Nuclear-Medizin最新文献_第2页

The use of discriminatory values for thyroid uptake and free thyroxine index. 甲状腺摄取和游离甲状腺素指数的鉴别值的使用。

Nuclear-Medizin Pub Date : 1975-12-15

T M Gimlette, C R Squire

引用次数: 0

Tc-99m labeled complexes of aldehydes and glutamate as cholescintigraphic agents. Tc-99m标记的醛和谷氨酸配合物作为胆固醇测定剂。

Nuclear-Medizin Pub Date : 1975-12-15

W E Barnes, L G Colombetti, J S Arnold

{"title":"Tc-99m labeled complexes of aldehydes and glutamate as cholescintigraphic agents.","authors":"W E Barnes, L G Colombetti, J S Arnold","doi":"","DOIUrl":"","url":null,"abstract":"Tc-99m pyridoxylidene glutamate has proven to be an excellent biliary scanning agent, far superior in many respect to the commonly used I-131 rose bengal. The preparation of the compound as previously reported by Baker et al is too time consuming and requires the use of an autoclave which is not available in most nuclear medicine departments. In our facility, we have been preparing similar compounds using several aldehydes and monosodium glutamate to make labeled complexes having the same pharmacological characteristics. The mixture of monosodium glutamate, aldehyde, and Tc-99m pertechnetate is made slightly alkaline, purged with helium, and placed in a sealed vial. The vial, which is protected by a wire basket, is then heated in a laboratory oven at 130 degrees C for a period of 15 to 20 minutes. During this time, the technetium is reduced to a lower valence state and bound to the complex formed. Chromatographic data show that these compounds are chemically similar to that previously reported. The compounds prepared concentrate in the gall bladder of the rabbit in less than 10 minutes. Kinetic studies have been performed on dogs with a scintillation camera and small digital computer to measure rates of blood clearance, liver and gall bladder uptake, and excretion into the intestine. The aldehyde -- glutamate complex promises to be a useful scanning agent for the diagnosis of biliary and hepatocellular diseases.","PeriodicalId":19324,"journal":{"name":"Nuclear-Medizin","volume":"14 4","pages":"330-8"},"PeriodicalIF":0.0,"publicationDate":"1975-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12391660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Anemia in terminal kidney insufficiency: ferrokinetics, erythrocyte survival times and erythrocyte enzymes in chronic dialysis patients]. [终末期肾功能不全贫血:慢性透析患者的铁动力学、红细胞存活时间和红细胞酶]。

Nuclear-Medizin Pub Date : 1975-12-15

K Junkers, R Jontofsohn, G Meuret, K G Blume, V Heinze

引用次数: 0

[Bone scintigraphy with 99mTc-pyrophosphate: pharmokinetics of the substance and clinical experiences with the scintigraphy]. [99mtc焦磷酸盐骨显像:物质的药效学和显像的临床经验]。

Nuclear-Medizin Pub Date : 1975-12-15

H Fill, W Zechmann, J Oberhammer, G Riccabona

{"title":"[Bone scintigraphy with 99mTc-pyrophosphate: pharmokinetics of the substance and clinical experiences with the scintigraphy].","authors":"H Fill, W Zechmann, J Oberhammer, G Riccabona","doi":"","DOIUrl":"","url":null,"abstract":"Kinetics and clinical studies of bone scintiscanning with 99mTc-pyrophosphate in 92 patients with certified diagnosis allowed the following conclusions: 1. After i.v. injection 99mTc-pyrophosphate is distributed in 3 compartments, from which it is cleared with biological half-lives of 32.7 minutes, 5.1 hours and 22.54 hours respectively. The relative size of these compartments is 1 : 3 : 6. After application of the substance, an initially high renal excretion with a consecutive exponential drop can be observed. The optimal period for scintigraphic studies seems therefore to be from 3-6 hrs, as at this time there is still an adequate activity in bone structures, while the low background activity yields a good contrast on scintiscans. 2. The clinical results of bone scintigraphy with 99mTc-pyrophosphate with 88.6% correct diagnoses can be considered as \"very good\". This feature can partly be attributed to an improved correlation of radiographic and scintigraphic images by the use of a specially designed, combined radiographic-photoscanning detector system. 3. Preliminary results concerning the quantitative uptake of 99mTc-pyrophosphate in fractures of the extremities suggest, that the quantitative analyses of the registered data can provide valuable prognostic information in traumatic, inflammatory and neoplastic bone lesions.","PeriodicalId":19324,"journal":{"name":"Nuclear-Medizin","volume":"14 4","pages":"310-22"},"PeriodicalIF":0.0,"publicationDate":"1975-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11392654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The synthesis and chemical properties of 3-chloromercury-2-hydroxipropyl-urea. 3-氯汞-2-羟丙基尿素的合成及其化学性质。

Nuclear-Medizin Pub Date : 1975-12-15

I Berkes, V Jovanovic, D Zivanov-Stakić

引用次数: 0

Bifunctional chelates for radio-pharmaceutical labeling. 放射性药物标记用双功能螯合剂。

Nuclear-Medizin Pub Date : 1975-12-15

D A Goodwin, C F Meares, C I Diamanti, M W Sundberg

引用次数: 0

Formation and in-vivo-distribution of different 99mTc-Sn-pyrophosphate complexes. 不同99mtc - sn -焦磷酸配合物的形成及体内分布。

Nuclear-Medizin Pub Date : 1975-12-15

C Schümichen, K H Roth, G Hoffmann