency of low TSat rose across ferritin tertiles (<i>P</i> < .05), whereas it decreased among pubertal children (n = 65; <i>P</i> < .005). Cases of anemia among pre-pubertal children were found in the highest ferritin tertile, whereas 4/6 anemia cases in pubertal children were found in the lowest ferritin tertile (<39 µg/L). Pubertal children within the lowest ferritin tertile + low TSat (n = 11) showed lower hemoglobin (-9%; <i>P</i> < .005) and hematocrit (-8%, <i>P</i> < .01) than those in the same tertile + normal TSat (n = 16). The overall prevalence of children with ferritin < 39 µg/L + low TSat was 9.2%.</p><p><strong>Conclusions: </strong>Higher ferritin cut-off values are required to define ID in children with OW/OB. Such cut-off remains to be validated in larger, multi-ethnic cohorts of children with OW/OB.</p>","PeriodicalId":19396,"journal":{"name":"Nutrition and Metabolic Insights","volume":"12 ","pages":"1178638819839064"},"PeriodicalIF":1.7,"publicationDate":"2019-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1178638819839064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37214198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Pattern and Their Association With Level of Asthma Control Among Patients With Asthma at Al-Shifa Medical Complex in Gaza Strip, Palestine.","authors":"Abdel Hamid Hassan El Bilbeisi,&nbsp;Ali Albelbeisi,&nbsp;Saeed Hosseini,&nbsp;Kurosh Djafarian","doi":"10.1177/1178638819841394","DOIUrl":"https://doi.org/10.1177/1178638819841394","url":null,"abstract":"<p><strong>Background: </strong>This study was conducted to identify major dietary patterns and their association with level of asthma control among patients with asthma in Gaza Strip, Palestine.</p><p><strong>Methods: </strong>This cross-sectional study was conducted among a representative sample of Palestinian patients with asthma (both sex, aged 19-64 years) receiving care in chest department at Al-Shifa Medical Complex. Asthma control level was obtained using asthma control test. Data regarding other variables were obtained using an interview-based questionnaire and a semi-quantitative food frequency questionnaire. Statistical analysis was performed using SPSS version 20.</p><p><strong>Results: </strong>Two major dietary patterns were identified including (1) Prudent pattern characterized by a high intake of whole grains, beans and legumes, fish and shellfish products, vegetables, tomatoes, fruits, and vegetable oils, and (2) Western pattern characterized by a high intake of refined grains, red meat, poultry, fast foods, eggs, low-fat dairy product, high-fat dairy products, hydrogenated fats, olive, sugar, sweets, desserts, and snacks. After adjustment for confounding variables, patients in the lowest tertile (T1) of Prudent pattern had a lower odds for poorly controlled asthma (odds ratio [OR] = 0.044, 95% confidence interval [CI] = [0.002-1.316], <i>P</i> value < 0.05), whereas patients in the lowest tertile (T1) of Western pattern had a higher odds for poorly controlled asthma (OR = 2.499, 95% CI = [1.288-4.850], <i>P</i> value < 0.05), compared with those in the highest tertile (T3).</p><p><strong>Conclusion: </strong>A Prudent pattern may be associated with a lower prevalence of poorly controlled asthma, whereas a Western pattern may be associated with a higher prevalence of poorly controlled asthma.</p>","PeriodicalId":19396,"journal":{"name":"Nutrition and Metabolic Insights","volume":"12 ","pages":"1178638819841394"},"PeriodicalIF":1.7,"publicationDate":"2019-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1178638819841394","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37214199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Considerations of Cardiovascular Diseases and Treatments.","authors":"Marko Boban,&nbsp;Nikola Bulj,&nbsp;Matea Kolačević Zeljković,&nbsp;Vjekoslav Radeljić,&nbsp;Tomislav Krcmar,&nbsp;Matias Trbusic,&nbsp;Diana Delić-Brkljačić,&nbsp;Tamara Alebic,&nbsp;Aleksandar Vcev","doi":"10.1177/1178638819833705","DOIUrl":"https://doi.org/10.1177/1178638819833705","url":null,"abstract":"<p><p>Nutritional considerations of many chronic diseases are not fully understood or taken into consideration in everyday clinical practice. Therefore, it is not surprising that high proportion of hospitalized patients with cardiovascular diseases remains underdiagnosed with malnutrition. Malnourished patients have increased risk of poor clinical outcomes, complications rate, prolonged hospital stay, more frequent rehospitalizations, and lower quality of life. The purpose of this review is to recapitulate recent data on nutritional considerations in cardiovascular medicine.</p>","PeriodicalId":19396,"journal":{"name":"Nutrition and Metabolic Insights","volume":"12 ","pages":"1178638819833705"},"PeriodicalIF":1.7,"publicationDate":"2019-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1178638819833705","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37100283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Synergistic Role of Diet and Exercise in the Prevention, Pathogenesis, and Management of Ulcerative Colitis: An Underlying Metabolic Mechanism.","authors":"Jonah Stavsky, Radhashree Maitra","doi":"10.1177/1178638819834526","DOIUrl":"10.1177/1178638819834526","url":null,"abstract":"<p><p>Ulcerative colitis (UC) is a biologically complex condition characterized by chronic, relapsing inflammation of the gastrointestinal tract. The relative incidence of this debilitating condition is increasing and sociologically damaging outcomes are a continued reality. Several etiological theories for UC are currently under investigation, spanning between genetic and environmental determinants. From an environmental perspective, previous literature reviews have demonstrated the independent effectiveness of specific diet and exercise patterns in modifying UC immuno-pathophysiology. This article explores the <i>synergistic</i> role of diet and aerobic exercise in the prevention, pathogenesis, and management of UC in the context of recent immunological research. Through a unifying mechanism-that is, microbial influence of colonic inflammation and immuno-pathophysiology-the simultaneous reduction of pro-inflammatory dietary sulfurous amino acid intake (ie methionine, cysteine, homocysteine, and taurine) and the upregulation of aerobic exercise frequency (which spurs the colonization of anti-inflammatory butyrate, acetate, and propionate producing microbial taxa) demonstrate the clinical efficacy of incorporating both diet and exercise modifications for UC prevention and management through pathogenic alterations.</p>","PeriodicalId":19396,"journal":{"name":"Nutrition and Metabolic Insights","volume":"12 ","pages":"1178638819834526"},"PeriodicalIF":2.3,"publicationDate":"2019-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/df/10.1177_1178638819834526.PMC6425530.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37265787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Anthropometric Measures in Nutrition and Metabolism: Comment on Anthropometrically Predicted Visceral Adipose Tissue and Blood-Based Biomarkers: A Cross-Sectional Analysis.","authors":"Justin C Brown,&nbsp;Michael O Harhay,&nbsp;Meera N Harhay","doi":"10.1177/1178638819831712","DOIUrl":"https://doi.org/10.1177/1178638819831712","url":null,"abstract":"<p><p>Visceral adipose tissue (VAT)-fat stored deep in the abdominal cavity that surrounds vital organs-is associated with a variety of chronic health conditions. Computed tomography and magnetic resonance imaging are the gold standards to quantify VAT. However, the high cost, limited accessibility, and potential exposure to radiation limit the use of these imaging modalities. In this commentary, we review the application of a previously validated regression equation that estimates anthropometrically predicted VAT (apVAT) to explain variance in blood-based biomarkers and predict mortality in a large sample of adults. In our first study (Brown et al. 2018 <i>Eur J Nutr</i>; doi:10.1007/s00394-016-1308-8), apVAT accounted for more variance in biomarkers of glucose homeostasis, inflammation, and lipid metabolism, than body mass index (BMI), waist circumference (WC), or the combination of BMI + WC. In our second study (Brown et al. 2017 <i>Am J Hum Biol</i>; doi:10.1002/ajhb.22898), compared with BMI, WC, and BMI + WC, apVAT more accurately predicted mortality from all causes, cardiovascular disease, and cancer. These studies demonstrate that apVAT can be used in clinical practice and in clinical nutrition and metabolism research when imaging modalities to quantify VAT may not be feasible.</p>","PeriodicalId":19396,"journal":{"name":"Nutrition and Metabolic Insights","volume":"12 ","pages":"1178638819831712"},"PeriodicalIF":1.7,"publicationDate":"2019-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1178638819831712","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37185233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postprandial Plasma Amino Acid Responses Between Standard Whey Protein Isolate and Whey Protein Isolate Plus Novel Technology.","authors":"Matthew H Sharp,&nbsp;Matthew W Stefan,&nbsp;Ryan P Lowery,&nbsp;Jacob M Wilson","doi":"10.1177/1178638819827970","DOIUrl":"10.1177/1178638819827970","url":null,"abstract":"<p><strong>Background: </strong>Muscle mass is an important determinant of metabolic health and physical function. It has previously been demonstrated that the postprandial rise in circulating essential amino acids (EAA) acts as the main stimulus for muscle protein synthesis (MPS). This study investigated postprandial plasma amino acid (AA) responses of 2 different forms of whey protein isolate (WPI) with iso-caloric and iso-nitrogenous profiles to investigate plasma concentrations of EAA.</p><p><strong>Methods: </strong>In all, 12 healthy men (n = 12) between 19 and 32 years of age were recruited for a randomized, cross-over design, which involved consumption of protein supplements on 2 testing days separated by a 6-day washout period between conditions. On each testing day, subjects consumed either 29.6 g of WPI or WPI + io (whey protein isolate plus Ingredient Optimized Protein^®) mixed with 236 mL of water. Plasma EAA and branch chain amino acid (BCAA) concentrations were assessed from whole body donated by subjects at pre-consumption and 30, 60, 90, 120, and 180 minutes post consumption.</p><p><strong>Results: </strong>Plasma levels of total EAA concentration was significantly greater in WPI + io at 30, 60, 90, and 120 minutes post consumption (<i>P</i> < .01, <i>P</i> < .001, <i>P</i> < .01, and <i>P</i> < .01, respectively). Plasma levels of total BCAA concentration was significantly greater in WPI + io at 30, 60, 90, and 120 minutes post consumption (<i>P</i> < .01, <i>P</i> < .001, <i>P</i> < .01, and <i>P</i> < .05, respectively) compared with WPI. For leucine, only WPI + io had elevated levels compared with pre-test at 90 minutes post consumption (<i>P</i> < .001).</p><p><strong>Discussion: </strong>Both conditions significantly elevated EAA, BCAA, and leucine from basal levels. However, we conclude that the consumption of the treated WPI significantly raises plasma EAA, BCAA, and leucine to a greater extent compared with WPI with no treatment. Thus, supplementation with WPI that has undergone Ingredient Optimized^® technology may be highly beneficial for those who partake in regular exercise, elderly individuals, or those affected by a reduced sensitivity to amino acids.</p>","PeriodicalId":19396,"journal":{"name":"Nutrition and Metabolic Insights","volume":"12 ","pages":"1178638819827970"},"PeriodicalIF":1.7,"publicationDate":"2019-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/1178638819827970","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37068773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}