Nuclear medicine and biology最新文献

{"title":"[18F]FDG-PET provides insights into the liver-brain axis and confirms SUVgluc as a surrogate for MRGlu in a mouse model of liver fibrosis","authors":"Thomas Wanek ,&nbsp;Mari Teuter ,&nbsp;Asha Balakrishnan ,&nbsp;Tobias L. Ross ,&nbsp;Frank M. Bengel ,&nbsp;Michael Ott ,&nbsp;Marion Bankstahl ,&nbsp;Jens P. Bankstahl","doi":"10.1016/j.nucmedbio.2025.109095","DOIUrl":"10.1016/j.nucmedbio.2025.109095","url":null,"abstract":"<div><h3>Purpose</h3><div>The liver-brain axis regulates metabolic homeostasis, with glucose metabolism playing a key role. Liver dysfunction, such as fibrosis, may impact brain metabolism and consequently, brain function. Positron emission tomography (PET) imaging provides a non-invasive approach to study glucose metabolism in both organs. A recent longitudinal PET/CT study utilizing 2-deoxy-2-[¹⁸F]-fluoro-<span>d</span>-glucose ([¹⁸F]FDG) amongst other radiotracers revealed significant metabolic changes in the liver in a mouse model of liver fibrosis. Here, we retrospectively analyzed those data to quantify potential associated changes in brain glucose metabolism.</div></div><div><h3>Procedures</h3><div>Eleven male C57BL/6N mice underwent repeated PET imaging with [¹⁸F]FDG at baseline, pre-fibrosis, fibrosis, and remission stages. Cerebral glucose metabolism was assessed using standardized uptake value (<em>SUV</em>), blood glucose-corrected <em>SUV</em> (<em>SUV</em>_{<em>gluc</em>}), and kinetic modeling (Patlak and two-tissue compartment models) for calculation of the glucose metabolic rate (<em>MR</em>_<em>Glu</em>).</div></div><div><h3>Results</h3><div>Both <em>SUV</em>_{<em>gluc</em>} and <em>MR</em>_<em>Glu</em> significantly decreased during pre-fibrosis and fibrosis on whole brain level and recovered at remission. <em>SUV</em>_{<em>gluc</em>} statistical parametric mapping identified multiple brain areas with reduced glucose metabolism, which was confirmed by regional analysis showing progressive reduction in SUV_gluc. Correlation analyses confirmed <em>SUV</em>_{<em>gluc</em>} as a reliable surrogate for <em>MR</em>_<em>Glu</em>, unlike uncorrected <em>SUV</em>. Liver [¹⁸F]FDG uptake increased during fibrosis and normalized at remission, mirroring changes in blood glucose concentrations.</div></div><div><h3>Conclusions</h3><div>[¹⁸F]FDG PET imaging revealed that liver fibrosis alters glucose metabolism in both liver and brain, emphasizing the potential of molecular imaging for future assessment of metabolic interaction between liver and brain. [¹⁸F]FDG uptake in terms of <em>SUV</em>_{<em>gluc</em>} strongly correlated with <em>MR</em>_<em>Glu</em> from kinetic modeling, supporting its utility as a valid surrogate parameter to quantify cerebral glucose metabolism in mice.</div></div>","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109095"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144997488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of the binding potential of the PET ligand [18F]FEDAC to translocator protein 18 kDa (TSPO) in the brain of experimental stroke model rats","authors":"Tomoteru Yamasaki ,&nbsp;Yiding Zhang ,&nbsp;Wakana Mori ,&nbsp;Katsushi Kumata ,&nbsp;Hidekatsu Wakizaka ,&nbsp;Daisuke Arashi ,&nbsp;Yusuke Kurihara ,&nbsp;Masanao Ogawa ,&nbsp;Nobuki Nengaki ,&nbsp;Masayuki Fujinaga ,&nbsp;Ming-Rong Zhang","doi":"10.1016/j.nucmedbio.2025.109579","DOIUrl":"10.1016/j.nucmedbio.2025.109579","url":null,"abstract":"<div><h3>Purpose</h3><div>Translocator protein 18 kDa (TSPO) is a biomarker for neuroinflammation, and [¹⁸F]FEDAC was developed as a clinically usable radioligand for its imaging. Here, quantitative PET analyses of [¹⁸F]FEDAC in the brain of transient middle cerebral artery occlusion (tMCAO) rats were conducted for the first time.</div></div><div><h3>Methods</h3><div>Quantitative PET analysis was performed on rats subjected to tMCAO, with blood sampling also conducted as part of the study. To estimate the kinetic parameters of [¹⁸F]FEDAC, two-tissue compartment model (2TCM) and simplified reference tissue model (SRTM) analyses were conducted.</div></div><div><h3>Results</h3><div>The input rate (<em>K</em>₁) and distribution volume (<em>V</em>_T) (a macroparameter consisting of the <em>K</em>₁–<em>k</em>₄ rate constants from 2TCM analysis) of [¹⁸F]FEDAC in the ipsilateral area of tMCAO rats were 0.38 ± 0.19 mL/cm³/min and 5.4 ± 2.7 mL/cm³, respectively, which are roughly twice as high as those in the contralateral area. These results strongly suggest that ipsilateral binding potential (BP_ND), a quantitative index derived from the <em>V</em>_T ratio with respect to the reference region, depends not only on the binding of [¹⁸F]FEDAC to TSPO, but also on increases in the input rate from blood. Therefore, in SRTM analyses, we corrected apparent BP_ND using <em>R</em>1, an index for probe delivery. In validation studies, SRTM analysis with the corrected BP_ND (corBP_ND), using the cerebellum as a reference, showed a high correlation with direct BP_ND (<em>k</em>₃/<em>k</em>₄) in 2TCM analyses.</div></div><div><h3>Conclusion</h3><div>The acquisition of quantitative PET images of TSPO distribution in the tMCAO rat brain was successfully achieved by scaling with corBP_ND.</div></div>","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109579"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ubiquitin-specific protease 14 (USP14): An emerging biomarker for molecular imaging of cancer.","authors":"Jenilee Woodfield,&nbsp;Melinda Wuest,&nbsp;Frank Wuest","doi":"10.1016/j.nucmedbio.2025.109190","DOIUrl":"10.1016/j.nucmedbio.2025.109190","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109190"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radioiodinated Carborane-based Indomethacin-Derivatives as Cyclooxygenase-2 Radiotracers","authors":"Jonas Schädlich ,&nbsp;Christoph Selg ,&nbsp;Cathleen Haase-Kohn ,&nbsp;Klaus Kopka ,&nbsp;Evamarie Hey-Hawkins ,&nbsp;Jens Pietzsch ,&nbsp;Markus Laube","doi":"10.1016/j.nucmedbio.2025.109132","DOIUrl":"10.1016/j.nucmedbio.2025.109132","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109132"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"211At-metal N-Heterocyclic Carbene complexes: a promising alternative for targeted alpha therapy","authors":"Sébastien Guillet ,&nbsp;Samuel Mador ,&nbsp;Mathilde Ligeour ,&nbsp;Cyrille Alliot ,&nbsp;Nicolas Galland ,&nbsp;Francois Guerard","doi":"10.1016/j.nucmedbio.2025.109131","DOIUrl":"10.1016/j.nucmedbio.2025.109131","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109131"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bifunctional Chelators for Cu-64/Pb-212 Theranostic Applications","authors":"Daniel Hubin,&nbsp;Meltem Ocak,&nbsp;Longbo Li,&nbsp;Christine Lovingier,&nbsp;Carolyn Anderson","doi":"10.1016/j.nucmedbio.2025.109125","DOIUrl":"10.1016/j.nucmedbio.2025.109125","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109125"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in Pretargeted Imaging of Programmed Cell Death Ligand 1 (PD-L1) in Syngeneic Murine Models: In Vitro Studies with a Gallium-68-Labeled Tris(Hydroxypyridinone)-Tetrazine (THP-Tz) Tracer","authors":"Alessia Centanni ,&nbsp;Daniel Hauken ,&nbsp;Surachet Imlimthan ,&nbsp;You-Cheng Khng ,&nbsp;Outi Keinänen ,&nbsp;Mirkka Sarparanta","doi":"10.1016/j.nucmedbio.2025.109112","DOIUrl":"10.1016/j.nucmedbio.2025.109112","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109112"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"177Lu-labeled antibody-drug conjugate: a dual mechanistic treatment modality in solid tumors with heterogeneous antigen expression","authors":"Aiko Yamaguchi ,&nbsp;Chisato Yamazaki ,&nbsp;Yasuaki Anami ,&nbsp;Summer Y.Y. Ha ,&nbsp;Robert Ta ,&nbsp;Wei Xiong ,&nbsp;Ningyan Zhang ,&nbsp;Zhiqiang An ,&nbsp;Kyoji Tsuchikama ,&nbsp;Charles Manning","doi":"10.1016/j.nucmedbio.2025.109165","DOIUrl":"10.1016/j.nucmedbio.2025.109165","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109165"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted Alpha Therapy of Ovarian Cancer with ²¹²Pb-Labeled Anti-PTK7 Antibody: Efficient Production at Non-Clinical Scale and Preclinical Insights","authors":"Yani Berckmans ,&nbsp;Roxanne Wouters ,&nbsp;Zeljka Raskovic-Lovre ,&nbsp;Sara van Mechelen ,&nbsp;Kim Lindland ,&nbsp;Tina Bønsdorff ,&nbsp;An Coosemans ,&nbsp;Frederik Cleeren","doi":"10.1016/j.nucmedbio.2025.109166","DOIUrl":"10.1016/j.nucmedbio.2025.109166","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109166"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pilot PET Imaging Study of Microtubule Dynamics in Older Adults with Cognitive Impairment","authors":"Naresh Damuka ,&nbsp;Bhuvanachandra Bhoopal ,&nbsp;Mack Miller ,&nbsp;Ivan Krizan ,&nbsp;Krishna Gollapelli ,&nbsp;Caleb Bradley ,&nbsp;Samuel Lockhart ,&nbsp;Akiva Mintz ,&nbsp;Suzanne Craft ,&nbsp;Kiran Solingapuram Sai","doi":"10.1016/j.nucmedbio.2025.109105","DOIUrl":"10.1016/j.nucmedbio.2025.109105","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"150 ","pages":"Article 109105"},"PeriodicalIF":3.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145473728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}