npj Aging最新文献_第4页

Free-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts. 在两个不同的观察队列中，自由生活的腕部和髋部加速度测量可预测无痴呆症的老年人在 1 年或 5 年内的认知能力下降情况。

npj Aging Pub Date : 2022-06-06 DOI: 10.1038/s41514-022-00087-w

Chengjian Shi, Niser Babiker, Jacek K Urbanek, Robert L Grossman, Megan Huisingh-Scheetz, Andrey Rzhetsky

{"title":"Free-living wrist and hip accelerometry forecast cognitive decline among older adults without dementia over 1- or 5-years in two distinct observational cohorts.","authors":"Chengjian Shi, Niser Babiker, Jacek K Urbanek, Robert L Grossman, Megan Huisingh-Scheetz, Andrey Rzhetsky","doi":"10.1038/s41514-022-00087-w","DOIUrl":"10.1038/s41514-022-00087-w","url":null,"abstract":"The prevalence of major neurocognitive disorders is expected to rise over the next 3 decades as the number of adults ≥65 years old increases. Noninvasive screening capable of flagging individuals most at risk of subsequent cognitive decline could trigger closer monitoring and preventive strategies. In this study, we used free-living accelerometry data to forecast cognitive decline within 1- or 5-years in older adults without dementia using two cohorts. The first cohort, recruited in the south side of Chicago, wore hip accelerometers for 7 continuous days. The second cohort, nationally recruited, wore wrist accelerometers continuously for 72 h. Separate classifier models forecasted 1-year cognitive decline with over 85% accuracy using hip data and forecasted 5-year cognitive decline with nearly 70% accuracy using wrist data, significant improvements compared to demographics and comorbidities alone. The proposed models are readily translatable to clinical practices serving ageing populations.","PeriodicalId":19348,"journal":{"name":"npj Aging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10771455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic associations with healthy ageing among Chinese adults. 中国成年人健康老龄化的遗传关联。

npj Aging Pub Date : 2022-05-02 DOI: 10.1038/s41514-022-00086-x

Xuling Chang, Yan-Feng Zhou, Ling Wang, Jianjun Liu, Jian-Min Yuan, Chiea-Chuen Khor, Chew-Kiat Heng, An Pan, Woon-Puay Koh, Rajkumar Dorajoo

引用次数: 0

Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men. 慢性烟酰胺单核苷酸补充可提高健康老年男性血液烟酰胺腺嘌呤二核苷酸水平并改变肌肉功能。

npj Aging Pub Date : 2022-05-01 DOI: 10.1038/s41514-022-00084-z

Masaki Igarashi, Yoshiko Nakagawa-Nagahama, Masaomi Miura, Kosuke Kashiwabara, Keisuke Yaku, Mika Sawada, Rie Sekine, Yuichiro Fukamizu, Toshiya Sato, Takanobu Sakurai, Jiro Sato, Kenji Ino, Naoto Kubota, Takashi Nakagawa, Takashi Kadowaki, Toshimasa Yamauchi

{"title":"Chronic nicotinamide mononucleotide supplementation elevates blood nicotinamide adenine dinucleotide levels and alters muscle function in healthy older men.","authors":"Masaki Igarashi, Yoshiko Nakagawa-Nagahama, Masaomi Miura, Kosuke Kashiwabara, Keisuke Yaku, Mika Sawada, Rie Sekine, Yuichiro Fukamizu, Toshiya Sato, Takanobu Sakurai, Jiro Sato, Kenji Ino, Naoto Kubota, Takashi Nakagawa, Takashi Kadowaki, Toshimasa Yamauchi","doi":"10.1038/s41514-022-00084-z","DOIUrl":"https://doi.org/10.1038/s41514-022-00084-z","url":null,"abstract":"Preclinical studies have revealed that the elevation of nicotinamide adenine dinucleotide (NAD + ) upon the administration of nicotinamide mononucleotide (NMN), an NAD + precursor, can mitigate aging-related disorders; however, human data on this are limited. We investigated whether the chronic oral supplementation of NMN can elevate blood NAD + levels and alter physiological dysfunctions in healthy older participants. We administered 250 mg NMN per day to aged men for 6 or 12 weeks in a placebo-controlled, randomized, double-blind, parallel-group trial. Chronic NMN supplementation was well tolerated and caused no significant deleterious effect. Metabolomic analysis of whole blood samples demonstrated that oral NMN supplementation significantly increased the NAD + and NAD + metabolite concentrations. There were nominally significant improvements in gait speed and performance in the left grip test, which should be validated in larger studies; however, NMN exerted no significant effect on body composition. Therefore, chronic oral NMN supplementation can be an efficient NAD + booster for preventing aging-related muscle dysfunctions in humans.","PeriodicalId":19348,"journal":{"name":"npj Aging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158788/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40601925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence. 吡咯喹啉醌(PQQ)对HEI-OC1细胞早衰时线粒体功能的保护作用。

npj Aging Pub Date : 2022-04-19 DOI: 10.1038/s41514-022-00083-0

Ying Gao, Teru Kamogashira, Chisato Fujimoto, Shinichi Iwasaki, Tatsuya Yamasoba

{"title":"Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 cells under premature senescence.","authors":"Ying Gao, Teru Kamogashira, Chisato Fujimoto, Shinichi Iwasaki, Tatsuya Yamasoba","doi":"10.1038/s41514-022-00083-0","DOIUrl":"https://doi.org/10.1038/s41514-022-00083-0","url":null,"abstract":"The aim of this study was to investigate the effects of pyrroloquinoline quinone (PQQ), an oxidoreductase cofactor, on the H2O2-induced premature senescence model in HEI-OC1 auditory cells and to elucidate its mechanism of action in vitro. Cells were treated with PQQ for 1 day before H2O2 (100 μM) exposure. Mitochondrial respiratory capacity was damaged in this premature senescence model but was restored in cells pretreated with PQQ (0.1 nM or 1.0 nM). A decrease in mitochondrial potential, the promotion of mitochondrial fusion and the accelerated movement of mitochondria were all observed in PQQ-pretreated cells. The protein expression of sirtuin 1 (SIRT1) and peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) were significantly decreased under H2O2 exposure while they were increased with PQQ pretreatment, and PGC-1α acetylation was significantly decreased. In conclusion, PQQ has a protective effect on the premature senescence model of HEI-OC1 auditory cells and is associated with the SIRT1/PGC-1α signaling pathway, mitochondrial structure, and mitochondrial respiratory capacity.","PeriodicalId":19348,"journal":{"name":"npj Aging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40601930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Mitochondrial DNA oxidative mutations are elevated in Mexican American women potentially implicating Alzheimer's disease. 墨西哥裔美国妇女线粒体 DNA 氧化突变升高，可能与阿尔茨海默氏症有关。

npj Aging Pub Date : 2022-04-04 DOI: 10.1038/s41514-022-00082-1

Danielle Marie Reid, Robert C Barber, Roland J Thorpe, Jie Sun, Zhengyang Zhou, Nicole R Phillips

{"title":"Mitochondrial DNA oxidative mutations are elevated in Mexican American women potentially implicating Alzheimer's disease.","authors":"Danielle Marie Reid, Robert C Barber, Roland J Thorpe, Jie Sun, Zhengyang Zhou, Nicole R Phillips","doi":"10.1038/s41514-022-00082-1","DOIUrl":"10.1038/s41514-022-00082-1","url":null,"abstract":"Mexican Americans (MAs) are the fastest-growing Hispanic population segment in the US; as this population increases in age, so will the societal burden of age-related diseases such as Alzheimer's disease (AD). Mitochondrial DNA (mtDNA) damage may be implicated in MA AD risk since metabolic comorbidities are more prevalent in this group. Oxidative damage to guanosine (8oxoG) is one of the most prevalent DNA lesions and a putative indicator of mitochondrial dysfunction. Testing blood samples from participants of the Texas Alzheimer's Research and Care Consortium, we found mtDNA 8oxoG mutational load to be significantly higher in MAs compared to non-Hispanic whites and that MA females are differentially affected. Furthermore, we identified specific mtDNA haplotypes that confer increased risk for oxidative damage and suggestive evidence that cognitive function may be related to 8oxoG burden. Our understanding of these phenomena will elucidate population- and sex-specific mechanisms of AD pathogenesis, informing the development of more precise interventions and therapeutic approaches for MAs with AD in the future.","PeriodicalId":19348,"journal":{"name":"npj Aging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40601926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The deleterious effects of old social partners on Drosophila lifespan and stress resistance. 旧社会伙伴对果蝇寿命和抗逆性的有害影响。

npj Aging Pub Date : 2022-03-18 DOI: 10.1038/s41514-022-00081-2

Yu-Chiao Lin, MingYang Zhang, Sheng-Hao Wang, Chia-Wen Chieh, Pin-Yun Shen, Yi-Lin Chen, Yu-Chia Chang, Tsung-Han Kuo

{"title":"The deleterious effects of old social partners on Drosophila lifespan and stress resistance.","authors":"Yu-Chiao Lin, MingYang Zhang, Sheng-Hao Wang, Chia-Wen Chieh, Pin-Yun Shen, Yi-Lin Chen, Yu-Chia Chang, Tsung-Han Kuo","doi":"10.1038/s41514-022-00081-2","DOIUrl":"https://doi.org/10.1038/s41514-022-00081-2","url":null,"abstract":"Social interactions play important roles in the modulation of behavior, physiology, and, potentially, lifespan. Although longevity has been studied extensively in different model organisms, due to the complexity of social environments, the social modulation of aging remains poorly investigated. The present study used the fruit fly, Drosophila melanogaster, as a model to study lifespan and stress resistance under different social conditions. Our experiments first showed that social isolation increased fly lifespan, suggesting a potential deleterious effect of social companions. Furthermore, we exposed flies to different aged social partners and found that living with old animals significantly reduced lifespan and stress resistance in young animals. In contrast, living with young animals increased old animal lifespan, although the effects were less robust. Overall, our results suggest that while social interaction can influence fly health, specific social partners may have more pronounced effects than others. This study provides new evidence that different social environments have significant impacts on animal physiology and longevity.","PeriodicalId":19348,"journal":{"name":"npj Aging","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40584040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2