Nutrition in Clinical Practice最新文献

{"title":"Quality-of-life changes and influencing factors among patients receiving home enteral nutrition: A longitudinal study.","authors":"Chulin Chen, Meng Liu, Sitong Liu, Yang Yang, Xinying Wang","doi":"10.1002/ncp.11315","DOIUrl":"https://doi.org/10.1002/ncp.11315","url":null,"abstract":"<p><strong>Background: </strong>Home enteral nutrition (HEN) is a reliable and effective intervention. However, the impact of HEN on the changes in quality of life (QoL) over time remains unexplored. We aimed to investigate changes in QoL, emotional well-being, and functional status over time and identify the factors associated with QoL in patients requiring HEN.</p><p><strong>Methods: </strong>We retrospectively analyzed the data of 288 patients requiring HEN who were discharged from the Clinical Nutrition Therapy Center of a tertiary care teaching hospital in China between December 1, 2014, and April 31, 2024. Data on demographics, laboratory analysis results, bioelectrical impedance analysis results, physical function, emotional status, and QoL were retrieved from a prospectively maintained database.</p><p><strong>Results: </strong>Patients requiring HEN had QoL scores of 52.83 ± 14.01, 54.11 ± 14.79, and 56.78 ± 14.29 at discharge, 3-month follow-up, and 6-month follow-up, respectively. The Short Form 36 scores increased by 0.66 points per month (95% confidence interval [CI] 0.40-0.91; P < 0.05), whereas the Karnofsky Performance Scale (KPS) scores increased by 2.56 points per month (95% CI: 2.38-2.75; P < 0.05). The Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) declined by 1.33 (95% CI: -1.46 to -1.21; P < 0.05) and 0.38 (95% CI: -0.57 to -0.20; P < 0.05) points, respectively, each month. Multivariate analysis identified that complications (β = 7.191; P < 0.001), SAS (β = -0.135; P = 0.029), SDS (β = -0.293; P < 0.001), and KPS (β = 0.126; P = 0.003) were factors associated with QoL.</p><p><strong>Conclusion: </strong>QoL improved continuously among patients receiving HEN; however, it remained suboptimal. Healthcare providers should offer comprehensive, continuous, and dynamic support to help patients reintegrate into their social lives.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malnutrition risk in older adults with cancer: A prospective cross-sectional study in one setting.","authors":"Elif Değirmenci Aktaş, Tuğçe Aytulu, Dilek Yildirim","doi":"10.1002/ncp.11318","DOIUrl":"https://doi.org/10.1002/ncp.11318","url":null,"abstract":"<p><strong>Background: </strong>This descriptive and cross-sectional study evaluated the nutrition status of geriatric patients with cancer undergoing chemotherapy.</p><p><strong>Methods: </strong>Data were collected by researchers in the Medical Oncology Unit of a university hospital between January and September 2024 to assess the nutrition status of 100 geriatric patients with cancer undergoing chemotherapy. Malnutrition risk was evaluated using the Mini Nutritional Assessment (MNA).</p><p><strong>Results: </strong>The mean ± SD age of the study participants was 72.03 ± 5.40 years. The study found that 21% of the patients were undergoing treatment for colon cancer, 20% for lung cancer, and 16% for pancreatic cancer. Most patients were diagnosed at advanced stages, with 28% at stage III and 65% at stage IV. The nutrition risk assessment of the patients found that 34% had a normal MNA score (24-30 points), 30% were at risk of malnutrition (17-23.5 points), and 36% were malnourished (<17 points). The following symptoms affecting nutrition were observed: nausea and vomiting (39%), taste changes (24%), weakness and fatigue (73%), pain (5%), and weight loss (27%). The most commonly used type of chemotherapy was FOLFOX (folinic acid, 5-fluorouracil and oxaliplatin, 18%).</p><p><strong>Conclusion: </strong>Malnutrition was very common in geriatric patients with cancer undergoing chemotherapy. Therefore, it is crucial for healthcare professionals, particularly dietitians and nutritionists, to diagnose and manage malnutrition risk early and effectively.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderating role of skeletal bone age and sex in the association between phase angle with muscular strength and aerobic fitness among HIV-infected children and adolescents: A prospective cross-sectional study.","authors":"Priscila Custódio Martins, Luiz Rodrigo Augustemak de Lima, Andreia Pelegrini, Yara Maria Franco Moreno, Diego Augusto Santos Silva","doi":"10.1002/ncp.11305","DOIUrl":"https://doi.org/10.1002/ncp.11305","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to explore whether skeletal bone age (biological maturation marker) and sex moderate the association between the phase angle with muscular strength and aerobic fitness in children and adolescents with diagnosed with HIV.</p><p><strong>Methods: </strong>The sample consisted of 62 children and adolescents (aged 8-15 years) diagnosed with HIV. The phase angle was determined using bioelectrical impedance analysis. Muscular strength was assessed by handgrip strength, and aerobic fitness was assessed by an incremental test on a cycle ergometer. Skeletal bone age and sex were determined through hand and wrist x-rays (Greulich-Pyle method) and a questionnaire, respectively. Both simple and multiple linear regression models were performed, and moderation models with P ≥ 0.05 were constructed.</p><p><strong>Results: </strong>Among male children and adolescents with both normal and early skeletal bone age, muscular strength directly impacted phase angle values (b = 0.0197, P = 0.0001; b = 0.0286, P < 0.0001, respectively). However, for female children and adolescents, regardless of skeletal bone age, muscular strength did not influence the phase angle. In male children and adolescents with both normal and early skeletal bone age, aerobic fitness directly influenced the phase angle (b = 0.0007, P = 0.0001; b = 0.011, P = 0.0001, respectively). Similarly, in female children and adolescents with early skeletal bone age, aerobic fitness directly impacted the phase angle (b = 0.0006, P = 0.0282).</p><p><strong>Conclusion: </strong>Skeletal bone age and sex moderated the relationship between phase angle and both muscular strength and aerobic fitness, especially in children and adolescents with normal and early skeletal bone age, and predominantly in boys.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing mortality and malnutrition using calf circumference adjusted for body mass index and edema as muscle mass reduction indicators within the Global Leadership Initiative on Malnutrition criteria: A retrospective study.","authors":"Yuria Ishida, Keisuke Maeda, Akio Shimizu, Junko Ueshima, Ayano Nagano, Tatsuro Inoue, Koki Kawamura, Tatsuma Sakaguchi, Kenta Murotani, Naoharu Mori","doi":"10.1002/ncp.11316","DOIUrl":"https://doi.org/10.1002/ncp.11316","url":null,"abstract":"<p><strong>Background: </strong>Although calf circumference (CC) may be used to distinguish body composition, methods applying adjustment coefficients based on body mass index (BMI) and edema have been reported. This study evaluated whether malnutrition assessed using BMI- and edema-adjusted CC predicts mortality in hospitalized adult patients compared with unadjusted CC across cutoff values.</p><p><strong>Methods: </strong>This retrospective cohort study used the medical records of patients aged ≥18 years hospitalized between December 2017 and March 2022 and at risk for nutrition disorders through nutrition screening. Low muscle mass was defined using CC cutoff values of 34-30 cm for men and 33-29 cm for women.</p><p><strong>Results: </strong>The data of 11,606 patients were analyzed. The mean age was 71.2 ± 16.3 years, and 5949 patients (51.3%) were women. No significant difference was observed compared with the unadjusted state, regardless of sex, cutoff value, or adjustment method (male: unadjusted hazard ratio [HR]: 2.13 to 2.30 vs adjusted HR: 2.11 to 2.36; memale: unadjusted HR 1.75: to 2.59 vs adjusted HR: 1.75 to 3.00). Furthermore, even when edema was adjusted, no significant difference was observed in the HR for mortality compared with the unadjusted state, regardless of sex, cutoff value, or adjustment method (male: unadjusted HR: 2.13 to 2.30 vs adjusted HR: 2.23 to 2.52; female: unadjusted HR: 1.75 to 2.59 vs adjusted HR: 2.02 to 3.57).</p><p><strong>Conclusion: </strong>When assessing low muscle mass using lower CC, we found that adjusting for BMI and edema did not result in a significant mortality difference compared with unadjusted actual measurements.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet, nutraceuticals, and lifestyle interventions for the treatment and management of irritable bowel syndrome.","authors":"Zoe N Memel, Neha D Shah, Kendall R Beck","doi":"10.1002/ncp.11307","DOIUrl":"https://doi.org/10.1002/ncp.11307","url":null,"abstract":"<p><p>Irritable bowel syndrome (IBS) is the most common gastrointestinal (GI) disorder of the gut-brain interaction and causes significant GI distress. The etiology of IBS is multifactorial, with food intolerances being a frequent contributing factor to IBS symptoms. Diet and lifestyle interventions are key components in comprehensive IBS care. In this review, we examine the current evidence-based dietary approaches for treating IBS. The low-FODMAP diet has the most robust data for improving overall symptom burden. In conjunction with guidance from a registered dietitian, certain patients may benefit from targeted dietary elimination of specific carbohydrates such as lactose or fructose or gluten. Among the nutraceuticals used to treat IBS, peppermint oil has sufficient evidence and appropriate safety data to recommend adjunctive use to reduce IBS symptoms. Although prebiotic and probiotic food sources may be beneficial to the microbiome, there is not enough evidence to support the routine use of prebiotic or probiotic supplements. Given the complexity of IBS, a holistic approach in which clinicians address a patients' diet, culture, sleep hygiene, exercise habits, and mental health may improve patients' overall quality of life.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current treatment options for adult patients with short gut syndrome: Do prebiotics, probiotics, and synbiotics play a role?","authors":"Elizabeth Reznik, Carolyn Newberry","doi":"10.1002/ncp.11319","DOIUrl":"https://doi.org/10.1002/ncp.11319","url":null,"abstract":"<p><p>Short bowel syndrome (SBS) is a malabsorptive disorder characterized by reduced small intestinal length that results in nutrient deficiencies. Most commonly in adults, it occurs in the setting of surgical bowel resection related to trauma, infarction, or inflammatory bowel disease. Management principles include optimizing nutrition and hydration status via parenteral nutrition and oral diet and utilizing antisecretory, antimotility, and enterohormone agents to enhance intestinal absorption, facilitate intestinal adaptation, and reduce stool output. Other therapeutics include antibiotics to treat small intestinal bacterial overgrowth (SIBO) and microbial dysbiosis. Considering limitations to antibiotic use, in addition to a greater understanding of the nuances of the microbiome in digestive health regulation, there is also burgeoning interest in the role of prebiotics, probiotics, and synbiotics in SBS management. This review highlights current management principles of SBS with a broader discussion of clinical indications and safety considerations for use of prebiotics, probiotics, and synbiotics in this population. Although current research is in its infancy, prebiotics, probiotics, and synbiotics may represent a viable future therapeutic option in the management of this complex disorder, with further studies needed to define definitive regimens and update guidelines.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of dietetic staffing requirements for adult intestinal failure services using a best-practice model.","authors":"Sharon Carey, Brooke Chapman, Emma Osland","doi":"10.1002/ncp.11308","DOIUrl":"https://doi.org/10.1002/ncp.11308","url":null,"abstract":"<p><strong>Background: </strong>The number of people diagnosed with chronic intestinal failure (CIF) worldwide is low. The condition is clinically complex to manage and resource intense. Guidance on best-practice staffing levels is lacking. This paper proposes a methodology for determining dietetic staffing levels for adult CIF to estimate dietetic staffing levels allowing patients access to best-practice care.</p><p><strong>Methods: </strong>After undertaking a literature search, a novel method for developing recommended adequate dietetic staffing within adult CIF services was utilized. This included (1) mapping the current patient journey and best-practice dietetic care throughout the journey, (2) allocating clinical and nonclinical hours at each phase of the patient journey, and (3) calculating percentage clinical time, and (4) finalizing estimated dietetic staffing requirements per patient.</p><p><strong>Results: </strong>Current literature informed mapping the patient journey and dietetic best practice for CIF. Australian data were included where possible to reflect patient care locally. Direct and indirect clinical hours were allocated to each activity. Allowing for nonclinical activity of 40% for a senior clinician, total hours required to provide best-practice care per patient was calculated as 0.028 of a full-time dietitian per adult with CIF. This equates to the management of 36 people with CIF per full-time dietitian.</p><p><strong>Conclusion: </strong>Use of a bottom-up methodology allows calculation of staffing to meet best practice. Proposed dietetic staffing levels obtained from this study are far greater than current allocated staffing within the Australian adult CIF setting. Adequate dietetic resourcing may reduce patient complications and improve quality of life, resulting in enhanced patient and clinical outcomes.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between the NUTRIC score and modified NUTRIC score to predict hospital mortality in patients undergoing cardiac surgery: A retrospective study.","authors":"Jing Xu, Dandong Luo, Ruibin Chi, Jia Deng, Heng Fang, Qingrui Wu, Wang Xu, Jianyang Huang, Chunbo Chen","doi":"10.1002/ncp.11306","DOIUrl":"https://doi.org/10.1002/ncp.11306","url":null,"abstract":"<p><strong>Background: </strong>Nutrition status evaluation is essential for patients undergoing cardiac surgery. The Nutrition Risk in the Critically Ill (NUTRIC) and modified NUTRIC (mNUTRIC) scores are nutrition risk assessment tools specifically for patients in the intensive care unit (ICU). The objective of this study was to validate and compare the accuracy of these two nutrition scores in predicting hospital mortality in patients undergoing cardiac surgery.</p><p><strong>Methods: </strong>This retrospective study screened adult patients undergoing cardiopulmonary bypass cardiac surgery in the ICU from June 2020 to August 2022. Patients were grouped according to NUTRIC score and mNUTRIC score within 24 h of ICU admission. Logistic regression was used to analyze the risk factors affecting the prognosis of these patients. The area under the receiver operating characteristic curve (AUC-ROC) was used to compare the predictive performance of these two nutrition scores for hospital mortality.</p><p><strong>Results: </strong>Data from 252 eligible patients (55.6% of whom were male) were analyzed. It was found that Acute Physiological and Chronic Health Evaluation Ⅱ score, aortic surgery, serum albumin level, NUTRIC score, and mNUTRIC score were independent influencing factors of hospital mortality. The AUC-ROC of the NUTRIC score and the mNUTRIC score for predicting hospital mortality were 0.830 (95% confidence interval [CI]: 0.778-0.874) and 0.824 (95% CI: 0.771-0.869), respectively. There was no significant difference in ROC curves between the two scores (P = 0.492).</p><p><strong>Conclusions: </strong>Both the NUTRIC and mNUTRIC scores showed good predictive performance for hospital mortality in patients undergoing cardiac surgery, and the mNUTRIC score might be a more convenient and cost-effective tool for nutrition risk assessment.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle measures from computed tomography, bioelectrical impedance, and ultrasound in hematopoietic cell transplantation patients.","authors":"Rusha Bhandari, Kyuwan Lee, Xinyi Du, Sohpia Albanese, Meagan Echevarria, Caitlyn Estrada, Alexander Flores, Aleksi Iukuridze, David Iukuridze, Janice Kim, Lanie Lindenfeld, Stephanie Rodarte, Nathan Salce, F Lennie Wong, Saro H Armenian","doi":"10.1002/ncp.11304","DOIUrl":"10.1002/ncp.11304","url":null,"abstract":"<p><strong>Background: </strong>Low muscle mass is associated with adverse outcomes following hematopoietic cell transplantation (HCT). Computed tomography (CT) is a gold standard approach to measuring skeletal muscle but is associated with radiation exposure and no longer routinely performed in all patients before HCT. Alternative methods are needed for early identification, intervention, and serial evaluation of low muscle mass after HCT. Optimal methods should be portable and readily accessible. We thus evaluated the correlation between quadriceps muscle ultrasound (US), whole-body bioelectrical impedance analysis (BIA), and muscle CT in patients planned to undergo HCT.</p><p><strong>Methods: </strong>This study included 71 consecutive patients ≥18 years who underwent first HCT between 2020 and 2024. Pearson correlation examined the relationship between skeletal muscle measurements of cross-sectional area (CSA) from CT images at the third lumbar vertebra (L3), whole-body skeletal muscle mass (SMM) from BIA, and CSA from quadriceps muscle US.</p><p><strong>Results: </strong>Median age at evaluation was 52.6 years (range: 18.6-76.6). CT-derived L3 skeletal muscle CSA positively correlated with quadriceps muscle US CSA (r = 0.73; P < 0.0001) and BIA SMM (r = 0.92; P < 0.0001). Quadriceps muscle US and BIA SMM were also positively correlated (r = 0.74; P < 0.0001). Positive correlations were consistent across body mass index (BMI) and age categories.</p><p><strong>Conclusions: </strong>Quadriceps muscle US and whole-body BIA offer reliable alternatives to estimate skeletal muscle without radiation exposure. US is more readily available, allowing for detailed phenotypic evaluation of individual muscles and identification of muscle compromise that may occur following HCT. This can enable development and monitoring of tailored and targeted interventions to improve muscle health and HCT outcomes.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost savings of home parenteral nutrition compared with hospital parenteral nutrition: A multicenter prospective analysis.","authors":"Andrés Martinuzzi, Adriana Crivelli, Agustin Flores, Ezequiel Manrique, Fabricio Pochettino, Hector Solar Muñiz, Maria Cristina Billinger, Veronica Garrido, Maria Fernanda Cascaron, Gabriela Capurro, Victoria Gonzalez, Ailen Dietrich, Daria Foursova, Antonio Carello, Omar Aviles, Natalia Dieguez, Gabriel Gondolesi","doi":"10.1002/ncp.11301","DOIUrl":"https://doi.org/10.1002/ncp.11301","url":null,"abstract":"<p><strong>Background: </strong>Several publications demonstrate the impact of home parenteral nutrition (HPN) in reducing healthcare costs. The question is are HPN practices in Latin America also cost saving when compared with hospital PN? This study aimed to compare the direct healthcare and nonhealthcare costs of HPN with hospital PN through a prospective, analytical, and longitudinal, multicenter noninterventional study.</p><p><strong>Materials and methods: </strong>Adult patients receiving PN were included during the last week of hospital PN (week -1 before discharge), through the first week of HPN (week +1), and up to the first month of HPN (month +1). Clinical, nutrition, and cost variables were recorded. The total direct cost from hospital PN week -1 was compared with HPN week +1. Additionally, HPN month +1 was compared with an estimate of the total costs of hospital PN month -1.</p><p><strong>Results: </strong>Forty-four patients were included for analysis. Comparing HPN week +1 vs hospital PN week -1. HPN was associated with lower total direct healthcare costs (mean difference -$1498.1, 95% CI -1203.2 to -1789.9). Lastly, the total direct cost (healthcare and nonhealthcare) was lower in the HPN setting vs the hospital setting for 1 week (mean difference $ -1452.0, 95% CI -1756.28 to -1148.4). The cost reduction of HPN for 1 week was 32% (20.3%-42.8%) and for 1 month was 36% (27.5%-48.5%).</p><p><strong>Conclusion: </strong>HPN is cost saving compared with hospital PN, with most of the cost reduction related to direct healthcare costs.</p>","PeriodicalId":19354,"journal":{"name":"Nutrition in Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}