Npg Asia Materials最新文献

{"title":"Pressure-controlled luminescence in fast-response barium fluoride crystals","authors":"Marilou Cadatal-Raduban, Luong Viet Mui, Masahiro Yamashita, Yuki Shibazaki, Toshihiko Shimizu, Nobuhiko Sarukura, Kohei Yamanoi","doi":"10.1038/s41427-024-00570-8","DOIUrl":"10.1038/s41427-024-00570-8","url":null,"abstract":"Cross-luminescence (CL) in a barium fluoride (BaF2) scintillator arising from the recombination of a valence band electron and a core band hole results in a fast picosecond decay time. However, the CL emission wavelength in the vacuum ultraviolet region is difficult to detect, and intrinsically intense and slow nanosecond self-trapped exciton (STE) luminescence occurs. Herein, we report a redshift in the CL emission wavelength with high-pressure application. The wavelength of the CL emission shifted from 221 nm to 240 nm when 5.0 GPa was applied via a sapphire anvil cell. Increasing the pressure decreases the core-valence bandgap due to the downward expansion of the valence band, resulting in a decrease in the valence band minimum. The onset of a phase transition from a cubic crystal structure to an orthorhombic crystal structure at 3.7 GPa inhibited the recombination of conduction band electrons and self-trapped holes, leading to the disappearance of the STE emission. Manipulating the band structure of BaF2 by high-pressure application enables control of its luminescence emission, providing a pathway toward solving the problems inherent in this leading fast-response scintillator. Cross-luminescence (CL) in a barium fluoride arising from the recombination of a valence band electron and a core band hole, and intrinsically intense self-trapped exciton (STE) luminescence occurs. Herein, we report a redshift in the CL emission wavelength with high-pressure application via a sapphire anvil cell. Increasing the pressure decreases the core-valence bandgap due to the downward expansion of the valence band. The onset of a phase transition from a cubic crystal structure to an orthorhombic crystal structure at 3.7 GPa inhibited the recombination of conduction band electrons and self-trapped holes, leading to the disappearance of the STE emission.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-12"},"PeriodicalIF":8.6,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00570-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burst plasma preparation of metallic nanoparticles on carbon fabrics for antibacterial and electrocatalytic applications","authors":"Guiyin Xu, Zheyi Meng, Yunteng Cao, Zixu Tao, Qing-Jie Li, Myles Stapelberg, Bing Han, Rui Gao, Qipeng Yu, Meng Gu, Benedetto Marelli, Hailiang Wang, Meifang Zhu, Ju Li","doi":"10.1038/s41427-024-00566-4","DOIUrl":"10.1038/s41427-024-00566-4","url":null,"abstract":"Metal nanoparticles have extraordinary properties, but their integration into mesostructures has been challenging. Producing uniformly dispersed nanoparticles attached to substrates in industrial quantities is difficult. Herein, a “plasmashock” method was developed to synthesize metal nanoparticles anchored on different types of carbonaceous substrates using liquid salt solution precursors. These self-supporting, nanoparticle-loaded carbon fabrics are mechanically robust and have been tested as antibacterial substrates and electrocatalysts for reducing carbon dioxide and nitrite. A piece of silver–carbon nanotube paper with a silver loading of ~0.13 mg cm−2 treated after a few-second plasmashock presents good antibacterial and electrocatalytic properties in wastewater, even after 20 bactericidal immersion cycles, due to the strong bonding of the nanoparticles to the substrate. The results prove the effectiveness of this plasmashock method in creating free-standing functional composite films or membranes. A “plasmashock” method was developed to synthesize metal nanoparticles anchored on different kinds of carbonaceous substrates using liquid salt solution precursors. These self-supporting, nanoparticles-loaded carbon fabrics are mechanically robust and tested as antibacterial substrate and electrocatalysts for reducing carbon dioxide and nitrite.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-11"},"PeriodicalIF":8.6,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00566-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sulfur/reduced graphite oxide and dual-anion solid polymer‒electrolyte integrated structure for high-loading practical all-solid-state lithium–sulfur batteries","authors":"Eun Mi Kim, Jinseok Han, Guk-Tae Kim, Huan Li, Meng Yang Cui, Ganghwan Park, Dong-Ho Baek, Bo Jin, Sang Mun Jeong, Jae-Kwang Kim","doi":"10.1038/s41427-024-00568-2","DOIUrl":"10.1038/s41427-024-00568-2","url":null,"abstract":"The demand for high-capacity batteries with long cycle life and safety has been increasing owing to the expanding mid-to-large battery market. Li–S batteries are suitable energy-storage devices because of their reversibility, high theoretical capacity, and inexpensive construction materials. However, their performance is limited by various factors, including the shuttle effect and dendrite growth at the anode. Here, an integrated electrode for use in all-solid-state (ASS) Li–S batteries was formed via hot pressing. In detail, S particles dispersed in a functionalized reduced graphite oxide (rGO) cathode with a binder-less polymer electrolyte (PE) and a dual-anion ionic liquid-containing cross-linked poly(ethylene oxide)–Li bis(fluoromethanesulfonyl)imide–N-butyl-N-methylpyrrolidinium bis(trifluoromethanesulfonyl) imide-based solid polymer electrolyte (SPE, PEO–LiFSI0.1(Pyr14TFSI)0.4) were hot-pressed into an integrated electrode, which serves as both the cathode and electrolyte. The resulting S/rGO-based solid-state Li–S batteries exhibited more stable performance than Li–S batteries using liquid electrolytes did, indicating that the dual-anion SPE layer effectively suppressed dendritic Li formation and the shuttle effect with high ionic conductivity. At 0.1 C, the battery discharge capacities were 957 and 576 mAh g−1 in the first cycle and after 100 cycles, respectively. At 1 C, the reversible capacity was 590 and 417 mAh g−1 in the first cycle and after 100 cycles, respectively (capacity retention = 71%). Therefore, the proposed S/rGO/PE//LiFSI0.1(Pyr14TFSI)0.4-integrated electrodes are beneficial for ASS Li–S batteries. Sulfur particles disperse in a functionalized reduced graphite oxide (rGO) cathode with a binder-less polymer electrolyte and a dual-anion ionic liquid-containing cross-linked PEO–LiFSI0.1(Pyr14TFSI)0.4 are hot-pressed into an integrated electrode, serving as both the cathode and electrolyte. Dual-anion solid polymer electrolyte and rGO-functional integrated sulfur electrode presents a novel method to improve the electrochemical properties of lithium-sulfur batteries.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-13"},"PeriodicalIF":8.6,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00568-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the charge density wave mechanism in vanadium-based Bi-layered kagome metals","authors":"Yi-Chen Yang, Soohyun Cho, Tong-Rui Li, Xiang-Qi Liu, Zheng-Tai Liu, Zhi-Cheng Jiang, Jian-Yang Ding, Wei Xia, Zi-Cheng Tao, Jia-Yu Liu, Wen-Chuan Jing, Yu Huang, Yu-Ming Shi, Soonsang Huh, Takeshi Kondo, Zhe Sun, Ji-Shan Liu, Mao Ye, Yi-Lin Wang, Yan-Feng Guo, Da-Wei Shen","doi":"10.1038/s41427-024-00567-3","DOIUrl":"10.1038/s41427-024-00567-3","url":null,"abstract":"The charge density wave (CDW), as a hallmark of vanadium-based kagome superconductor AV3Sb5 (A = K, Rb, Cs), has attracted intensive attention. However, the fundamental controversy regarding the underlying mechanism of CDW therein persists. Recently, the vanadium-based bi-layered kagome metal ScV6Sn6, reported to exhibit a long-range charge order below 94 K, has emerged as a promising candidate to further clarify this core issue. Here, employing micro-focusing angle-resolved photoemission spectroscopy (μ-ARPES) and first-principles calculations, we systematically studied the unique CDW order in vanadium-based bi-layered kagome metals by comparing ScV6Sn6 with its isostructural counterpart YV6Sn6, which lacks a CDW ground state. Combining ARPES data and the corresponding joint density of states (DOS), we suggest that the VHS nesting mechanism might be invalid in these materials. Besides, in ScV6Sn6, we identified multiple hybridization energy gaps resulting from CDW-induced band folding, along with an anomalous band dispersion, implying a potential electron-phonon coupling-driven mechanism underlying the formation of the CDW order. Our finding not only comprehensively maps the electronic structure of V-based bi-layer kagome metals but also provides constructive experimental evidence for the unique origin of CDW in this system. We investigated the origins of charge density wave (CDW) mechanisms in the bi-layered kagome metal ScV6Sn6 by comparing its electronic structure with that of its isostructural counterpart YV6Sn6, which does not exhibit a CDW state. Our ARPES measurements reveal that the Van Hove singularity (VHS) nesting mechanism may not be valid in the CDW state. In ScV6Sn6, the electronic structure shows a CDW-induced band gap accompanied by anomalous band dispersion near the M point of the Brillouin zone. These findings provide experimental evidence for the origin of CDW in vanadium-based kagome metals.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-9"},"PeriodicalIF":8.6,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00567-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unprecedented mechanical wave energy absorption observed in multifunctional bioinspired architected metamaterials","authors":"Zhendong Li, Xinxin Wang, Kexin Zeng, Zichao Guo, Chong Li, Xiang Yu, Seeram Ramakrishna, Zhonggang Wang, Yang Lu","doi":"10.1038/s41427-024-00565-5","DOIUrl":"10.1038/s41427-024-00565-5","url":null,"abstract":"In practical engineering, noise and impact hazards are pervasive, indicating the pressing demand for materials that can absorb both sound and stress wave energy simultaneously. However, the rational design of such multifunctional materials remains a challenge. Herein, inspired by cuttlebone, we present bioinspired architected metamaterials with unprecedented sound-absorbing and mechanical properties engineered via a weakly-coupled design. The acoustic elements feature heterogeneous multilayered resonators, whereas the mechanical responses are based on asymmetric cambered cell walls. These metamaterials experimentally demonstrated an average absorption coefficient of 0.80 from 1.0 to 6.0 kHz, with 77% of the data points exceeding the desired 0.75 threshold, all with a compact 21 mm thickness. An absorptance-thickness map is devised for assessing the sound-absorption efficiency. The high-fidelity microstructure-based model reveals the air friction damping mechanism, with broadband behavior attributed to multimodal hybrid resonance. Empowered by the cambered design of cell walls, metamaterials shift catastrophic failure toward a progressive deformation mode characterized by stable stress plateaus and ultrahigh specific energy absorption of 50.7 J/g—a 558.4% increase over the straight-wall design. After the deformation mechanisms are elucidated, a comprehensive research framework for burgeoning acousto-mechanical metamaterials is proposed. Overall, our study broadens the horizon for multifunctional material design. Noise and impact hazards are pervasive in engineering, necessitating materials capable of absorbing both sound and stress wave energy. Here, we present bioinspired metamaterials with exceptional sound-absorbing and mechanical properties using a weakly-coupled design strategy. These materials incorporate multi-layered resonators for superior acoustic performance and cambered cell walls for enhanced structural strength. They achieve an average absorption coefficient of 0.80 across the 1.0 to 6.0 kHz range, all within a sleek 21 mm thickness. Furthermore, the design transitions failure modes from catastrophic to progressive, resulting in a remarkable 558.4% increase in energy absorption compared to conventional designs.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-14"},"PeriodicalIF":8.6,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00565-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142216206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vortex confinement through an unquantized magnetic flux","authors":"Geunyong Kim, Jinyoung Yun, Jinho Yang, Ilkyu Yang, Dirk Wulferding, Roman Movshovich, Gil Young Cho, Ki-Seok Kim, Garam Hahn, Jeehoon Kim","doi":"10.1038/s41427-024-00564-6","DOIUrl":"10.1038/s41427-024-00564-6","url":null,"abstract":"Geometrically confined superconductors often experience a breakdown in the quantization of magnetic flux owing to the incomplete screening of the supercurrent against field penetration. In this study, we report that magnetic field confinement occurs regardless of the dimensionality of the system, even extending to 1D linear potential systems. By using a vector-field magnetic force microscope, we successfully create a vortex‒antivortex pair connected by a 1D unquantized magnetic flux in ultrathin superconducting films. Through an investigation of the manipulation and thermal behavior of the vortex pair, we uncover a long-range interaction mediated by the unquantized magnetic flux. These findings suggest a universal phenomenon of unquantized magnetic flux formation, independent of the geometry of the system. Our results present an experimental route for investigating the impact of confinement on superconducting properties and order parameters in unconventional superconductors characterized by extremely low dimensionality. We demonstrate a 1D linear potential system in superconducting films by creating vortex-antivortex pairs linked by either quantized or unquantized magnetic flux. Our study of vortex pair manipulation and thermal behavior reveals a 1D force mediated by unquantized magnetic flux. This discovery suggests a universal mechanism for forming 1D force systems, offering a new paradigm in the physics of 1D forces.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-8"},"PeriodicalIF":8.6,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00564-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142216157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lithium-ion battery recycling—a review of the material supply and policy infrastructure","authors":"P. M. Tembo, C. Dyer, V. Subramanian","doi":"10.1038/s41427-024-00562-8","DOIUrl":"10.1038/s41427-024-00562-8","url":null,"abstract":"The current change in battery technology followed by the almost immediate adoption of lithium as a key resource powering our energy needs in various applications is undeniable. Lithium-ion batteries (LIBs) are at the forefront of the industry and offer excellent performance. The application of LIBs is expected to continue to increase. The adoption of renewable energies has spurred this LIB proliferation and resulted in a dramatic increase in LIB waste. In this review, we address waste LIB collection and segregation approaches, waste LIB treatment approaches, and related economics. We have coined a “green score” concept based on a review of several quantitative analyses from the literature to compare the three mainstream recycling processes: pyrometallurgical, hydrometallurgical, and direct recycling. In addition, we analyze the current trends in policymaking and in government incentive development directed toward promoting LIB waste recycling. Future LIB recycling perspectives are analyzed, and opportunities and threats to LIB recycling are presented. Lithium-ion battery (LIB) waste management is an integral part of the LIB circular economy. LIB refurbishing & repurposing and recycling can increase the useful life of LIBs and constituent materials, while serving as effective LIB waste management approaches. A combined effort by governments, industries and end-users will be integral in improving LIB waste collection rates which are largely lacking. A developed pseudo technical green score concept highlights direct recycling as a preferable recycling approach based on various life cycle assessment indicators. Standardized costing for the treatment of end-of-life LIBs shows pyrometallurgy as the least costly recycling approach.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-20"},"PeriodicalIF":8.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00562-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142216179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring the grain boundary structure and chemistry of the dendrite-free garnet solid electrolyte Li6.1Ga0.3La3Zr2O12","authors":"Rae-Hyun Lee, Chea-Yun Kang, Jong-Kyu Lee, Bong-Soo Jin, Kyong-Nam Kim, Hyun-Soo Kim, Jung-Rag Yoon, Seung-Hwan Lee","doi":"10.1038/s41427-024-00563-7","DOIUrl":"10.1038/s41427-024-00563-7","url":null,"abstract":"Garnet-type Li6.1Ga0.3La3Zr2O12 (LGLZO) exhibits high ionic conductivity and extremely low electronic conductivity. The electrochemical properties strongly depend on the characteristics of the grain boundaries and pores in the oxide–ceramic electrolyte. Currently, the main issue of LGLZO is its large grain boundary resistance due to high-temperature sintering. Herein, we propose an effective method for reinforcing the chemical and structural characteristics of the grain boundaries using a Li2O-B2O3-Al2O3 (LBA) sintering aid. In this study, the LBA sintering aid is critical because it fills grain boundaries and void spaces. As a result, LGLZO solid-state electrolytes with sintering aids significantly enhance the ionic conductivity and reduce the activation energy, especially in the grain boundary region. Another crucial issue is the formation of Li dendrites in LGLZO. Since dendritic Li propagates along the grain boundaries, the optimized LGLZO solid-state electrolyte demonstrates excellent stability against Li metals. Overall, the LGLZO electrolyte with the LBA sintering aid exhibits stable long-term cycling performance due to the well-designed grain boundaries. The addition of Li2O-B2O3-Al2O3 (LBA) sintering aid to Li6.1Ga0.3La3Zr2O12 (LGLZO) solid electrolytes enhances grain boundary characteristics and reduces porosity. This modification leads to a substantial increase in ionic conductivity and mechanical stability, while effectively preventing Li dendrite formation. The optimized LGLZO sample with LBA exhibits improved long-term cycling performance, making it a promising candidate for high-performance all-solid-state batteries. These findings underscore the critical role of grain boundary engineering in enhancing the electrochemical properties of garnet-type electrolytes.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-12"},"PeriodicalIF":8.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00563-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142216236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High tolerance of the superconducting current to large grain boundary angles in potassium-doped BaFe2As2","authors":"Takafumi Hatano, Dongyi Qin, Kazumasa Iida, Hongye Gao, Zimeng Guo, Hikaru Saito, Satoshi Hata, Yusuke Shimada, Michio Naito, Akiyasu Yamamoto","doi":"10.1038/s41427-024-00561-9","DOIUrl":"10.1038/s41427-024-00561-9","url":null,"abstract":"Superconducting magnets based on high-temperature superconductors (HTSs) have become critical components in cutting-edge technologies such as advanced medical applications. In HTSs, weak links of superconductivity are inevitable at high-angle grain boundaries (GBs). Thus, two adjacent grains should be crystallographically aligned within the critical angle (θc), for which the intergrain critical current density (Jc) starts to decrease exponentially. The θc of several iron-based superconductors (IBSs) is larger than that of cuprates. However, the decreases in both θc and intergrain Jc under magnetic fields for IBSs are still substantial, hampering their applications in polycrystalline forms. Here, we report that potassium-doped BaFe2As2 (Ba122:K) exhibits superior GB performance to that of previously reported IBSs. A transport Jc of over 0.1 MA/cm2 across [001]-tilt GBs with misorientation angles up to θGB = 24° was recorded even at 28 K, which is a required level for practical applications. Additionally, even in an applied magnetic field, θc was unaltered, and the decay of the intergrain Jc was small. Our results highlight the exceptional potential of Ba122:K for polycrystalline applications and pave the way for next-generation superconducting magnets. We have fabricated artificial grain boundaries in K-doped BaFe2As2 (Ba122:K), one of the Fe-based superconductors. The crystalline orientation map, acquired through the scanning precession electron diffraction measurements, revealed that spontaneous connectivity modification occurred at the grain boundary, which may mitigate weak-link behavior. Specifically, a self-field critical current density Jc of over 0.1 MA/cm2 across the grain boundary with misorientation angles up to 24° was recorded even at 28 K. This performance surpasses the grain boundary properties of hitherto reported Fe-based superconductors. Our results highlight the exceptional potential of Ba122:K for polycrystalline applications and pave the way for next-generation superconducting magnets.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-10"},"PeriodicalIF":8.6,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00561-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142216238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multifunctional mesoporous silica drug delivery nanosystem that ameliorates tumor hypoxia and increases radiotherapy efficacy","authors":"Yanhong Chu, LiFeng Wang, Yaohua Ke, Xiaoyu Feng, Wenmei Rao, Wei Ren, Kai Xin, Yan Wang, Lixia Yu, Baorui Liu, Qin Liu","doi":"10.1038/s41427-024-00560-w","DOIUrl":"10.1038/s41427-024-00560-w","url":null,"abstract":"Radiotherapy (RT) is a widely used treatment with strong therapeutic effects, but overcoming challenges related to hypoxia-induced tumor resistance and ineffective antitumor immune responses is crucial for optimal outcomes. In this study, we developed a versatile nanosystem using mesoporous silica nanoparticles (MSNs), R837, and a small quantity of manganese peroxide (Mn/ZnO2). The synthesized MSN@R837-Mn/ZnO2 nanoparticles exhibited precise tumor targeting and accumulation, controlled drug release under acidic conditions, and increased sensitivity in magnetic resonance imaging. These attributes collectively augmented the therapeutic efficacy of RT by alleviating hypoxia and immunosuppression. Tumor cells treated with RT combined with these nanoparticles displayed reduced oxidative stress, alleviated hypoxia, and normalized blood vessel formation. Notably, all mice in the RT + PD-1 + MSN@R837-Mn/ZnO2 group achieved complete tumor regression with extended survival. Safety assessments confirmed the absence of MSN@R837-Mn/ZnO2 toxicity, highlighting its potential as a promising approach with dual functionality for the diagnostic imaging and treatment of cancer. Radiotherapy (RT) faces challenges like hypoxia-induced tumor resistance and weak antitumor immune responses. This study developed a nanosystem using mesoporous silica nanoparticles (MSNs), R837, and manganese peroxide (Mn/ZnO2). The MSN@R837-Mn/ZnO2 nanoparticles showed precise tumor targeting, controlled drug release in acidic conditions, and enhanced MRI sensitivity, boosting RT efficacy by reducing hypoxia and immunosuppression. Tumor cells treated with RT and these nanoparticles had less oxidative stress, improved hypoxia, and normalized blood vessels. Remarkably, all mice in the RT+PD-1+MSN@R837-Mn/ZnO2 group achieved complete tumor regression and extended survival, with no toxicity observed, indicating its potential for cancer imaging and treatment.","PeriodicalId":19382,"journal":{"name":"Npg Asia Materials","volume":"16 1","pages":"1-17"},"PeriodicalIF":8.6,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41427-024-00560-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142216239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}