npj Aging

Accelerated epigenetic aging and decreased natural killer cells based on DNA methylation in patients with untreated major depressive disorder.

Pub Date : 2023-09-06 DOI: 10.1038/s41514-023-00117-1 Ryota Shindo, Takaki Tanifuji, Satoshi Okazaki, Ikuo Otsuka, Toshiyuki Shirai, Kentaro Mouri, Tadasu Horai, Akitoyo Hishimoto

Elevated plasma sclerostin is associated with high brain amyloid-β load in cognitively normal older adults.

Pub Date : 2023-09-04 DOI: 10.1038/s41514-023-00114-4 Jun Yuan, Steve Pedrini, Rohith Thota, James Doecke, Pratishtha Chatterjee, Hamid R Sohrabi, Charlotte E Teunissen, Inge M W Verberk, Erik Stoops, Hugo Vanderstichele, Bruno P Meloni, Christopher Mitchell, Stephanie Rainey-Smith, Kathryn Goozee, Andrew Chi Pang Tai, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow, Junjie Gao, Delin Liu, Frank Mastaglia, Charles Inderjeeth, Minghao Zheng, Ralph N Martins

Severe COVID-19 patients exhibit elevated levels of autoantibodies targeting cardiolipin and platelet glycoprotein with age: a systems biology approach.

Pub Date : 2023-08-24 DOI: 10.1038/s41514-023-00118-0 Dennyson Leandro M Fonseca, Igor Salerno Filgueiras, Alexandre H C Marques, Elroy Vojdani, Gilad Halpert, Yuri Ostrinski, Gabriela Crispim Baiocchi, Desirée Rodrigues Plaça, Paula P Freire, Shahab Zaki Pour, Guido Moll, Rusan Catar, Yael Bublil Lavi, Jonathan I Silverberg, Jason Zimmerman, Gustavo Cabral-Miranda, Robson F Carvalho, Taj Ali Khan, Harald Heidecke, Rodrigo J S Dalmolin, Andre Ducati Luchessi, Hans D Ochs, Lena F Schimke, Howard Amital, Gabriela Riemekasten, Israel Zyskind, Avi Z Rosenberg, Aristo Vojdani, Yehuda Shoenfeld, Otavio Cabral-Marques