Nigerian Journal of Natural Products and Medicine最新文献_第2页

Anticancer and antioxidant studies of the methanol extract and fractions of Conyza sumatrensis (retz.) E. H. Walker (asteraceae 苏门答腊树甲醇提取物及其组分的抗癌和抗氧化研究紫菀科

Nigerian Journal of Natural Products and Medicine Pub Date : 2020-05-13 DOI: 10.4314/njnpm.v23i1.10

E. Ikpefan, B. Ayinde, B. Mudassar, A. Farooq

{"title":"Anticancer and antioxidant studies of the methanol extract and fractions of Conyza sumatrensis (retz.) E. H. Walker (asteraceae","authors":"E. Ikpefan, B. Ayinde, B. Mudassar, A. Farooq","doi":"10.4314/njnpm.v23i1.10","DOIUrl":"https://doi.org/10.4314/njnpm.v23i1.10","url":null,"abstract":"The in vitro antiproliferative and antioxidant studies of the leaf extract and fractions of Conyza sumatrensis was investigated by applying the Sulforhodamine-B and 2, 2-diphenyl-1-picrylhydrazyl assays (DPPH-RSA) respectively. While the antiproliferative activity was carried out at 1-250 and 1-100 μg/ mL for the extract and fractions against breast (MCF-7) and lung (NCI-H460) cancer cell lines, the antioxidant study was conducted using DPPH at 31.25 -500 μg/ mL with the total phenolic and flavonoid contents calculated as well with reference to quercetin and gallic acid respectively. The extract and fractions were observed to elicit cytotoxic and growth inhibitory effects against breast (MCF-7) and lung cancer cell lines (NCI-H460) respectively. At 250 μg/mL, the extract of C. sumatrensis gave cytotoxicity of –1.76 ± 0.20 % against MCF-7 cell lines and inhibited growth of NCI-H460 at +94.40 ± 1.0 % respectively. While the chloroform fraction at 100 μg/mL gave -5.38 ± 0.33 % and 91 ± 1.61 % against MCF-7 and NCI-H460 cell lines, the aqueous fraction was observed to be inactive. For the DPPH-RSA activity, the chloroform fraction demonstrated an IC50 value of 125.5 μg/ mL compare to quercetin at 62.5 μg/ mL. The bioactivities were more pronounced in the chloroform fraction. This work has shown that C. sumatrensis has antiproliferative and antioxidant activities which could be tied to the secondary metabolites present in the plant.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"62 1","pages":"77-82"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90868231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

In vivo antimalarial activity of methanol extracts and fractions of Brachystegia eurycoma and Mondia whiteion chloroquine-resistant Plasmodium berghei 白僵菌和白僵菌对氯喹耐药伯氏疟原虫甲醇提取物及组分的体内抗疟活性研究

Nigerian Journal of Natural Products and Medicine Pub Date : 2020-05-13 DOI: 10.4314/njnpm.v23i1.3

A. A. Owolabi, D. A. Fadare, O. Ogbole, E. Ajaiyeoba

{"title":"In vivo antimalarial activity of methanol extracts and fractions of Brachystegia eurycoma and Mondia whiteion chloroquine-resistant Plasmodium berghei","authors":"A. A. Owolabi, D. A. Fadare, O. Ogbole, E. Ajaiyeoba","doi":"10.4314/njnpm.v23i1.3","DOIUrl":"https://doi.org/10.4314/njnpm.v23i1.3","url":null,"abstract":"Malaria remains a major public health problem in the tropics. According to WHO estimates, sub-Saharan Africa continues to carry a disproportionately high share of global malaria burden. Oxidative stress plays significant role in malaria pathogenesis. Recently, there is increasing effort to develop more potent antimalarials from plant source. Brachystegia eurycoma and Mondia whitei are used locally for malaria treatment. Medicinal plants used in therapy quite often possess antioxidant activities as a result of its inherent phytoconstituents. The phytochemical composition of Brachystegia eurycoma and Mondia whitei were qualitatively examined. The antioxidant activities of the methanolic extracts of the leaves of two medicinal plants were determined using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) antioxidant assay. The Brine shrimp lethality assay (BSLA) and Lorke‘s acute toxicity study were used to estimate their toxicities; while Peter‘s 4-day chemosuppresive test was employed to evaluate their antimalarial activities. The flavonoid and saponins content were particularly high in both plants. Using ascorbic acid as reference (IC50 9.26 μg/mL), the antioxidant IC50 values of B. eurycoma and M. whitei were 11.14 μg/ mL and 19.81μg/mL respectively; the BSLA LC50 were 1.8 mg/mL and 1.2 mg/mL; acute toxicity LD50 were 5000 mg/kg and 4500 mg/kg. Brachystegia eurycoma showed stronger daily average antimalarial activity (62.0 %) than Mondia whitei (39.3%), the standard drug, chloroquine, was 85.4%. The chloroform fraction of Brachystegia eurycoma was the most active with (65%) daily average suppression. This suggests that the extracts of leaves of the plants have good antioxidant activities, are non-toxic and supports their antimalarial use in ethnomedicine.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"42 1","pages":"13-21"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86621365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

In vivo and in silico toxicity profiling of aerial part of Andrographis paniculata revealed potential to precipitate organs toxicity 对穿心莲地上部的体内和硅毒性分析显示穿心莲有器官沉淀毒性的潜力

Nigerian Journal of Natural Products and Medicine Pub Date : 2020-05-13 DOI: 10.4314/njnpm.v23i1.15

A. Agbaje, M. O. Daniyan, I. Olawuni

{"title":"In vivo and in silico toxicity profiling of aerial part of Andrographis paniculata revealed potential to precipitate organs toxicity","authors":"A. Agbaje, M. O. Daniyan, I. Olawuni","doi":"10.4314/njnpm.v23i1.15","DOIUrl":"https://doi.org/10.4314/njnpm.v23i1.15","url":null,"abstract":"The many medicinal properties of Andrographis paniculata have made it an important resource in drug discovery. The commonly used powdered aerial part of A. paniculata is however a subject of abuse occasioned by indiscriminate use, raising safety concerns. In this study, we evaluated the safety profile of the suspension of the powdered aerial part of A. paniculata in male and female rats using single and repeated dose toxicity profiling, and the in silico toxicity profiling of its known phytochemicals, with a view to establishing organs safety. Our results showed significant sex dependent alterations in key haematological and biochemical indices. Significant alteration in liver and kidney histo-architectures were consistent with the observed significant increase in AST/ALT ratio and with the in silico toxicity screening of A. paniculata phytochemicals, including andrographolide, which showed potential for hepatotoxicity, binding of proteins and DNA, and inhibition of hERG II. We conclude that, while taking advantage of the many medicinal benefits of this plant, the unguarded and indiscriminate uses may precipitate organ toxicity, induce cellular alteration and potentiate possible cardiovascular risk.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"34 1","pages":"112-125"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87029703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicological evaluation of the stem bark of Burkea africana hook. (Caesalpiniaceae) in wistar rats 非洲栎茎皮的毒理学评价。在wistar大鼠中

Nigerian Journal of Natural Products and Medicine Pub Date : 2020-05-13 DOI: 10.4314/njnpm.v23i1.5

O. Eboji, A. Sowemimo, O. Ogunkunle, M. Sofidiya, K. Badmos, F. Abdulkareem

{"title":"Toxicological evaluation of the stem bark of Burkea africana hook. (Caesalpiniaceae) in wistar rats","authors":"O. Eboji, A. Sowemimo, O. Ogunkunle, M. Sofidiya, K. Badmos, F. Abdulkareem","doi":"10.4314/njnpm.v23i1.5","DOIUrl":"https://doi.org/10.4314/njnpm.v23i1.5","url":null,"abstract":"Burkea africana Hook. (Caesalpiniaceae) is used traditionally to treat ulcers, headaches, skin disease and tumors. The study investigated the acute, sub-acute and chronic toxicity profiles of the ethanolic extract of Burkea africana stem bark. Rats of either sexes were used in this study (n=10). For acute toxicity, a single dose of 5,000 mg/kg was administered while for the sub-acute and chronic toxicity study, three doses (40, 200 and 1000 mg/kg) of the extract were administered orally for 28 and 90 days respectively. At the end of each study, the biochemical, hematological and histological parameters were evaluated. No mortality or behavioral changes were observed in the acute toxicity study. Extract caused significant changes in the hematological parameters after the sub-acute toxicity study. In the chronic toxicity study, the extract caused significant increase in the white blood cell count of the 200 mg/kg group. There was significant increase in the platelet count of treated groups compared to control in the sub-acute and chronic toxicity studies, with an observed total mortality of all the animals in the 1000 mg/kg group on the 44th day. No adverse pathology was observed in the organs examined. The extract elicited a hematological response and short term consumption of the extract at low doses might be relatively safe. However, long term consumption at high doses should be discouraged.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"63 1 1","pages":"33-40"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87741059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective effects of aqueous extract of Aloe barbadensis on the cortical cells of adult Wistar rats following monosodium glutamate-induced neurotoxicity 芦荟水提物对谷氨酸钠诱导的成年Wistar大鼠皮质细胞的神经保护作用

Nigerian Journal of Natural Products and Medicine Pub Date : 2020-05-13 DOI: 10.4314/njnpm.v23i1.13

S. O. Bamigboye, O. Ayannuga, A. Abijo

{"title":"Neuroprotective effects of aqueous extract of Aloe barbadensis on the cortical cells of adult Wistar rats following monosodium glutamate-induced neurotoxicity","authors":"S. O. Bamigboye, O. Ayannuga, A. Abijo","doi":"10.4314/njnpm.v23i1.13","DOIUrl":"https://doi.org/10.4314/njnpm.v23i1.13","url":null,"abstract":"The study assessed the oxidative state and cellular changes of the cerebral cortex following monosodium glutamate-induced neurotoxicity in Wistar rats, with a view to evaluate the effects of varying doses of aqueous extract of Aloe barbadensis (AB) over a four-week period. Eighty Wistar rats (8 weeks old) were randomly assigned into 4 groups of 20 rats; Group 1 (Control group) received 3 mL/kg of distilled water. Groups 2, 3 and 4 received 3 g/kg/day of MSG dissolved in distilled water. In addition, Groups 3 and 4 received 100 and 200 mg/kg/day of AB extract respectively. Oral administration of the above lasted for 28 days in all groups. Five rats per group were sacrificed weekly for 4 weeks. The brain was harvested; one cerebral hemisphere was homogenised for oxidative state assessment. The other hemisphere was fixed in 10% neutral buffered formalin and stained with H&E and Cresyl violet. Data were analyzed using student t-test and p-value < 0.05 was considered significant. Malodialdehyde concentration and densities of degenerating neuron and oligodendrocyte were significantly higher in group 2 compared with group 1 over the 4-week period. No significant difference was noted between groups 1, 3 and 4 for same parameters. Nissl bodies depletion was noted in group 2 across the 4 weeks, lesser degree of depletion was noted in groups 3 and 4. This study concludes that oral administration of MSG resulted in increased lipid peroxidation and depletion of Nissl bodies resulting in degeneration of cortical cells. Aloe barbadensis at 100 mg/kg was sufficient to protect the brain.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"37 1","pages":"92-103"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73400977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shilajit: An organic powerhouse 希拉吉特:一个有机的发电站

Nigerian Journal of Natural Products and Medicine Pub Date : 2020-05-13 DOI: 10.4314/njnpm.v23i1.1

S. Thakkar, K. Laddha

引用次数: 0

Chemical composition and antioxidant activity of Waltheria Indica Linn whole plant 印度白刺全株化学成分及抗氧化活性研究

Nigerian Journal of Natural Products and Medicine Pub Date : 2020-05-13 DOI: 10.4314/njnpm.v23i1.9

B. Rafiu, I. Lawal, M. B. Olaniyi

{"title":"Chemical composition and antioxidant activity of Waltheria Indica Linn whole plant","authors":"B. Rafiu, I. Lawal, M. B. Olaniyi","doi":"10.4314/njnpm.v23i1.9","DOIUrl":"https://doi.org/10.4314/njnpm.v23i1.9","url":null,"abstract":"Waltheria indica is a promising medicinal plant belonging to family Malvaceae, which many biological activities of the solvent extracts of its various parts have been scientifically evaluated. The aim of this study was to evaluate and analyze the minerals, crude fibre and fat contents, the phytochemical constituents as well as the antioxidants activity of the powder sample of W. indica whole plant. Fresh sample of whole W. indica plant was collected and airdried at room temperature. The mineral constituents were determined by spectrophotometry. The crude fibre, fat contents and the qualitative and quantitative phytochemical compositions were determined using standard analytical procedure. The antioxidants activity was determined using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric reducing antioxidant potential (FRAP) assays. The mineral analysis results revealed the presence of micro and macro nutrients such as potassium, calcium, magnesium and manganese among others which are within the acceptable health range. The values (23.8%; 0.15%) obtained for both crude fibre and fat contents were reasonable. The qualitative phytochemical screening established the presence of alkaloids, terpenoids, flavonoids, tannins, anthraquinones and phenol. Steroids are in abundance while Cardiac glycosides are absent. The quantity of alkaloids (1.9%), saponins (1.4%), flavonoids (3.1%) and tannins (17422μg/GAE) are in appreciable amount which may be responsible for its various activities. W. indica showed good inhibitory scavenging activity and better reducing ability compared to ascorbic acid. The results obtained from this study provide further scientific evidence to support the ethno-medicinal information on the uses of W. indica in the treatment of various health issues.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"131 1","pages":"69-76"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79616274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Traditional soups in Nigeria: A review of six botanicals 尼日利亚的传统汤:六种植物的回顾

Nigerian Journal of Natural Products and Medicine Pub Date : 2020-05-13 DOI: 10.4314/njnpm.v23i1.4

Idayat Titilayo Gbadamosi, A. O. Kalejaye

{"title":"Traditional soups in Nigeria: A review of six botanicals","authors":"Idayat Titilayo Gbadamosi, A. O. Kalejaye","doi":"10.4314/njnpm.v23i1.4","DOIUrl":"https://doi.org/10.4314/njnpm.v23i1.4","url":null,"abstract":"Ethnobotanical investigations by workers have revealed the use of juvenile leaves of Cissus populnea L. (ogbolo), Sesamum indicum L. (eeku),Gongronema latifolium Benth. (Madunmaro), Mangifera indica L. (Mongoro), Ipomoea batatas (L.) Lam. (Odunkun) and Ceiba pentandra (L.) Gaertn. (Araba) for preparing soups in Nigeria. In spite of this, the consumption of these traditional soups seems to be abandoned and only consumed during scarcity of commonly used vegetables such as Corchorus olitorius L. (Ewedu). Certain traditional soups are associated with particular Nigerian ethnic groups. As examples, Gongronema latifolium to Igbo people of southeast Nigeria, while Sesamum indicum to the Yorubas and Hausas, southwest and northern Nigeria respectively. For ethnomedicinal purposes Cissus populnea and Sesamum indicum soups enhance sexual performance in men as well as production and cleansing of sperm. Mangifera indica soup is used as anti-anaemic; Gongronema latifolium soup forms part of a recipe for the management of sexually transmitted infections (STIs) and Ceiba pentandra soup is used for treating diarrhoea disorder. Despite the therapeutic and nutritional benefits of the soups, their consumption is gradually waning due to erosion of traditional knowledge and deforestation of medicinal plants occasioned by increasing urbanization. This review documents the therapeutic uses and pharmacological effects of six medicinal plants used as traditional soups, with the view that an awareness of their health benefits could lead to a resurgence of their consumption in diet.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"45 6-7 1","pages":"22-32"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77729095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro evaluation of antisickling activity of herbal combination of three medicinal plants 三种药用植物复方抗镰刀病活性的体外评价

Nigerian Journal of Natural Products and Medicine Pub Date : 2020-05-13 DOI: 10.4314/njnpm.v23i1.7

O. O. Amujoyegbe, M. Idu, J. Agbedahunsi, G. Bazuaye

{"title":"In vitro evaluation of antisickling activity of herbal combination of three medicinal plants","authors":"O. O. Amujoyegbe, M. Idu, J. Agbedahunsi, G. Bazuaye","doi":"10.4314/njnpm.v23i1.7","DOIUrl":"https://doi.org/10.4314/njnpm.v23i1.7","url":null,"abstract":"Sickle cell disorder is a genetic ailment with enormous social and economic burden for patients and caregivers. The most promising management apart from being expensive particularly for poor African people, faces some major incompatibility problems. The patients consequently rely on herbal therapy which could be prepared in single or combination forms to manage the painful episodes and its complications. This present study aimed to formulate polyherbal combination and evaluate three purposively selected plants previously reported for their antisickling activities. The polyherbal products were formulated using both aqueous and 70% ethanol extracts into different combinational ratio with the best in 1:1:1 and evaluated for its antisickling activity. The antisickling activity involved both the inhibitory and reversal effects at varying concentrations from 1.0 mg/ml to 6.0 mg/ml using ciklavit as the positive control. The best inhibitory activity was found in ethanol extract of Piper guineense, Gongronema latifolium and Cymbopogon citratus (PGC) with 70.09 ± 0.67% when compared with the positive control (59.25 ± 0.05%) at 4.0 mg/mg while the reversal ability was 67.87 ± 1.23%. The aqueous extracts of the combinations had activity above 50% with the exception of PGC (2:3:1) which is a little less than 50% (46.67 ± 0.98%) while the highest was 60.02 ± 0.87%. The polyherbal ethanol extract had better effects than the aqueous extract and the standard drug used in this study.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"7 1","pages":"54-62"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86433534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical analyses, anxiolytic and anti-amnesic effect of methanol stem bark extract of Vitex doniana (sweet) in mice 荆荆(甜)甲醇茎皮提取物对小鼠的植物化学分析及抗焦虑和抗遗忘作用

Nigerian Journal of Natural Products and Medicine Pub Date : 2020-05-13 DOI: 10.4314/njnpm.v23i1.14

L. Akinpelu, M. Adebayo, A. Fajana, M. A. Adeniyi-Ake, S. E. Ubogu, N. Aminu

{"title":"Phytochemical analyses, anxiolytic and anti-amnesic effect of methanol stem bark extract of Vitex doniana (sweet) in mice","authors":"L. Akinpelu, M. Adebayo, A. Fajana, M. A. Adeniyi-Ake, S. E. Ubogu, N. Aminu","doi":"10.4314/njnpm.v23i1.14","DOIUrl":"https://doi.org/10.4314/njnpm.v23i1.14","url":null,"abstract":"This study investigated the oral acute toxicity (LD50), anxiolytic and anti-amnesic effects of the methanol stem bark extract of Vitex doniana (MSVD) in mice. The anxiolytic and anti-amnesic effects were assessed using standard protocols. The phytoconstituents in MSVD was quantified. The MSVD was further analysed using Ultraviolet-visible (UV-VIS) and Fourier Transform Infra red (FTIR) fingerprints. The LD50 was > 5000 mg/kg suggesting its safety. The MSVD (125, 250 and 500 mg/kg, p.o.) showed significant (p<0.05) increase in the percentage open arm entry and duration on elevated plus maze as well as reduced the anxiety index as indexed from the open arm avoidance index indicating an anti-anxiety effect. Subsequently, MSVD significantly (p<0.05) increased the percentage alternation reduced by scopolamine consistent with anti-amnesic effect. The phytoconstituents estimation of MSVD showed abundance of flavonoids. The UV-VIS spectra corresponded to the presence of flavonoid, phenolic acid derivatives and terpenoids while the FTIR revealed the presence of amine, hydroxyl, alkane, carboxylic, amide, ether, aromatic and carbonyl functional groups among others in MSVD. This study therefore, concluded that flavonoids, either in synergy or additive with other phytocompounds in MSVB may be responsible for the observed anxiolytic and anti-amnesic effects elicited by MSVD in this study.","PeriodicalId":19356,"journal":{"name":"Nigerian Journal of Natural Products and Medicine","volume":"86 1","pages":"104-111"},"PeriodicalIF":0.0,"publicationDate":"2020-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85619897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0