NeuroMolecular Medicine最新文献_第8页

Gastrodin Attenuates Lipopolysaccharide-Induced Inflammatory Response and Migration via the Notch-1 Signaling Pathway in Activated Microglia. 天麻素通过激活的小胶质细胞Notch-1信号通路减弱脂多糖诱导的炎症反应和迁移。

IF 3.5 4区医学

NeuroMolecular Medicine Pub Date : 2022-06-01 Epub Date: 2021-06-09 DOI: 10.1007/s12017-021-08671-1

Yue-Yi Yao, Run Li, Yan-Ji Guo, Yu Zhao, Jia-Zhi Guo, Qing-Long Ai, Lian-Mei Zhong, Di Lu

{"title":"Gastrodin Attenuates Lipopolysaccharide-Induced Inflammatory Response and Migration via the Notch-1 Signaling Pathway in Activated Microglia.","authors":"Yue-Yi Yao, Run Li, Yan-Ji Guo, Yu Zhao, Jia-Zhi Guo, Qing-Long Ai, Lian-Mei Zhong, Di Lu","doi":"10.1007/s12017-021-08671-1","DOIUrl":"https://doi.org/10.1007/s12017-021-08671-1","url":null,"abstract":"Microglia-mediated neuroinflammation is known to play a pivotal role in the pathogenesis of different neurological diseases. Gastrodin, a phenolic glucoside, has been reported to exert anti-inflammatory effects in activated microglia challenged with lipopolysaccharide (LPS); however, the underlying mechanism has remained obscure. The present study aimed to ascertain if Gastrodin would regulate the Notch signaling pathway involved in microglia activation. We show here that LPS increased the expression of various members of the Notch-1 pathway, including intracellular Notch receptor domain (NICD), recombining binding protein suppressor of hairless (RBP-Jκ) and transcription factor hairy and enhancer of split-1 (Hes-1) in microglia in postnatal rat brain and in BV-2 microglia. Remarkably, Gastrodin was found to markedly attenuate the expression of the above various biomarkers both in vivo and in vitro. Moreover, increased phosphorylation level of ERK, JNK and P38 induced by LPS was attenuated with pretreatment of Notch-1 signaling inhibitor, N-[N-(3,5-difluorophenacetyl)-1-alany1-Sphenyglycinet-butylester (DAPT) as well as Gastrodin. Gastrodin mimicked the effects of DAPT by inhibiting the LPS-induced expression of IL-1β, IL-6, IL-23, TNF-α and NO. Moreover, lentivirus transfection mediated NICD overexpression inhibited the anti-inflammatory effects of Gastrodin. Furthermore, the activation of Notch-1 signaling promoted microglia migration and Gastrodin could inhibit the migration of activated BV-2 microglia by regulating the Notch-1 signaling pathway. In light of the above, our results indicate that Notch-1 signaling pathway is involved in the anti-inflammatory effects of Gastrodin against LPS-induced microglia activation. These findings provide a new biological target of Gastrodin for the treatment of neuroinflammatory disorders.","PeriodicalId":19304,"journal":{"name":"NeuroMolecular Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12017-021-08671-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39080313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Irisin-Associated Neuroprotective and Rehabilitative Strategies for Stroke. 鸢尾素相关中风的神经保护和康复策略。

IF 3.5 4区医学

NeuroMolecular Medicine Pub Date : 2022-06-01 Epub Date: 2021-07-03 DOI: 10.1007/s12017-021-08666-y

Melissa Ann Huberman, Nathan D d'Adesky, Qismat Bahar Niazi, Miguel A Perez-Pinzon, Helen M Bramlett, Ami P Raval

{"title":"Irisin-Associated Neuroprotective and Rehabilitative Strategies for Stroke.","authors":"Melissa Ann Huberman, Nathan D d'Adesky, Qismat Bahar Niazi, Miguel A Perez-Pinzon, Helen M Bramlett, Ami P Raval","doi":"10.1007/s12017-021-08666-y","DOIUrl":"https://doi.org/10.1007/s12017-021-08666-y","url":null,"abstract":"Irisin, a newly discovered protein hormone that is secreted in response to low frequency whole body vibration (LFV), could be a promising post-stroke rehabilitation therapy for patients who are frail and cannot comply with regular rehabilitation therapy. Irisin is generated from a membrane-bound precursor protein fibronectin type III domain-containing protein 5 (FNDC5). Aside from being highly expressed in muscle, FNDC5 is highly expressed in the brain. The cleaved form of FNDC5 was found in the cerebrospinal fluid as well as in various regions of the brain. Numerous studies suggest that irisin plays a key role in brain metabolism and inflammation regulation. Both the metabolism and inflammation govern stroke outcome, and in a published study, we demonstrated that LFV therapy following middle cerebral artery occlusion significantly reduced innate immune response, improved motor function and infarct volume in reproductively senescent female rats. The observed effect of LFV therapy could be working via irisin, therefore, the current review focuses to understand various aspects of irisin including its mechanism of action on the brain.","PeriodicalId":19304,"journal":{"name":"NeuroMolecular Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12017-021-08666-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39144770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Value of miR-137 in Children with Medulloblastoma and its Regulatory Effect on Tumor Progression. miR-137在儿童髓母细胞瘤中的预后价值及其对肿瘤进展的调节作用。

IF 3.5 4区医学

NeuroMolecular Medicine Pub Date : 2022-06-01 Epub Date: 2021-08-18 DOI: 10.1007/s12017-021-08684-w

Wenyuan Ji, Xuan Zhe, Lusheng Li, Yang Cheng, Xueling Zhao, Ping Liang, Chunxi Long, Jianjun Zhou

{"title":"Prognostic Value of miR-137 in Children with Medulloblastoma and its Regulatory Effect on Tumor Progression.","authors":"Wenyuan Ji, Xuan Zhe, Lusheng Li, Yang Cheng, Xueling Zhao, Ping Liang, Chunxi Long, Jianjun Zhou","doi":"10.1007/s12017-021-08684-w","DOIUrl":"https://doi.org/10.1007/s12017-021-08684-w","url":null,"abstract":"Medulloblastoma is a malignant tumor with high incidence and poor prognosis in adolescents and children. MicroRNA-137 (miR-137) has been found to be abnormally expressed in cancers such as pancreatic cancer. The purpose of this study is to explore the expression of miR-137 in MB and its role in cell physiological activities to determine the significance of miR-137 in the prognosis of MB. First, the expression of miR-137 in MB tissues and cell lines was analyzed by qRT-PCR. Then the Kaplan-Meier survival curve was used to analyze the significance of miR-137 expression in the prognosis, and the Cox regression model was used to explore the correlation between miR-137 expression and clinical characteristics. The effects of miR-137 on MB cell activities were analyzed by MTT assay, Transwell assays, and flow cytometry. It can be concluded from the results that the expression of miR-137 is down-regulated in MB tissues and cells. The down-regulation of miR-137 was significantly related to the poor prognosis of MB, and significantly related to clinical indicators. Up-regulated miR-137 inhibited cell proliferation, migration, invasion, and cell cycle progression, as well as induced cell apoptosis by targeting KDM1A. This study can conclude that miR-137 may be used as a prognostic biomarker of MB.","PeriodicalId":19304,"journal":{"name":"NeuroMolecular Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12017-021-08684-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39326796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Butanol Extract of Tinospora cordifolia Alleviates Acute Sleep Deprivation-Induced Impairments in Cognitive Functions and Neuromuscular Coordination in Middle-Aged Female Rats. 丁醇提取物缓解急性睡眠剥夺引起的中年雌性大鼠认知功能和神经肌肉协调障碍。

IF 3.5 4区医学

NeuroMolecular Medicine Pub Date : 2022-06-01 Epub Date: 2021-08-19 DOI: 10.1007/s12017-021-08683-x

Payal Bajaj, Harpal Singh, Shikha Kalotra, Gurcharan Kaur

{"title":"Butanol Extract of Tinospora cordifolia Alleviates Acute Sleep Deprivation-Induced Impairments in Cognitive Functions and Neuromuscular Coordination in Middle-Aged Female Rats.","authors":"Payal Bajaj, Harpal Singh, Shikha Kalotra, Gurcharan Kaur","doi":"10.1007/s12017-021-08683-x","DOIUrl":"https://doi.org/10.1007/s12017-021-08683-x","url":null,"abstract":"Sleep deprivation due to present-day lifestyle and late-hours work commitments are associated with a broad spectrum of neurobehavioral complications. Moreover, women, as they age, become prone to the cumulative effects of menopause such as sleep disturbances, adiposity, and inflammation which are attributed to a compromised immuno-neuro-endocrine axis. So far, no effective therapeutic remedy is available to mitigate the adverse effects of SD. The current study was aimed to elucidate the neuroprotective potential of n-Butanol fraction obtained from hydroalcoholic extract of Tinospora cordifolia stem (B-TCE). Four groups of female rats are (1) Vehicle-undisturbed sleep, (2) Vehicle-sleep deprived (between 6 a.m. and 6 p.m.), (3) B-TCE oral feeding for 2 weeks and sleep deprivation, and (4) B-TCE alone undisturbed sleep group. Novel Object Recognition test was used to study cognitive impairments and Rotarod for motor coordination. Rats were then sacrificed to study the expression of various marker proteins in the hippocampus and piriform cortex regions of the brain by western blotting. SD was observed to impair the exploratory behavior and neuromuscular coordination, whereas, B-TCE pre-treatment was observed to ameliorate these behavioral functions'- impairments and further suppressed the changes in the expression of markers for synaptic plasticity, inflammation, cell survival, and apoptosis pathways. The current data suggest that B-TCE may be effective in the management of acute SD-associated impairments in learning and memory functions and neuromuscular coordination.","PeriodicalId":19304,"journal":{"name":"NeuroMolecular Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12017-021-08683-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39326125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Long Noncoding RNA LINC01518 Modulates Proliferation and Migration in TGF-β1-Treated Human Tenon Capsule Fibroblast Cells Through the Regulation of hsa-miR-216b-5p. 长链非编码RNA LINC01518通过调控hsa-miR-216b-5p调控TGF-β1处理的人榫囊成纤维细胞的增殖和迁移

IF 3.5 4区医学

NeuroMolecular Medicine Pub Date : 2022-06-01 Epub Date: 2021-05-15 DOI: 10.1007/s12017-021-08662-2

Ning Kong, YaLi Bao, Haixia Zhao, Xin Kang, Xue Tai, Xu Chen, Wenqi Guo, Ying Shen

{"title":"Long Noncoding RNA LINC01518 Modulates Proliferation and Migration in TGF-β1-Treated Human Tenon Capsule Fibroblast Cells Through the Regulation of hsa-miR-216b-5p.","authors":"Ning Kong, YaLi Bao, Haixia Zhao, Xin Kang, Xue Tai, Xu Chen, Wenqi Guo, Ying Shen","doi":"10.1007/s12017-021-08662-2","DOIUrl":"https://doi.org/10.1007/s12017-021-08662-2","url":null,"abstract":"In this study, we investigated the expression and functions of long noncoding RNAs (LncRNAs) of LINC01518 in an in vitro model of TGF-β1-treated human Tenon capsule fibroblast (HTF) cells. qRT-PCR was used to examine LINC01518 expression in in situ human glaucoma tissues, and in vitro HTF cells treated with TGF-β1. Lentivirus-mediated LINC01518 knockdown was performed in HTF cells to investigate its effect on TGF-β1-induced cell proliferation, migration and autophagy signaling pathway. The potential ceRNA candidate of LINC01518, hsa-miR-216b-5p, was probed by dual-luciferase assay and qRT-PCR. Hsa-miR-216b-5p was also knocked down in LINC01518-downregulated HTF cells to investigate the function of this lncRNA-miRNA epigenetic axis in TGF-β1-treated HTF cells. LINC01518 was upregulated in human glaucoma tissues and cultured HTF cells. LINC01518 downregulation significantly suppressed TGF-β1-induced cell proliferation, migration and autophagy signaling pathway in HTF cells. Hsa-miR-216b-5p was confirmed to be a ceRNA target of LINC01518. Knocking down hsa-miR-216b-5p reversed the suppressing effects of LINC01518 downregulation in TGF-β1-treated HTF cells. Our study demonstrated that LINC01518 is a functional factor in regulating proliferation and migration in TGF-β1-treated HTF cells, and hsa-miR-216b -5p may also be involved. Targeting the epigenetic axis of LINC01518/hsa-miR-216b-5p may provide new insight into the pathological development of human glaucoma.","PeriodicalId":19304,"journal":{"name":"NeuroMolecular Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12017-021-08662-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38986493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Hypercapnia Modulates the Activity of Adenosine A1 Receptors and mitoK⁺_ATP-Channels in Rat Brain When Exposed to Intermittent Hypoxia. 间歇性缺氧时高碳酸血症调节大鼠脑腺苷A1受体和mitoK+ atp通道的活性

IF 3.5 4区医学

NeuroMolecular Medicine Pub Date : 2022-06-01 Epub Date: 2021-06-11 DOI: 10.1007/s12017-021-08672-0

P P Tregub, N A Malinovskaya, E D Osipova, A V Morgun, V P Kulikov, D A Kuzovkov

{"title":"Hypercapnia Modulates the Activity of Adenosine A1 Receptors and mitoK+ATP-Channels in Rat Brain When Exposed to Intermittent Hypoxia.","authors":"P P Tregub, N A Malinovskaya, E D Osipova, A V Morgun, V P Kulikov, D A Kuzovkov","doi":"10.1007/s12017-021-08672-0","DOIUrl":"https://doi.org/10.1007/s12017-021-08672-0","url":null,"abstract":"The mechanisms and signaling pathways of the neuroprotective effects of hypercapnia and its combination with hypoxia are not studied sufficiently. The study aims to test the hypothesis of the potentiating effect of hypercapnia on the systems of adaptation to hypoxia, directly associated with A1-adenosine receptors and mitochondrial ATP-dependent K+ -channels (mitoK+ATP-channels). We evaluated the relative number of A1-adenosine receptors and mitoK+ATP-channels in astrocytes obtained from male Wistar rats exposed to various respiratory conditions (15 times of hypoxia and/or hypercapnia). In addition, the relative number of these molecules in astrocytes was evaluated on an in vitro model of chemical hypoxia, as well as in the cerebral cortex after photothrombotic damage. This study indicates an increase in the relative number of A1-adenosine receptors in astrocytes and in cells next to the stroke region of the cerebral cortex in rats exposed to hypoxia and hypercapnic hypoxia, but not hypercapnia alone. Hypercapnia and hypoxia increase the relative number of mitoK+ATP-channels in astrocytes and in cells of the peri-infarct region of the cerebral cortex in rats. In an in vitro study, hypercapnia mitigates the effects of acute chemical hypoxia observed in astrocytes for A1-adenosine receptors and mitoK+ATP-channels. Hypercapnia, unlike hypoxia, does not affect the relative number of A1 receptors to adenosine. At the same time, both hypercapnia and hypoxia increase the relative number of mitoK+ATP-channels, which can potentiate their protective effects with combined exposure.","PeriodicalId":19304,"journal":{"name":"NeuroMolecular Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12017-021-08672-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39082905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Diagnostic Performance of miR-485-3p in Patients with Parkinson's Disease and its Relationship with Neuroinflammation. miR-485-3p在帕金森病患者中的诊断价值及其与神经炎症的关系

IF 3.5 4区医学

NeuroMolecular Medicine Pub Date : 2022-06-01 Epub Date: 2021-07-19 DOI: 10.1007/s12017-021-08676-w

Xia Lin, Rui Wang, Ran Li, Taotao Tao, Danhong Zhang, Yuxiang Qi

{"title":"Diagnostic Performance of miR-485-3p in Patients with Parkinson's Disease and its Relationship with Neuroinflammation.","authors":"Xia Lin, Rui Wang, Ran Li, Taotao Tao, Danhong Zhang, Yuxiang Qi","doi":"10.1007/s12017-021-08676-w","DOIUrl":"https://doi.org/10.1007/s12017-021-08676-w","url":null,"abstract":"Parkinson's disease (PD) is one of the most common progressive neurodegenerative diseases. Some microRNAs (miRNAs) play critical roles in the development of many neurological diseases. This study aims to evaluate the clinical significance and biological function of miR-485-3p in the development and progression of PD. The expression of miR-485-3p in serum of PD patients was analyzed by quantitative real-time PCR (qRT-PCR). LPS-treated microglia BV2 cells were used to mimic neuroinflammation in the pathogenesis of PD. The levels of inflammatory cytokines, including IL-1β, IL-6 and TNF-α, were detected by enzyme-linked immunosorbent assay (ELISA). The diagnosis value of miR-485-3p was evaluated by plotting receiver operating characteristic (ROC) curves. A luciferase reporter assay was performed to demonstrate the interaction between miR-485-3p and FBXO45. The results showed that miR-485-3p was significantly up-regulated in serum of PD patients compared with that in both Alzheimer's disease (AD) and healthy cases, and had diagnostic accuracy for PD screening. The activated microglia BV2 cells induced by LPS also had elevated miR-485-3p, and the knockdown of miR-485-3p inhibited the release of pro-inflammatory cytokines. FBXO protein 45 (FBXO45) served as a potential target of miR-485-3p, which was speculated to mediate the function of miR-485-3p. Our results suggest that the up-regulated expression of miR-485-3p in PD may be a novel diagnostic biomarker for PD. Reducing the expression level of miR-485-3p can inhibit the inflammatory responses of BV2 cells, which indicated that miR-485-3p, as a regulator of neuroinflammation, may have the potential as a therapeutic target in PD.","PeriodicalId":19304,"journal":{"name":"NeuroMolecular Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12017-021-08676-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39201857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Correction to: Receptor-Interacting Protein 140 Enhanced Temozolomide-Induced Cellular Apoptosis Through Regulation of E2F1 in Human Glioma Cell Lines. 更正:受体相互作用蛋白140通过调节人脑胶质瘤细胞系中E2F1增强替莫唑胺诱导的细胞凋亡。

IF 3.5 4区医学

NeuroMolecular Medicine Pub Date : 2022-06-01 DOI: 10.1007/s12017-021-08680-0

Hong-Chieh Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Chiung-Yin Huang, Ko-Ting Chen, Ya-Jui Lin, Hsiao-Wei Cheng, Chun-Hao Huang, Hsiang-Tsui Wang

引用次数: 0

Role of Exosomes in Mediating the Cross-Talk Between Adipose Tissue and the Brain. 外泌体在介导脂肪组织与大脑之间的交叉对话中的作用

IF 3.5 4区医学

NeuroMolecular Medicine Pub Date : 2022-06-01 Epub Date: 2021-05-12 DOI: 10.1007/s12017-021-08664-0

Sri Meghana Yerrapragada, Ji Chen Bihl

引用次数: 0

Revealing the Modular Similarities and Differences Among Alzheimer's Disease, Vascular Dementia, and Parkinson's Disease in Genomic Networks. 揭示基因组网络中阿尔茨海默病、血管性痴呆和帕金森病的模块异同。

IF 3.5 4区医学

NeuroMolecular Medicine Pub Date : 2022-06-01 Epub Date: 2021-06-12 DOI: 10.1007/s12017-021-08670-2

Yafei Chen, Qiong Liu, Jun Liu, Penglu Wei, Bing Li, Nongyun Wang, Zhenquan Liu, Zhong Wang

{"title":"Revealing the Modular Similarities and Differences Among Alzheimer's Disease, Vascular Dementia, and Parkinson's Disease in Genomic Networks.","authors":"Yafei Chen, Qiong Liu, Jun Liu, Penglu Wei, Bing Li, Nongyun Wang, Zhenquan Liu, Zhong Wang","doi":"10.1007/s12017-021-08670-2","DOIUrl":"https://doi.org/10.1007/s12017-021-08670-2","url":null,"abstract":"Alzheimer's disease (AD), vascular dementia (VD), and Parkinson's disease (PD) exert increasingly lethal or disabling effects on humans, but the associations among these diseases at the molecular level remain unclear. In our research, lists of genes related to these three diseases were acquired from public databases. We constructed gene-gene networks of the lists of disease-related genes using the STRING database and selected the plug-in MCODE as the most suitable method to divide the three disease-associated networks into modules through an entropy calculation. Notably, 1173 AD-related, 203 VD-related, and 722 PD-related genes as well as 72 overlapping genes were observed among the three diseases. By dividing the modules from the gene network, we divided the AD-related gene network into 27 modules, the VD-related gene network into 8 modules, and the PD-related gene network into 17 modules. After the enrichment analysis of each disease-related gene, 146 overlapping biological processes and 32 overlapping pathways were identified. Ultimately, through similarity analysis of the genes, biological processes, and pathways, we found that AD and VD were the most closely related at the biological process and pathway levels, with similarity coefficients of 0.2784 and 0.3626, respectively. After analyzing the overlapping gene network, we found that INS might play an important role in the network and that insulin and its signaling pathways may play a key role in these neurodegenerative diseases. Our research illustrates a new method for in-depth research on the three diseases, which may accelerate the progress of developing new therapeutics and may be applied to prevent neurodegenerative diseases.","PeriodicalId":19304,"journal":{"name":"NeuroMolecular Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12017-021-08670-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39085552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7