{"title":"不同99mtc - sn -焦磷酸配合物的形成及体内分布。","authors":"C Schümichen, K H Roth, G Hoffmann","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The formation of two different 99mTc-Sn-pyrophosphate complexes was determined by evaluation of their in vivo distribution in rats. It was found that formation of a 2 : 2 Sn : PyP complex, which is bone seeking, is depending as well on the pyrophosphate as on the hydrogen ion concentration in the equilibrium. On the contrary, formation of a 2 : 1 Sn : PyP complex, which shows no bone affinity but concentrate in the kidneys, is hydrogen ion independent and occurs even at very low pyrophosphate concentrations. The probable structure of these complexes is discussed.</p>","PeriodicalId":19324,"journal":{"name":"Nuclear-Medizin","volume":"14 4","pages":"323-9"},"PeriodicalIF":0.0000,"publicationDate":"1975-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Formation and in-vivo-distribution of different 99mTc-Sn-pyrophosphate complexes.\",\"authors\":\"C Schümichen, K H Roth, G Hoffmann\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The formation of two different 99mTc-Sn-pyrophosphate complexes was determined by evaluation of their in vivo distribution in rats. It was found that formation of a 2 : 2 Sn : PyP complex, which is bone seeking, is depending as well on the pyrophosphate as on the hydrogen ion concentration in the equilibrium. On the contrary, formation of a 2 : 1 Sn : PyP complex, which shows no bone affinity but concentrate in the kidneys, is hydrogen ion independent and occurs even at very low pyrophosphate concentrations. The probable structure of these complexes is discussed.</p>\",\"PeriodicalId\":19324,\"journal\":{\"name\":\"Nuclear-Medizin\",\"volume\":\"14 4\",\"pages\":\"323-9\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nuclear-Medizin\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nuclear-Medizin","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
通过对两种不同99mtc - sn -焦磷酸配合物在大鼠体内分布的评价来确定它们的形成。研究发现，在平衡状态下，2∶2 Sn: PyP络合物的形成既取决于焦磷酸盐，也取决于氢离子浓度。相反，2:1 Sn: PyP复合物的形成是不依赖氢离子的，即使在非常低的焦磷酸盐浓度下也会发生。讨论了这些配合物的可能结构。
Formation and in-vivo-distribution of different 99mTc-Sn-pyrophosphate complexes.
The formation of two different 99mTc-Sn-pyrophosphate complexes was determined by evaluation of their in vivo distribution in rats. It was found that formation of a 2 : 2 Sn : PyP complex, which is bone seeking, is depending as well on the pyrophosphate as on the hydrogen ion concentration in the equilibrium. On the contrary, formation of a 2 : 1 Sn : PyP complex, which shows no bone affinity but concentrate in the kidneys, is hydrogen ion independent and occurs even at very low pyrophosphate concentrations. The probable structure of these complexes is discussed.
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