Neuropsychologia最新文献_第9页

Reward prediction-error promotes the neural encoding of episodic learning 奖励预测错误促进情景学习的神经编码。

IF 2 3区心理学

Neuropsychologia Pub Date : 2025-03-10 DOI: 10.1016/j.neuropsychologia.2025.109120

Fangfang Liu , Yingjie Jiang , Bin Du

{"title":"Reward prediction-error promotes the neural encoding of episodic learning","authors":"Fangfang Liu , Yingjie Jiang , Bin Du","doi":"10.1016/j.neuropsychologia.2025.109120","DOIUrl":"10.1016/j.neuropsychologia.2025.109120","url":null,"abstract":"<div><div>Reward prediction-error carries significant implications for learning, facilitating the process by influencing prior knowledge and shaping future expectations and decisions. However, the electrophysiological mechanism through which reward prediction-error impacts learning remains incompletely understood. This study aimed to investigate the neural characteristics of reward prediction-error and its effect on recognition memory using Event-Related Potentials (ERPs). Behavioral results indicate that unsigned reward prediction-error indeed enhances recognition performance, with reaction times being slower in “remember” responses compared to correct predictions. The ERP findings conform to a three-stage model of reward prediction-error, suggesting that physical salience is swiftly detected (N1), followed by the processing of positive reward prediction-error (Feedback-Related Negativity, FRN), and ultimately, unsigned reward prediction-error or outcome evaluation (P300). Moreover, early physical salience signals were associated with subsequent “know” responses, while later unsigned reward prediction-error signals predicted subsequent recognition performance. This study not only revealed the neural processing mechanisms of reward prediction-error but also explored its impact on recognition performance, particularly familiarity or recollection processing.</div></div>","PeriodicalId":19279,"journal":{"name":"Neuropsychologia","volume":"211 ","pages":"Article 109120"},"PeriodicalIF":2.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Memories or decisions? Bridging accounts of frontopolar function 记忆还是决定？额极函数的桥接描述。

IF 2 3区心理学

Neuropsychologia Pub Date : 2025-03-08 DOI: 10.1016/j.neuropsychologia.2025.109119

Erica A. Boschin, Matthew Ainsworth, Juan M. Galeazzi, Mark J. Buckley

{"title":"Memories or decisions? Bridging accounts of frontopolar function","authors":"Erica A. Boschin, Matthew Ainsworth, Juan M. Galeazzi, Mark J. Buckley","doi":"10.1016/j.neuropsychologia.2025.109119","DOIUrl":"10.1016/j.neuropsychologia.2025.109119","url":null,"abstract":"<div><div>Frontopolar cortex (FPC), for a long time elusive to functional description, is now associated with a wide range of cognitive processes. Prominent accounts of FPC function emerged from studies of memory (e.g., episodic and prospective memory; EM and PM, respectively) and of executive function (e.g., planning, multi-tasking, relational reasoning, cognitive branching, etc). In recent years, FPC function has begun to be described within the context of value-based decision making in terms of monitoring the value of alternatives and optimizing cognitive resources to balance the explore/exploit dilemma in the face of volatile environments. In this perspective, we propose that the broad counterfactual inference and behavioural flexibility account can help re-interpret findings from EM and PM studies and offer an explanatory bridge between the memory and executive function accounts. More specifically, we propose that counterfactual value monitoring in FPC modulates the reallocation of cognitive resources between present and past information and contributes to efficient episodic and prospective retrieval by concurrently assessing the value of competing memories in relation to the decision at hand and proactively evaluating future potential scenarios to anticipate optimal engagement of intentions.</div></div>","PeriodicalId":19279,"journal":{"name":"Neuropsychologia","volume":"211 ","pages":"Article 109119"},"PeriodicalIF":2.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of representations is key to the enactment benefit: Insights from individuals with stroke lesions 表象整合是执行效益的关键：来自中风病损患者的启示。

IF 2 3区心理学

Neuropsychologia Pub Date : 2025-03-07 DOI: 10.1016/j.neuropsychologia.2025.109118

Yadurshana Sivashankar , Brady R. Roberts , Myra A. Fernandes

{"title":"Integration of representations is key to the enactment benefit: Insights from individuals with stroke lesions","authors":"Yadurshana Sivashankar , Brady R. Roberts , Myra A. Fernandes","doi":"10.1016/j.neuropsychologia.2025.109118","DOIUrl":"10.1016/j.neuropsychologia.2025.109118","url":null,"abstract":"<div><div>Previous research has suggested that performing an action during encoding, related to the meaning of a target word (known as ‘enactment’), benefits later memory retrieval relative to when the word is simply read. It has been suggested that enactment confers this memory benefit by promoting the formation of a multimodal memory trace through the integration of verbal and motoric representations, facilitated by the parietal lobe. More recent work has proposed that cognitive planning preceding the execution of enactment, via engagement of frontal lobe-based processes, is most critical for the memory benefit. Here, evidence for these two accounts was assessed by comparing memory in healthy controls relative to individuals with lesions to parietal or frontal brain areas. Frontal stroke participants and controls both showed significant enactment effects: Recall was better for words enacted at encoding relative to those that were silently read. In contrast, participants with parietal lesions did not show the effect. Results suggest that the integration of multimodal representations by parietal lobe-based processes is a critical step necessary to evoke the benefit of enactment on memory performance.</div></div>","PeriodicalId":19279,"journal":{"name":"Neuropsychologia","volume":"211 ","pages":"Article 109118"},"PeriodicalIF":2.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking through suppression: Face expertise selectively modulates very early awareness of high level face properties 突破抑制：面部专业知识选择性地调节非常早期的高层次面部特性意识。

IF 2 3区心理学

Neuropsychologia Pub Date : 2025-03-07 DOI: 10.1016/j.neuropsychologia.2025.109104

Michael Papasavva , Louise Ewing , Inês Mares , Marie L. Smith

{"title":"Breaking through suppression: Face expertise selectively modulates very early awareness of high level face properties","authors":"Michael Papasavva , Louise Ewing , Inês Mares , Marie L. Smith","doi":"10.1016/j.neuropsychologia.2025.109104","DOIUrl":"10.1016/j.neuropsychologia.2025.109104","url":null,"abstract":"<div><div>Neurotypical variability in face recognition abilities is known to be driven by differences present across multiple elements of an extended processing pathway, i.e., from early visual perception through to later explicit retrieval and recall. Here across two experiments, we utilised breaking Continuous Flash Suppression paradigms to explore the earliest stage of face encoding: the lead up to conscious detection. We investigated whether faces selectively receive preferential access to awareness among participants with relatively stronger (cf. weaker) face recognition abilities at the categorical level (contrasting detection of faces with another object category) and higher levels of face processing (exploring differences associated with orientation and attractiveness). Both experiments identified selectively faster access to awareness for faces over a non-face object control (houses) in better face recognisers at both the group and individual level. Experiment two further clarified that these expertise-related effects are selective to upright (cf. inverted) faces, indicating that this link is unlikely to be solely driven by sensitivity to low level visual cues. We also observed expertise-related modulation of attractiveness effects on CFS breakthrough, consistent with the possibility that individuals with higher levels of face processing ability have accelerated early access to even this high-level stimulus dimension. Taken together these experiments provide new insight into very early face perception, and the extent to which expertise modulates this processing stage at both the group and individual level.</div></div>","PeriodicalId":19279,"journal":{"name":"Neuropsychologia","volume":"211 ","pages":"Article 109104"},"PeriodicalIF":2.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential eye movements and greater pupil size during mental scene construction in autobiographical recall 在自传式回忆中，不同的眼动和更大的瞳孔在心理场景建构中的作用。

IF 2 3区心理学

Neuropsychologia Pub Date : 2025-03-06 DOI: 10.1016/j.neuropsychologia.2025.109117

P. Bernardis , M. Grassi , D.G. Pearson

{"title":"Differential eye movements and greater pupil size during mental scene construction in autobiographical recall","authors":"P. Bernardis , M. Grassi , D.G. Pearson","doi":"10.1016/j.neuropsychologia.2025.109117","DOIUrl":"10.1016/j.neuropsychologia.2025.109117","url":null,"abstract":"<div><div>There is growing evidence supporting a role for eye movements during autobiographical recall, but their potential functionality remains unclear. We hypothesise that the oculomotor system facilitates the process of mental scene construction, in which complex scenes associated with an autobiographical event are generated and maintained during recall. To explore this, we examined spontaneous eye movements during retrieval of cued autobiographical memories. Participants’ verbal descriptions of each memory were recorded in synchronisation with their eye movements and pupil size during recall. For each memory participants described the place (details of the environment where the event took place) and the event (details of what happened). Narratives were analyzed using the Autobiographical Interview procedure, which separated internal spatial (place) and non-spatial (event, thoughts and emotion) details. Eye movements during recall of spatial details had significantly higher fixation duration and smaller saccade amplitude and peak velocity, and a higher number of consecutive unidirectional saccades, in comparison to recall of non-spatial details. Recurrence quantification analysis indicated longer sequences of refixations and more repetitions of the same fixation pattern when participants described spatial details. Recall of spatial details was also associated with significantly greater pupil area. Overall findings are consistent with the spontaneous production of more structured saccade patterns and greater cognitive load during the recall of internal spatial episodic scene details in comparison to episodic non-spatial details. These results are consistent with the oculomotor system facilitating the activation and correct positioning of elements of a complex scene relative to other imagined elements during autobiographical recall.</div></div>","PeriodicalId":19279,"journal":{"name":"Neuropsychologia","volume":"211 ","pages":"Article 109117"},"PeriodicalIF":2.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcranial random noise stimulation shifts time reproduction in opposite directions for ADHD and TD individuals 经颅随机噪声刺激使ADHD和TD个体的时间复制方向相反。

IF 2 3区心理学

Neuropsychologia Pub Date : 2025-03-01 DOI: 10.1016/j.neuropsychologia.2025.109105

Fatima Asad , Keri Gladhill , Matthew Peterson , Martin Wiener

{"title":"Transcranial random noise stimulation shifts time reproduction in opposite directions for ADHD and TD individuals","authors":"Fatima Asad , Keri Gladhill , Matthew Peterson , Martin Wiener","doi":"10.1016/j.neuropsychologia.2025.109105","DOIUrl":"10.1016/j.neuropsychologia.2025.109105","url":null,"abstract":"<div><div>Non-invasive brain stimulation is being explored as a potential method for enhancing cognitive function and reducing symptoms in individuals with Attention-Deficit/Hyperactivity Disorder (ADHD), the most common neurodevelopmental disorder in children. Time perception, the ability to estimate and process time intervals, is often impaired in individuals with ADHD and is crucial for daily tasks like planning, decision-making, task completion, etc., Here we examined the effect of Transcranial Random Noise Stimulation (tRNS) on time perception in ADHD individuals. A total of 40 participants, including 20 individuals with ADHD and 20 healthy controls, underwent tRNS over the prefrontal cortex while completing a time perception task. The findings indicate that tRNS improved time perception accuracy in the ADHD group, bringing their performance closer to accurate time intervals. In contrast, the healthy control group showed a decline in time perception accuracy, moving further away from accurate time intervals following stimulation. These results suggest that tRNS produced opposite effects on time perception in ADHD individuals compared to healthy controls. We conclude that tRNS may offer potential therapeutic benefits for individuals with ADHD. Future research could explore whether additional tRNS sessions or stimulation of different brain regions might yield even more promising results.</div></div>","PeriodicalId":19279,"journal":{"name":"Neuropsychologia","volume":"211 ","pages":"Article 109105"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The nature of syntactic working memory during relative clause processing: fMRI evidence from multiple anatomic ROIs 关系小句加工过程中句法工作记忆的性质：来自多个解剖roi的fMRI证据。

IF 2 3区心理学

Neuropsychologia Pub Date : 2025-02-28 DOI: 10.1016/j.neuropsychologia.2025.109107

Wenjia Zhang , Zhiqiang Yan , Jie Dong , Xinyi Liu , Aoke Zheng , Hong Liang , Hao Yan

{"title":"The nature of syntactic working memory during relative clause processing: fMRI evidence from multiple anatomic ROIs","authors":"Wenjia Zhang , Zhiqiang Yan , Jie Dong , Xinyi Liu , Aoke Zheng , Hong Liang , Hao Yan","doi":"10.1016/j.neuropsychologia.2025.109107","DOIUrl":"10.1016/j.neuropsychologia.2025.109107","url":null,"abstract":"<div><div>Relative clauses (RC) are a common embedded structure in natural language. They can be classified as Subject-extracted RC (SRC) and object-extracted RC (ORC). Previous studies have suggested an ORC advantage in Chinese. This is consistent with the memory-based theories, which propose that more syntactic working memory (SWM) is needed during the Chinese SRC processing than the ORC processing. However, it is still unclear about the nature of the SWM (language-specific vs. domain-general). In the current study, participants were asked to read Chinese SRC and ORC sentences while undergoing functional magnetic resonance imaging (fMRI) scanning. Because of the important role of the inferior frontal gyrus (IFG) and superior temporal gyrus (STG) in SWM, these two brain regions were divided into sub-regions. Critically, LIFG<sub>orbital</sub> is more related to language-specific processing whereas LIFG<sub>opercular</sub> is more related to domain-general processing. Activation analyses and Granger causality (GC) analyses were both conducted. The results first provided more neurophysiological evidence of the ORC advantage in Chinese. More importantly, the results of activation analyses showed that LIFG<sub>oper</sub> was more activated in the contrast of SRC > ORC. In contrast, the results of GC analyses showed that LIFG<sub>orb</sub> was more involved in the SRC-specific connectivity. Altogether, these results suggest that the SWM induced by the contrast of SRC > ORC was related to both the language-specific and domain-general processing.</div></div>","PeriodicalId":19279,"journal":{"name":"Neuropsychologia","volume":"211 ","pages":"Article 109107"},"PeriodicalIF":2.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards a genetics of semantics? False memories and semantic memory organization in Williams syndrome 走向语义学的遗传学？威廉姆斯综合征的错误记忆与语义记忆组织

IF 2 3区心理学

Neuropsychologia Pub Date : 2025-02-28 DOI: 10.1016/j.neuropsychologia.2025.109106

Carlos Romero-Rivas , Lucía Sabater , Pablo Rodríguez Gómez , Irene Hidalgo de la Guía , Sara Rodríguez-Cuadrado , Eva M. Moreno , Elena Garayzábal Heinze

{"title":"Towards a genetics of semantics? False memories and semantic memory organization in Williams syndrome","authors":"Carlos Romero-Rivas , Lucía Sabater , Pablo Rodríguez Gómez , Irene Hidalgo de la Guía , Sara Rodríguez-Cuadrado , Eva M. Moreno , Elena Garayzábal Heinze","doi":"10.1016/j.neuropsychologia.2025.109106","DOIUrl":"10.1016/j.neuropsychologia.2025.109106","url":null,"abstract":"<div><div>Williams syndrome (WS) is a rare genetic neurodevelopmental disorder caused by microdeletion of a critical region on chromosome 7q11.23. At the cognitive level, it is usually characterized by moderate intellectual disability and deficits in visuospatial skills, while showing relative strengths in verbal skills and nonverbal reasoning. Despite their apparent good performance with verbal skills, previous studies have suggested that the structure of semantic memory may be altered in people diagnosed with WS. In this study, we explored the organization of semantic memory in WS through the Deese-Roediger-McDermott (DRM) paradigm, a task in which participants are induced to produce false memories through semantic associations. 24 participants with WS and 24 controls matched for gender and verbal mental age participated in the study. Results showed that the WS group, compared to the control group, had less false memories of critical lures, and made associations with words less related to the items studied. Taken together, these results suggest that semantic memory organization may be atypical in WS. We discuss how certain genes usually associated with the WS cognitive phenotype, <em>GTF2I</em> and <em>GTF2IRD1</em>, might modulate the development of brain areas responsible for semantic processing, ultimately producing atypical associations between words in the semantic networks of the mental lexicon.</div></div>","PeriodicalId":19279,"journal":{"name":"Neuropsychologia","volume":"210 ","pages":"Article 109106"},"PeriodicalIF":2.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Somatosensory influence on auditory cortical response of self-generated sound 体感对自生声音听觉皮层反应的影响。

IF 2 3区心理学

Neuropsychologia Pub Date : 2025-02-26 DOI: 10.1016/j.neuropsychologia.2025.109103

Nozomi Endo , Coriandre Vilain , Kimitaka Nakazawa , Takayuki Ito

{"title":"Somatosensory influence on auditory cortical response of self-generated sound","authors":"Nozomi Endo , Coriandre Vilain , Kimitaka Nakazawa , Takayuki Ito","doi":"10.1016/j.neuropsychologia.2025.109103","DOIUrl":"10.1016/j.neuropsychologia.2025.109103","url":null,"abstract":"<div><div>Motor execution which results in the generation of sounds attenuates the cortical response to these self-generated sounds. This attenuation has been explained as a result of motor relevant processing. The current study shows that corresponding somatosensory inputs can also change the auditory processing of a self-generated sound. We recorded auditory event-related potentials (ERP) in response to self-generated sounds and assessed how the amount of auditory attenuation changed according to the somatosensory inputs. The sound stimuli were generated by a finger movement that pressed on a virtual object, which was produced by a haptic robotic device. Somatosensory inputs were modulated by changing the stiffness of this virtual object (low and high) in an unpredictable manner. For comparison purposes, we carried out the same test with a computer keyboard, which is conventionally used to induce the auditory attenuation of self-generated sound. While N1 and P2 attenuations were clearly induced in the control condition with the keyboard as has been observed in previous studies, when using the robotic device the amplitude of N1 was found to vary according to the stiffness of the virtual object. The amplitude of N1 in the low stiffness condition was similar to that found using the keyboard for the same condition but not in the high stiffness condition. In addition, P2 attenuation did not differ between stiffness conditions. The waveforms of auditory ERP after 200 ms also differed according to the stiffness conditions. The estimated source of N1 attenuation was located in the right parietal area. These results suggest that somatosensory inputs during movement can modify the auditory processing of self-generated sound. The auditory processing of self-generated sound may represent self-referenced processing like an embodied process or an action-perception mechanism.</div></div>","PeriodicalId":19279,"journal":{"name":"Neuropsychologia","volume":"211 ","pages":"Article 109103"},"PeriodicalIF":2.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebellum as a neural substrate for impoverishment in early psychosis 小脑作为早期精神病贫化的神经基质

IF 2 3区心理学

Neuropsychologia Pub Date : 2025-02-21 DOI: 10.1016/j.neuropsychologia.2025.109094

Eric Toyota , Michael Mackinley , Angelica M. Silva , Yuchao Jiang , Tyler C. Dalal , Caroline Nettekoven , Lena Palaniyappan

{"title":"Cerebellum as a neural substrate for impoverishment in early psychosis","authors":"Eric Toyota , Michael Mackinley , Angelica M. Silva , Yuchao Jiang , Tyler C. Dalal , Caroline Nettekoven , Lena Palaniyappan","doi":"10.1016/j.neuropsychologia.2025.109094","DOIUrl":"10.1016/j.neuropsychologia.2025.109094","url":null,"abstract":"<div><h3>Background</h3><div>Formal Thought Disorder and includes both positive (i.e., disorganized speech) and negative (i.e., impoverished speech) symptoms. Emerging evidence suggests that the cerebellum plays a critical role in cognitive functions, including language processing. This study leverages Natural Language Processing to objectively measure language disturbances in patients with first-episode psychosis and investigates the relationship between these disturbances and cerebellar structure.</div></div><div><h3>Methods</h3><div>Fifty-four patients with schizophrenia, either drug-naïve or minimally medicated, were recruited from an early psychosis program. Impoverished thought was assessed using the Thought Language Index while lexico-semantic features (affect, cognitive, linguistic, perception, time) were identified from speech samples analyzed using the Linguistic Inquiry Word Count-22 software. Structural cerebellar analysis was completed on 7.0 Tesla MRI scans using voxel-based morphometry (VBM) to measure global and regional grey matter volume changes.</div></div><div><h3>Results</h3><div>Linear regression analysis revealed that reduced perceptual word usage was the strongest predictor of impoverished thinking. Correlational analysis identified reduced cerebellar volumes in patients with lower LIWC-based perception scores. VBM localized this relationship to a cluster in the right posterolateral cerebellar hemisphere, an area related to executive demand and verb generation function.</div></div><div><h3>Conclusion</h3><div>The cerebellum contributes to impoverished thinking in early psychosis, likely by influencing the lexical expression of perceptual experiences. This underscores the cerebellum's role in higher-order cognitive processes relevant to psychotic disorders and its potential as a therapeutic target for language and cognitive deficits in schizophrenia.</div></div>","PeriodicalId":19279,"journal":{"name":"Neuropsychologia","volume":"210 ","pages":"Article 109094"},"PeriodicalIF":2.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143478830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0