Nuclear medicine and biology最新文献

{"title":"Chelation chemistry of manganese-52 for PET imaging applications","authors":"James M. Omweri ,&nbsp;Volkan Tekin ,&nbsp;Shefali Saini ,&nbsp;Hailey A. Houson ,&nbsp;Samith B. Jayawardana ,&nbsp;Daniel A. Decato ,&nbsp;Gayan B. Wijeratne ,&nbsp;Suzanne E. Lapi","doi":"10.1016/j.nucmedbio.2023.108874","DOIUrl":"10.1016/j.nucmedbio.2023.108874","url":null,"abstract":"<div><h3>Introduction</h3><p>Due to its decay and chemical properties, interest in manganese-52 has increased for development of long-lived PET radiopharmaceuticals. Its long half-life of 5.6 days, low average positron energy (242 keV), and sufficient positron decay branching ratio make it suitable for radiolabeling macromolecules for investigating slow biological processes. This work aims to establish suitable chelators for manganese-52 that can be radiolabeled at mild conditions through the evaluation of commercially available chelators.</p></div><div><h3>Methods</h3><p>Manganese-52 was produced through the nuclear reaction ^NatCr(p,n)⁵²Mn by irradiation of natural chromium targets on a TR24 cyclotron followed by purification through ion exchange chromatography. The radiolabeling efficiencies of chelators: DOTA, DiAmsar, TETA, DO3A, NOTA, 4′-Formylbenzo-15-crown-5, Oxo-DO3A, and DFO, were assessed by investigating the impact of pH, buffer type, and temperature. <em>In vitro</em> stability of [⁵²Mn]Mn(DO3A)⁻, [⁵²Mn]Mn(Oxo-DO3A)⁻, and [⁵²Mn]Mn(DOTA)²⁻ were evaluated in mouse serum. The radiocomplexes were also evaluated <em>in vivo</em> in mice. Crystals of [Mn(Oxo-DO3A)]⁻ were synthesized by reacting Oxo-DO3A with MnCl₂ and characterized by single crystal X-ray diffraction.</p></div><div><h3>Results</h3><p>Yields of 185 ± 19 MBq (5.0 ± 0.5 mCi) (n = 4) of manganese-52 were produced at the end of a 4 h, 15 μA, bombardment with 12.5 MeV protons. NOTA, DO3A, DOTA, and Oxo-DO3A chelators were readily radiolabeled with &gt;96 % radiochemical purity at all conditions. Manganese radiocomplexes of Oxo-DO3A, DOTA, and DO3A remained stable <em>in vitro</em> up to 5 days and exhibited different biodistribution profiles compared to [⁵²Mn]MnCl₂. The solid-state structure of Mn-Oxo-DO3A complex was determined by single-crystal X-ray diffraction.</p></div><div><h3>Conclusions</h3><p>DO3A and Oxo-DO3A are suitable chelators for manganese-52 which are readily radiolabeled at mild conditions with high molar activity, and demonstrate both <em>in vitro</em> and <em>in vivo</em> stability.</p></div>","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"128 ","pages":"Article 108874"},"PeriodicalIF":3.1,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0969805123006029/pdfft?md5=03b22d19bd51af10dd7051d5419ab246&pid=1-s2.0-S0969805123006029-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139031358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of 18F-Labelled CXCR4-Targeted Peptide Radiopharmaceuticals Through Strain-Promoted Click Chemistry","authors":"Julia Mason,&nbsp;Len Luyt","doi":"10.1016/j.nucmedbio.2023.108406","DOIUrl":"https://doi.org/10.1016/j.nucmedbio.2023.108406","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"126 ","pages":"Article 108406"},"PeriodicalIF":3.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138500794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"StarPEG Nanocarriers for PSMA Targeted Radioligand Imaging and Therapy","authors":"Anil Bidkar,&nbsp;Niranjan Meher,&nbsp;Gary Ashley,&nbsp;Anju Wadhwa,&nbsp;Kondapa Bobba,&nbsp;Becka Shuere,&nbsp;David Wilson,&nbsp;Youngho Seo,&nbsp;Daniel Santi,&nbsp;Henry VanBrocklin,&nbsp;Robert Flavell","doi":"10.1016/j.nucmedbio.2023.108400","DOIUrl":"https://doi.org/10.1016/j.nucmedbio.2023.108400","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"126 ","pages":"Article 108400"},"PeriodicalIF":3.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138500876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INTERNATIONAL SCIENTIFIC PROGRAM COMMITTEE","authors":"","doi":"10.1016/j.nucmedbio.2023.108853","DOIUrl":"https://doi.org/10.1016/j.nucmedbio.2023.108853","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"126 ","pages":"Article 108853"},"PeriodicalIF":3.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138500956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated cassette based synthesis of novel CB1 receptor tracer [18F]FPATPP produced via Ru-mediated 18F-fluorination","authors":"Noora Rajala,&nbsp;Anna Kirjavainen","doi":"10.1016/j.nucmedbio.2023.108469","DOIUrl":"https://doi.org/10.1016/j.nucmedbio.2023.108469","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"126 ","pages":"Article 108469"},"PeriodicalIF":3.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138500965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical evaluation of ePSMA-DM1: a PSMA-targeting theranostic small molecule drug conjugate","authors":"Yann Seimbille,&nbsp;Erika Murce,&nbsp;Evelien Spaan,&nbsp;Savanne Beekman,&nbsp;Maryana Handula,&nbsp;Corrina de Ridder,&nbsp;Debra Stuurman","doi":"10.1016/j.nucmedbio.2023.108472","DOIUrl":"https://doi.org/10.1016/j.nucmedbio.2023.108472","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"126 ","pages":"Article 108472"},"PeriodicalIF":3.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138500968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proof-of-concept optimization of copper-mediated radiosynthesis of [18F]FBnTP using a novel automated robotic high-throughput droplet radiochemistry system","authors":"Jason Jones,&nbsp;Yingqing Lu,&nbsp;R. Michael van Dam","doi":"10.1016/j.nucmedbio.2023.108424","DOIUrl":"https://doi.org/10.1016/j.nucmedbio.2023.108424","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"126 ","pages":"Article 108424"},"PeriodicalIF":3.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138501022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the binding affinity of a 64Cu-labeled PSMA ligand in a micro physiological system","authors":"Wiebke Sihver,&nbsp;Anne-Kathrin Nitt-Weber,&nbsp;Stephan Behrens,&nbsp;Florian Schmieder,&nbsp;Falco Reissig,&nbsp;Martin Walther,&nbsp;Martin Ullrich,&nbsp;Hans-Jurgen Pietzsch,&nbsp;Frank Sonntag","doi":"10.1016/j.nucmedbio.2023.108426","DOIUrl":"https://doi.org/10.1016/j.nucmedbio.2023.108426","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"126 ","pages":"Article 108426"},"PeriodicalIF":3.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138501024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auger electrons in radionuclide therapy: Szilárd-Chalmers effect/hot atom chemistry during the targeted delivery of the isotopes","authors":"Zoltán Szucs,&nbsp;Cathryn Driver,&nbsp;Dany Kotze,&nbsp;Monica Buys,&nbsp;Jan Zeevaart","doi":"10.1016/j.nucmedbio.2023.108415","DOIUrl":"https://doi.org/10.1016/j.nucmedbio.2023.108415","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"126 ","pages":"Article 108415"},"PeriodicalIF":3.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138501206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and translational evaluation of three novel PARP PET tracers in nonhuman primates and rodent glioma brain tumor model with intact blood-brain barrier","authors":"Jie Tong,&nbsp;Takuya Takuya,&nbsp;Monique A. Thomas,&nbsp;Mingming Chen,&nbsp;Daniel Holden,&nbsp;Stephen Kurpiewski,&nbsp;Samantha Katz,&nbsp;Baosheng Chen,&nbsp;William Mennie,&nbsp;Mike Wenn,&nbsp;Michael Kapinos,&nbsp;Li Zhang,&nbsp;Zachary Felchner,&nbsp;Hong Gao,&nbsp;David Labaree,&nbsp;Krista Fowles,&nbsp;Jim Ropchan,&nbsp;Nabeel Nabulsi,&nbsp;Henk De Feyter,&nbsp;Richard Carson,&nbsp;Jason Cai","doi":"10.1016/j.nucmedbio.2023.108453","DOIUrl":"https://doi.org/10.1016/j.nucmedbio.2023.108453","url":null,"abstract":"","PeriodicalId":19363,"journal":{"name":"Nuclear medicine and biology","volume":"126 ","pages":"Article 108453"},"PeriodicalIF":3.1,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138501286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}