Neurology最新文献

{"title":"Antibodies in Autoimmune Neuropathies: What to Test, How to Test, Why to Test.","authors":"","doi":"10.1212/WNL.0000000000210298","DOIUrl":"https://doi.org/10.1212/WNL.0000000000210298","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"104 3","pages":"e210298"},"PeriodicalIF":7.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In the Same Vein as My Father.","authors":"Leo Sison Acosta, Lealani Mae Y Acosta","doi":"10.1212/WNL.0000000000210306","DOIUrl":"https://doi.org/10.1212/WNL.0000000000210306","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"104 3","pages":"e210306"},"PeriodicalIF":7.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized Phase 2 Study of FcRn Antagonist Efgartigimod in Generalized Myasthenia Gravis.","authors":"","doi":"10.1212/WNL.0000000000210299","DOIUrl":"https://doi.org/10.1212/WNL.0000000000210299","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"104 3","pages":"e210299"},"PeriodicalIF":7.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Response: Teratogenesis, Perinatal, and Neurodevelopmental Outcomes After In Utero Exposure to Antiseizure Medication: Practice Guideline From the AAN, AES, and SMFM.","authors":"Mark Robert Keezer, Alison M Pack, Page B Pennell, George Saade, David Gloss, Heidi M Munger Clary","doi":"10.1212/WNL.0000000000209824","DOIUrl":"https://doi.org/10.1212/WNL.0000000000209824","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"104 3","pages":"e209824"},"PeriodicalIF":7.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Response: Teratogenesis, Perinatal, and Neurodevelopmental Outcomes After In Utero Exposure to Antiseizure Medication: Practice Guideline From the AAN, AES, and SMFM.","authors":"Mark Robert Keezer, Alison M Pack","doi":"10.1212/WNL.0000000000209894","DOIUrl":"https://doi.org/10.1212/WNL.0000000000209894","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"104 3","pages":"e209894"},"PeriodicalIF":7.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiological Significance of α-Synuclein in Sympathetic Nerves: In Vivo Observations.","authors":"Risa Isonaka, Patti Sullivan, David S Goldstein","doi":"10.1212/WNL.0000000000210215","DOIUrl":"10.1212/WNL.0000000000210215","url":null,"abstract":"<p><strong>Background and objectives: </strong>Lewy body diseases (LBDs) such as Parkinson disease (PD) feature increased deposition of α-synuclein (α-syn) in cutaneous sympathetic noradrenergic nerves. The pathophysiologic significance of sympathetic intraneuronal α-syn is unclear. We reviewed data about immunoreactive α-syn, tyrosine hydroxylase (TH, a marker of catecholaminergic fibers), and the sympathetic neurotransmitter norepinephrine (NE) in skin biopsies from control participants and patients with PD, the related LBD pure autonomic failure (PAF), the non-LBD synucleinopathy multiple system atrophy (MSA), or neurologic postacute sequelae of severe acute respiratory syndrome coronavirus 2 (neuro-PASC).</p><p><strong>Methods: </strong>In a retrospective observational study, we reviewed data about α-syn-TH colocalization indexes and immunoreactive α-syn and TH signal intensities in arrector pili muscles, blood vessels, and sweat glands from neck skin biopsies and NE concentrations in simultaneously obtained thigh skin biopsies from participants studied at the NIH Clinical Center. LBD, MSA, and control group data were assessed by analyses of variance with the Tukey post hoc test for multiple comparisons. Similar analyses were performed for patients with PD or neuro-PASC vs control.</p><p><strong>Results: </strong>Dermal α-syn-TH colocalization indexes and α-syn signal intensities from neck skin biopsies were examined in 18 controls (mean age 58 years, 50% female) and 53 LBD (66, 34%), 15 MSA (61, 33%), and 11 neuro-PASC (52, 82%) patients. The LBD group had higher α-syn-TH colocalization indexes than the controls (mean difference = 1.495, 95% CI 1.081-1.909, <i>p</i> < 0.0001) and increased α-syn signal intensities in all 3 skin constituents (arrector pili: mean difference = 2.743, 95% CI 1.608-3.879, <i>p</i> < 0.0001; blood vessels: mean difference = 2.157, 95% CI 1.095-3.219, <i>p</i> < 0.0001; sweat glands: mean difference = 4.136, 95% CI 1.704-6.567, <i>p</i> < 0.0001). The groups did not differ in either immunoreactive TH or NE. The neuro-PASC and PD groups had elevated α-syn-TH colocalization indexes compared with the controls, also with no group differences in immunoreactive TH or NE contents.</p><p><strong>Discussion: </strong>LBDs and neuro-PASC entail increased α-syn-TH colocalization indexes in skin biopsies, without evidence of local denervation or noradrenergic deficiency. The results fail to support toxicity of intraneuronal α-syn in cutaneous sympathetic noradrenergic nerves in either LBDs or neuro-PASC. The neuro-PASC data raise the possibility of sympathetic intraneuronal α-syn deposition as part of postinfectious immune or inflammatory processes.</p>","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"104 3","pages":"e210215"},"PeriodicalIF":7.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Are the Functions of Caveolins and Their Role in Neurologic Disorders?","authors":"Eduardo Benarroch","doi":"10.1212/WNL.0000000000213341","DOIUrl":"https://doi.org/10.1212/WNL.0000000000213341","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"104 3","pages":"e213341"},"PeriodicalIF":7.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142979433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Norman J. Schatz, MD (1936-2024).","authors":"Steven L Galetta, Teshamae S Monteith","doi":"10.1212/WNL.0000000000213331","DOIUrl":"https://doi.org/10.1212/WNL.0000000000213331","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"104 3","pages":"e213331"},"PeriodicalIF":7.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covert Vascular Brain Injury and Cognitive Dysfunction Among Chinese Adults Living in Canada and China: The CAHHM and PURE-MIND Studies.","authors":"Calvin Ke, Sonia S Anand, Eric E Smith, Karleen M Schulze, Alan Moody, Scott Lear, Paul Poirier, Trevor Dummer, Dipika Desai, Vivekanandan Thayalasuthan, Salim Yusuf, Koon Kang Teo, Andreas Wielgosz, Douglas Lee","doi":"10.1212/WNL.0000000000210246","DOIUrl":"10.1212/WNL.0000000000210246","url":null,"abstract":"<p><strong>Background and objective: </strong>It is unclear whether variation in covert cerebrovascular disease prevalence is attributable to ethnic differences or to other factors. We aimed to examine the associations of country of residence with covert vascular brain injury (VBI) and cognitive dysfunction among Chinese adults residing in Canada and China.</p><p><strong>Methods: </strong>This was a multisite cross-sectional study of Chinese adults aged 40-80 years in the Canadian Alliance for Healthy Hearts and Healthy Minds (CAHHM; January 1, 2014, to December 31, 2018) and Prospective Urban Rural Epidemiological-Mind (PURE-MIND; November 1, 2010, to July 31, 2015) cohorts living in Canada and China. The exposure was country of residence. The co-primary outcomes were covert VBI (defined as MRI findings of high white matter hyperintensities or covert brain infarct) and cognitive dysfunction (defined as a Montreal Cognitive Assessment [MoCA] score <26). We used generalized linear models to describe the association between country of residence and each outcome, adjusting for selected covariates.</p><p><strong>Results: </strong>We included 884 adults living in Canada (mean age 57.3 years, 55.4% female) and 473 living in China (mean age 56.8 years, 60.3% female). Participants in Canada had a lower prevalence of covert VBI (age 65-79 years: male, 11.5%; female, 12.2%) than those living in China (age 65-79 years: male, 62.9%; female, 52.1%). Prevalence of MoCA score <26 was lower among men and women in Canada (age 65-79 years: 40.2% and 30.0%, respectively) than among men and women in China (age 65-79 years: 74.3% and 79.2%). Living in China was associated with a 6-fold increase in the odds of covert VBI (5.85, 4.06-8.45), which remained significant after covariate adjustment. Living in China was associated with a 7-fold increase in the odds of MoCA score <26 (6.98, 5.38-9.04), which was no longer significant after covariate adjustment.</p><p><strong>Discussion: </strong>Despite sharing a similar ethnicity, the prevalence of covert VBI and cognitive dysfunction varied substantially by country of residence. Disparities in cognitive dysfunction were completely explained by differences in education and traditional cerebrovascular risk factors, whereas disparities in covert VBI prevalence were only partially explained by differences in such factors, suggesting a role for other environmental factors.</p>","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"104 3","pages":"e210246"},"PeriodicalIF":7.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Neurology® Open Access</i>: Welcoming a New Member of the <i>Neurology®</i> Family of Journals.","authors":"Amy C Kunchok, Morgan S Sorenson, Patricia K Baskin, José G Merino","doi":"10.1212/WNL.0000000000213350","DOIUrl":"https://doi.org/10.1212/WNL.0000000000213350","url":null,"abstract":"","PeriodicalId":19256,"journal":{"name":"Neurology","volume":"104 3","pages":"e213350"},"PeriodicalIF":7.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}