Nippon Ishinkin Gakkai Zasshi最新文献_第4页

Immune Response in Skin Lesion of Dermatophytosis 皮肤真菌病皮肤病变的免疫应答

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-02-28 DOI: 10.3314/JJMM.38.29

T. Koga

{"title":"Immune Response in Skin Lesion of Dermatophytosis","authors":"T. Koga","doi":"10.3314/JJMM.38.29","DOIUrl":"https://doi.org/10.3314/JJMM.38.29","url":null,"abstract":"白癬病巣における免疫応答についてサイトカインレベルで,とくに遅延型過敏反応(DTH)に深く関与するIFN-γ産生について検討した結果,中心治癒傾向のある辺縁隆起性環状紅斑,小水疱などの炎症症状を伴う白癬患者末梢血単核球は白癬菌抗原(トリコフィチン)刺激によりIFN-γを産生した.一方,中心治癒傾向のない落屑性紅斑,角質増殖など比較的炎症症状の乏しい慢性の経過をたどる白癬患者末梢血単核球のIFN-γ産生は低下していた.このことより,前者の臨床像は主としてDTHによる菌の排除機構が働いている像であり,また後者の臨床像は主として表皮角化亢進に伴う落屑による菌の排除機構が働いている像と考えられた.また培養表皮角化細胞はトリコフィチン刺激によりIL-8の産生を増強し,このことが白癬にみられる角層下膿疱の形成に関与している可能性が考えられた.このように白癬の臨床像形成および感染防御には,白癬菌抗原に対するDTHと白癬菌抗原による表皮角化細胞の刺激にもとづく刺激性皮膚炎が,重要な役割を担っていることが示唆された.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"4 1","pages":"29-31"},"PeriodicalIF":0.0,"publicationDate":"1997-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86277601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Taxonomical Outline of Dermatophytes in the Ascomycetes 子囊菌中皮菌的分类大纲

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-02-28 DOI: 10.3314/JJMM.38.1

S. Udagawa

{"title":"Taxonomical Outline of Dermatophytes in the Ascomycetes","authors":"S. Udagawa","doi":"10.3314/JJMM.38.1","DOIUrl":"https://doi.org/10.3314/JJMM.38.1","url":null,"abstract":"不整子嚢菌類ホネタケ目はAspergillus,Penicilliumのテレオモルフであるユーロチウム目と多くの点で対比される菌群である.本目には多数の皮膚糸状菌が含まれ,長らく医学的に関心が寄せられてきた.ホネタケ目には次の4科がある.アルスロデルマ科は子嚢果壁の特徴,子嚢胞子の形態,Chrysosporium, Microsporum, Trichophytonに属するアレウロ型分生子の形成などに基づく均質な菌群である.ギムノアスクス科は明色,菌糸のゆるい網目構造からなる子嚢果を形成し,円盤形,やや不規則な壁の子嚢胞子を内生する.ケラチン分解性とセルロース分解性の菌があり,分節分生子を形成する種がある.ミクソトリクム科は暗色の子嚢果で,しばしば樹枝状の付属物を形成する.子嚢果壁は厚壁の菌糸が網目状になり,子嚢胞子は紡錘形,通常縦に筋がある.Malbranchea,Oidiodendron属の分節型分生子がみられ,セルロース分解性を示す.ホネタケ科の属は非常に多様性であり,とくに子嚢果壁に変化がみられる.Aphanoascus,Arachnomycesは膜質の閉子嚢殻を形成する.Amauroascus,Nannizziopsisは単純な菌糸の網目構造である.一方,Onygenaの子嚢果は柄があって,その先端部で菌糸が広がり球形の頭部になる高度に特殊化された形態となる.本科は通常凹点のある子嚢胞子とケラチン分解性を特徴としている.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"2 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"1997-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88928383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Geographical Distribution of Species on Etiologic Fungi of Dermatophytosis in Northeast China 东北地区皮肤病病原真菌种类的地理分布

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-02-28 DOI: 10.3314/JJMM.38.9

G. You, Jing Wang, Bing-mei Liu, Song Yu, Lie Ma, De-yuang You, Xue-zhu Jin, Y. Bai

{"title":"Geographical Distribution of Species on Etiologic Fungi of Dermatophytosis in Northeast China","authors":"G. You, Jing Wang, Bing-mei Liu, Song Yu, Lie Ma, De-yuang You, Xue-zhu Jin, Y. Bai","doi":"10.3314/JJMM.38.9","DOIUrl":"https://doi.org/10.3314/JJMM.38.9","url":null,"abstract":"A survey of dermatophytes isolated from patients was made from 1980 to 1996 in Northeast China. We analyzed 2031 strains of dermatophytes, which are positive in culture in 3 provinces (Heilongjiang, Jilin, Liaoning): 742 strains were obtained from the China-Japan Friendship Hospital of Heilongjiang (1980-1993), 846 strains from the 2nd Hospital of Bethuene Medical University (1986-1989), and 443 strains from the People's Hospital of Liaoning Province (1989-1996).The result of the survey indicated that the main etiologic fungus of dermatophytosis in Northeast China was T. rubrum 1163 strains (57.26%), T. mentagrophytes 402 (19.79%), M. canis 296 (14.57%), E. floccosum 100 (4.92%), T. verrucosum 28 (1.38%), M. ferrugineum 10 (0.49%), M. gypseum 10 (0.49%), T. schoenleinii 4 (0.20%), T. tonsurans 3 (0.15%), and the root 15 strains were Candida albicans (4) Aspergillus (7), Penicillum (2) and Alternaria (2).The first 3 species are basically the same as those in Beijing, Tianjing, and Taiyuan. M. canis is rarely seen in Huanan, Huazhong, and Qinghai. However, T. verrucosum is notably influenced by geographical factors. Kerion celsi and sycosis trichophytica are caused by T. verrucosum (43.75%) in Heilongjiang. T. verrucosum is hardy and can live in cold areas. It once exploded simultaneously in human and animals in Hellongjiang, Xinjiang, and NingXia China.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"1 1","pages":"9-12"},"PeriodicalIF":0.0,"publicationDate":"1997-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89415172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Case of Familial Chronic Mucocutaneous Candidiasis 家族性慢性皮肤粘膜念珠菌病1例

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-02-28 DOI: 10.3314/JJMM.38.47

A. Kuwano, A. Shôji

引用次数: 0

A Case of Systemic Fusarium solani Infection Complicating Acute Lymphocytic Leukemia 急性淋巴细胞白血病并发系统性茄镰刀菌感染1例

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-02-28 DOI: 10.3314/JJMM.38.81

Kazuhiro Endo, T. Kashimura, Katsuhiko Yoshida, A. Handa, T. Sakata, Katsuro Ito, M. Fukuda, I. Jinnai, I. Murohashi, M. Bessho, M. Saito, K. Hirashima, Y. Inoue

{"title":"A Case of Systemic Fusarium solani Infection Complicating Acute Lymphocytic Leukemia","authors":"Kazuhiro Endo, T. Kashimura, Katsuhiko Yoshida, A. Handa, T. Sakata, Katsuro Ito, M. Fukuda, I. Jinnai, I. Murohashi, M. Bessho, M. Saito, K. Hirashima, Y. Inoue","doi":"10.3314/JJMM.38.81","DOIUrl":"https://doi.org/10.3314/JJMM.38.81","url":null,"abstract":"症例は,19歳男性,1992年9月急性リンパ性白血病(FAB分類ALL L2)と診断しJapan Adult Leukemia study Group (JAL-SG)プロトコールにて治療し完全寛解に到った後,1994年8月,再発しprednisolone, vincristineによる寛解導入療法を行った.その後,cytarabine,l-asparaginaseにて治療し長期間,骨髄抑制が起こり,発熱と潰瘍底を形成し中心部が壊死に陥った皮疹が全身に認められるようになった.皮膚生検を行い,培養の結果Fusarium solaniを検出した.そのため,granulocyte colony-stimulating factor (G-CSF) 350μgを連日静注し,amphotericin B (AMPH)を点滴静注し1mgから開始し40mgまで増量した.しかし,原疾患の悪化に伴いPseudomonas aeruginosaによる敗血症を併発し死亡した.剖検では全身各種臓器にもFusariumによる播種性病変が認められた.とくに肺,消化管,腎,心,膵,筋肉に多発性病変を,また腎は一部梗塞を伴う病変を認めた.今後,免疫不全患者の増加によりこのような弱毒真菌感染症が増加するものと思われた.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"9 1","pages":"81-85"},"PeriodicalIF":0.0,"publicationDate":"1997-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74278797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticandidal Activity of Polymorphonuclear Leukocytes and Serum Transferrin in Tumor-Implanted Mice 肿瘤植入小鼠多形核白细胞和血清转铁蛋白抗药活性的研究

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-02-28 DOI: 10.3314/JJMM.38.61

Toshihiko Watanabe, T. Mikami, Tatsuji Matsumoto, Masuko Suzuki

引用次数: 1

Dermatophyte Flora of Japan 日本皮肤植物区系

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-02-28 DOI: 10.3314/JJMM.38.13

K. Nishimoto

引用次数: 0

Molecular Biological Approach to Phylogeny and Identification of Dermatophytes 皮肤植物系统发育与鉴定的分子生物学研究

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-02-28 DOI: 10.3314/JJMM.38.5

K. Makimura, Hideaki Goto, T. Mochizuki, A. Hasegawa, K. Uchida, H. Yamaguchi

引用次数: 1

Characterization of Elastolytic Proteinase from Aspergillus flavus:Comparison of Biochemical Properties to the Elastolytic Proteinase from Aspergillus fumigatus 黄曲霉弹性蛋白酶的鉴定:与烟曲霉弹性蛋白酶生化特性的比较

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-02-28 DOI: 10.3314/JJMM.38.53

Y. Hasegawa, T. Nikai, Y. Okumura, K. Ogawa, H. Sugihara

{"title":"Characterization of Elastolytic Proteinase from Aspergillus flavus:Comparison of Biochemical Properties to the Elastolytic Proteinase from Aspergillus fumigatus","authors":"Y. Hasegawa, T. Nikai, Y. Okumura, K. Ogawa, H. Sugihara","doi":"10.3314/JJMM.38.53","DOIUrl":"https://doi.org/10.3314/JJMM.38.53","url":null,"abstract":"An elastolytic proteinase was isolated from Aspergillus flavus by column chromatography using diethylaminoethyl (DEAE)-cellulose and carboxymethyl (CM)-Sephadex C-50. The proteinase was found to be homogeneous as indicated by a single band after disc polyacrylamide gel electrophoresis (PAGE). The enzyme had a molecular weight of 40, 000Da as determined by sodium dodecyl sulfate (SDS)-PAGE.The elastolytic activity was inhibited by leupeptin, diisopropyl fluorophosphate (DFP), α1-antitrypsin, α2-macroglobulin and ethylenediaminetetraacetic acid (EDTA). However, neither N-bromo-succinimide (NBS) nor antithrombin-III showed any inhibitory effect on the enzyme activity. The enzyme contained 414 amino acid residues and exhibited an isoelectric point of 8.6. Its carbohydrate content was calculated to be 3.6% using glucose as a standard, but elastolytic proteinase from A. fumigatus did not contain any carbohydrates. The Aα, Bβ and γ chains of human fibrinogen were cleaved by the enzyme.Elastolytic proteinase from A. flavus hydrolyzed Ser(9)-His(10), Val(12)-Glu(13), Glu(13)-Ala(14), Ala(14)-Leu(15), Leu(15)-Tyr(16), Tyr(16)-Leu(17), Glu(21)-Arg(22), Phe(25)-Tyr(26), Tyr(26)-Thr(27), Pro(28)-Lys(29) and Lys(29)-Ala(30) bonds of oxidized insulin B chain, showing that enzyme has proteolytic activity.However, elastolytic proteinase from A. fumigatus had a molecular weight of 32, 000Da, and the enzyme did not contain carbohydrate.","PeriodicalId":19301,"journal":{"name":"Nippon Ishinkin Gakkai Zasshi","volume":"9 1","pages":"53-59"},"PeriodicalIF":0.0,"publicationDate":"1997-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75131354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Clinical Evaluation of Shampoo Containing 0.75% Miconazole Nitrate for Dandruff 含0.75%硝酸咪康唑洗发水治疗头屑的临床评价

Nippon Ishinkin Gakkai Zasshi Pub Date : 1997-02-28 DOI: 10.3314/JJMM.38.99

K. Kudoh, H. Tagami

引用次数: 2