Iron Hemostasis in Patients With Subarachnoid Hemorrhage and the Role of Early CSF Drainage.

IF 7.7 1区 医学 Q1 CLINICAL NEUROLOGY
Neurology Pub Date : 2025-07-08 Epub Date: 2025-06-09 DOI:10.1212/WNL.0000000000213767
Tianshu Bi, Henner Koch, Benedikt Kremer, Anke Höllig
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引用次数: 0

Abstract

Early brain injury and delayed cerebral ischemia are combined intricate processes, and they represent the principal cause of subarachnoid hemorrhage (SAH)-related morbidity and mortality worldwide. Recent studies have shown that early lumbar CSF drainage can be used to decrease the incidence of delayed cerebral ischemia and improve long-term outcome. This approach has provided novel insights into post-SAH management that lessened the burden of secondary infarction and decreased the rate of unfavorable outcome. Given that the evaluation of this approach is contingent on prospective trial and early-stage randomized clinical trial, we review insights from studies that have elucidated the mechanisms underlying deterioration in SAH. We explore the role of iron homeostasis in the restoration of normal CSF circulation and the stabilization of optimal cerebral physiology to alleviate early brain injury and delayed neurologic impairment after SAH to advance the current understanding of SAH management.

蛛网膜下腔出血患者铁止血及早期脑脊液引流的作用。
早期脑损伤和延迟性脑缺血是一个复杂的综合过程,它们是世界范围内蛛网膜下腔出血(SAH)相关发病率和死亡率的主要原因。最近的研究表明,早期腰椎脑脊液引流可以减少迟发性脑缺血的发生率并改善长期预后。这种方法为sah后的治疗提供了新的见解,减轻了继发性梗死的负担,降低了不良结果的发生率。鉴于该方法的评估取决于前瞻性试验和早期随机临床试验,我们回顾了阐明SAH恶化机制的研究成果。我们探讨铁稳态在恢复正常脑脊液循环和稳定最佳脑生理中的作用,以减轻SAH后早期脑损伤和延迟性神经功能损害,以促进目前对SAH治疗的认识。
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来源期刊
Neurology
Neurology 医学-临床神经学
CiteScore
12.20
自引率
4.00%
发文量
1973
审稿时长
2-3 weeks
期刊介绍: Neurology, the official journal of the American Academy of Neurology, aspires to be the premier peer-reviewed journal for clinical neurology research. Its mission is to publish exceptional peer-reviewed original research articles, editorials, and reviews to improve patient care, education, clinical research, and professionalism in neurology. As the leading clinical neurology journal worldwide, Neurology targets physicians specializing in nervous system diseases and conditions. It aims to advance the field by presenting new basic and clinical research that influences neurological practice. The journal is a leading source of cutting-edge, peer-reviewed information for the neurology community worldwide. Editorial content includes Research, Clinical/Scientific Notes, Views, Historical Neurology, NeuroImages, Humanities, Letters, and position papers from the American Academy of Neurology. The online version is considered the definitive version, encompassing all available content. Neurology is indexed in prestigious databases such as MEDLINE/PubMed, Embase, Scopus, Biological Abstracts®, PsycINFO®, Current Contents®, Web of Science®, CrossRef, and Google Scholar.
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